Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0127 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.8362 | 0.8362 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0127 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0215 | 0.8362 | 0.8362 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0127 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0127 | 0.0152 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.025 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0215 | 0.8362 | 0.8362 |
Echinococcus granulosus | carboxylesterase 5A | 0.0215 | 0.8362 | 0.8362 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0215 | 0.8362 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.8362 | 0.8362 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0127 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.8362 | 0.8362 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0127 | 0.0127 |
Echinococcus multilocularis | acetylcholinesterase | 0.0215 | 0.8362 | 0.8362 |
Onchocerca volvulus | 0.0051 | 0.0686 | 1 | |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0127 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.8362 | 0.8362 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0127 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0215 | 0.8362 | 0.8362 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0686 | 0.0686 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0127 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0127 | 0.0127 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0127 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0686 | 0.0821 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0127 | 0.0127 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0127 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0215 | 0.8362 | 0.8362 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0127 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0215 | 0.8362 | 0.8362 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.025 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0686 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0215 | 0.8362 | 0.8362 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0127 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.