Detailed information for compound 799298

Basic information

Technical information
  • TDR Targets ID: 799298
  • Name: N-[(5-phenyltetrazol-2-yl)methyl]acetamide
  • MW: 217.227 | Formula: C10H11N5O
  • H donors: 1 H acceptors: 4 LogP: 1.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NCn1nnc(n1)c1ccccc1
  • InChi: 1S/C10H11N5O/c1-8(16)11-7-15-13-10(12-14-15)9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,11,16)
  • InChiKey: LRJLVAJFUBQGGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(5-phenyl-2-tetrazolyl)methyl]acetamide
  • N-[(5-phenyl-1,2,3,4-tetrazol-2-yl)methyl]ethanamide
  • A3329/0141366
  • ZINC00112025

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.0042 0.014 0.0359
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.007 0.0204
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0089 0.0268
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.005 0.0155
Toxoplasma gondii aspartyl protease ASP3 0.0042 0.014 0.0426
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0096 0.0366 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0067 0.0209
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0005 0.0014
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0005 0.0122
Trichomonas vaginalis hypothetical protein 0.0768 0.3192 1
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0739 0.307 0.7876
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0052 0.0183 0.0573
Leishmania major hypothetical protein, conserved 0.0025 0.007 0.1901
Schistosoma mansoni thyroid hormone receptor 0.002 0.0049 0.0085
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0049 0.0085
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0052 0.0183 0.0559
Mycobacterium ulcerans thioesterase 0.002 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0405 0.1667 0.4276
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0052 0.0183 0.0559
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0768 0.3192 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0022
Brugia malayi tailless protein 0.0009 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0294 0.0755
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0042 0.014 0.0439
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0004 0.0004
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0052 0.0183 0.4992
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.054 0.0951
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0073 0.0219
Brugia malayi glucose-6-phosphate dehydrogenase 0.0096 0.0366 0.094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0022
Brugia malayi MH2 domain containing protein 0.0122 0.0479 0.1229
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0012 0.0029
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0031 0.0094 0.2555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0049 0.0124
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0064 0.019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0022
Onchocerca volvulus 0.0052 0.0183 0.2354
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0052 0.0183 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0229 0.0404
Plasmodium falciparum plasmepsin X 0.0042 0.014 0.0426
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0061 0.0192
Schistosoma mansoni coup transcription factor 0.002 0.0049 0.0085
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0052 0.0183 0.0559
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0004 0.0004
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0191 0.0767 0.1967
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Onchocerca volvulus 0.0009 0.0004 0.0011
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0149 0.1909
Echinococcus granulosus dnaJ subfamily B 0.0407 0.1674 0.2953
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0052 0.0183 0.0573
Echinococcus multilocularis lamin 0.0026 0.0074 0.0074
Brugia malayi nuclear receptor RXR 0.0009 0.0004 0.0011
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0037 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0229 0.0404
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0073 0.0219
Mycobacterium ulcerans hypothetical protein 0.0023 0.0061 0.0192
Echinococcus multilocularis cpg binding protein 0.003 0.0091 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1901
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0067 0.0172
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0017 0.003
Echinococcus multilocularis geminin 0.0515 0.2127 0.2127
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0157
Onchocerca volvulus 0.002 0.0049 0.0593
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0009 0.0003 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0049 0.0085
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0005 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0049 0.0085
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0047 0.0146
Echinococcus granulosus microtubule associated protein 2 0.1358 0.567 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0037 0.0105
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0052 0.0183 0.0573
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0367 0.0647
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0061 0.0182
Brugia malayi STAT protein, DNA binding domain containing protein 0.0155 0.0614 0.1574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0236 0.0955 0.0955
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0768 0.3192 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0061 0.0158
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0104 0.0402 0.1247
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0179
Chlamydia trachomatis DNA ligase 0.001 0.0005 0.0014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0067 0.0199
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Giardia lamblia Replication factor C, subunit 1 0.001 0.0005 0.0111
Plasmodium vivax aspartyl proteinase, putative 0.0042 0.014 0.0426
