Detailed information for compound 799825

Basic information

Technical information
  • TDR Targets ID: 799825
  • Name: 5,7-dimethoxy-4-[2-(2-methylpropoxy)phenyl]-3 ,4-dihydro-1H-quinolin-2-one
  • MW: 355.428 | Formula: C21H25NO4
  • H donors: 1 H acceptors: 1 LogP: 3.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c2c(c1)NC(=O)CC2c1ccccc1OCC(C)C
  • InChi: 1S/C21H25NO4/c1-13(2)12-26-18-8-6-5-7-15(18)16-11-20(23)22-17-9-14(24-3)10-19(25-4)21(16)17/h5-10,13,16H,11-12H2,1-4H3,(H,22,23)
  • InChiKey: BDDYAARPWHYPIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-isobutoxyphenyl)-5,7-dimethoxy-3,4-dihydro-1H-quinolin-2-one
  • 4-(2-isobutoxyphenyl)-5,7-dimethoxy-3,4-dihydrocarbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0677 0.1561
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0677 0.0677
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0082 0.4339 1
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0063 0.3315 0.764
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.837 0.837
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0279 0.0298
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0063 0.3315 0.6827
Brugia malayi hypothetical protein 0.0007 0.0122 0.013
Schistosoma mansoni hypothetical protein 0.0183 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3585 0.8263
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0677 0.1119
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0677 0.1561
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.2124 0.4896
Schistosoma mansoni cpg binding protein 0.003 0.1455 0.1455
Brugia malayi hypothetical protein 0.0112 0.6053 0.6475
Loa Loa (eye worm) hypothetical protein 0.0024 0.1112 0.1189
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.837 0.8953
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0677 0.1561
Echinococcus granulosus methionine tRNA synthetase 0.0063 0.3315 0.3315
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0082 0.4339 1
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0007 0.0122 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Schistosoma mansoni hypothetical protein 0.0112 0.6053 0.6053
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0677 0.1119
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0007 0.0122 0.013
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0007 0.0122 0.013
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0007 0.0122 0.013
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0677 0.0677
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.2124 0.4896
Loa Loa (eye worm) hypothetical protein 0.0171 0.9348 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0007 0.0122 0.028
Schistosoma mansoni synaptojanin 0.0016 0.0677 0.0677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0677 0.0677
Leishmania major hypothetical protein, conserved 0.0016 0.0677 0.1561
Schistosoma mansoni cript-related 0.0016 0.0677 0.0677
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0007 0.0122 0.0122
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0063 0.3315 0.764
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0082 0.4339 1
Onchocerca volvulus 0.0039 0.1955 0.2242
Schistosoma mansoni methionine-tRNA synthetase 0.0063 0.3315 0.3315
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0677 0.1119
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0175 0.0175
Trichomonas vaginalis helicase, putative 0.0007 0.0137 0.0317
Entamoeba histolytica G protein alpha subunit, putative 0.0007 0.0122 0.0201
Loa Loa (eye worm) hypothetical protein 0.016 0.8718 0.9326
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0082 0.4339 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0063 0.3315 0.764
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0007 0.0122 0.0122
Plasmodium vivax methionine--tRNA ligase, putative 0.0024 0.1112 0.1186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.3585 0.8263
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3585 0.8263
Onchocerca volvulus 0.0016 0.0677 0.0777
Echinococcus multilocularis cpg binding protein 0.0032 0.1553 0.1553
Chlamydia trachomatis leucine--tRNA ligase 0.0024 0.1112 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0007 0.0122 0.013
Brugia malayi CCR4 0.0016 0.0677 0.0725
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.1876 0.4323
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0677 0.0677
Onchocerca volvulus 0.0007 0.0122 0.0139
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0024 0.1112 0.2562
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.2124 0.4896
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0007 0.0122 0.0122
Echinococcus multilocularis expressed protein 0.0007 0.0122 0.0122
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0007 0.0122 0.013
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0007 0.0122 0.0122
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0677 0.1561
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0082 0.4339 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.6053 0.6053
Echinococcus granulosus synaptojanin 1 0.0016 0.0677 0.0677
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Schistosoma mansoni cpg binding protein 0.0032 0.1553 0.1553
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0007 0.0122 0.013
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0677 0.1561
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.3585 0.8263
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0007 0.0122 0.0122
