Detailed information for compound 80094

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 564.653 | Formula: C29H32N4O6S
  • H donors: 2 H acceptors: 5 LogP: -0.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: CS(=O)(=O)O.CN(C[C@H]1OCCn2cc(c3c2cccc3)C2=C(c3cn(CC1)c1ccccc31)C(=O)NC2=O)C
  • InChi: 1S/C28H28N4O3.CH4O3S/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;1-5(2,3)4/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H3,(H,2,3,4)/t18-;/m0./s1
  • InChiKey: DUHQBKLTAVUXFF-FERBBOLQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References
Homo sapiens protein kinase C, epsilon Starlite/ChEMBL References
Homo sapiens calcium/calmodulin-dependent protein kinase II alpha References
Homo sapiens protein kinase C, delta Starlite/ChEMBL References
Homo sapiens calcium/calmodulin-dependent protein kinase II beta References
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens calcium/calmodulin-dependent protein kinase II gamma References
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL References
Rattus norvegicus Protein kinase C (PKC) Starlite/ChEMBL References
Homo sapiens protein kinase C, eta Starlite/ChEMBL References
Homo sapiens protein kinase C, gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis protein kinase c epsilon type Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma japonicum Protein kinase C epsilon type, putative Get druggable targets OG5_129314 All targets in OG5_129314
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) AGC/PKC/ETA protein kinase Get druggable targets OG5_129314 All targets in OG5_129314
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K06068 novel protein kinase C, putative Get druggable targets OG5_129314 All targets in OG5_129314
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi protein kinase C3,putative Get druggable targets OG5_131830 All targets in OG5_131830
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K06069 atypical protein kinase C, putative Get druggable targets OG5_131830 All targets in OG5_131830
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_129314 All targets in OG5_129314
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis protein kinase c iota type Get druggable targets OG5_131830 All targets in OG5_131830
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni atypical protein kinase C Get druggable targets OG5_131830 All targets in OG5_131830
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase Get druggable targets OG5_131830 All targets in OG5_131830
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi protein kinase C II. Get druggable targets OG5_129314 All targets in OG5_129314
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus protein kinase c epsilon type Get druggable targets OG5_129314 All targets in OG5_129314
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus serine:threonine protein kinase N2 Get druggable targets OG5_129314 All targets in OG5_129314
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis serine:threonine protein kinase N2 Get druggable targets OG5_129314 All targets in OG5_129314
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus protein kinase c iota type Get druggable targets OG5_131830 All targets in OG5_131830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Protein kinase c protein 2 Protein kinase C (PKC)   671 aa 652 aa 65.8 %
Schistosoma mansoni serine/threonine protein kinase Protein kinase C (PKC)   671 aa 651 aa 61.8 %
Onchocerca volvulus Protein kinase C (PKC)   671 aa 653 aa 65.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0076 0.0814 0.0764
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0168 0.0114
Entamoeba histolytica protein kinase, putative 0.0075 0.0798 0.2738
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0076 0.0814 0.0764
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0055 0.0456 0.0405
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0058 0.0504 0.5585
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0077 0.0836 0.2906
Loa Loa (eye worm) hypothetical protein 0.0143 0.1973 0.2269
Brugia malayi Ras association domain family 1 isoform A 0.0052 0.0403 0.0405
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0064 0.0615 0.0564
Brugia malayi C1-like domain containing protein 0.0055 0.0456 0.0466
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0084 0.003
Schistosoma mansoni protein kinase C mu 0.0055 0.0456 0.0405
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0077 0.0836 0.0786
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0798 0.0748
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0155 0.2179 0.2504
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1315 0.1459
Echinococcus multilocularis protein kinase c iota type 0.0209 0.3118 0.308
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.1145 0.1263
