Detailed information for compound 80080

Basic information

Technical information
  • TDR Targets ID: 80080
  • Name: 2-amino-3-methyl-5,5-diphenylimidazol-4-one
  • MW: 265.31 | Formula: C16H15N3O
  • H donors: 1 H acceptors: 1 LogP: 1.99 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C(=NC(C1=O)(c1ccccc1)c1ccccc1)N
  • InChi: 1S/C16H15N3O/c1-19-14(20)16(18-15(19)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3,(H2,17,18)
  • InChiKey: RNWLAFWLSSMCLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-3-methyl-5,5-diphenyl-imidazol-4-one
  • 2-amino-3-methyl-5,5-diphenyl-4-imidazolone
  • 2-azanyl-3-methyl-5,5-diphenyl-imidazol-4-one
  • 2-amino-3-methyl-5,5-diphenyl-2-imidazolin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens amyloid beta (A4) precursor protein Starlite/ChEMBL References
Homo sapiens renin Starlite/ChEMBL References
Homo sapiens beta-site APP-cleaving enzyme 2 Starlite/ChEMBL References
Homo sapiens beta-site APP-cleaving enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Brugia malayi Amyloid A4 extracellular domain containing protein Get druggable targets OG5_131699 All targets in OG5_131699
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131699 All targets in OG5_131699
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131699 All targets in OG5_131699
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131699 All targets in OG5_131699
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative Get druggable targets OG5_135830 All targets in OG5_135830
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni memapsin-2 (A01 family) Get druggable targets OG5_135830 All targets in OG5_135830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin VII beta-site APP-cleaving enzyme 1 401 aa 352 aa 21.3 %
Plasmodium falciparum plasmepsin V beta-site APP-cleaving enzyme 2 518 aa 439 aa 21.9 %
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0438 0.1403
Loa Loa (eye worm) glutaminase 0.0277 0.1925 0.4837
Brugia malayi aspartic protease BmAsp-2, identical 0.0056 0.0309 0.0768
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0067 0.0114
Brugia malayi Pre-SET motif family protein 0.006 0.0342 0.0849
Brugia malayi steroid hormone receptor 0.0023 0.0067 0.0159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0067 0.0127
Plasmodium vivax ferrodoxin reductase, putative 0.0109 0.0699 0.1567
Brugia malayi ecdysteroid receptor 0.0023 0.0067 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0067 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0067 0.0159
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0109 0.0699 0.1388
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0109 0.0699 0.2311
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0438 0.1266
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1167 0.844 0.8437
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0109 0.0699 0.2044
Schistosoma mansoni cathepsin D (A01 family) 0.0216 0.148 0.2676
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0699 0.0686
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0109 0.0699 0.2044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0067 0.0159
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0319 0.2239 0.4995
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0067 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0237 0.0595
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0237 0.0422
Schistosoma mansoni inositol monophosphatase 0.0073 0.0438 0.0787
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0438 0.0425
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0109 0.0699 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0014 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.138 1 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0109 0.0699 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0411 0.2907 0.7243
Leishmania major hypothetical protein, conserved 0.0109 0.0699 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Plasmodium falciparum plasmepsin V 0.0056 0.0309 0.0565
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0411 0.2907 1
Leishmania major cytochrome p450-like protein 0.0018 0.0035 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0067 0.0159
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0109 0.0699 0.1388
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0321 0.0634
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0109 0.0699 0.0686
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0109 0.0699 0.2044
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0109 0.0699 1
Trichomonas vaginalis mercuric reductase, putative 0.0411 0.2907 0.8631
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0067 0.0127
Onchocerca volvulus 0.0056 0.0309 0.0734
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0067 0.0127
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0067 0.0114
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0168 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0067 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0067 0.0159
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0109 0.0699 0.1388
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0411 0.2907 0.7243