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0049 0.0125
Brugia malayi topoisomerase 0.001 0.0005 0.0012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0004 0.0011
Onchocerca volvulus 0.003 0.0089 0.1117
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0229 0.0588
Brugia malayi Muscleblind-like protein 0.0734 0.3049 0.782
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0005 0.0122
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.0183 0.0564
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0479 0.1228
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0032 0.0098 0.266
Brugia malayi nuclear hormone receptor 0.002 0.0049 0.0125
Entamoeba histolytica hypothetical protein 0.001 0.0005 0.0052
Mycobacterium ulcerans polyketide synthase 0.0024 0.0067 0.0209
Loa Loa (eye worm) STAT protein 0.0155 0.0614 0.1574
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0061 0.0707
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0049 0.0048
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0768 0.3192 1
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0005 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0049 0.0085
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0049 0.0048
Schistosoma mansoni hypothetical protein 0.004 0.0131 0.0231
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0137 0.0351
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0004 0.0011
Echinococcus granulosus tar DNA binding protein 0.0063 0.0229 0.0404
Echinococcus granulosus GPCR family 2 0.0078 0.0294 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0014
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0052 0.0183 0.0564
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0004 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0285
Loa Loa (eye worm) hypothetical protein 0.0078 0.0294 0.0754
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0049 0.0085
Brugia malayi Pepsin A precursor 0.0042 0.014 0.036
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0096 0.0366 0.1147
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0229 0.0588
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0049 0.0048
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0104 0.0402 0.1247
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0137 0.0137
Brugia malayi nuclear receptor RXR 0.0011 0.0009 0.0023
Entamoeba histolytica hypothetical protein 0.0215 0.0866 1
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Echinococcus multilocularis muscleblind protein 1 0.0734 0.3049 0.3048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0023 0.0059
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0052 0.0183 0.4992
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0094
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0104 0.0402 0.1247
Loa Loa (eye worm) hypothetical protein 0.0052 0.0183 0.0469
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0768 0.3192 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0049 0.0593
Plasmodium falciparum enoyl-acyl carrier reductase 0.0768 0.3192 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0052 0.0183 0.0573
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Echinococcus granulosus survival motor neuron protein 1 0.0936 0.3898 0.6875
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0104 0.0402 0.1259
Brugia malayi hypothetical protein 0.0215 0.0866 0.2221
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0096 0.0366 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0049 0.0085
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0183 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0014
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0047 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0285
Brugia malayi hypothetical protein 0.0009 0.0004 0.0011
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0062 0.0227 0.0697
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0379 0.0668
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0677 0.1736
Plasmodium falciparum plasmepsin VIII, putative 0.0042 0.014 0.0426
Loa Loa (eye worm) hypothetical protein 0.0099 0.0379 0.0972
Brugia malayi hypothetical protein 0.001 0.0005 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0137 0.0242
Brugia malayi ecdysteroid receptor 0.002 0.0049 0.0125
Mycobacterium ulcerans thioesterase TesA 0.002 0.005 0.0155
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0003
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0096 0.0366 0.0939
Loa Loa (eye worm) oxidoreductase 0.0052 0.0183 0.0469
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0032 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0033 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.1358 0.567 0.567
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0183 0.0573
Echinococcus granulosus lamin dm0 0.0026 0.0074 0.013
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0031 0.0082
Brugia malayi aspartic protease BmAsp-2, identical 0.0042 0.014 0.036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0162 0.0414
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0052 0.0183 0.2112
Loa Loa (eye worm) hypothetical protein 0.0583 0.2412 0.6187
Plasmodium falciparum plasmepsin I 0.0042 0.014 0.0426
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0061 0.0192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0094
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0005 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0229 0.0404
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0049 0.0048
Schistosoma mansoni hypothetical protein 0.0515 0.2127 0.3751
Schistosoma mansoni hypothetical protein 0.0078 0.0294 0.0518
Brugia malayi ecdysone receptor 0.0009 0.0004 0.0011
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.005 0.0146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0216 0.0666
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0061 0.0192
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0479 0.1228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0049 0.0125