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0076 0.0814 0.9717
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Echinococcus granulosus protein kinase c iota type 0.0209 0.3118 0.308
Echinococcus multilocularis N chimaerin 0.0052 0.0403 0.0352
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Entamoeba histolytica protein kinase, putative 0.0084 0.0966 0.3483
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0075 0.0798 0.0748
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.026 0.3993 0.3961
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.0814 0.8998
Toxoplasma gondii AGC kinase 0.0075 0.0798 0.9515
Brugia malayi RhoGEF domain containing protein 0.0052 0.0403 0.0405
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Brugia malayi Cam kinase protein 1 0.0076 0.0814 0.0879
Onchocerca volvulus 0.0061 0.0556 0.2155
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0084 0.0226
Onchocerca volvulus 0.0095 0.1145 0.4685
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0046 0.0312 0.1108
Echinococcus multilocularis serine:threonine protein kinase 38 0.0075 0.0798 0.0748
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0084 0.003
Brugia malayi protein kinase C II. 0.0302 0.4712 0.5388
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0061 0.0556 0.0505
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Loa Loa (eye worm) hypothetical protein 0.0167 0.2384 0.274
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Onchocerca volvulus 0.0095 0.1145 0.4685
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0403 0.0405
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0075 0.0798 0.0748
Schistosoma mansoni unc-13 (munc13) 0.0061 0.0556 0.0505
Onchocerca volvulus 0.0111 0.1418 0.5855
Brugia malayi Protein kinase domain containing protein 0.0075 0.0798 0.0861
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0424 0.4735
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0064 0.0615 0.0649
Toxoplasma gondii DNA topoisomerase 2, putative 0.0064 0.0615 0.7175
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0075 0.0798 0.0917
Echinococcus multilocularis aryl hydrocarbon receptor 0.0084 0.0957 0.0908
Schistosoma mansoni protein kinase 0.0609 1 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0076 0.0814 0.9717
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0318 0.0266
Onchocerca volvulus 0.0167 0.2384 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0046 0.0312 0.1108
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0075 0.0798 0.0917
Schistosoma mansoni protein kinase C 0.0061 0.0556 0.0505
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0084 0.003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Trypanosoma brucei DNA topoisomerase ii 0.005 0.0379 0.3929
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0052 0.0403 0.0464
Echinococcus granulosus Diacylglycerol kinase theta 0.0052 0.0403 0.0352
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.003
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0052 0.0403 0.0464
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0076 0.0814 0.0935
Leishmania major protein kinase, putative 0.0076 0.0814 0.9712
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0168 0.0114
Echinococcus multilocularis proteasome (prosome, macropain) 0.0077 0.0836 0.0786
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0111 0.1418 0.1578
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0076 0.0814 0.0879
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0144 0.199 0.2288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1315 0.1512
Schistosoma mansoni hypothetical protein 0.0039 0.018 0.0127
Loa Loa (eye worm) hypothetical protein 0.0218 0.3274 0.3764
Entamoeba histolytica protein kinase, putative 0.0075 0.0798 0.2738
Loa Loa (eye worm) hypothetical protein 0.0095 0.1145 0.1316
Echinococcus granulosus GPCR family 2 0.0033 0.0083 0.003
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0077 0.0836 1
Schistosoma mansoni hypothetical protein 0.0052 0.0403 0.0352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0083 0.003
Echinococcus multilocularis protein kinase c epsilon type 0.0302 0.4712 0.4683
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0278 0.4301 0.4271
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0084 0.003
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0076 0.0814 0.0764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0318 0.0266
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.1145 0.1263
Echinococcus granulosus calcium dependent protein kinase 0.0072 0.0761 0.0711
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0077 0.0836 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0609 1 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0076 0.0814 0.9717
