Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0248 | 0.0331 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2005 | 0.2678 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0317 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.1389 | 0.214 |
Schistosoma mansoni | lamin | 0.0027 | 0.0248 | 0.0248 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0141 | 0.0189 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0116 | 0.1586 | 0.1586 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0031 | 0.0318 | 0.1863 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1607 | 0.2147 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0424 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0064 | 0.0085 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0141 | 0.0141 |
Entamoeba histolytica | hypothetical protein | 0.0178 | 0.2501 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0424 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.1389 | 0.1389 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0043 | 0.0495 | 0.0495 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0.0317 | 0.4198 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0317 | 0.1858 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0344 | 0.046 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0141 | 0.0189 |
Echinococcus multilocularis | cpg binding protein | 0.006 | 0.074 | 0.074 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.1389 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0107 | 0.1444 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.074 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2005 | 0.2678 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0017 | 0.0108 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0344 | 0.0344 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0744 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0744 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.1389 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0105 | 0.1408 | 0.1408 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0883 | 0.0883 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0248 | 0.0248 |
Onchocerca volvulus | Huntingtin homolog | 0.0145 | 0.2005 | 0.3088 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0317 | 0.0317 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0883 | 0.0883 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0141 | 0.0189 |
Schistosoma mansoni | lamin | 0.0027 | 0.0248 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0036 | 0.0047 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0056 | 0.0692 | 0.0925 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0344 | 0.0344 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0744 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0141 | 0.0189 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0681 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1282 | 0.1282 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0883 | 0.0883 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0141 | 0.0141 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0014 | 0.006 | 0.006 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0056 | 0.0692 | 0.0925 |
Onchocerca volvulus | 0.0056 | 0.0692 | 0.1066 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0744 | 0.0744 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0141 | 0.0141 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0744 | 0.0744 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0883 | 0.1179 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0048 | 0.056 | 0.056 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0744 | 0.0744 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0048 | 0.056 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0056 | 0.0692 | 0.0692 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0317 |
Echinococcus multilocularis | SUMO activating enzyme subunit 2 | 0.0031 | 0.0318 | 0.0318 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0681 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0883 | 0.0883 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0916 | 0.1224 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0344 | 0.0344 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0141 | 0.0141 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.1409 | 0.1882 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0.0317 | 0.4198 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0344 | 0.046 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.1389 | 0.1389 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0178 | 0.2501 | 0.2501 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1282 | 0.1282 |
Onchocerca volvulus | 0.0019 | 0.0141 | 0.0218 | |
Entamoeba histolytica | hypothetical protein | 0.0178 | 0.2501 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0248 | 0.0248 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1282 | 0.1282 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.074 | 0.074 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | histone methyltransferase | 0.0017 | 0.0111 | 0.0149 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.1389 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.1389 | 0.1856 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0116 | 0.1586 | 0.1586 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0048 | 0.056 | 0.056 |
Echinococcus granulosus | cpg binding protein | 0.006 | 0.074 | 0.074 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | ThiF family protein | 0.0031 | 0.0318 | 0.0425 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0027 | 0.0253 | 0.1368 |
Schistosoma mansoni | kinase | 0.0052 | 0.0633 | 0.0633 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0344 | 0.0344 |
Onchocerca volvulus | 0.0446 | 0.6492 | 1 | |
