Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3115 | 0.3547 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.3797 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1838 | 0.1526 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.3797 | 0.3797 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3115 | 0.3547 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.3797 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1838 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.3797 | 0.5 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0028 | 0.0874 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1838 | 0.1526 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.3797 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1838 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.3797 | 0.4626 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.3797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1742 | 0.1742 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.3797 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.3797 | 0.4626 |
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.0075 | 0.7193 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.3115 | 0.3115 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1838 | 0.1526 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0096 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3115 | 0.3547 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.159 | 0.159 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0035 | 0.1742 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3653 | 0.3653 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1838 | 0.1057 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1838 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3115 | 0.3547 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Echinococcus granulosus | irregular chiasm roughest protein | 0.0075 | 0.7193 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3115 | 0.3547 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.3797 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3115 | 0.3547 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1635 | 0.1635 |
Echinococcus granulosus | nephrin | 0.0075 | 0.7193 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0096 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.3797 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0075 | 0.7193 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0075 | 0.7193 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.3797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.3797 | 0.4626 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.3797 | 0.4626 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3653 | 0.3045 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3115 | 0.3547 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3653 | 0.3045 |
Plasmodium falciparum | apical sushi protein | 0.0028 | 0.0874 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Brugia malayi | hypothetical protein | 0.0096 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.159 | 0.0784 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3797 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3797 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.3797 | 0.4626 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.3797 | 0.3203 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1838 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0096 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.7193 | 1 |
Echinococcus multilocularis | nephrin | 0.0075 | 0.7193 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0075 | 0.7193 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.7193 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3653 | 0.3653 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3797 | 0.5 |
Plasmodium vivax | apical sushi protein, putative | 0.0028 | 0.0874 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.3115 | 0.2456 |
Echinococcus granulosus | nephrin | 0.0075 | 0.7193 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1838 | 0.1526 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.159 | 0.1133 |
Onchocerca volvulus | 0.0028 | 0.0874 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0874 | 0.0874 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.3797 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7350 nM | Inhibition of [125I]-AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries | ChEMBL. | 8515425 |
IC50 (binding) | = 7350 nM | Inhibition of [125I]-AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries | ChEMBL. | 8515425 |
ID50 (functional) | = 15 mg kg-1 | In vivo inhibition of pressor response to angiotensin II in conscious normotensive rats | ChEMBL. | 8515425 |
ID50 (functional) | = 15 mg kg-1 | In vivo inhibition of pressor response to angiotensin II in conscious normotensive rats | ChEMBL. | 8515425 |
Kb (functional) | = 870 nM | Inhibition of angiotensin II induced vasoconstriction of rabbit aorta | ChEMBL. | 8515425 |
Kb (functional) | = 870 nM | Inhibition of angiotensin II induced vasoconstriction of rabbit aorta | ChEMBL. | 8515425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.