Loa Loa (eye worm) hypothetical protein 0.0061 0.0556 0.0639
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0077 0.0836 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0076 0.0814 0.9717
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0072 0.0745 0.5898
Echinococcus multilocularis serine threonine protein kinase 0.0226 0.3411 0.3375
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0052 0.0403 0.0352
Mycobacterium ulcerans proteasome PrcB 0.0077 0.0836 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0076 0.0814 0.0764
Schistosoma mansoni protein kinase 0.0609 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0084 0.0388
Toxoplasma gondii proteasome subunit beta type, putative 0.0077 0.0836 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.052 0.0598
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0075 0.0798 0.0748
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0058 0.052 0.0539
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0798 0.0748
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0456 0.0405
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0059 0.0525 0.0545
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0504 0.5685
Loa Loa (eye worm) hypothetical protein 0.0058 0.052 0.0598
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0798 0.0748
Schistosoma mansoni atypical protein kinase C 0.0215 0.3222 0.3186
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.4301 0.4271
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0054 0.0062
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0059 0.0525 0.0474
Loa Loa (eye worm) AGC/AKT protein kinase 0.0075 0.0798 0.0917
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0076 0.0814 0.9717
Plasmodium falciparum DNA topoisomerase 2 0.0064 0.0615 0.7175
Loa Loa (eye worm) hypothetical protein 0.0076 0.0814 0.0935
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0276 0.4263 0.4232
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.003
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0064 0.0615 0.0649
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.1145 0.1263
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0504 0.5685
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0055 0.0456 0.0524
Echinococcus multilocularis protein kinase c eta type 0.0052 0.0403 0.0352
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0058 0.0504 0.5585
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0266 0.0213
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0302 0.4712 0.5416
Echinococcus multilocularis myotubularin protein 13 0.0052 0.0403 0.0352
Chlamydia trachomatis DNA gyrase subunit B 0.0035 0.0111 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0301 0.0286
Brugia malayi Protein kinase domain containing protein 0.0075 0.0798 0.0861
Echinococcus granulosus N chimaerin 0.0052 0.0403 0.0352
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Schistosoma mansoni tyrosinase precursor 0.0095 0.1145 0.1097
Plasmodium falciparum calcium-dependent protein kinase 3 0.0076 0.0814 0.9717
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0083 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0076 0.0814 0.0764
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0084 0.0388
Loa Loa (eye worm) RasGEF domain-containing protein 0.0052 0.0403 0.0464
Entamoeba histolytica diacylglycerol kinase, putative 0.0052 0.0403 0.0989
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0064 0.0615 0.0564
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0798 0.0748
Loa Loa (eye worm) hypothetical protein 0.0046 0.0301 0.0346
Echinococcus multilocularis Rac GTPase activating protein 1 0.0052 0.0403 0.0352
Brugia malayi RhoGAP domain containing protein 0.0052 0.0403 0.0405
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0059 0.0525 0.0603
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0077 0.0836 0.0961
Schistosoma mansoni hypothetical protein 0.0183 0.2656 0.2617
Brugia malayi p70 ribosomal S6 kinase beta 0.0075 0.0798 0.0861
Onchocerca volvulus Protein cycle homolog 0.0059 0.0525 0.2022
Echinococcus multilocularis serine:threonine protein kinase N2 0.0075 0.0798 0.0748
Plasmodium falciparum calcium-dependent protein kinase 1 0.0076 0.0814 0.9717
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0745 0.0799
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0533 0.8699 1
Schistosoma mansoni protein kinase C mu 0.0052 0.0403 0.0352
Brugia malayi protein kinase C3,putative 0.0138 0.1885 0.2118
Echinococcus multilocularis dna polymerase eta 0.0046 0.0301 0.0248
Leishmania major proteasome beta 5 subunit, putative 0.0077 0.0836 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0424 0.4647
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0168 0.0114
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0424 0.4647
