Detailed information for compound 801075

Basic information

Technical information
  • TDR Targets ID: 801075
  • Name: 6,7-diethoxy-1-[2-(trifluoromethyl)phenyl]-1, 2,3,4-tetrahydroisoquinoline
  • MW: 365.389 | Formula: C20H22F3NO2
  • H donors: 1 H acceptors: 0 LogP: 4.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc2c(cc1OCC)CCNC2c1ccccc1C(F)(F)F
  • InChi: 1S/C20H22F3NO2/c1-3-25-17-11-13-9-10-24-19(15(13)12-18(17)26-4-2)14-7-5-6-8-16(14)20(21,22)23/h5-8,11-12,19,24H,3-4,9-10H2,1-2H3
  • InChiKey: ZDZHGASVMDLROP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A2719/0115543
  • 6,7-Diethoxy-1-(2-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Neurogenic locus Notch protein precursor 0.0025 0.0267 0.0138
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0171 0.2805 0.7272
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0447 0.0838
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0158 0.0345
Schistosoma mansoni DNA polymerase IV / kappa 0.0037 0.0461 0.0543
Loa Loa (eye worm) CXXC zinc finger family protein 0.0146 0.2361 0.2271
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.1878 0.2322
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0271 0.0335
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0447 0.0838
Loa Loa (eye worm) hypothetical protein 0.0025 0.0267 0.0152
Loa Loa (eye worm) hypothetical protein 0.0048 0.0667 0.0557
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.019 0.3138 0.818
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0447 0.0334
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0277 0.0342
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0277 0.0342
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0399 0.0469
Mycobacterium ulcerans glutaminase 0.0295 0.4971 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.1878 0.1782
Loa Loa (eye worm) hypothetical protein 0.0036 0.0447 0.0334
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0277 0.0248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0635 0.0485
Schistosoma mansoni hypothetical protein 0.0416 0.7074 0.8744
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0271 0.0236
Schistosoma mansoni flap endonuclease-1 0.0025 0.0268 0.0302
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0635 0.0612
Mycobacterium tuberculosis Conserved protein 0.0036 0.0447 0.0838
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0118 0.1878 0.1748
Loa Loa (eye worm) hypothetical protein 0.0025 0.0267 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0042
Plasmodium falciparum thioredoxin reductase 0.0075 0.1131 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0271 0.0311
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0447 0.0838
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0277 0.0253
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.002 0.0025
Leishmania major DNA damage repair protein, putative 0.0037 0.0461 0.0571
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0474 0.8087 1
Echinococcus granulosus dna polymerase kappa 0.0118 0.1878 0.1748
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.1148 0.1007
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0271 0.0236
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0447 0.0294
Trichomonas vaginalis CAMK family protein kinase 0.0235 0.3914 0.4827
Loa Loa (eye worm) glutathione reductase 0.0075 0.1131 0.1026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0635 0.0524
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.039 0.0458
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0399 0.0469
Mycobacterium tuberculosis Probable oxidoreductase 0.019 0.3138 0.818
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0157 0.5682
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Echinococcus granulosus adam 0.0025 0.0267 0.0111
Brugia malayi glutathione reductase 0.0075 0.1131 0.1109
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0191 0.0167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0461 0.0571
Toxoplasma gondii exonuclease III APE 0.0019 0.0157 0.034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0454 0.0302
Trypanosoma brucei trypanothione reductase 0.0075 0.1131 0.1398
Loa Loa (eye worm) hypothetical protein 0.0298 0.5024 0.4965
Leishmania major hypothetical protein, conserved 0.0036 0.0447 0.0553
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0277 0.0598
Echinococcus granulosus dna polymerase eta 0.0118 0.1878 0.1748
Echinococcus granulosus GPCR family 2 0.0031 0.0366 0.0212
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0333 0.5634 0.5564
Mycobacterium ulcerans beta-lactamase 0.0036 0.0447 0.0602
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0188 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0635 0.0485
Echinococcus multilocularis protein jagged 2 0.0025 0.0267 0.0111
Echinococcus multilocularis expressed protein 0.0033 0.0403 0.025
Brugia malayi beta-lactamase 0.0036 0.0447 0.0424
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0277 0.0342
Echinococcus multilocularis geminin 0.0168 0.2757 0.2641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.009 0.0087
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0045 0.0609 0.0459
Echinococcus granulosus integrin alpha 3 0.0045 0.06 0.045
Giardia lamblia hypothetical protein 0.0025 0.0267 0.0138
Plasmodium falciparum glutathione reductase 0.0075 0.1131 1
Brugia malayi hypothetical protein 0.012 0.1911 0.1892
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0157 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0277 0.0318