Echinococcus multilocularis GPCR, family 2 0.0078 0.0294 0.0294
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0004 0.0011
Loa Loa (eye worm) RNA binding protein 0.0063 0.0229 0.0588
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0037 0.0102
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Brugia malayi glutaminase DH11.1 0.0535 0.2213 0.5678
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0118 0.0358
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Brugia malayi intermediate filament protein 0.0026 0.0074 0.019
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0077 0.0227
Schistosoma mansoni hypothetical protein 0.004 0.0131 0.0231
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0216 0.038
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0042 0.014 0.0359
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0118 0.0367
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0229 0.0404
Schistosoma mansoni microtubule-associated protein tau 0.1358 0.567 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Echinococcus granulosus intermediate filament protein 0.0026 0.0074 0.013
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0005 0.0000010796
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0049 0.0085
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.014 0.0359
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0073 0.0229
Plasmodium falciparum plasmepsin II 0.0042 0.014 0.0426
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Echinococcus multilocularis survival motor neuron protein 1 0.0936 0.3898 0.3898
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0052 0.0183 0.0559
Schistosoma mansoni transcription factor LCR-F1 0.0215 0.0866 0.1526
Echinococcus multilocularis protein patched 0.0041 0.0137 0.0137
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0052 0.0183 0.4992
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0033 0.0093
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0061 0.167
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0049 0.0085
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0096 0.0366 0.0366
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0768 0.3192 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0216 0.038
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0052 0.0183 0.0564
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0049 0.0085
Plasmodium falciparum plasmepsin VI 0.0042 0.014 0.0426
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0367 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0049 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.0204
Echinococcus multilocularis tumor protein p63 0.0674 0.2798 0.2798
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0285
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.1006 0.2581
Brugia malayi TAR-binding protein 0.0063 0.0229 0.0588
Plasmodium falciparum plasmepsin IV 0.0042 0.014 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0049 0.0124
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0373 0.0658
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.0007
Schistosoma mansoni intermediate filament proteins 0.0026 0.0074 0.013
Trypanosoma brucei pteridine reductase 1 0.0052 0.0183 0.4992
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0005 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0061 0.0192
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0009 0.0003 0.0009
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0183 0.0573
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0005 0.0014
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0006 0.0008
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0104 0.0402 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0096 0.0366 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0042 0.014 0.014
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0096 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.1592
Loa Loa (eye worm) hypothetical protein 0.0313 0.1279 0.3281
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0061 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0049 0.0125
Brugia malayi nuclear receptor NHR-88 0.002 0.0049 0.0125
Onchocerca volvulus 0.0049 0.0171 0.2199
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0096 0.0366 0.1147
Onchocerca volvulus 0.0029 0.0085 0.1064
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Plasmodium vivax aspartyl protease, putative 0.0042 0.014 0.0426
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0067 0.0209
Mycobacterium ulcerans polyketide synthase 0.0026 0.0073 0.0229
Brugia malayi 6-phosphogluconolactonase family protein 0.0009 0 0.0001
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0004 0.0011
Brugia malayi RNA binding protein 0.0063 0.0229 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0049 0.0125
Onchocerca volvulus 0.0026 0.0074 0.0925
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0009 0.0022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0004 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0049 0.0085
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0061 0.0192
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0005 0.0014
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0104 0.0402 0.1259
Brugia malayi CHE-14 protein 0.0041 0.0137 0.0352
Schistosoma mansoni hypothetical protein 0.017 0.0677 0.1193
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0074 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0055
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0118 0.0358
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0096 0.0366 0.0646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0162 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0049 0.0125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0022
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.0183 0.0564
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0367 0.0941
