Detailed information for compound 801376

Basic information

Technical information
  • TDR Targets ID: 801376
  • Name: ethyl 4-[[2-[[3-(4-fluorophenyl)-4-oxo-6,7-di hydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]ace tyl]amino]benzoate
  • MW: 485.551 | Formula: C23H20FN3O4S2
  • H donors: 1 H acceptors: 3 LogP: 3.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)CSc1nc2CCSc2c(=O)n1c1ccc(cc1)F
  • InChi: 1S/C23H20FN3O4S2/c1-2-31-22(30)14-3-7-16(8-4-14)25-19(28)13-33-23-26-18-11-12-32-20(18)21(29)27(23)17-9-5-15(24)6-10-17/h3-10H,2,11-13H2,1H3,(H,25,28)
  • InChiKey: KURGKYKEOBQEPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[2-[[3-(4-fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]-1-oxoethyl]amino]benzoic acid ethyl ester
  • 4-[[2-[[3-(4-fluorophenyl)-4-keto-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetyl]amino]benzoic acid ethyl ester
  • ethyl 4-[2-[[3-(4-fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]ethanoylamino]benzoate
  • Oprea1_451626

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0037 0.132 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Brugia malayi N-terminal motif family protein 0.0189 0.7998 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0173 0.0217
Loa Loa (eye worm) hypothetical protein 0.0037 0.132 0.165
Mycobacterium ulcerans lipase LipD 0.0037 0.132 0.5
Brugia malayi hypothetical protein 0.0009 0.0117 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.3935 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Brugia malayi chromobox protein homolog 3 0.004 0.1456 0.1821
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.1589 0.1987
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0219 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0173 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0173 0.0217
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0173 0.0217
Onchocerca volvulus 0.0011 0.0173 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Schistosoma mansoni chromobox protein 0.0071 0.2826 0.7182
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0219 0.0557
Brugia malayi beta-lactamase family protein 0.0037 0.132 0.165
Loa Loa (eye worm) hypothetical protein 0.0189 0.7998 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0219 0.0557
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0117 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0173 0.0217
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0219 0.0557
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0219 0.0557
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0173 0.044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0173 0.044
Loa Loa (eye worm) hypothetical protein 0.0037 0.132 0.165
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0219 0.0274
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0117 0.0298
Brugia malayi CHD4 protein 0.0012 0.0219 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1589 0.4038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0173 0.044
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0219 0.0557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Onchocerca volvulus 0.0012 0.0219 0.0274
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0219 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0173 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0173 0.044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0173 0.044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0173 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.3935 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0173 0.0217
Brugia malayi beta-lactamase family protein 0.0037 0.132 0.165
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0173 0.044
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0219 0.0557
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.3935 0.492
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0173 0.0217
Entamoeba histolytica hypothetical protein 0.0012 0.0219 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Loa Loa (eye worm) hypothetical protein 0.0037 0.132 0.165
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0173 0.044
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0173 0.044
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0117 0.0146
Schistosoma mansoni kinase 0.0049 0.1857 0.4719
Echinococcus granulosus Chromobox protein 3 0.0012 0.0219 0.0557
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0117 0.0298
Brugia malayi Protein cec-1. 0.0012 0.0219 0.0274
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0173 0.044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.132 0.3354
Schistosoma mansoni chromobox protein 0.0012 0.0219 0.0557
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2826 0.7182
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0173 0.044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0173 0.0217
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0173 0.0217
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0173 0.044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.132 0.165
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.2618 0.3273
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0219 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0173 0.0217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0173 0.044
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0173 0.0217
Brugia malayi nuclear receptor NHR-88 0.0011 0.0173 0.0217
Onchocerca volvulus 0.0037 0.132 0.165
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.1079 0.1349
Onchocerca volvulus 0.0037 0.132 0.165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Brugia malayi steroid hormone receptor 0.0011 0.0173 0.0217
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0117 0.0298
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0219 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0219 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Echinococcus multilocularis chromobox protein 1 0.0071 0.2826 0.7182
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.132 0.3354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Loa Loa (eye worm) helicase 0.0012 0.0219 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2618 0.6652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1809 0.4598
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0173 0.044
Echinococcus granulosus chromobox protein 1 0.0071 0.2826 0.7182
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0173 0.044
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0219 0.085
Trichomonas vaginalis esterase, putative 0.0037 0.132 0.3354
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0173 0.0217
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0173 0.044
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0219 0.0557
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0219 0.0557
Brugia malayi TAR-binding protein 0.0066 0.2618 0.3273
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.3935 0.492
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0219 0.0557
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2618 0.6652
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1456 0.3701
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0219 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1809 0.4598
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0117 0.0298
Echinococcus granulosus chromobox protein 2 0.0012 0.0219 0.0557
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.132 0.3354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0173 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Brugia malayi beta-lactamase 0.0037 0.132 0.165
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1801 0.4577
Brugia malayi RNA binding protein 0.0066 0.2618 0.3273
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0946 0.2405
Echinococcus multilocularis chromobox protein 1 0.0071 0.2826 0.7182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1809 0.4598
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0173 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Loa Loa (eye worm) hypothetical protein 0.0009 0.0117 0.0146
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0117 0.0298
Schistosoma mansoni dishevelled 0.0009 0.0117 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0173 0.044