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1536 0.1437
Giardia lamblia Tenascin-37 0.0025 0.0267 0.0138
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0367 0.6225 0.6164
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.039 0.0482
Echinococcus granulosus fibrillin 1 0.0025 0.0267 0.0111
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.002 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0235 0.3914 0.4827
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0157 0.0048
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0191 0.0212
Onchocerca volvulus 0.0036 0.0447 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0447 0.0525
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0315 0.0366
Giardia lamblia DINP protein human, muc B family 0.0118 0.1878 0.217
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0277 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Trypanosoma brucei unspecified product 0.0118 0.1878 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0277 0.0121
Trichomonas vaginalis glutaminase, putative 0.0295 0.4971 0.6137
Echinococcus granulosus geminin 0.0168 0.2757 0.2641
Trypanosoma brucei ISWI complex protein 0.0015 0.009 0.0112
Brugia malayi EGF-like domain containing protein 0.0025 0.0267 0.0243
Brugia malayi ImpB/MucB/SamB family protein 0.0118 0.1878 0.1859
Schistosoma mansoni ap endonuclease 0.0019 0.0157 0.0165
Echinococcus granulosus integrin alpha ps 0.0045 0.06 0.045
Echinococcus granulosus cpg binding protein 0.0154 0.2506 0.2386
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0277 0.0598
Schistosoma mansoni hypothetical protein 0.0045 0.06 0.0715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Schistosoma mansoni integrin alpha 0.0093 0.1444 0.1761
Echinococcus multilocularis integrin alpha ps 0.0045 0.06 0.045
Echinococcus granulosus integrin beta 2 0.0584 1 1
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0461 0.0571
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0599 0.0576
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.039 0.0482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0635 0.0757
Loa Loa (eye worm) hypothetical protein 0.0045 0.06 0.0489
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0025 0.0267 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Brugia malayi Integrin alpha pat-2 precursor 0.0093 0.1444 0.1423
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0399 0.0469
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0171 0.2805 0.884
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.1878 0.2322
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0271 0.0335
Schistosoma mansoni integrin alpha-4 0.0398 0.6751 0.8343
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0424
Echinococcus multilocularis integrin alpha ps 0.0093 0.1444 0.1307
Echinococcus multilocularis dna polymerase eta 0.0118 0.1878 0.1748
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0333 0.5634 0.5564
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0367 0.6225 0.6215
Loa Loa (eye worm) integrin alpha pat-2 0.0093 0.1444 0.1343
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0454 0.0302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0447 0.0838
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0191 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0271 0.0236
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0403 0.038
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0277 0.1524
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0132 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0635 0.0485
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.1131 0.1026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0399 0.0469
Brugia malayi ImpB/MucB/SamB family protein 0.0118 0.1878 0.1859
Leishmania major DNA polymerase eta, putative 0.0118 0.1878 0.2322
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0118 0.1878 0.4743
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.009 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0042
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.039 0.0482
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0157 0.0194
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0315 0.039
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0474 0.8087 0.8056
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0461 0.0571
Brugia malayi Flap endonuclease-1 0.0028 0.0315 0.0292
Trichomonas vaginalis hypothetical protein 0.0025 0.0267 0.0306
Mycobacterium ulcerans lipase LipD 0.0036 0.0447 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Schistosoma mansoni cpg binding protein 0.0146 0.2361 0.2898
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.1131 1
Giardia lamblia DNA damage repair protein 0.0037 0.0461 0.0384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.3805 1
Plasmodium vivax DNA repair protein REV1, putative 0.0037 0.0461 0.3677
Schistosoma mansoni integrin beta subunit 0.0464 0.7913 0.9784
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0447 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0635 0.0757
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0158 0.005
Echinococcus granulosus fibrillin 2 0.0025 0.0267 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0635 0.0485
Brugia malayi polk-prov protein 0.0037 0.0461 0.0439
Loa Loa (eye worm) hypothetical protein 0.012 0.1911 0.1816
Loa Loa (eye worm) hypothetical protein 0.0401 0.6805 0.6767
