Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0136 | 0.0136 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0136 | 0.0191 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.7139 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0165 | 0.5932 | 0.8309 |
Schistosoma mansoni | thyroid hormone receptor | 0.0165 | 0.5932 | 0.8309 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0165 | 0.5932 | 0.8309 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.5133 | 0.7191 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0136 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.000000038373 | 0.000000053754 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0136 | 0.0191 |
Echinococcus multilocularis | Ankyrin | 0.0017 | 0.0006 | 0.0008 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0145 | 0.5133 | 0.7191 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0136 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0136 | 0.0191 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0136 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0266 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0136 | 0.0191 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.2006 | 0.281 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0136 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Death domain containing protein | 0.0017 | 0.000000038373 | 0.000000038373 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0136 | 0.0191 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.000000038373 | 0.000000053754 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.000000038373 | 0.000000038373 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0136 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | geminin | 0.0195 | 0.7139 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0136 | 0.0136 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0136 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0017 | 0.0006 | 0.0008 |
Echinococcus multilocularis | geminin | 0.0195 | 0.7139 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0136 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.2006 | 0.281 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0085 | 0.2728 | 0.3822 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.281 |
Onchocerca volvulus | 0.002 | 0.0136 | 1 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0136 | 0.0191 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.000000038373 | 0.000000053754 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0145 | 0.5133 | 0.7191 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.7139 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0136 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0136 | 0.0191 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0136 | 0.0136 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0136 | 0.0191 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0136 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0136 | 0.0136 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0136 | 0.0191 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.0136 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0136 | 0.0136 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0136 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.000000038373 | 0.000000038373 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0136 | 0.0136 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.2006 | 0.281 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0136 | 0.0191 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0136 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0136 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0136 | 0.0136 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0136 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | Ankyrin | 0.0017 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0136 | 0.0136 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0136 | 0.0191 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0085 | 0.2728 | 0.3822 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.2006 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0136 | 0.0136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | = 0.017 uM | In vitro cytotoxicity of compound was determined against CH1 cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.017 uM | In vitro cytotoxicity of compound was determined against CH1 cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.029 uM | In vitro cytotoxicity of compound was determined against A2780 cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.029 uM | In vitro cytotoxicity of compound was determined against A2780 cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.082 uM | In vitro cytotoxicity of compound was determined against CH1 (cisplatin resistant) cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.082 uM | In vitro cytotoxicity of compound was determined against CH1 (cisplatin resistant) cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.2 uM | In vitro cytotoxicity of compound was determined against A2780 cell lines (cisplatin resistant) at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.2 uM | In vitro cytotoxicity of compound was determined against A2780 cell lines (cisplatin resistant) at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.35 uM | In vitro cytotoxicity of compound was determined against SKOV-3 cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Cytotoxicity (functional) | = 0.35 uM | In vitro cytotoxicity of compound was determined against SKOV-3 cell lines at 37 degree C for 96 hr | ChEMBL. | 10969982 |
Delta Tm (functional) | = 1.01 degrees C | Change in thermal denaturation temperature determined from calf thymus DNA after incubation at 37 degree centrigrade for 0 hours | ChEMBL. | 10969982 |
Delta Tm (functional) | = 1.22 degrees C | Change in thermal denaturation temperature determined from calf thymus DNA after incubation at 37 degree centrigrade for 4 hours | ChEMBL. | 10969982 |
Delta Tm (functional) | = 1.33 degrees C | Change in thermal denaturation temperature determined from calf thymus DNA after incubation at 37 degree centrigrade for 18 hours | ChEMBL. | 10969982 |
Resistance factor (functional) | = 4.8 | Resistance factor of compound was determined from cisplatin resistant CH1 cell lines to that of CH1 cell lines | ChEMBL. | 10969982 |
Resistance factor (functional) | = 6.9 | Resistance factor of compound was determined from cisplatin resistant A2780 cell lines to that of A2780 cell lines | ChEMBL. | 10969982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.