Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0532 | 0.2113 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.1196 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.252 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0332 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1637 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1196 | 0.7301 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0332 | 0.0332 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0532 | 0.2113 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1196 | 0.7301 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1637 | 0.6498 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.1196 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0532 | 0.0532 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0532 | 0.4453 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0287 | 0.1753 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1637 | 0.6498 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1196 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1637 | 0.6498 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.1196 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.1196 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1196 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0332 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1196 | 0.7301 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.1196 | 0.1196 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.252 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0332 | 0.1316 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.252 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1196 | 0.4744 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0532 | 0.4453 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0332 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.1196 | 0.7301 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1196 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0247 | 0.0247 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.1196 | 0.4744 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1196 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1196 | 0.4744 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0532 | 0.4453 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1196 | 0.7301 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0532 | 0.4453 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1637 | 0.6498 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.1196 | 0.1196 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.1196 | 0.1196 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1637 | 0.6498 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.1196 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.1196 | 0.1196 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.1196 | 1 |
Onchocerca volvulus | 0.0039 | 0.1196 | 1 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0532 | 0.0917 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0287 | 0.2401 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0532 | 0.4453 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.1196 | 0.1196 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.1575 | 0.6252 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.1196 | 0.4744 |
Brugia malayi | beta-lactamase | 0.0039 | 0.1196 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0287 | 0.1753 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.1196 | 0.1196 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1196 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0532 | 0.3251 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.1196 | 0.4744 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0332 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0532 | 0.3251 |
Onchocerca volvulus | 0.0039 | 0.1196 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0532 | 0.3251 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0532 | 0.4453 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0532 | 0.4453 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0332 | 0.1316 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0532 | 0.4453 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0332 | 0.2775 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.1196 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.1196 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1637 | 0.6498 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1196 | 0.7301 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0532 | 0.0917 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0287 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0532 | 0.0917 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.1196 | 0.1196 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0332 | 0.2775 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0532 | 0.4453 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.252 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0287 | 0.1753 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.252 | 1 |
Brugia malayi | hypothetical protein | 0.007 | 0.252 | 1 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.252 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.252 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.1196 | 0.1196 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0532 | 0.4453 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0332 | 0.2775 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0332 | 0.1316 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.1575 | 0.9622 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0332 | 0.2775 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.1196 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0532 | 0.0532 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0332 | 0.2026 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0332 | 0.2775 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0532 | 0.2113 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0332 | 0.0492 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0287 | 0.0287 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0332 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0287 | 0.1753 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0332 | 0.2775 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1196 | 0.4744 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0332 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.1196 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.1196 | 0.7301 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.252 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0532 | 0.4453 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0532 | 0.4453 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.1196 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.1196 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1196 | 0.7301 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0247 | 0.0247 |
Onchocerca volvulus | 0.0039 | 0.1196 | 1 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0247 | 0.0247 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1637 | 0.6498 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.1196 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.1196 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1637 | 0.6498 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0287 | 0.1753 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1196 | 0.4744 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0532 | 0.4453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.