Detailed information for compound 79948

Basic information

Technical information
  • TDR Targets ID: 79948
  • Name: [(4-hexylanilino)-phosphonomethyl]phosphonic acid
  • MW: 351.272 | Formula: C13H23NO6P2
  • H donors: 5 H acceptors: 6 LogP: 1.48 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCc1ccc(cc1)NC(P(=O)(O)O)P(=O)(O)O
  • InChi: 1S/C13H23NO6P2/c1-2-3-4-5-6-11-7-9-12(10-8-11)14-13(21(15,16)17)22(18,19)20/h7-10,13-14H,2-6H2,1H3,(H2,15,16,17)(H2,18,19,20)
  • InChiKey: VZUARTNOEPMXJJ-UHFFFAOYSA-N  

Network

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Synonyms

  • [(4-hexylanilino)-phosphono-methyl]phosphonic acid
  • [[(4-hexylphenyl)amino]-phosphono-methyl]phosphonic acid
  • [[(4-hexylphenyl)amino]-phosphonomethyl]phosphonic acid
  • Phosphonic acid, [[(4-hexylphenyl)amino]methylene]bis-
  • AIDS-257683
  • AIDS257683

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0121 0.0577 0.2128
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Brugia malayi chromobox protein homolog 3 0.0039 0.0146 0.0492
Entamoeba histolytica hexokinase 2 0.0192 0.0956 1
Brugia malayi hexokinase type II 0.0061 0.0263 0.0887
Trichomonas vaginalis MYB3r3, putative 0.0047 0.0186 0.1386
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.004 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Plasmodium falciparum thioredoxin reductase 0.0033 0.0113 0.118
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Leishmania major hypothetical protein, conserved 0.0025 0.0073 0.0689
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0439 0.0978
Leishmania major DNA polymerase kappa, putative 0.0018 0.0034 0.028
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0026 0.0057
Schistosoma mansoni hypothetical protein 0.0336 0.1713 0.3821
Schistosoma mansoni lamin 0.0029 0.0095 0.0212
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0095 0.0213
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0299 0.1517 0.3384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.018 0.0401
Schistosoma mansoni lamin 0.0029 0.0095 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0024 0.008
Onchocerca volvulus 0.0031 0.0101 0.0374
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0244 0.0185
Onchocerca volvulus Matrilysin homolog 0.0237 0.119 0.4387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1025 0.3457
Schistosoma mansoni coup transcription factor 0.0016 0.0024 0.0053
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0023 0.0078
Echinococcus multilocularis musashi 0.0029 0.0095 0.0212
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0034 0.028
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0034 0.028
Loa Loa (eye worm) hypothetical protein 0.0061 0.0263 0.0887
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0439 0.0978
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.004 0.0134
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0076 0.0255
Brugia malayi polk-prov protein 0.0018 0.0034 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0073 0.0762
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0024 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0034 0.028
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0378 0.3901
Echinococcus granulosus lamin dm0 0.0029 0.0095 0.0212
Loa Loa (eye worm) hypothetical protein 0.005 0.0204 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.1494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Schistosoma mansoni glutaminase 0.0266 0.1345 0.3
Plasmodium vivax SET domain protein, putative 0.0029 0.0095 0.0998
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0073 0.0262
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0024 0.0053
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.004 0.0089
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0024 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.004 0.0134
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0034 0.028
Brugia malayi MH2 domain containing protein 0.0016 0.0026 0.0087
Brugia malayi hypothetical protein 0.0019 0.004 0.0134
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.009 0.02
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0284 0.0958
Loa Loa (eye worm) hypothetical protein 0.0121 0.0577 0.1948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0024 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0024 0.0053
Trypanosoma brucei unspecified product 0.0057 0.0244 0.2488
Brugia malayi MH2 domain containing protein 0.0239 0.12 0.405
Plasmodium falciparum glutathione reductase 0.0033 0.0113 0.118
Schistosoma mansoni smad1 5 8 and 0.0016 0.0026 0.0057
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.004 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0034 0.028
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0067 0.0226
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000021558 0.00000000022545
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.004 0.0089
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0284 0.0633
Loa Loa (eye worm) hypothetical protein 0.0237 0.119 0.4017
Brugia malayi Hexokinase family protein 0.0192 0.0956 0.3227
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0073 0.0689
Brugia malayi PXA domain containing protein 0.0019 0.004 0.0134
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0024 0.0087
Echinococcus granulosus Chromo domain 0.0011 0.000000000021558 0.000000000048052
Plasmodium vivax glutathione reductase, putative 0.0094 0.0439 0.4591
Loa Loa (eye worm) RGS-3 protein 0.0019 0.004 0.0134
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0113 0.111
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0008 0.0078
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.000000000021558 0.000000000048052
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0023 0.0079
Brugia malayi TAR-binding protein 0.0188 0.0931 0.3141
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0284 0.0633
Echinococcus granulosus hexokinase 0.0192 0.0956 0.2131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0024 0.008
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Echinococcus multilocularis hexokinase 0.0192 0.0956 0.2131
