Detailed information for compound 800298

Basic information

Technical information
  • TDR Targets ID: 800298
  • Name: 1-[4-(chloro-difluoromethoxy)phenyl]-3-[4-(4- nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-di one
  • MW: 480.849 | Formula: C21H19ClF2N4O5
  • H donors: 0 H acceptors: 4 LogP: 3.72 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(C(=O)N1c1ccc(cc1)OC(Cl)(F)F)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C21H19ClF2N4O5/c22-21(23,24)33-17-7-5-15(6-8-17)27-19(29)13-18(20(27)30)26-11-9-25(10-12-26)14-1-3-16(4-2-14)28(31)32/h1-8,18H,9-13H2
  • InChiKey: VEYIQUYORJTKTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(chloro-difluoro-methoxy)phenyl]-3-[4-(4-nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
  • 1-[4-(chloro-difluoromethoxy)phenyl]-3-[4-(4-nitrophenyl)-1-piperazinyl]pyrrolidine-2,5-dione
  • 1-[4-(chloro-difluoro-methoxy)phenyl]-3-[4-(4-nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-quinone
  • A2244/0094500

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0222 0.7006
Brugia malayi RNA, U transporter 1 0.0081 0.0978 0.1843
Schistosoma mansoni alpha-glucosidase 0.0136 0.1771 0.1742
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.052 0.098
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0043 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0445 0.0839
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0043 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0593
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0108 0.0203
Trichomonas vaginalis esterase, putative 0.0035 0.0315 0.1391
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0315 0.0709
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0317 0.14
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0114 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0317 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0207 0.0172
Echinococcus granulosus smad 0.0016 0.0043 0.0007
Onchocerca volvulus 0.0035 0.0315 0.279
Brugia malayi MH1 domain containing protein 0.0016 0.0043 0.0081
Trypanosoma brucei unspecified product 0.0014 0.0016 0.0506
Loa Loa (eye worm) hypothetical protein 0.0028 0.0222 0.0418
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0153 0.0287
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0315 0.9932
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0315 0.5852
Echinococcus multilocularis tar DNA binding protein 0.0382 0.5308 0.5291
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0593
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2088 0.206
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0382 0.5308 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0064 0.2033
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0093 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0108 0.0477
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0814 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0108 0.3405
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2088 0.206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.052 0.098
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0317 0.14
Schistosoma mansoni smad1 5 8 and 0.0016 0.0043 0.0007
Brugia malayi Smad1 0.0016 0.0043 0.0081
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0814 0.0781
Schistosoma mansoni hypothetical protein 0.0181 0.2412 0.2384
Leishmania major hypothetical protein, conserved 0.0035 0.0315 0.3866
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0186 0.588
Schistosoma mansoni tar DNA-binding protein 0.0382 0.5308 0.5291
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0317 0.8621
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0317 0.14
Brugia malayi MH2 domain containing protein 0.0016 0.0043 0.0081
Schistosoma mansoni hypothetical protein 0.0304 0.4191 0.417
Trypanosoma brucei unspecified product 0.0014 0.0016 0.0506
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0108 0.0072
Schistosoma mansoni ran 0.0021 0.0114 0.0078
Toxoplasma gondii ABC1 family protein 0.0035 0.0315 0.287
Trypanosoma cruzi ISWI complex protein 0.0018 0.0064 0.2033
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.3207 0.6042
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0108 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.052 0.098
Schistosoma mansoni smad 0.0016 0.0043 0.0007
Brugia malayi TAR-binding protein 0.0382 0.5308 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.3589
Onchocerca volvulus 0.0035 0.0315 0.279
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0144 0.0638
Plasmodium vivax importin-beta 2, putative 0.0028 0.0222 0.3153
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0814 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2088 0.3934
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0144 0.4558
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0368 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Loa Loa (eye worm) hypothetical protein 0.0081 0.0979 0.1845
Echinococcus multilocularis microtubule associated protein 2 0.0708 1 1
Schistosoma mansoni hypothetical protein 0.0181 0.2412 0.2384
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0108 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0315 0.9932
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0317 0.14
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0315 0.2929
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.3589
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1913 0.1884
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0093 0.0058
Echinococcus granulosus zinc finger protein 0.0028 0.0209 0.0173
Echinococcus multilocularis geminin 0.0181 0.2412 0.2384
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0317 0.2901
Echinococcus granulosus dna polymerase eta 0.0021 0.0108 0.0072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0871 0.0838
Leishmania major importin beta-1 subunit, putative 0.0023 0.0144 0.1774
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0315 0.2929
Trichomonas vaginalis ran, putative 0.0021 0.0114 0.0503
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0315 0.028
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0315 0.0709
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0315 0.1391
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0186 0.588
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0214