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Schistosoma mansoni myst-related protein 0.0017 0.0123 0.0123
Mycobacterium tuberculosis Conserved protein 0.0036 0.0447 0.0838
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0277 1
Loa Loa (eye worm) integrin beta-2 0.0584 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0447 0.0294
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0461 0.0571
Schistosoma mansoni terminal deoxycytidyl transferase 0.0118 0.1878 0.23
Echinococcus multilocularis adam 0.0025 0.0267 0.0111
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0277 0.1933
Schistosoma mansoni serine/threonine protein kinase 0.0474 0.8087 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0277 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0447 0.0553
Mycobacterium ulcerans DNA polymerase IV 0.0118 0.1878 0.3575
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0315 0.016
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0461 0.0571
Trypanosoma cruzi ISWI complex protein 0.0015 0.009 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1241 0.1534
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.039 0.0841
Plasmodium vivax glutathione reductase, putative 0.0075 0.1131 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0366 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0447 0.0525
Entamoeba histolytica hypothetical protein 0.0017 0.0123 0.0128
Mycobacterium tuberculosis Conserved protein 0.0036 0.0447 0.0838
Echinococcus granulosus mixed lineage leukemia protein mll 0.0036 0.0454 0.0302
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0399 0.0469
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0271 0.0335
Trypanosoma cruzi DNA polymerase eta, putative 0.0118 0.1878 0.2322
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0118 0.1878 0.1748
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0367 0.6225 0.6164
Schistosoma mansoni integrin alpha-ps 0.0093 0.1444 0.1761
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0042
Echinococcus multilocularis fibrillin 2 0.0025 0.0267 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0132 0.0139
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0191 0.0034
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0424
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0461 0.0996
Giardia lamblia Kinase, PLK 0.0474 0.8087 1
Trypanosoma brucei unspecified product 0.0081 0.1241 0.1534
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0424
Plasmodium falciparum glutathione reductase 0.0026 0.0277 0.1524
Schistosoma mansoni hypothetical protein 0.0168 0.2757 0.3389
Giardia lamblia Neurogenic locus notch-like protein 0.0025 0.0267 0.0138
Brugia malayi CXXC zinc finger family protein 0.0146 0.2361 0.2343
Schistosoma mansoni DNA polymerase eta 0.0118 0.1878 0.23
Brugia malayi beta-lactamase family protein 0.0036 0.0447 0.0424
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0157 0.017
Trichomonas vaginalis hypothetical protein 0.0018 0.0132 0.0139
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0157 0.0194
Loa Loa (eye worm) hypothetical protein 0.0045 0.06 0.0489
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0366 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0367 0.6225 0.618
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0045 0.0609 0.0459
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0315 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0447 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.009 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0461 0.0571
Giardia lamblia High cysteine protein 0.0025 0.0267 0.0138
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0401 0.6805 0.6797
Leishmania major DNA polymerase kappa, putative 0.0037 0.0461 0.0571
Brugia malayi beta-lactamase family protein 0.0036 0.0447 0.0424
Brugia malayi hypothetical protein 0.0298 0.5024 0.5012
Echinococcus multilocularis cpg binding protein 0.0154 0.2506 0.2386
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0156
Loa Loa (eye worm) hypothetical protein 0.0031 0.0366 0.0252
Loa Loa (eye worm) RecQ helicase 0.0021 0.0191 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0366 0.0212
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0114 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.8087 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0366 0.0212
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0118 0.1878 0.23
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0461 0.0996
Trypanosoma cruzi polo-like protein kinase, putative 0.0474 0.8087 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0157 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1241 0.1534
Loa Loa (eye worm) hypothetical protein 0.0025 0.0267 0.0152
Toxoplasma gondii ABC1 family protein 0.0036 0.0447 0.0965
Schistosoma mansoni hypothetical protein 0.0067 0.0995 0.1204
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0403 0.029
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0447 0.0602
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0277 0.0342
Brugia malayi EGF-like domain containing protein 0.0025 0.0267 0.0243
Onchocerca volvulus 0.0036 0.0447 0.0525
Echinococcus granulosus flap endonuclease 1 0.0028 0.0315 0.016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Giardia lamblia Tenascin-X 0.0025 0.0267 0.0138
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0271 0.0236
Loa Loa (eye worm) hypothetical protein 0.0036 0.0447 0.0334
Giardia lamblia High cysteine protein 0.0025 0.0267 0.0138