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0109 0.0699 0.1388
Mycobacterium ulcerans monoxygenase 0.0109 0.0699 0.2311
Onchocerca volvulus 0.0029 0.0114 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0168 0.0461
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Schistosoma mansoni lamin 0.0029 0.0114 0.0199
Plasmodium falciparum thioredoxin reductase 0.0411 0.2907 0.7243
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0018 0.0034
Plasmodium vivax plasmepsin V, putative 0.0056 0.0309 0.0565
Toxoplasma gondii aspartyl protease 0.0056 0.0309 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0126 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Echinococcus granulosus geminin 0.0183 0.124 0.2469
Echinococcus multilocularis cpg binding protein 0.0031 0.0126 0.0244
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0114 0.0277
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0342 0.0675
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0067 0.0127
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0109 0.0699 0.2044
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0035 0.0088
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.138 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0114 0.0286
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0109 0.0699 0.0686
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0109 0.0699 0.1683
Plasmodium falciparum glutathione reductase 0.0411 0.2907 0.7243
Echinococcus multilocularis geminin 0.0183 0.124 0.2469
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0109 0.0699 0.1683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0067 0.0169
Brugia malayi follicle stimulating hormone receptor 0.0257 0.1784 0.4478
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0109 0.0699 0.1505
Echinococcus multilocularis lamin 0.0029 0.0114 0.022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0067 0.0114
Brugia malayi nuclear receptor NHR-88 0.0023 0.0067 0.0159
Echinococcus granulosus neuropeptide s receptor 0.0474 0.3373 0.6729
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0411 0.2907 0.651
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0067 0.0114
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0342 0.0675
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0109 0.0699 0.0686
Loa Loa (eye worm) hypothetical protein 0.0291 0.2031 0.5104
Loa Loa (eye worm) hypothetical protein 0.0101 0.0639 0.1606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0188 0.0519
Plasmodium vivax SET domain protein, putative 0.006 0.0342 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0342 0.0612
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0067 0.0127
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0302 0.2109 0.5295
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0109 0.0699 0.2044
Trypanosoma brucei NADH dehydrogenase 0.0109 0.0699 0.0686
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Trichomonas vaginalis glutathione reductase, putative 0.0411 0.2907 0.8631
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0411 0.2907 0.2897
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0056
Plasmodium vivax aspartyl proteinase, putative 0.0101 0.0639 0.1413
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0411 0.2907 0.7281
Plasmodium falciparum glutathione reductase 0.0557 0.3979 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0067 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0102 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0342 0.0612
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0067 0.0114
Leishmania major NADH dehydrogenase, putative 0.0109 0.0699 0.0686
Echinococcus granulosus GPCR family 2 0.0016 0.0018 0.0028
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0025
Schistosoma mansoni cpg binding protein 0.0031 0.0126 0.0221
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0035 0.0088
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0438 0.0867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0089 0.0076
Trichomonas vaginalis glutamate synthase, putative 0.0109 0.0699 0.2044
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0089 0.0076
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.3373 0.6729
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0319 0.2239 0.4995
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0109 0.0699 0.1567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0205
Schistosoma mansoni hypothetical protein 0.0103 0.0655 0.1181
Entamoeba histolytica thioredoxin reductase, putative 0.0109 0.0699 1
Plasmodium vivax aspartyl protease, putative 0.0056 0.0309 0.0565
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0411 0.2907 0.7243
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.3373 0.6729
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0109 0.0699 0.2311
Echinococcus multilocularis glutamate synthase 0.0109 0.0699 0.1388
Giardia lamblia NADH oxidase lateral transfer candidate 0.0411 0.2907 1
Trichomonas vaginalis set domain proteins, putative 0.0474 0.3366 1
Giardia lamblia Thioredoxin reductase 0.0109 0.0699 0.1731
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0109 0.0699 0.2044