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0168 0.0114
Echinococcus multilocularis RNA directed DNA polymerase 0.0143 0.1973 0.193
Echinococcus granulosus raf serine:threonine protein kinase 0.0052 0.0403 0.0352
Echinococcus granulosus proteasome prosome macropain 0.0077 0.0836 0.0786
Entamoeba histolytica protein kinase, putative 0.0075 0.0798 0.2738
Brugia malayi hypothetical protein 0.0058 0.052 0.0539
Loa Loa (eye worm) hypothetical protein 0.0167 0.2384 0.274
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0046 0.0312 0.1108
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0076 0.0814 0.9717
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0052 0.0403 0.0352
Onchocerca volvulus 0.0052 0.0403 0.1501
Loa Loa (eye worm) hypothetical protein 0.0058 0.052 0.0598
Brugia malayi Protein kinase domain containing protein 0.0075 0.0798 0.0861
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0083 0.0096
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0533 0.8699 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0083 0.003
Schistosoma mansoni serine/threonine kinase 0.0075 0.0798 0.0748
Brugia malayi diacylglycerol kinase 0.0052 0.0403 0.0405
Toxoplasma gondii diacylglycerol kinase, putative 0.0052 0.0403 0.4471
Entamoeba histolytica hypothetical protein 0.0052 0.0403 0.0989
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Plasmodium falciparum proteasome subunit beta type-5 0.0077 0.0836 1
Echinococcus granulosus protein kinase c epsilon type 0.0302 0.4712 0.4683
Leishmania major DNA topoisomerase ii 0.0058 0.0504 0.5685
Brugia malayi hypothetical protein 0.0039 0.018 0.0146
Echinococcus multilocularis geminin 0.0183 0.2656 0.2617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0076 0.0814 0.0764
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.1145 0.1316
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0318 0.0306
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Schistosoma mansoni rac gtpase activating protein 0.0052 0.0403 0.0352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0083 0.003
Brugia malayi jmjC domain containing protein 0.0103 0.1284 0.1423
Schistosoma mansoni hypothetical protein 0.0072 0.0745 0.0695
Brugia malayi jmjC domain containing protein 0.0038 0.0168 0.0132
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0077 0.0836 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0075 0.0798 0.0917
Echinococcus granulosus myotubularin protein 13 0.0052 0.0403 0.0352
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0424 0.4523
Entamoeba histolytica PH domain containing protein kinase, putative 0.017 0.2436 1
Schistosoma mansoni hypothetical protein 0.0276 0.4263 0.4232
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0055 0.0456 0.0405
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.1145 0.1263
Schistosoma mansoni diacylglycerol kinase theta 0.0052 0.0403 0.0352
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0076 0.0814 0.0935
Onchocerca volvulus 0.0052 0.0403 0.1501
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0143 0.1973 0.193
Schistosoma mansoni vav2 0.0052 0.0403 0.0352
Echinococcus granulosus dna polymerase eta 0.0046 0.0301 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0168 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.4712 0.4683
Entamoeba histolytica DNA topoisomerase II, putative 0.0064 0.0615 0.1926
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0084 0.0957 0.11
Echinococcus granulosus protein kinase C gamma type 0.0226 0.3411 0.3375
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0072 0.0745 0.0856
Schistosoma mansoni hypothetical protein 0.0183 0.2656 0.2617
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.1145 0.1263
Plasmodium vivax DNA topoisomerase II, putative 0.0064 0.0615 0.7175
Loa Loa (eye worm) tyrosinase 1 0.0095 0.1145 0.1316
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0084 0.0388
Loa Loa (eye worm) hypothetical protein 0.0043 0.0252 0.029
Brugia malayi Protein kinase domain containing protein 0.0055 0.0456 0.0466
Entamoeba histolytica diacylglycerol kinase, putative 0.0052 0.0403 0.0989
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0301 0.3045
Entamoeba histolytica protein kinase, putative 0.0075 0.0798 0.2738
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1315 0.1459
Echinococcus granulosus Rac GTPase activating protein 1 0.0052 0.0403 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0814 0.0764
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.4301 0.4271
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0084 0.003
Brugia malayi Hr1 repeat family protein 0.0075 0.0798 0.0861
Schistosoma mansoni jumonji domain containing protein 0.0082 0.092 0.0871
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0052 0.0403 0.0352
Brugia malayi ShTK domain containing protein 0.0095 0.1145 0.1263