Schistosoma mansoni smad1 5 8 and 0.0016 0.0043 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0043 0.0007
Schistosoma mansoni DNA polymerase eta 0.0021 0.0108 0.0072
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0317 0.0282
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0405 0.037
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0814 0.0781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0814 0.2421
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.3589
Brugia malayi MH1 domain containing protein 0.0016 0.0043 0.0081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0315 0.0593
Brugia malayi Bromodomain containing protein 0.0091 0.1124 0.2117
Loa Loa (eye worm) beta-lactamase 0.0035 0.0315 0.0593
Echinococcus granulosus cpg binding protein 0.0032 0.0275 0.024
Brugia malayi hypothetical protein 0.0017 0.0054 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0382 0.5308 0.5291
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0043 0.0007
Loa Loa (eye worm) hypothetical protein 0.0175 0.2333 0.4395
Trypanosoma brucei glucosidase, putative 0.0035 0.0317 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0317 0.0597
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0102 0.0067
Schistosoma mansoni bromodomain containing protein 0.0078 0.093 0.0898
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0108 0.0203
Echinococcus multilocularis smad 0.0016 0.0043 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0144 0.0638
Loa Loa (eye worm) hypothetical protein 0.0026 0.0186 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0382 0.5308 0.5291
Trichomonas vaginalis conserved hypothetical protein 0.017 0.2264 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0315 0.028
Schistosoma mansoni hypothetical protein 0.0404 0.5631 0.5615
Brugia malayi RNA recognition motif domain containing protein 0.0382 0.5308 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2427 0.24
Leishmania major hypothetical protein, conserved 0.0026 0.0186 0.2289
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0186 0.1037
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0093 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0102 0.0067
Echinococcus multilocularis cpg binding protein 0.0032 0.0275 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Schistosoma mansoni alpha-glucosidase 0.0136 0.1771 0.1742
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0214
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0457 0.0423
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0108 0.3405
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.0506
Brugia malayi beta-lactamase family protein 0.0035 0.0315 0.0593
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0315 0.1391
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0186 0.286
Brugia malayi MH2 domain containing protein 0.0236 0.3207 0.6042
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0186 0.588
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0317 0.14
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0457 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0315 0.2929
Leishmania major GTP-binding protein, putative 0.0021 0.0114 0.1397
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.2427 0.4573
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0317 0.0597
Schistosoma mansoni Smad4 0.0016 0.0043 0.0007
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.2333 0.4395
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0108 0.3405
Mycobacterium tuberculosis Conserved protein 0.0035 0.0315 0.0709
Echinococcus multilocularis zinc finger protein 0.0028 0.0209 0.0173
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0814 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0108 0.3405
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0558
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0036 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.052 0.098
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0315 0.0709
Plasmodium falciparum importin beta, putative 0.0028 0.0222 0.4265
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0108 0.0072
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1913 0.1884
Loa Loa (eye worm) Smad1 0.0016 0.0043 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.2427 0.24
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0317 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.0506
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0405 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Echinococcus granulosus dnaJ subfamily B 0.0404 0.5631 0.5615
Echinococcus multilocularis dna polymerase eta 0.0021 0.0108 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0814 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2088 0.206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0102 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0315 0.028
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0457 0.4904
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0108 0.2936
Loa Loa (eye worm) TAR-binding protein 0.0382 0.5308 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.059 0.1111
Brugia malayi Importin beta-1 subunit 0.0028 0.0222 0.0418
Loa Loa (eye worm) hypothetical protein 0.0021 0.0108 0.0203
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0871 0.0838
Schistosoma mansoni alpha glucosidase 0.0035 0.0317 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0457 0.202
Entamoeba histolytica hypothetical protein 0.0023 0.0144 0.3929
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0315 0.1391
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2088 0.3934
Entamoeba histolytica Ran family GTPase 0.0021 0.0114 0.3094
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0108 0.3405
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1816 0.1786
Leishmania major hypothetical protein, conserved 0.0018 0.0064 0.0791
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3025 1
Brugia malayi PHD-finger family protein 0.0034 0.0297 0.0559
Trypanosoma brucei ISWI complex protein 0.0018 0.0064 0.2033
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0368 1
Schistosoma mansoni cpg binding protein 0.0032 0.0275 0.024
Trypanosoma brucei unspecified product 0.0021 0.0108 0.3405
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0315 0.0709
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0222 0.1546