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Treponema pallidum exodeoxyribonuclease (exoA) 0.0082 0.4339 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.837 0.837
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0007 0.0122 0.0122
Schistosoma mansoni GTP-binding protein alpha subunit 0.0007 0.0122 0.0122
Schistosoma mansoni cpg binding protein 0.0032 0.1553 0.1553
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.3585 0.3585
Giardia lamblia Methionyl-tRNA synthetase 0.0063 0.3315 0.764
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0677 0.0677
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0175 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0677 0.0777
Loa Loa (eye worm) hypothetical protein 0.0171 0.9348 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.837 0.837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0082 0.4339 1
Brugia malayi hypothetical protein 0.016 0.8718 0.9326
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0007 0.0122 0.013
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.3585 0.8263
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Schistosoma mansoni methionine-tRNA synthetase 0.0024 0.1112 0.1112
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0677 0.0677
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Chlamydia trachomatis methionine--tRNA ligase 0.0024 0.1112 1
Giardia lamblia hypothetical protein 0.0016 0.0677 0.1561
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0175 0.0175
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.3585 0.3585
Onchocerca volvulus 0.0016 0.0677 0.0777
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0063 0.3315 0.3546
Brugia malayi G-protein alpha subunit 0.0007 0.0122 0.013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.2124 0.3138
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0007 0.0122 0.0122
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.1876 0.5658
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0677 0.0677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0024 0.1112 0.1112
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0082 0.4339 1
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0677 0.1119
Echinococcus multilocularis leucyl tRNA synthetase 0.0024 0.1112 0.1112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Brugia malayi protein ZK524.3 0.0024 0.1112 0.1189
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.4339 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Brugia malayi exodeoxyribonuclease III family protein 0.0082 0.4339 0.4641
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0137 0.0317
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0007 0.0122 0.013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0279 0.0279
Giardia lamblia Inositol 5-phosphatase 4 0.0016 0.0677 0.1561
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0677 0.1561
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0677 0.1561
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.837 0.8953
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0039 0.1955 0.2091
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0677 0.1561
Schistosoma mansoni hypothetical protein 0.0016 0.0677 0.0677
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.2124 0.4896
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.3585 0.3585
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0007 0.0122 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.837 0.837
Echinococcus multilocularis muscleblind protein 1 0.0171 0.9348 0.9348
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0677 0.1561
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0007 0.0122 0.0122
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0082 0.4339 0.4339
Leishmania major hypothetical protein, conserved 0.0016 0.0677 0.1561
Onchocerca volvulus 0.0007 0.0122 0.0139
Schistosoma mansoni inositol monophosphatase 0.0042 0.2124 0.2124
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0677 0.1561
Schistosoma mansoni synaptojanin 0.0016 0.0677 0.0677
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3585 0.8263
Leishmania major methionyl-tRNA synthetase, putative 0.0063 0.3315 0.764
Brugia malayi Muscleblind-like protein 0.0171 0.9348 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0677 0.1561
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.6053 0.6053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0137 0.0317
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0677 0.0677
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.3585 0.3585
Schistosoma mansoni nocturnin 0.0016 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0082 0.4339 1
Giardia lamblia Leucyl-tRNA synthetase 0.0024 0.1112 0.2562
Brugia malayi methionyl-tRNA synthetase 0.0024 0.1112 0.1189
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0007 0.0122 0.028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0082 0.4339 0.4339
Schistosoma mansoni GTP-binding protein alpha subunit 0.0007 0.0122 0.0122
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0007 0.0122 0.013
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Schistosoma mansoni inositol monophosphatase 0.0042 0.2124 0.2124
Schistosoma mansoni ap endonuclease 0.0082 0.4339 0.4339
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0063 0.3315 1
Brugia malayi Inositol-1 0.0042 0.2124 0.2272
Echinococcus granulosus expressed protein 0.0007 0.0122 0.0122
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0677 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Loa Loa (eye worm) inositol-1 0.0042 0.2124 0.2272