Brugia malayi Protein kinase c protein 2 0.0206 0.3069 0.3488
Plasmodium vivax proteasome subunit beta type-5, putative 0.0077 0.0836 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0052 0.0403 0.0464
Loa Loa (eye worm) AGC/PKN protein kinase 0.0075 0.0798 0.0917
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0062
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0067 0.0165
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0055 0.0456 0.0466
Onchocerca volvulus 0.0095 0.1145 0.4685
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0836 1
Echinococcus multilocularis calcium dependent protein kinase 0.0072 0.0761 0.0711
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0052 0.0403 0.0352
Brugia malayi Probable DNA topoisomerase II 0.0064 0.0615 0.0649
Brugia malayi RhoGAP domain containing protein 0.0052 0.0403 0.0405
Plasmodium falciparum calcium-dependent protein kinase 2 0.0076 0.0814 0.9717
Loa Loa (eye worm) hypothetical protein 0.0054 0.044 0.0506
Giardia lamblia DNA topoisomerase II 0.0061 0.0566 0.6552
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0077 0.0836 1
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Loa Loa (eye worm) hypothetical protein 0.0167 0.2384 0.274
Brugia malayi Pleckstrin Homology Domain 0.0052 0.0403 0.0405
Echinococcus granulosus protein kinase c eta type 0.0052 0.0403 0.0352
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0084 0.003
Echinococcus multilocularis serine:threonine protein kinase N2 0.0241 0.3669 0.3635
Brugia malayi hypothetical protein 0.0034 0.0101 0.0055
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0059 0.0525 0.0545
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0266 0.0213
Echinococcus multilocularis unc 13 (munc13) 0.0061 0.0556 0.0505
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0075 0.0798 0.0917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0318 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Echinococcus granulosus NDR protein kinase 0.0075 0.0798 0.0748
Schistosoma mansoni protein kinase 0.0609 1 1
Schistosoma mansoni diacylglycerol kinase theta 0.0052 0.0403 0.0352
Loa Loa (eye worm) raf kinase 0.0052 0.0403 0.0464
Leishmania major DNA polymerase eta, putative 0.0046 0.0301 0.3045
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0424 0.4735
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0076 0.0814 0.9717
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0084 0.0097
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.1284 0.1237
Schistosoma mansoni DNA polymerase eta 0.0046 0.0301 0.0248
Leishmania major hypothetical protein, conserved 0.0053 0.0424 0.4647
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0318 0.0266
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0075 0.0798 0.0748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0096
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0077 0.0836 0.5
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0075 0.0798 0.0748
Echinococcus granulosus unc 13 munc13 0.0061 0.0556 0.0505
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.1145 0.1316
Echinococcus multilocularis raf serine:threonine protein kinase 0.0052 0.0403 0.0352
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.063 0.0724
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0424 0.4735
Loa Loa (eye worm) hypothetical protein 0.0241 0.3669 0.4217
Entamoeba histolytica protein kinase, putative 0.0076 0.0814 0.2808
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.018 0.0127
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.018 0.0127
Echinococcus multilocularis GPCR, family 2 0.0033 0.0083 0.003
Brugia malayi hypothetical protein 0.0053 0.0424 0.0428
Trypanosoma brucei rac serine-threonine kinase, putative 0.0075 0.0798 0.9496
Loa Loa (eye worm) hypothetical protein 0.0058 0.052 0.0598
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.1284 0.1237
Loa Loa (eye worm) hypothetical protein 0.0195 0.2864 0.3292
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0084 0.0035
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.0379 0.4067
Schistosoma mansoni DNA topoisomerase II 0.0064 0.0615 0.0564
Echinococcus granulosus RNA directed DNA polymerase 0.0143 0.1973 0.193
Loa Loa (eye worm) AGC/NDR protein kinase 0.0075 0.0798 0.0917
Plasmodium falciparum calcium-dependent protein kinase 4 0.0076 0.0814 0.9717
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0301 0.2884
Brugia malayi hypothetical protein 0.0059 0.0525 0.0545
Loa Loa (eye worm) hypothetical protein 0.0111 0.1418 0.163
Loa Loa (eye worm) hypothetical protein 0.0095 0.1145 0.1316
Onchocerca volvulus 0.0095 0.1145 0.4685
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0084 0.003
Brugia malayi Proteasome A-type and B-type family protein 0.0077 0.0836 0.0905