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0117 0.0298
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0173 0.044
Onchocerca volvulus 0.0012 0.0219 0.0274
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.7998 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0117 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0173 0.0217
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1809 0.2262
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.2618 0.3273
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0117 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0173 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0173 0.044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.132 0.3354
Schistosoma mansoni hypothetical protein 0.0012 0.0219 0.0557
Brugia malayi ecdysteroid receptor 0.0011 0.0173 0.0217
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0219 0.0274
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0173 0.044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Giardia lamblia Kinase, PLK 0.0097 0.3935 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0173 0.044
Entamoeba histolytica hypothetical protein 0.0012 0.0219 0.0557
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1809 0.4598
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0173 0.0217
Echinococcus granulosus Chromo domain 0.0012 0.0219 0.0557
Echinococcus multilocularis tar DNA binding protein 0.0066 0.2618 0.6652
Trichomonas vaginalis hypothetical protein 0.0012 0.0219 0.0557
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0173 0.0217
Schistosoma mansoni chromobox protein 0.0071 0.2826 0.7182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.1456 0.1821
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0173 0.044
Brugia malayi DIX domain containing protein 0.0009 0.0117 0.0146
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.132 0.165
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3935 1
Onchocerca volvulus 0.0031 0.1079 0.1349
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0219 0.5
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0219 0.0557
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0173 0.044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3935 1
Brugia malayi SET domain containing protein 0.0012 0.0219 0.0274
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.132 0.3354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0173 0.0217
Schistosoma mansoni dishevelled 0.0009 0.0117 0.0298
Loa Loa (eye worm) beta-lactamase 0.0037 0.132 0.165
Mycobacterium leprae Probable lipase LipE 0.0037 0.132 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.132 0.3354
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.132 0.3354
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2618 0.6652
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1801 0.4577
Loa Loa (eye worm) hypothetical protein 0.0037 0.132 0.165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0173 0.0217
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0117 0.0146
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0173 0.0217
Onchocerca volvulus 0.0009 0.0117 0.0146
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0173 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1809 0.4598
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.3935 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Echinococcus multilocularis chromobox protein 2 0.0012 0.0219 0.0557
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0173 0.044
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Mycobacterium ulcerans hypothetical protein 0.0037 0.132 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0219 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1589 0.4038
Loa Loa (eye worm) RNA binding protein 0.0066 0.2618 0.3273
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0219 0.085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0173 0.044
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.3935 1
Brugia malayi hypothetical protein 0.0009 0.0117 0.0146
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0173 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0117 0.0298
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0173 0.0217
Loa Loa (eye worm) hypothetical protein 0.0009 0.0117 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0173 0.0217
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0219 0.0557
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2618 0.6652
Loa Loa (eye worm) hypothetical protein 0.0037 0.132 0.165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0219 0.0557
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2618 0.6652
Echinococcus multilocularis Chromo domain 0.0012 0.0219 0.0557
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0173 0.044
Schistosoma mansoni coup transcription factor 0.0011 0.0173 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0173 0.0217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1809 0.4598
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0117 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Mycobacterium leprae conserved hypothetical protein 0.0037 0.132 0.5
Entamoeba histolytica hypothetical protein 0.0012 0.0219 0.0557
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0117 0.0298
Loa Loa (eye worm) TAR-binding protein 0.0066 0.2618 0.3273
Trypanosoma brucei polo-like protein kinase 0.0097 0.3935 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0173 0.044
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.2826 0.3533
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.132 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3935 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0946 0.2405
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1456 0.3701
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.132 0.3354
Schistosoma mansoni chromobox protein 0.0012 0.0219 0.0557
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.3935 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0173 0.0217
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.132 0.3354
Brugia malayi Heterochromatin protein 1 0.0071 0.2826 0.3533
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0219 0.0557
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2826 0.7182
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.132 0.3354
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0117 0.0298
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0219 0.085
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.132 0.3354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1809 0.2262
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0173 0.044
Echinococcus granulosus tar DNA binding protein 0.0066 0.2618 0.6652
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0117 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0219 0.0557
Loa Loa (eye worm) hypothetical protein 0.0011 0.0173 0.0217
Brugia malayi hypothetical protein 0.0012 0.0219 0.0274
Schistosoma mansoni dep domain containing protein 0.0009 0.0117 0.0298
Loa Loa (eye worm) hypothetical protein 0.0037 0.132 0.165
Onchocerca volvulus 0.0037 0.132 0.165
Echinococcus granulosus chromobox protein 1 0.0071 0.2826 0.7182
Mycobacterium ulcerans beta-lactamase 0.0037 0.132 0.5
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0117 0.0298
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0173 0.0217
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0117 0.0298
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.132 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1456 0.1821
Plasmodium vivax hypothetical protein, conserved 0.0037 0.132 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0219 0.0557
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0219 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1809 0.4598
Onchocerca volvulus 0.0012 0.0219 0.0274
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0117 0.0146
Loa Loa (eye worm) hypothetical protein 0.0009 0.0117 0.0146
Brugia malayi nuclear hormone receptor 0.0011 0.0173 0.0217
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.3935 0.492

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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