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.7074 0.7028
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0447 0.3541
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0277 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0474 0.8087 0.8056
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0315 0.068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0271 0.0236
Trichomonas vaginalis DNA polymerase eta, putative 0.0118 0.1878 0.2303
Toxoplasma gondii histone lysine methyltransferase SET1 0.0276 0.4631 1
Toxoplasma gondii hypothetical protein 0.0025 0.0267 0.0576
Schistosoma mansoni hypothetical protein 0.0168 0.2757 0.3389
Plasmodium falciparum thioredoxin reductase 0.0026 0.0277 0.1524
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0461 0.0571
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0461 0.0571
Toxoplasma gondii thioredoxin reductase 0.0075 0.1131 0.2442
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0171 0.2805 0.7272
Loa Loa (eye worm) hypothetical protein 0.0036 0.0447 0.0334
Echinococcus multilocularis integrin beta 2 0.0584 1 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0447 0.0334
Entamoeba histolytica deoxycytidyl transferase, putative 0.0118 0.1878 0.2303
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0069 0.0149
Treponema pallidum NADH oxidase 0.0026 0.0277 1
Brugia malayi EGF-like domain containing protein 0.0025 0.0267 0.0243
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0271 0.0311
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0157 0.0194
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0157 0.017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.019 0.3138 0.818
Mycobacterium tuberculosis Probable reductase 0.0171 0.2805 0.7272
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0157 0.017
Echinococcus multilocularis integrin alpha 3 0.0045 0.06 0.045
Schistosoma mansoni ap endonuclease 0.0019 0.0157 0.0165
Echinococcus granulosus integrin alpha ps 0.0093 0.1444 0.1307
Brugia malayi Kelch motif family protein 0.012 0.1911 0.1892
Trichomonas vaginalis rotamase, putative 0.0032 0.039 0.0458
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0158 0.0811
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0118 0.1878 0.2303
Mycobacterium leprae Probable lipase LipE 0.0036 0.0447 0.0614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0157 0.0194
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0158 0.0002
Schistosoma mansoni rotamase 0.0033 0.0403 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0277 0.1933
Leishmania major DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0447 0.0602
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0271 0.0311
Mycobacterium ulcerans DNA polymerase IV 0.0118 0.1878 0.3575
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.1148 0.1007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0277 0.0342
Mycobacterium ulcerans hypothetical protein 0.0036 0.0447 0.0602
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.1878 0.2322
Leishmania major DNA polymerase eta, putative 0.0037 0.0461 0.0571
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0315 0.039
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0146 0.0231
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0366 0.0252
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.1131 0.1398
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0461 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.1878 0.4743
Trypanosoma brucei polo-like protein kinase 0.0474 0.8087 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0271 0.0236
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0995 0.0973
Loa Loa (eye worm) hypothetical protein 0.0067 0.0995 0.0888
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0277 0.0248
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0461 0.0996
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0315 0.039
Schistosoma mansoni myst-related protein 0.0017 0.0123 0.0123
Brugia malayi EGF-like domain containing protein 0.0025 0.0267 0.0243
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0399 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0399 0.0469
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0474 0.8087 0.8064
Loa Loa (eye worm) glutaminase 0.0295 0.4971 0.4911
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0118 0.1878 0.1782
Loa Loa (eye worm) kelch domain-containing protein family protein 0.012 0.1911 0.1816
Schistosoma mansoni cpg binding protein 0.0154 0.2506 0.3078
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0447 0.0529
Loa Loa (eye worm) glutaminase 2 0.0295 0.4971 0.4911
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0271 0.0248
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0277 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0454 0.0534
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0447 0.0529
Giardia lamblia Tenascin-like 0.0025 0.0267 0.0138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0157 0.0338
Mycobacterium tuberculosis Probable dehydrogenase 0.0171 0.2805 0.7272
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Loa Loa (eye worm) hypothetical protein 0.0048 0.0667 0.0557
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0447 0.0553
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0366 0.0343
Schistosoma mansoni cpg binding protein 0.0154 0.2506 0.3078
Onchocerca volvulus 0.0025 0.0267 0.0301
Brugia malayi glutaminase DH11.1 0.0295 0.4971 0.4958
Echinococcus granulosus expressed protein 0.0033 0.0403 0.025
