Detailed information for compound 801218

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.962 | Formula: C25H30ClNO6
  • H donors: 1 H acceptors: 3 LogP: 3.84 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOCCOC(=C1C(=NC2=C(C1c1ccc(cc1)Cl)C(=O)C(C(C2)C)C(=O)OC)C)O
  • InChi: 1S/C25H30ClNO6/c1-5-10-32-11-12-33-25(30)20-15(3)27-18-13-14(2)19(24(29)31-4)23(28)22(18)21(20)16-6-8-17(26)9-7-16/h6-9,14,19,21,30H,5,10-13H2,1-4H3
  • InChiKey: OAHVEIKUHJZAAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0293 0.1003
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0308 0.131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.107 0.366
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0049 0.0166
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0293 0.1003
Echinococcus multilocularis caax prenyl protease 1 0.0069 0.1554 0.1554
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.011 0.011
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0044 0.015
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0293 0.1003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0008 0.0008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0308 0.4008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Brugia malayi hypothetical protein 0.0009 0.0044 0.015
Echinococcus multilocularis nAChR subunit 0.001 0.008 0.008
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.011 0.011
Schistosoma mansoni hypothetical protein 0.041 1 1
Onchocerca volvulus 0.0019 0.0293 0.4978
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0308 0.4596
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.008 0.008
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0069 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0223 0.0223
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0044 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0293 0.1003
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0069 0.1554 1
Onchocerca volvulus 0.0019 0.0293 0.4978
Loa Loa (eye worm) hypothetical protein 0.005 0.107 0.366
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0293 0.1003
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0678 0.2318
Brugia malayi CXXC zinc finger family protein 0.0029 0.0544 0.1863
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0768 0.0768
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.107 0.366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0223 0.0223
Onchocerca volvulus Putative nachr subunit 0.0019 0.0293 0.4978
Mycobacterium tuberculosis Conserved protein 0.0012 0.012 0.1794
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0475 0.1624
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0044 0.0044
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0293 0.0293
Schistosoma mansoni nAChR subunit 0.0009 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0034 0.0678 0.0678
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0475 0.3055
Brugia malayi Flap endonuclease-1 0.0026 0.0475 0.1624
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1345 0.1345
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0293 0.0293
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0293 0.1003
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Brugia malayi Cation transporter family protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0308 0.1054
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0454 0.8761
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0293 0.0293
Schistosoma mansoni cpg binding protein 0.003 0.0585 0.0585
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0293 0.0293
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Brugia malayi TAR-binding protein 0.0125 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Entamoeba histolytica CAAX prenyl protease, putative 0.0069 0.1554 1
Schistosoma mansoni hypothetical protein 0.0016 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0475 0.3055
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0293 0.0293
Toxoplasma gondii CAAX metallo endopeptidase 0.0069 0.1554 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.2923 0.2923
Echinococcus granulosus tar DNA binding protein 0.0125 0.2923 0.2923
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0223 0.0762
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.2923 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0544 0.1863
Echinococcus granulosus nAChR subunit 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0768 0.4521
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0308 0.1982
Brugia malayi hypothetical protein 0.0025 0.0454 0.1553
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0293 0.0293
Brugia malayi Cytochrome P450 family protein 0.0025 0.0457 0.1564
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0176
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0293 0.0293
Toxoplasma gondii exonuclease III APE 0.0019 0.0308 0.1982
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.008 0.0273
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0475 0.0475
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0044 0.015
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.067 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0293 0.1003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0768 0.4945
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0293 0.0293
Onchocerca volvulus 0.001 0.008 0.0716
Loa Loa (eye worm) hypothetical protein 0.0025 0.0454 0.1553
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Brugia malayi Inositol-1 0.0038 0.0768 0.2628
Loa Loa (eye worm) hypothetical protein 0.0016 0.0223 0.0762
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0293 0.0293
Plasmodium falciparum flap endonuclease 1 0.0026 0.0475 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0293 0.0293
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0308 0.1982
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Echinococcus granulosus flap endonuclease 1 0.0026 0.0475 0.0475
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0454 0.2922
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0768 0.4945
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.067 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0293 0.1003
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.2923 1
Mycobacterium ulcerans hypothetical protein 0.0012 0.012 0.1565
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0454 0.2922
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0008 0.0008
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0293 0.1003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1183 0.7616
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0768 0.4521
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0293 0.1003
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0044 0.0044
Loa Loa (eye worm) peptidase family M48 containing protein 0.0069 0.1554 0.5315
Brugia malayi hypothetical protein 0.0016 0.0233 0.0797
Entamoeba histolytica hypothetical protein 0.0036 0.0721 0.4348
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.008 0.0273
Onchocerca volvulus 0.0019 0.0293 0.4978
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0768 0.4521
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0293 0.1003
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0475 0.3055
Echinococcus granulosus nAChR subunit 0.001 0.008 0.008
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0293 0.0293
Brugia malayi hypothetical protein 0.0036 0.0721 0.2465
Brugia malayi Cation transporter family protein 0.0019 0.0293 0.1003
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0475 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.2923 0.2923
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0044 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0721 0.0721
Brugia malayi Peptidase family M48 containing protein 0.0069 0.1554 0.5315
Brugia malayi RNA binding protein 0.0125 0.2923 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0293 0.0293
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0293 0.1003
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0044 0.015
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0293 0.1003
Schistosoma mansoni hypothetical protein 0.0011 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.04 0.195