Schistosoma mansoni axis inhibition protein axin 0.0019 0.004 0.0089
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1904 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0024 0.008
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0034 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Brugia malayi RNA binding protein 0.0188 0.0931 0.3141
Brugia malayi MH1 domain containing protein 0.0016 0.0026 0.0087
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0024 0.008
Mycobacterium ulcerans glutaminase 0.0266 0.1345 0.1315
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0113 0.0381
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0034 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.1494
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0204 0.0688
Echinococcus granulosus intermediate filament protein 0.0029 0.0095 0.0212
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0416
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Brugia malayi Hexokinase family protein 0.0121 0.0577 0.1949
Brugia malayi Hexokinase family protein 0.006 0.0254 0.0858
Loa Loa (eye worm) glutaminase 0.0266 0.1345 0.4538
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0244 0.1811
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0156 0.0347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0095 0.0213
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000021558 0.000000000048085
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0034 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.1085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Trypanosoma brucei unspecified product 0.004 0.0149 0.1494
Brugia malayi hypothetical protein 0.0025 0.0073 0.0246
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Echinococcus granulosus axis inhibition protein axin 0.0019 0.004 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0034 0.028
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0284 0.2969
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0026 0.0057
Loa Loa (eye worm) hypothetical protein 0.0237 0.119 0.4017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0204 0.0688
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000021558 0.000000000077661
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Leishmania major trypanothione reductase 0.0094 0.0439 0.4548
Brugia malayi hypothetical protein 0.0016 0.0026 0.0087
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0237 0.119 0.2655
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.018 0.0607
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.000000000021558 0.000000000072747
Schistosoma mansoni chromobox protein 0.007 0.0307 0.0686
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0024 0.0053
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0076 0.0717
Schistosoma mansoni hypothetical protein 0.0011 0.000000000021558 0.000000000048085
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.1078 0.1369
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0015 0.0033
Echinococcus granulosus expressed protein 0.0368 0.1885 0.4202
Echinococcus multilocularis hexokinase type 2 0.0192 0.0956 0.2131
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0537 0.2776 0.2694
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0024 0.008
Onchocerca volvulus 0.0011 0.000000006517 0.000000024018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0342
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.004 0.0134
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0213
Brugia malayi Heterochromatin protein 1 0.007 0.0307 0.1037
Loa Loa (eye worm) hexokinase 0.0121 0.0577 0.1949
Trichomonas vaginalis C-MYB, putative 0.0047 0.0186 0.1386
Brugia malayi intermediate filament protein 0.0029 0.0095 0.0321
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0861 0.4486 1
Echinococcus multilocularis chromobox protein 1 0.007 0.0307 0.0685
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0034 0.0123
Brugia malayi glutathione reductase 0.0094 0.0439 0.1481
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0213
Brugia malayi hypothetical protein 0.012 0.0574 0.1938
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Brugia malayi glutaminase DH11.1 0.0266 0.1345 0.4538
Brugia malayi hexokinase 0.0192 0.0956 0.3227
Brugia malayi hypothetical protein 0.0019 0.004 0.0134
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0024 0.0053
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0251
Schistosoma mansoni hypothetical protein 0.0034 0.012 0.0268
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0244 0.0543
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.004 0.0089
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0034 0.0357
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0051 0.0534
Mycobacterium ulcerans hydrolase 0.0288 0.1463 0.1434
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0024 0.008
Plasmodium falciparum thioredoxin reductase 0.0094 0.0439 0.4591
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.00000000022545
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0024 0.0053
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0066 0.0148
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0073 0.0762
Brugia malayi Hemopexin family protein 0.0336 0.1713 0.578
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0024 0.0087
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.12 0.405
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0113 0.111
Brugia malayi Matrixin family protein 0.0572 0.2963 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0188 0.0931 0.3141
Echinococcus granulosus dna polymerase kappa 0.0057 0.0244 0.0543
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0439 0.4548
Echinococcus granulosus axis inhibition protein axin 0.0019 0.004 0.0089
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.000000000021558 0.000000000048052
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0024 0.008
Brugia malayi nuclear receptor NHR-88 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.032 0.0714
Giardia lamblia Myb 1-like protein 0.0047 0.0188 0.7327
