Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PAN domain-containing protein | 0.0034 | 0.0543 | 0.1443 |
Brugia malayi | Protein kinase domain containing protein | 0.0053 | 0.1165 | 0.3098 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0053 | 0.1165 | 0.2114 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0053 | 0.1165 | 0.6338 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.1184 | 0.209 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0022 | 0.0144 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0607 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.1924 | 1 |
Toxoplasma gondii | microneme protein MIC17A | 0.0034 | 0.0543 | 0.0509 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0056 | 0.1287 | 0.2336 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1287 | 0.3424 |
Toxoplasma gondii | microneme protein, putative | 0.0034 | 0.0543 | 0.0509 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0022 | 0.0144 | 0.0383 |
Toxoplasma gondii | PAN domain-containing protein | 0.0316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0022 | 0.0144 | 0.0383 |
Toxoplasma gondii | propionate-CoA ligase | 0.0022 | 0.0144 | 0.0109 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0075 | 0.1924 | 1 |
Brugia malayi | Csnk2b protein | 0.0072 | 0.1817 | 0.4833 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0075 | 0.1924 | 0.3443 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0053 | 0.1165 | 0.6338 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.1184 | 0.209 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0.0543 | 0.0509 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0022 | 0.0144 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0075 | 0.1924 | 0.3443 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.1184 | 0.209 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0022 | 0.0144 | 0.0188 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0072 | 0.1817 | 0.941 |
Toxoplasma gondii | PAN domain-containing protein | 0.0034 | 0.0543 | 0.0509 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0022 | 0.0144 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Trichomonas vaginalis | hypothetical protein | 0.0182 | 0.5509 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.1924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0036 | 0.0095 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0022 | 0.0144 | 0.0748 |
Onchocerca volvulus | 0.0022 | 0.0144 | 0.0573 | |
Leishmania major | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0748 |
Brugia malayi | AMP-binding enzyme family protein | 0.0022 | 0.0144 | 0.0383 |
Toxoplasma gondii | 1,3(4)-beta-glucanase | 0.0034 | 0.0543 | 0.0509 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.1924 | 0.3318 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0022 | 0.0144 | 0.0188 |
Toxoplasma gondii | PAN domain-containing protein | 0.0034 | 0.0543 | 0.0509 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0075 | 0.1924 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0022 | 0.0144 | 0.0383 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0075 | 0.1924 | 1 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Onchocerca volvulus | 0.0022 | 0.0144 | 0.0573 | |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0072 | 0.1817 | 1 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Toxoplasma gondii | microneme protein MIC4 | 0.0034 | 0.0543 | 0.0509 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0748 |
Loa Loa (eye worm) | casein kinase II | 0.0021 | 0.0109 | 0.029 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.1165 | 0.6054 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0072 | 0.1817 | 0.941 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0022 | 0.0144 | 0.0383 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0075 | 0.1924 | 0.3318 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0053 | 0.1165 | 0.6338 |
Loa Loa (eye worm) | phosphatidylinositol-specific phospholipase C | 0.0019 | 0.0036 | 0.0095 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.1924 | 0.3318 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3298 |
Onchocerca volvulus | 0.0075 | 0.1924 | 1 | |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0034 | 0.0543 | 0.1443 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.1924 | 0.5118 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1287 | 0.3424 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0056 | 0.1287 | 0.2336 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1165 | 0.3098 |
Brugia malayi | AMP-binding enzyme family protein | 0.0022 | 0.0144 | 0.0383 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0182 | 0.5509 | 1 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0072 | 0.1817 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Toxoplasma gondii | PAN domain-containing protein | 0.0034 | 0.0543 | 0.0509 |
Brugia malayi | AMP-binding enzyme family protein | 0.0022 | 0.0144 | 0.0383 |
Loa Loa (eye worm) | oxidoreductase | 0.0022 | 0.0144 | 0.0383 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0022 | 0.0144 | 0.0193 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0072 | 0.1817 | 0.9433 |
Toxoplasma gondii | kringle domain-containing protein | 0.0053 | 0.1165 | 0.1133 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0022 | 0.0144 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0022 | 0.0144 | 0.0607 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0022 | 0.0144 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1287 | 0.3424 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0075 | 0.1924 | 0.3318 |
Toxoplasma gondii | PAN domain-containing protein | 0.0034 | 0.0543 | 0.0509 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.1924 | 0.5118 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0022 | 0.0144 | 0.0188 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0022 | 0.0144 | 0.0188 |