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.003
Echinococcus granulosus geminin 0.0183 0.2656 0.2617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0318 0.0266
Echinococcus multilocularis Diacylglycerol kinase theta 0.0052 0.0403 0.0352
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.018 0.0127
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0403 0.0352
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0061 0.0556 0.0505
Leishmania major mitochondrial DNA topoisomerase II 0.005 0.0379 0.4067
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0798 0.8285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0083 0.0034
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.026 0.3993 0.3961
Loa Loa (eye worm) TOPoisomerase family member 0.0064 0.0615 0.0707
Loa Loa (eye worm) hypothetical protein 0.0084 0.0952 0.1094
Brugia malayi hypothetical protein 0.0084 0.0952 0.1039
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.003
Echinococcus granulosus aryl hydrocarbon receptor 0.0084 0.0957 0.0908
Brugia malayi diacylglycerol kinase 0.0052 0.0403 0.0405
Onchocerca volvulus 0.0084 0.0952 0.3856
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0798 0.0748
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0075 0.0798 0.0748
Schistosoma mansoni tyrosinase precursor 0.0095 0.1145 0.1097
Echinococcus granulosus serine:threonine protein kinase N2 0.017 0.2436 0.2395
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0318 0.0365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0318 0.0266
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0424 0.4735
Loa Loa (eye worm) hypothetical protein 0.0043 0.0252 0.029
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.0379 0.4067
Schistosoma mansoni unc-13 (munc13) 0.0065 0.0625 0.0575
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0084 0.0226
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Loa Loa (eye worm) hypothetical protein 0.0053 0.0424 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0318 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0464
Brugia malayi isocitrate dehydrogenase 0.0033 0.0084 0.0035
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0084 0.0226
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0076 0.0814 0.9705
Plasmodium vivax calcium-dependent protein kinase, putative 0.0076 0.0814 0.9717
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0456 0.0405
Loa Loa (eye worm) hypothetical protein 0.0105 0.1315 0.1512
Echinococcus granulosus Protein kinase C brain isozyme 0.0278 0.4301 0.4271
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0084 0.0388

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0047 uM Inhibition of Protein kinase C beta 1 ChEMBL. 12749884
IC50 (binding) = 0.0047 uM Inhibition of Protein kinase C beta 1 ChEMBL. 12749884
IC50 (binding) = 0.0059 uM Inhibition of Protein kinase C beta 2 ChEMBL. 12749884
IC50 (binding) = 0.0059 uM Inhibition of Protein kinase C beta 2 ChEMBL. 12749884
IC50 (binding) = 0.052 uM Inhibition of Protein kinase C eta ChEMBL. 12749884
IC50 (binding) = 0.052 uM Inhibition of Protein kinase C eta ChEMBL. 12749884
IC50 (binding) = 0.25 uM Inhibition of Protein kinase C delta ChEMBL. 12749884
IC50 (binding) = 0.25 uM Inhibition of Protein kinase C delta ChEMBL. 12749884
IC50 (binding) = 0.3 uM Inhibition of Protein kinase C gamma ChEMBL. 12749884
IC50 (binding) = 0.3 uM Inhibition of Protein kinase C gamma ChEMBL. 12749884
IC50 (binding) = 0.32 uM Inhibition of purified rat brain protein kinase C (RB-PKC) ChEMBL. 12749884
IC50 (binding) = 0.32 uM Inhibition of purified rat brain protein kinase C (RB-PKC) ChEMBL. 12749884
IC50 (binding) = 0.36 uM Inhibition of Protein kinase C alpha ChEMBL. 12749884
IC50 (binding) = 0.36 uM Inhibition of Protein kinase C alpha ChEMBL. 12749884
IC50 (binding) = 0.6 uM Inhibition of Protein kinase C epsilon ChEMBL. 12749884
IC50 (binding) = 0.6 uM Inhibition of Protein kinase C epsilon ChEMBL. 12749884
IC50 (binding) = 6.2 uM Inhibition of purified mammalian brain [Ca2+]/Calmodulin dependent kinase ChEMBL. 12749884
IC50 (binding) = 6.2 uM Inhibition of purified mammalian brain [Ca2+]/Calmodulin dependent kinase ChEMBL. 12749884
IC50 (binding) > 100 uM Inhibition of Protein kinase C zeta ChEMBL. 12749884
IC50 (binding) > 100 uM Inhibition of cAMP dependent protein kinase catalytic subunit of bovine heart ChEMBL. 12749884
IC50 (binding) > 100 uM Inhibition of purified rat brain casein kinase II ChEMBL. 12749884
IC50 (binding) > 100 uM Inhibition of Src protein tryrosine kinase ChEMBL. 12749884
IC50 (binding) > 100 uM Inhibition of Protein kinase C zeta ChEMBL. 12749884
IC50 (binding) > 100 uM Inhibition of Src protein tryrosine kinase ChEMBL. 12749884

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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