Onchocerca volvulus 0.0052 0.0183 0.2354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0049 0.0124
Mycobacterium ulcerans oxidoreductase 0.0052 0.0183 0.0573
Echinococcus granulosus tumor protein p63 0.0674 0.2798 0.4934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0294 0.0754
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0067 0.0209
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0564
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0067 0.0199
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0215 0.0866 0.0865
Echinococcus multilocularis protein dispatched 1 0.0047 0.0162 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0014
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0005 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.007 0.1901
Leishmania major pteridine reductase 1 0.0052 0.0183 0.4992
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Plasmodium falciparum plasmepsin V 0.0042 0.014 0.0426
Brugia malayi nuclear receptor NHR-88 0.0009 0.0004 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Loa Loa (eye worm) DR-78 0.0009 0.0004 0.001
Trichomonas vaginalis glutaminase, putative 0.0535 0.2213 0.6935
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0004 0.0007
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0052 0.0183 0.0559
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0052 0.0183 0.0573
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0405 0.1667 0.4277
Loa Loa (eye worm) hypothetical protein 0.0936 0.3898 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0012 0.002
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0005 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0091 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0162 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0061 0.0192
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Schistosoma mansoni hypothetical protein 0.0191 0.0767 0.1352
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0032 0.01
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0004 0.0011
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0062 0.0227 0.071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0005 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0137 0.0429
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0009 0.0003 0.0009
Plasmodium falciparum plasmepsin III 0.0042 0.014 0.0426
Schistosoma mansoni topbp1 0.001 0.0005 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0215 0.0866 0.1526
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0066 0.0167
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0033 0.0104 0.0316
Brugia malayi CXXC zinc finger family protein 0.0029 0.0085 0.0217
Plasmodium vivax plasmepsin V, putative 0.0042 0.014 0.0426
Echinococcus multilocularis expressed conserved protein 0.009 0.0343 0.0342
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.004 0.0131 0.0231
Schistosoma mansoni lamin 0.0026 0.0074 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.0184
Onchocerca volvulus 0.0009 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.014 0.0359
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0061 0.0182
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0067 0.0209
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0216 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0216 0.0675
Brugia malayi conserved hypotetical protein 0.0009 0.0004 0.0011
Echinococcus multilocularis musashi 0.0026 0.0074 0.0074
Brugia malayi hypothetical protein 0.0009 0.0004 0.0011
Leishmania major oxidoreductase-like protein 0.0052 0.0183 0.4992
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0004 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0005 0.0012
Brugia malayi hypothetical protein 0.0042 0.014 0.036
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0236 0.0955 0.1684
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0009 0.0003 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0049 0.0125
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0294 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0229 0.0404
Plasmodium vivax plasmepsin IV, putative 0.0042 0.014 0.0426
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0049 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0061 0.0158
Onchocerca volvulus 0.0191 0.0767 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0162 0.0285
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0004 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0049 0.0125
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0564
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0033 0.0093
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0183 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0014
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0183 0.047
Brugia malayi hypothetical protein 0.0042 0.014 0.036
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0089 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0061 0.167
Schistosoma mansoni lamin 0.0026 0.0074 0.013
Plasmodium vivax aspartyl protease, putative 0.0042 0.014 0.0426
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0017 0.0017
Echinococcus granulosus muscleblind protein 0.0734 0.3049 0.5376
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0073 0.0219
Plasmodium vivax aspartyl protease, putative 0.0042 0.014 0.0426
Brugia malayi aspartic protease BmAsp-1, identical 0.0042 0.014 0.036
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.0183 0.0564
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0003 0.0009
Schistosoma mansoni topbp1 0.001 0.0005 0.0008
Schistosoma mansoni hypothetical protein 0.004 0.0131 0.0231
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0037 0.0101
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0049 0.0085
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0294 0.0755
Brugia malayi steroid hormone receptor 0.002 0.0049 0.0125
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0216 0.5884