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0411 0.2907 0.5264
Schistosoma mansoni sulfide quinone reductase 0.0109 0.0699 0.126
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0067 0.0127
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0101 0.0639 0.1268
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0411 0.2907 0.2897
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0198 0.0388
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0067 0.0114
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0067 0.0127
Brugia malayi hypothetical protein 0.0056 0.0309 0.0768
Schistosoma mansoni glutamate synthase 0.0109 0.0699 0.126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1024 0.7395 0.7392
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0277
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0438 0.0867
Brugia malayi Cytochrome P450 family protein 0.0018 0.0035 0.0078
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.0019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0557 0.3979 0.7941
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0237 0.0465
Trichomonas vaginalis glutamate synthase, putative 0.0109 0.0699 0.2044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0067 0.0159
Loa Loa (eye worm) hypothetical protein 0.0156 0.1045 0.2627
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0271 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0119 0.0314
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0056 0.0309 0.0695
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0035 0.0021
Schistosoma mansoni sulfide quinone reductase 0.0109 0.0699 0.126
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0109 0.0699 0.2044
Echinococcus granulosus intermediate filament protein 0.0029 0.0114 0.022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1024 0.7395 0.7392
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.3373 0.6729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0168 0.0461
Mycobacterium ulcerans glutaminase 0.0277 0.1925 0.658
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0411 0.2907 1
Brugia malayi nuclear hormone receptor 0.0023 0.0067 0.0159
Echinococcus granulosus cpg binding protein 0.0031 0.0126 0.0244
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0101 0.0639 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0168 0.0461
Mycobacterium ulcerans NADH dehydrogenase 0.0109 0.0699 0.2311
Brugia malayi Thioredoxin reductase 0.0557 0.3979 1
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0067 0.0114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.027 0.0669
Plasmodium falciparum plasmepsin VII 0.0056 0.0309 0.0565
Mycobacterium tuberculosis Probable dehydrogenase 0.0319 0.2239 0.4995
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0109 0.0699 0.0686
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0067 0.0127
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0067 0.0127
Toxoplasma gondii aspartyl protease ASP1 0.0101 0.0639 0.1531
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0109 0.0699 0.2311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0237 0.0666
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0109 0.0699 0.0686
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0067 0.0127
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0438 0.0425
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0109 0.0699 0.1388
Brugia malayi glutamate synthase 0.0109 0.0699 0.1748
Onchocerca volvulus 0.0029 0.0114 0.0142
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0109 0.0699 0.1505
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0089 0.0076
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0035 0.0021
Leishmania major hypothetical protein, conserved 0.0109 0.0699 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0067 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0067 0.0169
Loa Loa (eye worm) glutaminase 2 0.0277 0.1925 0.4837
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0067 0.0169
Mycobacterium tuberculosis Probable reductase 0.0319 0.2239 0.4995
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0067 0.0159
Brugia malayi Inositol-1 0.0073 0.0438 0.1092
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0067 0.0159
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0223 0.0397
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0699 0.0686
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0109 0.0699 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Schistosoma mansoni disulfide oxidoreductase 0.0109 0.0699 0.126
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0109 0.0699 0.2044
Mycobacterium tuberculosis Probable oxidoreductase 0.0621 0.4447 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0557 0.3979 0.7941
Loa Loa (eye worm) hypothetical protein 0.0036 0.0162 0.0407
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1024 0.7395 0.7392
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0109 0.0699 1
Plasmodium falciparum thioredoxin reductase 0.0557 0.3979 1
Echinococcus multilocularis 0.0018 0.0035 0.0062
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0114 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0342 0.0612
