Detailed information for compound 801832

Basic information

Technical information
  • TDR Targets ID: 801832
  • Name: N-(3-methoxyphenyl)-3-(4-methoxyphenyl)-5-met hyl-4-oxopyridazino[5,4-b]indole-1-carboxamid e
  • MW: 454.477 | Formula: C26H22N4O4
  • H donors: 1 H acceptors: 2 LogP: 4.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1nc(C(=O)Nc2cccc(c2)OC)c2c(c1=O)n(C)c1c2cccc1
  • InChi: 1S/C26H22N4O4/c1-29-21-10-5-4-9-20(21)22-23(25(31)27-16-7-6-8-19(15-16)34-3)28-30(26(32)24(22)29)17-11-13-18(33-2)14-12-17/h4-15H,1-3H3,(H,27,31)
  • InChiKey: KRWGDCLBGNELDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methoxyphenyl)-3-(4-methoxyphenyl)-5-methyl-4-oxo-pyridazino[5,4-b]indole-1-carboxamide
  • N-(3-methoxyphenyl)-3-(4-methoxyphenyl)-5-methyl-4-oxo-1-pyridazino[5,4-b]indolecarboxamide
  • 4-keto-N-(3-methoxyphenyl)-3-(4-methoxyphenyl)-5-methyl-pyridazino[5,4-b]indole-1-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0005 0.0607
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0257 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3564 0.3751
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1153 0.1214
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0394 0.1148
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0354 0.0372
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.3433 0.7583
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.3433 0.3613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.3361 0.3916
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.3433 0.3613
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0076 1
Trichomonas vaginalis ran, putative 0.0021 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2517 0.2648
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0005 0.018
Schistosoma mansoni hypothetical protein 0.0303 0.9503 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.4528 1
Brugia malayi hypothetical protein 0.0121 0.3361 0.4858
Plasmodium vivax importin-beta 2, putative 0.0028 0.0257 0.652
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3564 0.3751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2517 0.2648
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0394 0.0415
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0005 0.0117
Onchocerca volvulus Huntingtin homolog 0.0121 0.3361 0.3916
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0076
Echinococcus multilocularis tar DNA binding protein 0.0127 0.3564 0.3751
Echinococcus granulosus snurportin 1 0.0303 0.9503 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0318 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0394 0.0415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2517 0.2648
Brugia malayi Pre-SET motif family protein 0.0226 0.692 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0394 0.0415
Brugia malayi Pre-SET motif family protein 0.0032 0.0394 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0394 0.0415
Brugia malayi RNA binding protein 0.0127 0.3564 0.5151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0394 0.0415
Leishmania major GTP-binding protein, putative 0.0021 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0184 0.5504 0.5792
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0394 0.0415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.3564 0.3751
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0394 0.0415
Loa Loa (eye worm) hypothetical protein 0.0055 0.1153 0.1214
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.3433 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2517 0.2648
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1153 0.1667
Loa Loa (eye worm) RNA binding protein 0.0127 0.3564 0.3751
Schistosoma mansoni ran 0.0021 0.0005 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0127 0.3564 0.3751
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0567 0.0597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0038 0.0567 0.0597
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1153 0.1667
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.3433 1
Onchocerca volvulus 0.0257 0.7972 1
Treponema pallidum fructose-bisphosphate aldolase 0.0318 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.3433 0.7583
Plasmodium vivax SET domain protein, putative 0.0032 0.0394 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.3361 0.3537
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0394 0.0415
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0005 0.0005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.692 0.7282
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.2517 0.3637
Trichomonas vaginalis set domain proteins, putative 0.0257 0.7972 0.7972
Echinococcus granulosus tar DNA binding protein 0.0127 0.3564 0.3751
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.4528 0.5
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3564 0.3751
Echinococcus multilocularis snurportin 1 0.0303 0.9503 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0005 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.3433 0.7583
Loa Loa (eye worm) hypothetical protein 0.0121 0.3361 0.3537
Schistosoma mansoni hypothetical protein 0.0184 0.5504 0.5792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0257 0.027
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.3433 0.3613
Loa Loa (eye worm) hypothetical protein 0.0028 0.0257 0.027
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3564 0.3751
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0567 0.082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2517 0.2648
Schistosoma mansoni importin beta-1 0.0028 0.0257 0.027
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3564 0.3751
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0005
Brugia malayi RNA, U transporter 1 0.0081 0.2019 0.2917
Entamoeba histolytica hypothetical protein 0.0023 0.0076 0.0076
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0005 0.0005
Schistosoma mansoni ran 0.0021 0.0005 0.0005
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.4528 1
Echinococcus multilocularis geminin 0.0184 0.5504 0.5792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0076 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0076 0.0222
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0257 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.2517 0.2648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2517 0.2648
Echinococcus granulosus importin subunit beta 1 0.0028 0.0257 0.027
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.9503 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0257 0.0748
Brugia malayi TAR-binding protein 0.0127 0.3564 0.5151
Plasmodium falciparum importin beta, putative 0.0028 0.0257 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0005 0.0607
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.3433 0.7583
Echinococcus granulosus geminin 0.0184 0.5504 0.5792
Brugia malayi Importin beta-1 subunit 0.0028 0.0257 0.0371
Entamoeba histolytica Ran family GTPase 0.0021 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2517 0.2648
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.3564 0.5151
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.3433 0.3613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.