Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PHD-finger family protein | 0.0024 | 0.1356 | 0.0234 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0947 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0114 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1149 | 0.124 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7961 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.7961 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.1149 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0618 | 0.0774 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7961 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7978 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.7961 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7961 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.7961 | 0.9979 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.736 | 0.9245 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.4092 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0114 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.7961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0114 | 0.0123 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.7961 | 0.7696 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.7961 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0106 | 0.0114 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.1149 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.7961 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.1149 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.1149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9262 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.7961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4417 | 0.4769 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.7961 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.7961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0114 | 0.0123 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0114 | 0.0123 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.1149 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.1149 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3667 | 0.2845 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.7961 | 0.8595 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.7961 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.1149 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0947 | 0.119 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0114 | 0.0123 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7961 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0947 | 0.119 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0114 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1149 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.7961 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0618 | 0.0667 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1149 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.7961 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1149 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.4092 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1149 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1149 | 1 |
Onchocerca volvulus | 0.0023 | 0.1149 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.7961 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.736 | 0.9245 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1149 | 0.124 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.7961 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1149 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0435 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1149 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3679 | 0.3972 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0435 | 0.0546 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0435 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4087 | 0.4413 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1149 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.7961 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0114 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.