Brugia malayi glutathione reductase 0.0557 0.3979 1
Onchocerca volvulus 0.0056 0.0309 0.0734
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0237 0.0223
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0089 0.0138
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0151 0.0293
Brugia malayi Pre-SET motif family protein 0.0416 0.2946 0.74
Plasmodium vivax aspartyl protease, putative 0.0056 0.0309 0.0565
Brugia malayi CXXC zinc finger family protein 0.0029 0.0114 0.0276
Echinococcus granulosus lamin 0.0029 0.0114 0.022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0028
Schistosoma mansoni glutamate synthase 0.0109 0.0699 0.126
Loa Loa (eye worm) hypothetical protein 0.006 0.0342 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0067 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0041 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.027 0.0679
Schistosoma mansoni hypothetical protein 0.0109 0.0699 0.126
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0067 0.0127
Loa Loa (eye worm) hypothetical protein 0.0056 0.0309 0.0777
Trypanosoma cruzi trypanothione reductase, putative 0.0411 0.2907 0.2897
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0438 0.0425
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0319 0.2239 0.4995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0114 0.0287
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0109 0.0699 0.1683
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0109 0.0699 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0205
Entamoeba histolytica disulphide oxidoreductase, putative 0.0109 0.0699 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0109 0.0699 1
Echinococcus granulosus dnaJ subfamily B 0.0414 0.2929 0.5844
Plasmodium falciparum plasmepsin VI 0.0101 0.0639 0.1413
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0368 0.066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0237 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0168 0.0461
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0153 0.0375
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0109 0.0699 0.1505
Mycobacterium ulcerans hypothetical protein 0.0109 0.0699 0.2311
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0411 0.2907 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0109 0.0699 0.2044
Brugia malayi aspartic protease BmAsp-1, identical 0.0056 0.0309 0.0768
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0067 0.0114
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1024 0.7395 0.7392
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Loa Loa (eye worm) hypothetical protein 0.0109 0.0699 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0109 0.0699 0.1505
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0018 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0621 0.4447 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0237 0.0223
Leishmania major hypothetical protein, conserved 0.0026 0.0089 0.0076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0557 0.3979 0.8941
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0198 0.0498
Echinococcus multilocularis lamin dm0 0.0029 0.0114 0.022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.138 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0015 0.0038
Plasmodium falciparum plasmepsin IV 0.0101 0.0639 0.1413
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0067 0.0159
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0109 0.0699 0.1056
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.501 0.9077
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.027 0.0669
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.0679
Loa Loa (eye worm) cytochrome P450 0.0018 0.0035 0.0088
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0109 0.0699 0.0686
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0438 0.4356
Brugia malayi cytochrome P450 0.0018 0.0035 0.0078
Schistosoma mansoni hypothetical protein 0.0183 0.124 0.2241
Brugia malayi Eukaryotic aspartyl protease family protein 0.0056 0.0309 0.0768
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0067 0.0114
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.501 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0411 0.2907 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0109 0.0699 0.0686
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0237 0.0223
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0067 0.0159
Loa Loa (eye worm) hypothetical protein 0.005 0.0271 0.068
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0109 0.0699 0.1748
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0411 0.2907 0.2897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1167 0.844 0.8437
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0168 0.0155
Brugia malayi intermediate filament protein 0.0029 0.0114 0.0277
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0156 0.0425
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0156 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0168 0.0461
Plasmodium falciparum ferrodoxin reductase-like protein 0.0109 0.0699 0.1567
Schistosoma mansoni cpg binding protein 0.0029 0.0114 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0067 0.0169