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0026 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0024 0.0053
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.1078 0.1369
Loa Loa (eye worm) Smad1 0.0016 0.0026 0.0087
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0024 0.0053
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0284 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0024 0.008
Onchocerca volvulus Matrix metalloproteinase homolog 0.0525 0.2713 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0025 0.0266
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0015 0.0033
Echinococcus multilocularis hexokinase 0.0192 0.0956 0.2131
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0537 0.2776 0.2789
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0024 0.008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0284 0.2913
Onchocerca volvulus Matrilysin homolog 0.0525 0.2713 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0113 0.118
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0416
Trichomonas vaginalis MYB, putative 0.0047 0.0188 0.1395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.018 0.0401
Echinococcus granulosus tar DNA binding protein 0.0188 0.0931 0.2075
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0537 0.2776 1
Echinococcus multilocularis chromobox protein 1 0.007 0.0307 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.018 0.0401
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1159 0.3912
Loa Loa (eye worm) glutathione reductase 0.0094 0.0439 0.1481
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0113 0.111
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0244 0.2488
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0066 0.0224
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.004 0.0089
Brugia malayi PXA domain containing protein 0.0019 0.004 0.0134
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0034 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0086 0.0637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0024 0.008
Loa Loa (eye worm) hexokinase 0.0192 0.0956 0.3227
Leishmania major hexokinase, putative 0.0192 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0321
Schistosoma mansoni intermediate filament proteins 0.0029 0.0095 0.0212
Trypanosoma brucei trypanothione reductase 0.0094 0.0439 0.4548
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0322
Schistosoma mansoni chromobox protein 0.007 0.0307 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0024 0.008
Leishmania major hexokinase, putative 0.0192 0.0956 1
Brugia malayi Flap endonuclease-1 0.0026 0.0076 0.0255
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0113 0.111
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Echinococcus multilocularis geminin 0.086 0.4483 0.9993
Echinococcus multilocularis Smad4 0.0016 0.0026 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0024 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0244 0.2488
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0024 0.0053
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000021558 0.00000000022545
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Echinococcus multilocularis dna polymerase eta 0.0083 0.0378 0.0842
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0113 0.111
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0066 0.0494
Leishmania major DNA polymerase eta, putative 0.0083 0.0378 0.3901
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0246
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Trichomonas vaginalis glutaminase, putative 0.0266 0.1345 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0244 0.1811
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Echinococcus multilocularis tar DNA binding protein 0.0188 0.0931 0.2075
Schistosoma mansoni Smad4 0.0016 0.0026 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0052
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0284 0.2913
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Echinococcus granulosus hexokinase type 2 0.0192 0.0956 0.2131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0113 0.0839
Brugia malayi hypothetical protein 0.0072 0.032 0.108
Loa Loa (eye worm) hypothetical protein 0.0083 0.0378 0.1274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0113 0.118
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0087 0.0397 0.4106
Echinococcus multilocularis smad 0.0016 0.0026 0.0057
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0252
Giardia lamblia DINP protein human, muc B family 0.0057 0.0244 1
Brugia malayi RNA recognition motif domain containing protein 0.0188 0.0931 0.3141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.018 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Onchocerca volvulus 0.0192 0.0956 0.3524
Loa Loa (eye worm) RecQ helicase 0.0024 0.0066 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0024 0.008
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0024 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0024 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.004 0.0089
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0034 0.028
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.1078 0.1369
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.004 0.0089
Loa Loa (eye worm) matrixin family protein 0.0572 0.2963 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.0307 0.2286
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0034 0.028
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0073 0.0689
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.032 0.0714
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.004 0.0134
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0076 0.0168
Loa Loa (eye worm) hypothetical protein 0.0288 0.1463 0.4936
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Mycobacterium tuberculosis Probable reductase 0.0216 0.1078 0.1369
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0024 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0073 0.0762
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.004 0.0089
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0307 0.1037