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0317 0.14
Schistosoma mansoni tar DNA-binding protein 0.0382 0.5308 0.5291
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0108 0.1326
Mycobacterium tuberculosis Conserved protein 0.0035 0.0315 0.0709
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0043 0.0007
Schistosoma mansoni hypothetical protein 0.0034 0.0296 0.0261
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0315 0.0709
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1913 0.3604
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0144 0.0638
Loa Loa (eye worm) RNA binding protein 0.0382 0.5308 1
Echinococcus multilocularis snurportin 1 0.0304 0.4191 0.417
Onchocerca volvulus 0.0091 0.1129 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0193
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0108 0.0477
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.4191 0.7896
Schistosoma mansoni microtubule-associated protein tau 0.0708 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.0153 0.0117
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0036 0.0068
Mycobacterium tuberculosis Conserved protein 0.0035 0.0315 0.0709
Mycobacterium ulcerans beta-lactamase 0.0035 0.0315 0.2929
Brugia malayi MH2 domain containing protein 0.0016 0.0043 0.0081
Echinococcus granulosus importin subunit beta 1 0.0028 0.0222 0.0187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0593
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0043 0.0007
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0108 0.0072
Leishmania major DNA polymerase eta, putative 0.0021 0.0108 0.1326
Echinococcus granulosus snurportin 1 0.0304 0.4191 0.417
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0186 0.2114
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0036 0.0068
Mycobacterium ulcerans hypothetical protein 0.0035 0.0315 0.2929
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2427 0.24
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0317 0.8621
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0315 0.1391
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0676 0.8019
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0814 0.0781
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0068
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0317 0.3893
Schistosoma mansoni smad1 5 8 and 0.0016 0.0043 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.022 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0593
Schistosoma mansoni importin beta-1 0.0028 0.0222 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2427 0.24
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0317 0.14
Brugia malayi CXXC zinc finger family protein 0.0028 0.022 0.0415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.2427 0.24
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.3405
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0222 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0102 0.0067
Leishmania major DNA polymerase kappa, putative 0.0021 0.0108 0.1326
Brugia malayi beta-lactamase family protein 0.0035 0.0315 0.0593
Schistosoma mansoni zinc finger protein 0.0028 0.0209 0.0173
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.5631 0.5615
Schistosoma mansoni cpg binding protein 0.0032 0.0275 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0814 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0222 0.7006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0593
Onchocerca volvulus 0.0028 0.022 0.1953
Echinococcus granulosus Smad4 0.0016 0.0043 0.0007
Schistosoma mansoni cpg binding protein 0.0028 0.022 0.0185
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0296 0.0558
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0207 0.0172
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0315 0.0709
Brugia malayi beta-lactamase 0.0035 0.0315 0.0593
Echinococcus multilocularis Smad4 0.0016 0.0043 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.2427 0.24
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0457 0.4904
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0457 0.202
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0814 0.0781
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0093 0.0058
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0028
Onchocerca volvulus 0.0035 0.0315 0.279
Schistosoma mansoni zinc finger protein 0.0018 0.0064 0.0028
Brugia malayi Bromodomain containing protein 0.0047 0.0495 0.0932
Schistosoma mansoni ran 0.0021 0.0114 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0317 0.14
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0108 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0315 0.9932
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.2427 0.4573
Echinococcus granulosus geminin 0.0181 0.2412 0.2384
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0224
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0317 0.14
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0315 0.0593
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0043 0.0007
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0368 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0315 0.028
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0315 0.1391
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0154 0.029
Loa Loa (eye worm) acetyltransferase 0.0146 0.1913 0.3604
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0315 0.0709
Brugia malayi hypothetical protein 0.0026 0.0186 0.0351
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0679 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0382 0.5308 0.5291
Echinococcus granulosus dna polymerase kappa 0.0021 0.0108 0.0072
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0207 0.0172
Echinococcus granulosus tar DNA binding protein 0.0382 0.5308 0.5291
Brugia malayi RNA binding protein 0.0382 0.5308 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.2427 0.24
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0186 0.286
Loa Loa (eye worm) hypothetical protein 0.005 0.0535 0.1008
Mycobacterium leprae Probable lipase LipE 0.0035 0.0315 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.3207 0.6042
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0315 0.5
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0114 0.0078

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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