Leishmania major | protein kinase ck2 regulatory subunit, putative | 0.0072 | 0.1817 | 0.9443 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.1924 | 0.3318 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Brugia malayi | PAN domain containing protein | 0.0034 | 0.0543 | 0.1443 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0022 | 0.0144 | 0.0188 |
Trypanosoma brucei | Casein kinase II subunit beta, putative | 0.0072 | 0.1817 | 1 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0034 | 0.0543 | 0.1443 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.1924 | 0.3318 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.013 | 0.3759 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0022 | 0.0144 | 0.0065 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0607 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0034 | 0.0543 | 0.1443 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0056 | 0.1287 | 0.213 |
Plasmodium falciparum | casein kinase II beta chain | 0.0072 | 0.1817 | 0.3298 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0022 | 0.0144 | 0.0188 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0022 | 0.0144 | 0.0383 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0056 | 0.1287 | 0.2278 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0053 | 0.1165 | 0.2114 |
Brugia malayi | casein kinase II, putaitve | 0.0021 | 0.0109 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0036 | 0.0095 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 0.5509 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 0.5509 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 0.5509 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182 | 0.5509 | 1 |
Toxoplasma gondii | PAN/Apple domain-containing protein | 0.0034 | 0.0543 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0383 |
Toxoplasma gondii | subtilisin SUB12 | 0.0034 | 0.0543 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.1924 | 0.5118 |
Brugia malayi | Phosphatidylinositol-specific phospholipase C, X domain containing protein | 0.0019 | 0.0036 | 0.0095 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0053 | 0.1165 | 0.3098 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0034 | 0.0543 | 0.1443 |
Giardia lamblia | Casein kinase II beta chain | 0.0072 | 0.1817 | 1 |
Onchocerca volvulus | 0.0022 | 0.0144 | 0.0573 | |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0261 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Onchocerca volvulus | 0.0022 | 0.0144 | 0.0573 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0075 | 0.1924 | 0.3318 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1287 | 0.3424 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0.0543 | 0.0509 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0022 | 0.0144 | 0.0607 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0022 | 0.0144 | 0.0607 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.1184 | 0.209 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0022 | 0.0144 | 0.0188 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0072 | 0.1817 | 0.9433 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0075 | 0.1924 | 0.3318 |
Leishmania major | phospholipase c-like protein | 0.0019 | 0.0036 | 0.0186 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0072 | 0.1817 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0022 | 0.0144 | 0.0607 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0261 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0072 | 0.1817 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0022 | 0.0144 | 0.0607 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.1165 | 0.6411 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0072 | 0.1817 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1924 | 0.5118 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1287 | 0.3424 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1924 | 0.5118 |
Toxoplasma gondii | casein kinase ii regulatory subunit protein | 0.0072 | 0.1817 | 0.1788 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0022 | 0.0144 | 0.0793 |
Onchocerca volvulus | 0.0053 | 0.1165 | 0.5979 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.1924 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0072 | 0.1817 | 0.941 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182 | 0.5509 | 0.5493 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0022 | 0.0144 | 0.0607 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182 | 0.5509 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0053 | 0.1165 | 0.3098 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0075 | 0.1924 | 0.3318 |
Brugia malayi | Variant SH3 domain containing protein | 0.013 | 0.3759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1924 | 0.5118 |
Onchocerca volvulus | 0.0034 | 0.0543 | 0.2684 | |
Toxoplasma gondii | microneme protein MIC17B | 0.0034 | 0.0543 | 0.0509 |
Plasmodium falciparum | casein kinase II beta chain | 0.0072 | 0.1817 | 0.3298 |
Toxoplasma gondii | microneme protein MIC17C | 0.0034 | 0.0543 | 0.0509 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0022 | 0.0144 | 0.0188 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0075 | 0.1924 | 0.3318 |
Toxoplasma gondii | ck2 beta subunit | 0.0072 | 0.1817 | 0.1788 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0022 | 0.0144 | 0.0188 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Loa Loa (eye worm) | Csnk2b protein | 0.0072 | 0.1817 | 0.4833 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0543 | 0.1443 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3298 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0072 | 0.1817 | 0.3163 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 0.5509 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.