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.004 0.0089
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.1078 0.1369
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0095 0.0321
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Echinococcus multilocularis lamin 0.0029 0.0095 0.0212
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0244 0.021
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1367 0.7164 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Echinococcus granulosus smad 0.0016 0.0026 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.1085
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0086 0.0637
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0284 0.2913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.018 0.0401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0213
Loa Loa (eye worm) matrixin family protein 0.0525 0.2713 0.9156
Brugia malayi hypothetical protein 0.015 0.0733 0.2474
Brugia malayi SET domain containing protein 0.0012 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.015 0.0733 0.2474
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0095 0.0321
Schistosoma mansoni hypothetical protein 0.086 0.4483 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0113 0.111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.004
Onchocerca volvulus 0.0029 0.0095 0.0351
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0024 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi Pre-SET motif family protein 0.0205 0.1025 0.3457
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0073 0.0689
Echinococcus multilocularis sodium channel protein 0.0087 0.0397 0.0885
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0024 0.0053
Schistosoma mansoni smad1 5 8 and 0.0016 0.0026 0.0057
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0113 0.111
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0113 0.111
Plasmodium falciparum flap endonuclease 1 0.0026 0.0076 0.079
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.004 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.012 0.0406
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.1206 0.155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.004
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0024 0.0053
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.0089
Echinococcus granulosus bloom syndrome protein 0.0024 0.0066 0.0148
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0113 0.0079
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000021558 0.000000000048052
Brugia malayi ecdysteroid receptor 0.0016 0.0024 0.008
Schistosoma mansoni DNA polymerase eta 0.0083 0.0378 0.0842
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0024 0.0053
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0146 0.0538
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0076 0.0272
Onchocerca volvulus 0.0192 0.0956 0.3524
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0113 0.111
Entamoeba histolytica hypothetical protein 0.0011 0.000000000021558 0.00000000022545
Plasmodium vivax hexokinase, putative 0.0192 0.0956 1
Echinococcus multilocularis expressed protein 0.0368 0.1885 0.4202
Onchocerca volvulus 0.0237 0.119 0.4387
Trypanosoma brucei unspecified product 0.004 0.0149 0.1494
Trypanosoma cruzi hexokinase, putative 0.0192 0.0956 1
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0113 0.0839
Loa Loa (eye worm) hypothetical protein 0.0061 0.0263 0.0887
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0024 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0188 0.1395
Schistosoma mansoni hexokinase 0.0192 0.0956 0.2133
Loa Loa (eye worm) glutaminase 2 0.0266 0.1345 0.4538
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0024 0.0053
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0284 0.2913
Schistosoma mansoni hypothetical protein 0.0072 0.032 0.0714
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0076 0.079
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000021558 0.000000000048085
Echinococcus granulosus lamin 0.0029 0.0095 0.0212
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.1201
Echinococcus granulosus chromobox protein 1 0.007 0.0307 0.0685
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0188 0.1395
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0244 0.2547
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.0378 0.1274
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.032 0.0714
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.004 0.0089
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0162 0.0595
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.1078 0.1369
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0026 0.0087
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0439 0.1481
Loa Loa (eye worm) TAR-binding protein 0.0188 0.0931 0.3141
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.004 0.0134
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.004 0.0134
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.1206 0.0209
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0034 0.0076
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0095 0.0213
Onchocerca volvulus 0.0234 0.1174 0.4328
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.004 0.0089
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0095 0.0321
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.004 0.0089
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0416
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0024 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Schistosoma mansoni smad 0.0016 0.0026 0.0057
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0537 0.2776 0.2751
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.004 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.018 0.0401
Brugia malayi MH1 domain containing protein 0.0016 0.0026 0.0087
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0024 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1904 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.004 0.0089
Loa Loa (eye worm) hexokinase type II 0.0192 0.0956 0.3227