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0768 0.3192 1
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.1674 0.1674
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0049 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0189
Brugia malayi AMP-binding enzyme family protein 0.003 0.0089 0.0227
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0004 0.0007
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0104 0.0402 0.1259
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0096 0.0366 0.0646
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0067 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0162 0.0415
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.027 0.1097 0.1934
Toxoplasma gondii aspartyl protease 0.0042 0.014 0.0426
Plasmodium vivax aspartyl proteinase, putative 0.0042 0.014 0.0426
Plasmodium falciparum plasmepsin VII 0.0042 0.014 0.0426
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0042 0.014 0.0359
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.1006 0.2581
Brugia malayi hypothetical protein 0.0025 0.007 0.0179
Echinococcus granulosus replication factor c subunit 1 0.001 0.0005 0.0008
Brugia malayi hypothetical protein 0.0936 0.3898 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0367 0.0941
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0073 0.0229
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0052 0.0183 0.4992
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0052 0.0183 0.0322
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0049 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0072 0.0826
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0047 0.0146
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0085 0.0216
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0052 0.0183 0.4992
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0061 0.0192
Brugia malayi DKFZp564C0469 protein 0.001 0.0005 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0216 0.0215
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0001
Echinococcus granulosus expressed conserved protein 0.009 0.0343 0.0604
Onchocerca volvulus 0.0026 0.0074 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0049 0.0125
Onchocerca volvulus 0.0042 0.014 0.1795
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0004 0.0011
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0067 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0049 0.0125
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0005 0.0122
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0049 0.0125
Entamoeba histolytica hypothetical protein 0.0215 0.0866 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0049 0.0125
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0159 0.0407
Echinococcus granulosus FTZ F1 alpha 0.002 0.0049 0.0085
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0183 0.0573
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0004 0.001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0004 0.0004
Mycobacterium ulcerans glutaminase 0.0535 0.2213 0.6935
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0004 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0074 0.0189
Echinococcus multilocularis lamin dm0 0.0026 0.0074 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0049 0.0125
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0192 0.0587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0162 0.0161
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0367 0.4238
Schistosoma mansoni hypothetical protein 0.0078 0.0294 0.0518
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0073 0.0229
Brugia malayi nuclear hormone receptor 0.0009 0.0004 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0049 0.0085
Schistosoma mansoni patched 1 0.0041 0.0137 0.0242
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0049 0.0048
Schistosoma mansoni cathepsin D (A01 family) 0.0042 0.014 0.0247
Chlamydia trachomatis oxoacy-ACP reductase 0.0052 0.0183 0.0573
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0229 0.0229
Schistosoma mansoni glutaminase 0.0535 0.2213 0.3903
Echinococcus granulosus geminin 0.0515 0.2127 0.3751
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0042 0.014 0.0247
Schistosoma mansoni hypothetical protein 0.0078 0.0294 0.0518
Onchocerca volvulus 0.0099 0.0379 0.4923
Echinococcus granulosus lamin 0.0026 0.0074 0.013
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.007 0.0204
Plasmodium falciparum plasmepsin IX 0.0042 0.014 0.0426
Loa Loa (eye worm) aspartyl protease 6 0.0042 0.014 0.0359
Schistosoma mansoni cpg binding protein 0.003 0.0091 0.0161
Loa Loa (eye worm) glutaminase 0.0535 0.2213 0.5677
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.0204
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0229 0.0588
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0219 0.0386
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0052 0.0183 0.0573
Loa Loa (eye worm) retinol dehydrogenase 12 0.0052 0.0183 0.0469
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0183 0.0573
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0049 0.0085
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0049 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0157
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0183 0.047
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.054 0.0539
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0216 0.0675
Schistosoma mansoni cpg binding protein 0.0029 0.0085 0.0149
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0022
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0048 0.0141
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0183 0.0573
Schistosoma mansoni cathepsin D (A01 family) 0.0042 0.014 0.0247
Schistosoma mansoni thyroid hormone receptor 0.002 0.0049 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0049 0.0085
Echinococcus granulosus cpg binding protein 0.003 0.0091 0.0161
Trypanosoma brucei oxidoreductase-like protein 0.0052 0.0183 0.4992