Schistosoma mansoni glutamate synthase 0.0109 0.0699 0.126
Schistosoma mansoni cpg binding protein 0.0031 0.0126 0.0221
Treponema pallidum NADH oxidase 0.0411 0.2907 1
Plasmodium vivax glutathione reductase, putative 0.0557 0.3979 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0067 0.0159
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0067 0.0127
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0035 0.0021
Brugia malayi Cytochrome P450 family protein 0.0018 0.0035 0.0078
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0135 0.0887 0.16
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0237 0.0585
Plasmodium falciparum plasmepsin I 0.0101 0.0639 0.1413
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0411 0.2907 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Brugia malayi hypothetical protein 0.0056 0.0309 0.0768
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0067 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0557 0.3979 0.3971
Plasmodium falciparum plasmepsin X 0.0056 0.0309 0.0565
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0109 0.0699 0.1683
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0067 0.0127
Onchocerca volvulus 0.0109 0.0699 0.1915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0045
Plasmodium vivax aspartyl proteinase, putative 0.0056 0.0309 0.0565
Toxoplasma gondii aspartyl protease ASP3 0.0056 0.0309 0.0695
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0109 0.0699 0.0686
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1167 0.844 0.8437
Echinococcus granulosus glutamate synthase 0.0109 0.0699 0.1388
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0411 0.2907 0.5799
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0382 0.0786
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0438 0.1022
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0411 0.2907 0.7302
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0109 0.0699 0.1388
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0237 0.0223
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.2946 0.7403
Echinococcus multilocularis GPCR, family 2 0.0016 0.0018 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0204
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0035 0.0021
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0035 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0014 0.0034
Leishmania major cytochrome p450-like protein 0.0018 0.0035 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Brugia malayi Cytochrome P450 family protein 0.0018 0.0035 0.0078
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0438 0.1266
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0109 0.0699 0.1748
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0109 0.0699 0.1388
Plasmodium vivax plasmepsin IV, putative 0.0101 0.0639 0.1413
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0035 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0067 0.0127
Toxoplasma gondii thioredoxin reductase 0.0557 0.3979 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0101 0.0639 0.1606
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0168 0.0155
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0109 0.0699 0.2311
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0385
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0109 0.0699 0.1731
Giardia lamblia Glutamate synthase 0.0109 0.0699 0.1731
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0067 0.0114
Brugia malayi Pepsin A precursor 0.0056 0.0309 0.0768
Plasmodium falciparum plasmepsin IX 0.0056 0.0309 0.0565
Schistosoma mansoni cathepsin D (A01 family) 0.0216 0.148 0.2676
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0025
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0342 0.0777
Plasmodium vivax thioredoxin reductase, putative 0.0557 0.3979 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0015 0.0028
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0109 0.0699 0.2311
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0067 0.0159
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.1784 0.4484
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0225
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0109 0.0699 0.2311
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0109 0.0699 0.1505
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0411 0.2907 0.5799
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0109 0.0699 0.1056
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0109 0.0699 0.0686
Schistosoma mansoni memapsin-2 (A01 family) 0.0556 0.3968 0.7188
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0056 0.0309 0.0777
Plasmodium falciparum plasmepsin VIII, putative 0.0056 0.0309 0.0565
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0621 0.4447 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0382 0.0786
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0067 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0204
Mycobacterium ulcerans ferredoxin reductase 0.0109 0.0699 0.2311
Brugia malayi glutaminase DH11.1 0.0277 0.1925 0.4832
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0169
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0101 0.0639 0.1151