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0293 0.1003
Echinococcus multilocularis tar DNA binding protein 0.0125 0.2923 0.2923
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0293 0.1003
Brugia malayi Cation transporter family protein 0.0019 0.0293 0.1003
Schistosoma mansoni ap endonuclease 0.0019 0.0308 0.0308
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0454 0.2922
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0051
Echinococcus granulosus GPCR family 2 0.0016 0.0223 0.0223
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0293 0.1003
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0768 0.4945
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0044 0.015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0768 0.4945
Schistosoma mansoni hypothetical protein 0.0016 0.0223 0.0223
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0293 0.0293
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0308 0.5
Echinococcus multilocularis nAChR subunit 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Mycobacterium ulcerans heat shock protein HtpX 0.0012 0.012 0.1565
Loa Loa (eye worm) inositol-1 0.0038 0.0768 0.2628
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0008
Onchocerca volvulus 0.0029 0.0544 1
Leishmania major hypothetical protein, conserved 0.0025 0.0454 0.2922
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.04 0.195
Mycobacterium ulcerans peptidase M48 like-protein 0.0012 0.012 0.1565
Brugia malayi hypothetical protein 0.0009 0.0044 0.015
Brugia malayi hypothetical protein 0.0009 0.0044 0.015
Mycobacterium ulcerans hypothetical protein 0.0012 0.012 0.1565
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0308 0.2897
Onchocerca volvulus 0.0019 0.0293 0.4978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Onchocerca volvulus 0.0019 0.0293 0.4978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) GABA receptor subunit 0.001 0.008 0.0273
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0034 0.0678 0.2318
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0069 0.1554 1
Loa Loa (eye worm) TAR-binding protein 0.0125 0.2923 1
Loa Loa (eye worm) RNA binding protein 0.0125 0.2923 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0768 0.0768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0308 0.1982
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0293 0.1003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0293 0.1003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0044 0.015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0223 0.0762
Brugia malayi hypothetical protein 0.0009 0.0044 0.015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0721 0.0721
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0768 0.4672
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0044 0.0044
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0069 0.1554 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Entamoeba histolytica hypothetical protein 0.0036 0.0721 0.4348
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Echinococcus multilocularis cpg binding protein 0.003 0.0585 0.0585
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0293 0.0293
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0069 0.1554 1
Mycobacterium tuberculosis Probable protease transmembrane protein heat shock protein HtpX 0.0012 0.012 0.1794
Onchocerca volvulus 0.0019 0.0293 0.4978
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0293 0.0293
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0044 0.0044
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0475 0.268
Onchocerca volvulus 0.001 0.008 0.0716
Echinococcus multilocularis GPCR, family 2 0.0016 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0036 0.0721 0.4348
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.008 0.008
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0293 0.1003
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0044 0.0044
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0293 0.0293
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0293 0.0293
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.107 0.366
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0293 0.0293
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0293 0.0293
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0223 0.0223
Schistosoma mansoni flap endonuclease-1 0.0023 0.0413 0.0413
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0308 0.1549
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.008 0.0273
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0044 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0454 0.8761
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0475 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0044 0.015
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0721 0.0721
Entamoeba histolytica hypothetical protein 0.0036 0.0721 0.4348
Schistosoma mansoni nAChR subunit 0.0019 0.0293 0.0293
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0454 0.8761
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0475 0.2473
Schistosoma mansoni cpg binding protein 0.003 0.0585 0.0585
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0768 1
Schistosoma mansoni hypothetical protein 0.0016 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.001 0.008 0.0273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0223 0.0223
Brugia malayi hypothetical protein 0.0009 0.0044 0.015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Schistosoma mansoni tar DNA-binding protein 0.0125 0.2923 0.2923
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0768 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0457 0.1564
Schistosoma mansoni tar DNA-binding protein 0.0125 0.2923 0.2923
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0293 0.1003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0293 0.0293
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0293 0.0293
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0008 0.0008
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0293 0.0293
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0044 0.0044
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0293 0.0293
Mycobacterium leprae CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN 0.0012 0.012 0.1794
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0069 0.1554 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0044 0.0044
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0308 0.1054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.008 0.0273
Schistosoma mansoni hypothetical protein 0.0016 0.0223 0.0223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0293 0.1003
Schistosoma mansoni nAChR subunit 0.0009 0.0044 0.0044
Echinococcus granulosus caax prenyl protease 1 0.0069 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.015
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0308 0.131
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0293 0.0293
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0308 0.1982
Schistosoma mansoni tar DNA-binding protein 0.0125 0.2923 0.2923
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0768 0.4945
Schistosoma mansoni cpg binding protein 0.0029 0.0544 0.0544
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0044 0.015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0223 0.0762
Echinococcus multilocularis dnaJ subfamily B 0.041 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0721 0.0721
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0454 0.2922
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0293 0.0293
Schistosoma mansoni inositol monophosphatase 0.0038 0.0768 0.0768
Echinococcus granulosus cpg binding protein 0.003 0.0585 0.0585
Schistosoma mansoni ap endonuclease 0.0019 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0019 0.0293 0.1003
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0293 0.0293
Mycobacterium leprae PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX 0.0012 0.012 0.1794
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0069 0.1554 1
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0044 0.015
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0475 0.3055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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