Detailed information for compound 800982

Basic information

Technical information
  • TDR Targets ID: 800982
  • Name: N-[3,5-bis(trifluoromethyl)phenyl]-2-methylsu lfanylbenzamide
  • MW: 379.32 | Formula: C16H11F6NOS
  • H donors: 1 H acceptors: 1 LogP: 5.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
  • InChi: 1S/C16H11F6NOS/c1-25-13-5-3-2-4-12(13)14(24)23-11-7-9(15(17,18)19)6-10(8-11)16(20,21)22/h2-8H,1H3,(H,23,24)
  • InChiKey: OONLHBIUGVEMJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3,5-bis(trifluoromethyl)phenyl]-2-methylsulfanyl-benzamide
  • N-[3,5-bis(trifluoromethyl)phenyl]-2-(methylthio)benzamide
  • ZINC02998150
  • A2685/0114458
  • N-(3,5-Bis-trifluoromethyl-phenyl)-2-methylsulfanyl-benzamide
  • EU-0052997

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0793 0.0793
Schistosoma mansoni nuclear receptor 0.001 0.0217 0.0217
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0814 0.0748
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0627 0.3217
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.087 0.1254
Schistosoma mansoni hypothetical protein 0.0184 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0814 0.1504
Brugia malayi Nuclear hormone receptor E75 0.001 0.0217 0.0313
Leishmania major DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.1102 0.137
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0814 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.087 0.1254
Brugia malayi MH2 domain containing protein 0.0009 0.0131 0.0189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.024 0.0346
Loa Loa (eye worm) DR-78 0.001 0.0217 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.087 0.0749
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0436 0.0805
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.087 0.1238
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0448 0.0827
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.4912 0.8837
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.4912 0.8837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.087 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.087 0.1254
Schistosoma mansoni zinc finger protein 0.001 0.0217 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0131 0.0131
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.087 0.0749
Brugia malayi steroid hormone receptor 0.0022 0.087 0.1254
Brugia malayi hypothetical protein 0.0039 0.1835 0.2645
Brugia malayi nuclear receptor RXR 0.0012 0.0287 0.0413
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.024 0.011
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.087 0.1254
Loa Loa (eye worm) hypothetical protein 0.0011 0.024 0.0341
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0217 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.087 0.1257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.087 0.0749
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0814 0.1159
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.5502 1
Giardia lamblia Kinase, PLK 0.0103 0.5412 1
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.087 0.087
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.06 0.1109
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0814 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0814 0.0793
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0436 0.0805
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.06 0.0475
Trypanosoma brucei trypanothione reductase 0.0041 0.1948 0.3599
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.06 0.0854
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.087 0.1254
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.6937 0.9874
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.087 0.087
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0448 0.0827
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0217 0.0217
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.06 0.1109
Trypanosoma brucei polo-like protein kinase 0.0103 0.5412 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0217 0.0313
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0436 0.0628
Brugia malayi nuclear receptor RXR 0.001 0.0217 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.087 0.1254
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0217 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.087 0.1254
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Brugia malayi ecdysone receptor 0.001 0.0217 0.0313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.087 0.1238
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0436 0.0805
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.5412 1
Echinococcus multilocularis geminin 0.0184 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.06 0.0475
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0436 0.2236
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.087 0.0749
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0217 0.0313
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0436 0.0805
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.06 0.0475
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.5412 0.7703
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.087 0.1254
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.4912 0.8837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.087 0.1238
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.087 0.0749
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0217 0.0087
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.024 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0448 0.0827
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0436 0.0805
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0223 0.0321
Leishmania major DNA polymerase eta, putative 0.0021 0.0814 0.1504
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0436 0.2236
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.087 0.1238
Schistosoma mansoni thyroid hormone receptor 0.0022 0.087 0.087
Echinococcus granulosus bloom syndrome protein 0.0026 0.1102 0.0984
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0408
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0814 0.1174
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Schistosoma mansoni DNA polymerase eta 0.0021 0.0814 0.0814
Brugia malayi hypothetical protein 0.0012 0.0287 0.0413
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0436 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0217 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.4912 0.8837
Onchocerca volvulus 0.0022 0.087 0.1257
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0436 0.0035
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0223 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.087 0.0749