Trypanosoma cruzi NADH dehydrogenase, putative 0.0109 0.0699 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0237 0.0666
Toxoplasma gondii NADPH-glutathione reductase 0.0411 0.2907 0.7281
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0109 0.0699 0.1388
Mycobacterium ulcerans dehydrogenase 0.0109 0.0699 0.2311
Trichomonas vaginalis glutaminase, putative 0.0277 0.1925 0.5701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0204
Loa Loa (eye worm) thioredoxin reductase 0.0557 0.3979 1
Leishmania major cytochrome p450-like protein 0.0018 0.0035 0.0021
Schistosoma mansoni hypothetical protein 0.0034 0.0153 0.0271
Echinococcus granulosus microtubule associated protein 2 0.0698 0.501 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.006 0.0046
Onchocerca volvulus 0.0474 0.3366 1
Leishmania major hypothetical protein, conserved 0.0109 0.0699 0.0686
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0237 0.0465
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0109 0.0699 0.1567
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0411 0.2907 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0109 0.0699 0.0686
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0109 0.0699 0.2311
Leishmania major trypanothione reductase 0.0557 0.3979 0.3971
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0067 0.0114
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0067 0.0114
Schistosoma mansoni inositol monophosphatase 0.0073 0.0438 0.0787
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0067 0.0169
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.032 0.0722
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0411 0.2907 0.7243
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0109 0.0699 0.2044
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0309 0.0553
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0342 0.0675
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0438 0.1266
Schistosoma mansoni hypothetical protein 0.0414 0.2929 0.5304
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0109 0.0699 0.1388
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0438 0.0425
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0035 0.0088
Loa Loa (eye worm) glutathione reductase 0.0557 0.3979 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0109 0.0699 0.1388
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0109 0.0699 0.1756
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0109 0.0699 0.1683
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0109 0.0699 0.0686
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0109 0.0699 0.1505
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0014 0.0017
Trypanosoma brucei trypanothione reductase 0.0557 0.3979 0.3971
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0109 0.0699 0.1505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0257
Schistosoma mansoni lamin 0.0029 0.0114 0.0199
Brugia malayi hypothetical protein 0.0026 0.0089 0.0214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0411 0.2907 0.2897
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0035 0.0088
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0621 0.4447 1
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.2929 0.5844
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0319 0.2239 0.4995
Plasmodium vivax aspartyl protease, putative 0.0056 0.0309 0.0565
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0067 0.0159
Loa Loa (eye worm) inositol-1 0.0073 0.0438 0.1101
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0369 0.2604 0.6541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0067 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0067 0.0127
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0114 0.0287
Echinococcus granulosus lamin dm0 0.0029 0.0114 0.022
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0109 0.0699 0.1567
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0198 0.0488
Echinococcus multilocularis musashi 0.0029 0.0114 0.022
Schistosoma mansoni glutaminase 0.0277 0.1925 0.3483
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0198 0.0388
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0035 0.0021
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0223 0.0397
Schistosoma mansoni intermediate filament proteins 0.0029 0.0114 0.0199
Onchocerca volvulus 0.006 0.0342 0.0832
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0109 0.0699 0.1505
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0101 0.0639 0.1865
Loa Loa (eye worm) hypothetical protein 0.0078 0.0472 0.1187
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0109 0.0699 0.1056
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0309 0.0777
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0699 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0342 0.0612
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0025
Schistosoma mansoni cytochrome P450 0.0018 0.0035 0.0056
Onchocerca volvulus 0.005 0.0271 0.0616
Trichomonas vaginalis apoptosis inducing factor, putative 0.0109 0.0699 0.2044
Schistosoma mansoni coup transcription factor 0.0023 0.0067 0.0114
Echinococcus granulosus tumor protein p63 0.0345 0.2425 0.4837