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0023
Onchocerca volvulus 0.001 0.0005 0.0019
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.017 0.0677 0.1735
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0118 0.0367
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0023 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0216 0.0675
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0049 0.0125
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0038 0.0109
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0004 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0049 0.0125
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0049 0.0593
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Loa Loa (eye worm) hypothetical protein 0.0734 0.3049 0.782
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.005 0.0176 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.0137 0.0351
Schistosoma mansoni hypothetical protein 0.0078 0.0294 0.0518
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0049 0.0085
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0216 0.0662
Brugia malayi hypothetical protein 0.0016 0.0033 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0049 0.0593
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.014 0.0247
Echinococcus granulosus nibrin 0.001 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0157
Echinococcus multilocularis muscleblind protein 0.0734 0.3049 0.3048
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0094
Brugia malayi hypothetical protein 0.0011 0.0009 0.0023
Treponema pallidum DNA ligase (lig) 0.001 0.0005 0.0122
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0032 0.01
Entamoeba histolytica hypothetical protein 0.0215 0.0866 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0037 0.0115
Loa Loa (eye worm) hypothetical protein 0.0734 0.3049 0.782
Onchocerca volvulus 0.0023 0.0061 0.0761
Schistosoma mansoni DNA ligase IV 0.001 0.0005 0.0008
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0073 0.0229
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0564
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0061 0.0707
Toxoplasma gondii aspartyl protease ASP1 0.0042 0.014 0.0426
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0003 0.0009
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0052 0.0183 0.0322
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0004 0.0011
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0004 0.001
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0052 0.0183 0.4992
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0049 0.0048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0009 0.0015
Brugia malayi hypothetical protein 0.001 0.0005 0.0012
Schistosoma mansoni dihydropteridine reductase 0.0052 0.0183 0.0322
Brugia malayi hypothetical protein 0.0011 0.0009 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0005 0.0122
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0067 0.0199
Onchocerca volvulus 0.0042 0.014 0.1795
Schistosoma mansoni hypothetical protein 0.0215 0.0866 0.1526
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0064 0.019
Schistosoma mansoni zinc finger protein 0.0009 0.0004 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1901
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0004 0.0007
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0042 0.014 0.0426
Schistosoma mansoni nuclear hormone receptor 0.002 0.0049 0.0085
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0023 0.0061
Schistosoma mansoni survival motor neuron protein 0.0191 0.0767 0.1352
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0049 0.0125
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0768 0.3192 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0009 0.0015
Brugia malayi nuclear receptor NHR-67 0.0009 0.0004 0.0011
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0009 0.0003 0.0009
Schistosoma mansoni memapsin-2 (A01 family) 0.1042 0.4344 0.766
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0061 0.0158
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0005 0.0122
Loa Loa (eye worm) glutaminase 2 0.0535 0.2213 0.5677
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0049 0.0048
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0137 0.0242
Entamoeba histolytica hypothetical protein 0.0215 0.0866 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0049 0.0124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.001
Echinococcus multilocularis nibrin 0.001 0.0005 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0052 0.0183 0.0559
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.002 0.0049
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0052 0.0183 0.4992
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0037 0.0101
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0061 0.0192
Brugia malayi Eukaryotic aspartyl protease family protein 0.0042 0.014 0.036
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0052 0.0183 0.0564
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0049 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0049 0.0124
Schistosoma mansoni hypothetical protein 0.0407 0.1674 0.2953
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0183 0.0573
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.036
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0061 0.167
Schistosoma mansoni hypothetical protein 0.0515 0.2127 0.3751
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0124
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0294 0.0518
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0039
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0073 0.0229
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0042 0.014 0.0426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0049 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0033 0.0093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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