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.5502 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.087 0.087
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0814 0.1504
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0436 0.0805
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.1835 0.1726
Brugia malayi MH1 domain containing protein 0.0009 0.0131 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.024 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0217 0.0087
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0615 0.3157
Brugia malayi Thioredoxin reductase 0.0041 0.1948 0.2808
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.087 0.0749
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0287 0.0413
Brugia malayi Smad1 0.0009 0.0131 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Plasmodium falciparum glutathione reductase 0.0041 0.1948 1
Brugia malayi nuclear hormone receptor 0.0022 0.087 0.1254
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.5412 0.5351
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.087 0.0749
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0814 0.1174
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0418 0.0773
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0814 0.0748
Schistosoma mansoni DNA helicase recq1 0.0011 0.024 0.024
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.087 0.0749
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0436 0.0805
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.6937 0.9874
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.5412 1
Entamoeba histolytica hypothetical protein 0.0039 0.1835 0.2836
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0287 0.0158
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.024 0.0443
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Echinococcus granulosus dna polymerase eta 0.0021 0.0814 0.0692
Plasmodium falciparum thioredoxin reductase 0.0041 0.1948 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.06 0.3081
Brugia malayi nuclear hormone receptor 0.001 0.0217 0.0313
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0436 0.5
Mycobacterium tuberculosis Probable reductase 0.0094 0.4912 0.8837
Schistosoma mansoni nuclear hormone receptor 0.0022 0.087 0.087
Brugia malayi hypothetical protein 0.001 0.0217 0.0313
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.1979 0.1872
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.087 0.1254
Plasmodium falciparum thioredoxin reductase 0.0014 0.0436 0.2236
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0436 0.2236
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.06 0.0325
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.087 0.087
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Trypanosoma brucei unspecified product 0.0021 0.0814 0.1504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.087 0.1238
Giardia lamblia DINP protein human, muc B family 0.0021 0.0814 0.1504
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.1835 0.1726
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Plasmodium falciparum glutathione reductase 0.0014 0.0436 0.2236
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0814 0.1504
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.024 0.1231
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.1948 0.2985
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.024 0.1231
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.5412 0.5351
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0408
Echinococcus multilocularis bloom syndrome protein 0.0026 0.1102 0.0984
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.1948 0.2772
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0287 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.087 0.1254
Schistosoma mansoni coup transcription factor 0.0022 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0408
Schistosoma mansoni nuclear hormone receptor 0.001 0.0217 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.087 0.0749
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Loa Loa (eye worm) hypothetical protein 0.0131 0.7026 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0418 0.0773
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.024 0.1231
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0814 0.1504
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.5412 1
Schistosoma mansoni DNA helicase recq5 0.0011 0.024 0.024
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.1979 0.1872
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.1102 0.137
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Treponema pallidum NADH oxidase 0.0014 0.0436 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0814 1
Schistosoma mansoni hypothetical protein 0.0039 0.1835 0.1835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.087 0.1238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Schistosoma mansoni smad1 5 8 and 0.0009 0.0131 0.0131
Brugia malayi nuclear receptor NHR-88 0.001 0.0217 0.0313
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.06 0.3081
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.5412 0.7802
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.1948 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.06 0.0865
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0814 0.0692
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.5412 1
Brugia malayi MH2 domain containing protein 0.013 0.6937 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0814 0.0814
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.087 0.0749
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0287 0.0287
Entamoeba histolytica hypothetical protein 0.0039 0.1835 0.2836
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0287 0.0408
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0287 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0436 0.0436
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0131 0.0187
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.4912 0.8837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.06 0.0475
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.06 0.0475
Brugia malayi MH1 domain containing protein 0.0009 0.0131 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.06 0.1109
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Plasmodium vivax glutathione reductase, putative 0.0041 0.1948 1
Trypanosoma brucei unspecified product 0.0014 0.0448 0.0827
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0131 0.0131
Echinococcus granulosus FTZ F1 alpha 0.0022 0.087 0.0749
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0436 0.2236
Schistosoma mansoni nuclear receptor 0.001 0.0217 0.0217
Echinococcus granulosus dna polymerase kappa 0.0021 0.0814 0.0692