Entamoeba histolytica serine/threonine protein kinase, putative 0.0474 0.8087 1
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0045 0.06 0.0578
Trichomonas vaginalis helicase, putative 0.0033 0.0399 0.0469
Trichomonas vaginalis rotamase, putative 0.0033 0.0403 0.0475
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0171 0.2805 0.7272
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0157 0.0804
Brugia malayi Thioredoxin reductase 0.0075 0.1131 0.1109
Echinococcus multilocularis integrin alpha ps 0.0093 0.1444 0.1307
Trypanosoma cruzi polo-like protein kinase, putative 0.0474 0.8087 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0474 0.8087 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0635 0.0757
Loa Loa (eye worm) hypothetical protein 0.0037 0.0461 0.0349
Schistosoma mansoni glutaminase 0.0295 0.4971 0.6135
Brugia malayi serine/threonine-protein kinase plk-2 0.0474 0.8087 0.8082
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0447 0.0838
Plasmodium falciparum flap endonuclease 1 0.0028 0.0315 0.1904
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0271 0.0358
Giardia lamblia Tenascin precursor 0.0025 0.0267 0.0138
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0447 0.0838
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0461 0.0571
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0277 0.0121
Trypanosoma brucei chrX additional, unordered contigs 0.0037 0.0461 0.0571
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0367 0.6225 0.769
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0447 0.0614
Loa Loa (eye worm) histone methyltransferase 0.0045 0.0609 0.0498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0399 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0403 0.0475
Leishmania major trypanothione reductase 0.0075 0.1131 0.1398
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0277 0.0342
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0315 0.2295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0267 0.0152
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0277 0.0342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0447 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Loa Loa (eye worm) hypothetical protein 0.0036 0.0447 0.0334
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.019 0.3138 1
Echinococcus granulosus dnaJ subfamily B 0.0416 0.7074 0.7028
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0461 0.0571
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0157 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0447 0.0838
Onchocerca volvulus 0.0026 0.0271 0.0306
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0277 0.0374
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1536 0.1516
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0315 0.0366
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0447 0.0529
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0271 0.0248
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0271 0.0358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0309 0.5205 0.6426
Schistosoma mansoni kinase 0.0241 0.4023 0.496
Loa Loa (eye worm) hypothetical protein 0.0036 0.0447 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Echinococcus granulosus bloom syndrome protein 0.0021 0.0191 0.0034
Mycobacterium ulcerans hypothetical protein 0.0026 0.0271 0.0236
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0118 0.1878 0.2322
Echinococcus multilocularis fibrillin 1 0.0025 0.0267 0.0111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0399 0.0469
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0156
Trichomonas vaginalis esterase, putative 0.0036 0.0447 0.0529
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0277 0.0248
Schistosoma mansoni integrin alpha-ps 0.0048 0.0667 0.0798
Onchocerca volvulus 0.0298 0.5024 0.6201
Plasmodium falciparum DNA repair protein REV1, putative 0.0037 0.0461 0.3357
Trypanosoma brucei unspecified product 0.0081 0.1241 0.1534
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0447 0.0553
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0157 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1241 0.1534
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0277 0.0318
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0447 0.0334
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0171 0.2805 0.7272
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0277 0.1524
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0277 0.0342
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0271 0.0248
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0036 0.0454 0.0302
Mycobacterium ulcerans hypothetical protein 0.0037 0.0461 0.0632
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1878 0.2322
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.1131 0.2704
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0424
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0277 0.0342
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0271 0.0236
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0277 0.0342
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0315 0.0201
Onchocerca volvulus 0.0146 0.2361 0.2898
Trypanosoma brucei DNA polymerase eta, putative 0.0118 0.1878 0.2322
Echinococcus multilocularis dna polymerase kappa 0.0118 0.1878 0.1748
Onchocerca volvulus 0.0036 0.0447 0.0525
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.039 0.0482

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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