Onchocerca volvulus | 0.0027 | 0.0248 | 0.0382 | |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0048 | 0.056 | 0.056 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.1389 | 0.1389 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0248 | 0.0331 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0141 | 0.0141 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0043 | 0.0043 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0424 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0141 | 0.0141 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0248 | 0.0248 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0141 | 0.0141 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0014 | 0.006 | 0.006 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0105 | 0.1408 | 0.1882 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0248 | 0.0248 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0043 | 0.0057 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0248 | 0.0331 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.1408 | 0.1408 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0317 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0248 | 0.0248 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0744 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0916 | 0.0916 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0344 | 0.0344 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0178 | 0.2501 | 0.2501 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0043 | 0.0043 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0.0317 | 0.1858 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0248 | 0.0248 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0141 | 0.0141 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1282 | 0.1282 |
Schistosoma mansoni | ubiquitin-activating enzyme E1b | 0.0031 | 0.0318 | 0.0318 |
Onchocerca volvulus | Huntingtin homolog | 0.0145 | 0.2005 | 0.3088 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.1409 | 0.1882 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.1389 | 1 |
Brugia malayi | ThiF family protein | 0.0048 | 0.056 | 0.0749 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0883 | 0.0883 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0141 | 0.0141 |
Echinococcus granulosus | geminin | 0.0167 | 0.2343 | 0.2343 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1607 | 0.2147 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0141 | 0.0189 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0883 | 0.0883 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.1282 | 0.1713 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1282 | 0.1282 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0317 | 0.0317 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0513 | 0.7485 | 0.7485 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0883 | 0.1179 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.012 | 0.1635 | 0.1635 |
Entamoeba histolytica | hypothetical protein | 0.0178 | 0.2501 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0116 | 0.1586 | 0.1586 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0883 | 0.1179 |
Echinococcus granulosus | sumo-activating enzyme subunit 2 | 0.0031 | 0.0318 | 0.0318 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0178 | 0.2501 | 0.2501 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.1282 | 0.1713 |
Entamoeba histolytica | hypothetical protein | 0.0178 | 0.2501 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0048 | 0.056 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0344 | 0.0344 |
Brugia malayi | hypothetical protein | 0.0178 | 0.2501 | 0.3341 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.1389 | 0.1856 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.1409 | 0.1882 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.1389 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0248 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.7485 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1409 | 0.1882 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0344 | 0.0344 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.1389 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0064 | 0.0085 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0883 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0141 | 0.0189 |
Leishmania major | ubiquitin-activating enzyme-like protein | 0.0031 | 0.0318 | 0.0006 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0014 | 0.006 | 0.006 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0613 | 0.4236 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1282 | 0.1282 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0014 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0027 | 0.0248 | 0.0382 | |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0014 | 0.006 | 0.006 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0031 | 0.0318 | 0.4213 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0248 | 0.0248 |
Brugia malayi | hypothetical protein | 0.0145 | 0.2005 | 0.2678 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1607 | 0.2147 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0015 | 0.0073 | 0.0228 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0344 | 0.0344 |
Onchocerca volvulus | 0.0105 | 0.1408 | 0.2169 | |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2343 | 0.2343 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0344 | 0.046 |
Echinococcus multilocularis | geminin | 0.0167 | 0.2343 | 0.2343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1282 | 0.1282 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.056 | 0.2157 |
Brugia malayi | ThiF family protein | 0.0031 | 0.0318 | 0.0425 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0031 | 0.0318 | 0.0006 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.1064 | 0.1064 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0883 | 0.1179 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0744 | 0.379 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0141 | 0.0141 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.1389 | 0.5423 |
Plasmodium falciparum | SUMO-activating enzyme subunit 2 | 0.0031 | 0.0318 | 0.4213 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.2501 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0036 | 0.0047 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0744 | 0.3984 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0248 | 0.0331 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0883 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0241 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.6492 | 0.8673 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0513 | 0.7485 | 0.7485 |
Brugia malayi | hypothetical protein | 0.0446 | 0.6492 | 0.8673 |
Brugia malayi | hypothetical protein | 0.0513 | 0.7485 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0017 | 0.0111 | 0.0111 |
Echinococcus granulosus | RUN | 0.0019 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.056 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0916 | 0.1224 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0744 | 0.0744 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0017 | 0.0111 | 0.0111 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0344 | 0.046 |
Toxoplasma gondii | ThiF family protein | 0.0031 | 0.0318 | 0.0006 |
Onchocerca volvulus | 0.0019 | 0.0141 | 0.0218 | |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2343 | 0.2343 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0613 | 0.4236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.