Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0035 | 0.0914 | 0.2209 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.6464 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0914 | 0.0914 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0057 | 0.237 | 0.237 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.162 | 0.162 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0914 | 0.0914 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.3571 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0845 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1077 | 0.1171 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0911 | 0.0911 |
Echinococcus granulosus | transcription factor btf3 | 0.0034 | 0.0845 | 0.0845 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.5661 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1859 | 0.4305 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.162 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0845 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0914 | 0.0914 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0785 | 0.183 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.162 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.162 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.5661 | 0.8342 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.237 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0057 | 0.237 | 0.155 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.237 | 0.237 |
Brugia malayi | beta-NAC-like protein | 0.0034 | 0.0845 | 0.2007 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1238 | 0.1817 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.5661 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.162 | 0.4278 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1072 | 0.2673 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2773 | 0.2773 |
Brugia malayi | Cytochrome P450 family protein | 0.0045 | 0.1545 | 0.4058 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.162 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.237 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0914 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.237 | 0.648 |
Leishmania major | trypanothione reductase | 0.0046 | 0.162 | 0.5078 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.237 | 0.237 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.162 | 0.3346 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0845 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.5661 | 0.8342 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3279 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1859 | 0.4979 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2529 | 0.2529 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.5661 | 0.8342 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1859 | 0.4979 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0911 | 0.0911 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0914 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.162 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.6464 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.2108 | 0.5302 |
Schistosoma mansoni | transcription factor btf3 | 0.0034 | 0.0845 | 0.0845 |
Echinococcus multilocularis | transcription factor btf3 | 0.0034 | 0.0845 | 0.0845 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.5661 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1859 | 0.4305 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.162 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0914 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.162 | 0.3346 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.6464 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.162 | 0.162 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0045 | 0.1545 | 0.3046 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.162 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2529 | 0.2529 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1368 | 0.2339 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0057 | 0.237 | 1 |
Loa Loa (eye worm) | ICD-1 protein | 0.0034 | 0.0845 | 0.0242 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.6464 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.162 | 0.4278 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 nM | In vitro affinity to bind competitively with sigma opioid receptor in the homogenized guinea pig whole brain using [3H]-DTG as radioligand;ND- Not determined | ChEMBL. | 1648140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.