Schistosoma mansoni smad1 5 8 and 0.0009 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0217 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.087 0.0749
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0436 0.5349
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.1948 0.3599
Schistosoma mansoni kinase 0.0052 0.257 0.257
Schistosoma mansoni Smad4 0.0009 0.0131 0.0131
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0436 0.5349
Schistosoma mansoni nuclear hormone receptor 0.001 0.0217 0.0217
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.087 0.1257
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.2494 0.4157
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0814 0.0692
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0217 0.0309
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0436 0.0805
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0408
Brugia malayi tailless protein 0.001 0.0217 0.0313
Echinococcus multilocularis dna polymerase eta 0.0021 0.0814 0.0692
Brugia malayi nuclear receptor NHR-88 0.0022 0.087 0.1254
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.06 0.1109
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0436 0.0805
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0217 0.0087
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.1835 0.1835
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.06 0.3081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.087 0.1238
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0436 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.087 0.1238
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0217 0.0087
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0418 0.0773
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.087 0.1254
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.087 0.1254
Brugia malayi nuclear receptor NHR-67 0.001 0.0217 0.0313
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.087 0.087
Brugia malayi hypothetical protein 0.001 0.0217 0.0313
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0131 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0217 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.06 0.06
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.5412 0.5412
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.087 0.0749
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0217 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0217 0.0313
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0217 0.0087
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0217 0.0309
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0924 0.4743
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.2494 0.4157
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.5412 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0436 0.0805
Schistosoma mansoni smad 0.0009 0.0131 0.0131
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0217 0.0087
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0217 0.0217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0217 0.0313
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0814 0.0692
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0436 0.2236
Brugia malayi hypothetical protein 0.0012 0.0287 0.0413
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.06 0.3081
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0814 0.0793
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0814 0.1504
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.1102 0.1589
Loa Loa (eye worm) glutathione reductase 0.0041 0.1948 0.2772
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.087 0.1254
Loa Loa (eye worm) Smad1 0.0009 0.0131 0.0187
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0217 0.0217
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.5412 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.06 0.1109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.087 0.087
Schistosoma mansoni hypothetical protein 0.0184 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.1835 0.2836
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0436 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.087 0.1254
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.087 0.1254
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Entamoeba histolytica hypothetical protein 0.0039 0.1835 0.2836
Leishmania major trypanothione reductase 0.0041 0.1948 0.3599
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.087 0.1257
Trypanosoma brucei unspecified product 0.0014 0.0448 0.0827
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Brugia malayi ecdysteroid receptor 0.0022 0.087 0.1254
Loa Loa (eye worm) hypothetical protein 0.0022 0.087 0.1238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0436 0.0805
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.087 0.0749
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.087 0.087
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.024 0.011
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0436 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.087 0.0749
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0217 0.0313
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.06 0.0475
Loa Loa (eye worm) hypothetical protein 0.001 0.0217 0.0309
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0814 0.1504
Loa Loa (eye worm) hypothetical protein 0.0021 0.0814 0.1159
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.5502 1
Brugia malayi MH2 domain containing protein 0.0009 0.0131 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.087 0.1254
Brugia malayi isocitrate dehydrogenase 0.0017 0.06 0.0865
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.024 0.0346
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0814 0.0793
Brugia malayi conserved hypotetical protein 0.001 0.0217 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0814 0.1504
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0217 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0436 0.5349
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0436 0.0308
Loa Loa (eye worm) RecQ helicase 0.0026 0.1102 0.1569
Brugia malayi glutathione reductase 0.0041 0.1948 0.2808
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0436 0.2236
Schistosoma mansoni thyroid hormone receptor 0.0022 0.087 0.087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.087 0.0749
Toxoplasma gondii thioredoxin reductase 0.0041 0.1948 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.5502 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.024 0.0341
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0287 0.0158

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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