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0109 0.0699 0.1748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0102 0.0263
Loa Loa (eye worm) programmed cell death 8 0.0109 0.0699 0.1756
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0109 0.0699 0.0686
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0101 0.0639 0.1531
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0035 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0018 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1167 0.844 0.8437
Plasmodium falciparum plasmepsin III 0.0056 0.0309 0.0565
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0319 0.2239 0.4995
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0109 0.0699 0.1505
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0237 0.0223
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0237 0.0223
Brugia malayi Cytochrome P450 family protein 0.0018 0.0035 0.0078
Onchocerca volvulus 0.0029 0.0114 0.0141
Brugia malayi hypothetical protein 0.0017 0.0023 0.0047
Plasmodium falciparum plasmepsin II 0.0101 0.0639 0.1413
Mycobacterium ulcerans glutamate synthase subunit beta 0.0109 0.0699 0.2311
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0302 0.2109 0.5295
Toxoplasma gondii selenide, water dikinase 0.0109 0.0699 0.1683
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0109 0.0699 0.1567
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.0019
Echinococcus multilocularis tumor protein p63 0.0345 0.2425 0.4837
Schistosoma mansoni hypothetical protein 0.0183 0.124 0.2241
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0067 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0151 0.0409
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0109 0.0699 0.1505
Loa Loa (eye worm) aspartyl protease 6 0.0056 0.0309 0.0777

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 3.4 uM Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA ChEMBL. 19968289
EC50 (binding) = 4.17 uM Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISA ChEMBL. 19959359
ED50 (functional) mg kg-1 Compound was evaluated for the metrazole seizure test in mice after - 0.5 hr; data not available ChEMBL. 2061925
ED50 (functional) mg kg-1 Compound was evaluated for the metrazole seizure test in mice after - 4 hr; data not available ChEMBL. 2061925
ED50 (functional) mg kg-1 Compound was evaluated for the anticonvulsant activity by using minimal electroshock seizure test in mice after - 0.5 hr; data not available ChEMBL. 2061925
ED50 (functional) mg kg-1 Compound was evaluated for the anticonvulsant activity by using minimal electroshock seizure test in mice after - 4 hr; data not available ChEMBL. 2061925
ED50 (functional) 0 mg kg-1 Compound was evaluated for the metrazole seizure test in mice after - 0.5 hr; data not available ChEMBL. 2061925
ED50 (functional) 0 mg kg-1 Compound was evaluated for the metrazole seizure test in mice after - 4 hr; data not available ChEMBL. 2061925
ED50 (functional) 0 mg kg-1 Compound was evaluated for the anticonvulsant activity by using minimal electroshock seizure test in mice after - 0.5 hr; data not available ChEMBL. 2061925
ED50 (functional) 0 mg kg-1 Compound was evaluated for the anticonvulsant activity by using minimal electroshock seizure test in mice after - 4 hr; data not available ChEMBL. 2061925
IC50 (binding) = 5.463 Inhibition of human BACE1 ChEMBL. 21093114
IC50 (binding) = 3440 nM Inhibition of human BACE1 by FRET assay ChEMBL. 20880704
IC50 (binding) = 7100 nM Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assay ChEMBL. 20043696
IC50 (binding) = 12000 nM Inhibition of BACE1 mediated hydrolysis of human amyloid precursor protein with Swedish and London mutation in HEK293 cells by ELISA ChEMBL. 20043696
IC50 (binding) = 0.77 uM Inhibition of human BACE2 by FRET based peptide cleavage assay ChEMBL. 19968289
IC50 (binding) = 0.77 uM Inhibition of human BACE2 by FRET assay ChEMBL. 19959359
IC50 (binding) = 0.77 uM Inhibition of human BACE2 by FRET assay ChEMBL. 20045648
IC50 (binding) = 3.4 uM Inhibition of human BACE1 by FRET assay ChEMBL. 19959359
IC50 (binding) = 3.4 uM Inhibition of human BACE1 by FRET assay ChEMBL. 20045648
IC50 (binding) = 3.44 uM Inhibition of human BACE1 by FRET based peptide cleavage assay ChEMBL. 19968289
IC50 (binding) = 3.6 uM Inhibition of BACE1 by FRET assay ChEMBL. 20202842
IC50 (binding) = 9.6 uM Inhibition of human recombinant renin by FRET based peptide cleavage assay ChEMBL. 19968289
IC50 (binding) > 100 uM Inhibition of human cathepsin D by FRET assay ChEMBL. 20045648
IC50 (binding) > 100 uM Inhibition of cathepsin D by FRET assay ChEMBL. 21835615
Inhibition (binding) = 34 % Inhibition of human cathepsin D at 100 uM by FRET assay ChEMBL. 19959359
Inhibition (binding) = 36 % Inhibition of human cathepsin D at 100 uM by FRET based peptide cleavage assay ChEMBL. 19968289
Inhibition (binding) = 38 % Inhibition of human cathepsin D at 50 uM preincubated for 30 mins ChEMBL. 20043696
permeability (ADMET) = 81 % Permeability across brain in Tg2576 mouse at 100 mg/kg, po ChEMBL. 20880704

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

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