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis muscleblind protein 0.0171 0.9348 0.9348
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0007 0.0122 0.0122
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0082 0.4339 0.7168
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0677 0.0677
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.4339 1
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.2124 0.3509
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.2124 0.2124
Echinococcus granulosus cpg binding protein 0.0032 0.1553 0.1553
Leishmania major hypothetical protein, conserved 0.0016 0.0677 0.1561
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Onchocerca volvulus 0.0007 0.0122 0.0139
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0677 0.1561
Brugia malayi methionyl-tRNA synthetase 0.0063 0.3315 0.3546
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0007 0.0122 0.0122
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Echinococcus multilocularis methionine tRNA synthetase 0.0063 0.3315 0.3315
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Treponema pallidum methionyl-tRNA synthetase 0.0024 0.1112 0.1186
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0007 0.0122 0.0122
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0677 0.0725
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0007 0.0122 0.0122
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.6053 0.6053
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Onchocerca volvulus 0.016 0.8718 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Plasmodium vivax methionine--tRNA ligase, putative 0.0063 0.3315 0.7203
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0677 0.0677
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.837 0.837
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.4339 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Echinococcus granulosus muscleblind protein 0.0171 0.9348 0.9348
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0063 0.3315 0.764
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0677 0.0677
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0677 0.1561
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0677 0.1561
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0007 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Plasmodium falciparum methionine--tRNA ligase, putative 0.0024 0.1112 0.1186
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis geminin 0.0183 1 1
Toxoplasma gondii methionyl-tRNA synthetase 0.0063 0.3315 0.764
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Onchocerca volvulus 0.003 0.1455 0.167
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0272 0.0291
Schistosoma mansoni ap endonuclease 0.0082 0.4339 0.4339
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.4339 1
Plasmodium vivax hypothetical protein, conserved 0.0024 0.1112 0.1186
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.298 0.6868
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.3366 0.3366
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.2124 0.2124
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0007 0.0122 0.013
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.2124 0.4896
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0007 0.0122 0.0122
Leishmania major leucyl-tRNA synthetase, putative 0.0024 0.1112 0.2562
Toxoplasma gondii tRNA ligases class I (M) protein 0.0024 0.1112 0.2562
Loa Loa (eye worm) hypothetical protein 0.0024 0.1112 0.1189
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0007 0.0122 0.013
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0024 0.1112 0.1112
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0063 0.3315 0.764
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Plasmodium falciparum methionine--tRNA ligase 0.0063 0.3315 0.7203
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0677 0.1119
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0007 0.0122 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Treponema pallidum leucyl-tRNA synthetase 0.0024 0.1112 0.1186
Toxoplasma gondii exonuclease III APE 0.0082 0.4339 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1455 0.1557
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0007 0.0122 0.028
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0007 0.0122 0.0122
Echinococcus multilocularis synaptojanin 1 0.0016 0.0677 0.0677
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0183 1 1
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0024 0.1112 0.1837
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0007 0.0122 0.0122
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0175 0.0175
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0007 0.0122 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.837 0.837
Schistosoma mansoni leucyl-tRNA synthetase 0.0024 0.1112 0.1112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0082 0.4339 0.4641
Loa Loa (eye worm) hypothetical protein 0.0024 0.1112 0.1189
Brugia malayi CXXC zinc finger family protein 0.003 0.1455 0.1557
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0677 0.0677
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.837 0.837
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0279 0.0279
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0677 0.1561
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0007 0.0122 0.0122

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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