Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.1214 | 0.481 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.1945 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2258 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0366 | 0.0173 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0045 | 0.2465 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0633 | 0.3255 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.1057 | 0.5436 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.1109 | 0.4065 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0779 | 0.172 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.1109 | 0.4065 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.1109 | 0.4065 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.1945 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0025 | 0.1086 | 0.0908 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0779 | 0.172 |
Mycobacterium ulcerans | polyketide synthase | 0.0027 | 0.1214 | 0.481 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.1109 | 0.5702 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.1214 | 0.6242 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.1109 | 0.4065 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0515 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.1945 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.1109 | 0.5702 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0027 | 0.1214 | 0.481 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.0102 | 0.0527 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.1109 | 0.5702 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.0622 | 0.3708 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0027 | 0.1214 | 0.481 |
Onchocerca volvulus | 0.0044 | 0.236 | 0.9285 | |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.0998 | 0.0818 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.1057 | 0.5436 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0027 | 0.1214 | 0.481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0779 | 0.172 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.1109 | 0.0123 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0021 | 0.0827 | 0.4254 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.1109 | 0.4065 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.1109 | 0.4065 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0027 | 0.1214 | 0.6242 |
Mycobacterium ulcerans | thioesterase TesA | 0.0021 | 0.0827 | 0.2064 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0157 | 1 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0027 | 0.1214 | 0.481 |
Mycobacterium ulcerans | thioesterase | 0.0021 | 0.0827 | 0.2064 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.1945 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0047 | 0.2622 | 0.1804 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0021 | 0.0827 | 0.2064 |
Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.1109 | 0.4065 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.038 | 0.1953 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0801 | 0.4119 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0027 | 0.1214 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0998 | 0.5131 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0027 | 0.1214 | 0.6242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.