Echinococcus granulosus flap endonuclease 1 0.0026 0.0076 0.0168
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.004 0.0089
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000021558 0.000000000072747
Trichomonas vaginalis pc-MYB2, putative 0.0047 0.0186 0.1386
Plasmodium falciparum hexokinase 0.0192 0.0956 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0024 0.0087
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0244 0.0822
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0113 0.0406
Loa Loa (eye worm) hypothetical protein 0.0313 0.1593 0.5377
Onchocerca volvulus 0.0192 0.0956 0.3524
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0023 0.0079
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1159 0.3912
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0244 0.2488
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0076 0.0717
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0113 0.0251
Onchocerca volvulus 0.0029 0.0095 0.0351
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0131 0.0633 0.2136
Leishmania major DNA damage repair protein, putative 0.0018 0.0034 0.028
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0139 0.031
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0244 0.0543
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Plasmodium falciparum glutathione reductase 0.0094 0.0439 0.4591
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0113 0.118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Brugia malayi CHD4 protein 0.0011 0.000000000021558 0.000000000072747
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Loa Loa (eye worm) hexokinase 0.0192 0.0956 0.3227
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.004 0.0089
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0026 0.0057
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1367 0.7164 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0406
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0067 0.0226
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.1201
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0024 0.0053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0024 0.0053
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000021558 0.000000000048052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0024 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.12 0.405
Treponema pallidum hexokinase (hxk) 0.0192 0.0956 0.0853
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0244 0.0822
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0024 0.008
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.004 0.0089
Echinococcus multilocularis GPCR, family 2 0.0016 0.0023 0.0052
Echinococcus multilocularis hexokinase 0.0192 0.0956 0.2131
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.00000000022545
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0244 0.0543
Brugia malayi Thioredoxin reductase 0.0094 0.0439 0.1481
Schistosoma mansoni smad1 5 8 and 0.0016 0.0026 0.0057
Trichomonas vaginalis MYB72, putative 0.0047 0.0186 0.1386
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0244 0.0185
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.004 0.0089
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0139 0.031
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0076 0.198
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1904 1 1
Schistosoma mansoni flap endonuclease-1 0.0023 0.0063 0.0139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0024 0.0053
Trypanosoma brucei DNA polymerase eta, putative 0.0083 0.0378 0.3901
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Onchocerca volvulus 0.0016 0.0024 0.0087
Echinococcus granulosus hexokinase 0.0192 0.0956 0.2131
Echinococcus multilocularis lamin dm0 0.0029 0.0095 0.0212
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0113 0.111
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0076 0.0562
Trypanosoma brucei hexokinase 0.0192 0.0956 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0024 0.008
Echinococcus granulosus dna polymerase eta 0.0083 0.0378 0.0842
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.004 0.0089
Brugia malayi MH2 domain containing protein 0.0016 0.0026 0.0087
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0244 0.0543
Brugia malayi Pre-SET motif family protein 0.0029 0.0095 0.0322
Loa Loa (eye worm) hexokinase 0.006 0.0254 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0024 0.008
Echinococcus granulosus chromobox protein 1 0.007 0.0307 0.0685
Loa Loa (eye worm) RNA binding protein 0.0188 0.0931 0.3141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0052
Onchocerca volvulus Hexokinase homolog 0.0121 0.0577 0.2128
Leishmania major DNA polymerase eta, putative 0.0043 0.0168 0.1693
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0024 0.0053
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.004 0.0296
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000021558 0.000000000072747
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0861 0.4486 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.004 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0008 0.0056
Loa Loa (eye worm) matrix metalloproteinase 0.0237 0.119 0.4017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.018 0.0401
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0076 0.0717
Trypanosoma brucei hexokinase, putative 0.0192 0.0956 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.00000000022545
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0047 0.0186 0.1949
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Onchocerca volvulus 0.0336 0.1713 0.6313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0052
Trichomonas vaginalis chromobox protein, putative 0.007 0.0307 0.2286
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0312
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0439 0.4591
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0244 0.2488
Trichomonas vaginalis pc-MYB2, putative 0.0047 0.0186 0.1386
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Loa Loa (eye worm) hypothetical protein 0.0237 0.119 0.4017
