Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.133 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.2573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.133 | 0.517 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.133 | 0.5088 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.133 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.133 | 0.517 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.133 | 0.515 |
Onchocerca volvulus | 0.0072 | 0.133 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.133 | 0.4481 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.133 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0321 | 0.1212 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.133 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.133 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0321 | 0.1212 |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.133 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.133 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.133 | 0.515 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0321 | 0.1212 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0321 | 0.1249 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.2481 | 0.9641 |
Onchocerca volvulus | 0.0072 | 0.133 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.2481 | 0.9641 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.2573 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.2481 | 0.9635 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0043 | 0.0167 |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.133 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.133 | 0.5088 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0321 | 0.1101 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.133 | 0.5088 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.133 | 0.517 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2573 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.133 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.133 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.031 | 0.1207 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0321 | 0.1212 |
Brugia malayi | beta-lactamase | 0.0072 | 0.133 | 0.5088 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.133 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2573 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0321 | 0.1212 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.133 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.133 | 1 | |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0011 | 0.0043 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0321 | 0.1212 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.133 | 0.517 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.133 | 0.517 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.133 | 0.517 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0321 | 0.1249 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.133 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.133 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.133 | 0.517 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.2573 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.133 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.133 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0321 | 0.1101 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.133 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.2573 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.133 | 0.4481 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.133 | 0.517 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0321 | 0.1249 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.2573 | 1 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.2573 | 1 |
Brugia malayi | RNA binding protein | 0.0127 | 0.2573 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2573 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.2573 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.