Brugia malayi nuclear hormone receptor 0.0016 0.0024 0.008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0024 0.0053
Toxoplasma gondii thioredoxin reductase 0.0094 0.0439 0.1581
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.004 0.0089
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0113 0.0406
Trypanosoma cruzi hexokinase, putative 0.0192 0.0956 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0168 0.1693
Onchocerca volvulus 0.015 0.0733 0.2702
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Schistosoma mansoni axis inhibition protein axin 0.0019 0.004 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0024 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.1494
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0026 0.0057
Echinococcus granulosus Smad4 0.0016 0.0026 0.0057
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0023 0.0078
Echinococcus multilocularis Chromobox protein 3 0.0011 0.000000006517 0.000000014526
Echinococcus granulosus sodium channel protein 0.0087 0.0397 0.0885
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0024 0.0088
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0066 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0024 0.0053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0439 0.0463
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0087 0.0397 0.0885
Onchocerca volvulus 0.0041 0.0156 0.0573
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0244 0.021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.1206 0.155
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0076 0.079
Mycobacterium leprae PROBABLE HYDROLASE 0.0288 0.1463 0.0632
Echinococcus granulosus geminin 0.086 0.4483 0.9993
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000021558 0.000000000072747
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0024 0.008
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.004 0.0089
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.004 0.0134
Leishmania major DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0931 0.2076
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0284 0.0958
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0204 0.0688
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0296
Brugia malayi Matrixin family protein 0.0237 0.119 0.4017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0023 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0024 0.0053
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.004 0.0134
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0244 0.0543
Entamoeba histolytica hypothetical protein 0.0072 0.032 0.3348
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.004 0.0089
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0095 0.0344
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.1206 0.155
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0134
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0288 0.1463 0.4936
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.004 0.0134
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0288 0.1463 0.1915
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1174 0.8733
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0052
Trichomonas vaginalis C-MYB, putative 0.0047 0.0186 0.1386
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0026 0.0057
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.004 0.0089
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0047 0.0188 0.0676
Echinococcus granulosus GPCR family 2 0.0016 0.0023 0.0052
Trypanosoma brucei hexokinase 0.0192 0.0956 1
Entamoeba histolytica hexokinase 1 0.0192 0.0956 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0052
Echinococcus multilocularis Chromo domain 0.0011 0.000000000021558 0.000000000048052
Echinococcus granulosus hexokinase 0.0192 0.0956 0.2131
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.018 0.0607
Brugia malayi steroid hormone receptor 0.0016 0.0024 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Brugia malayi Smad1 0.0016 0.0026 0.0087
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0186 0.1386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0024 0.008
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0113 0.3759
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0244 0.2488
Echinococcus granulosus Chromobox protein 3 0.0011 0.000000006517 0.000000014526
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0168 0.0606
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0034 0.028
Toxoplasma gondii hexokinase 0.0192 0.0956 0.3445
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0024 0.0053
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0113 0.0079
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0113 0.118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000021558 0.0000000001603
Schistosoma mansoni hypothetical protein 0.086 0.4483 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) uM Inhibitory activity against Leishmania major Farnesyl diphosphate synthase; ND denotes not determined ChEMBL. 14695831
IC50 (binding) 0 uM Inhibitory activity against Leishmania major Farnesyl diphosphate synthase; ND denotes not determined ChEMBL. 14695831
IC50 (functional) = 36 uM Antimicrobial activity against Entamoeba histolytica ChEMBL. 20185316
IC50 (functional) = 46.3 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) = 46.3 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) = 103 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (functional) = 132 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) = 132 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate ChEMBL. 17149863
LD50 (ADMET) = 373 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (ADMET) = 373 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
TI (ADMET) = 2.83 Therapeutic index was expressed as ratio of LD50 for KB cell line to IC50 against Entamoeba histolytica ChEMBL. 14695831
TI (ADMET) = 8.06 Therapeutic index was expressed as ratio of LD50 for KB cell line to IC50 against Plasmodium falciparum ChEMBL. 14695831

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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