Detailed information for compound 801833

Basic information

Technical information
  • TDR Targets ID: 801833
  • Name: N-ethyl-N-(2-fluorophenyl)-5-methyl-3-(4-meth ylphenyl)-4-oxopyridazino[5,4-b]indole-1-carb oxamide
  • MW: 454.496 | Formula: C27H23FN4O2
  • H donors: 0 H acceptors: 2 LogP: 5.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1nn(c2ccc(cc2)C)c(=O)c2c1c1ccccc1n2C)c1ccccc1F
  • InChi: 1S/C27H23FN4O2/c1-4-31(22-12-8-6-10-20(22)28)26(33)24-23-19-9-5-7-11-21(19)30(3)25(23)27(34)32(29-24)18-15-13-17(2)14-16-18/h5-16H,4H2,1-3H3
  • InChiKey: AVWUQBMOGXXZQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-N-(2-fluorophenyl)-5-methyl-3-(4-methylphenyl)-4-oxo-pyridazino[5,4-b]indole-1-carboxamide
  • N-ethyl-N-(2-fluorophenyl)-5-methyl-3-(4-methylphenyl)-4-oxo-1-pyridazino[5,4-b]indolecarboxamide
  • N-ethyl-N-(2-fluorophenyl)-4-keto-5-methyl-3-(4-methylphenyl)pyridazino[5,4-b]indole-1-carboxamide
  • EU-0093099

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0488 0.9292 0.9291
Loa Loa (eye worm) runx1 0.0058 0.0768 0.0869
Onchocerca volvulus 0.0073 0.1051 0.1152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0498 0.0498
Echinococcus granulosus lamin 0.0028 0.0172 0.0172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0356 0.2205
Schistosoma mansoni ap endonuclease 0.0058 0.0756 0.0747
Giardia lamblia Kinase, PLK 0.0099 0.1579 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0069 0.0986 0.1116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0067 0.093 0.093
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0464 0.8814 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0756 0.4756
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0356 0.2205
Trypanosoma brucei polo-like protein kinase 0.0099 0.1579 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0016 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0756 0.5758
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.1188 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0036 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1188 0.1344
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0756 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0036 0.003
Schistosoma mansoni inositol monophosphatase 0.0038 0.0356 0.0346
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1579 0.1571
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1579 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1051 0.6635
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0986 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0069 0.0986 0.0978
Brugia malayi beta-lactamase family protein 0.0073 0.1051 0.1179
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0133 0.2242 0.2242
Loa Loa (eye worm) RGS-3 protein 0.002 0.001 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0036 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0036 0.0026
Onchocerca volvulus 0.0063 0.087 0.0947
Schistosoma mansoni inositol monophosphatase 0.0038 0.0356 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0036 0.0036
Echinococcus granulosus axis inhibition protein axin 0.002 0.001 0.001
Schistosoma mansoni lamin 0.0028 0.0172 0.0163
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0036 0.0026
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0238
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0247 0.0247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1051 0.1042
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1051 1
Echinococcus granulosus tar DNA binding protein 0.0067 0.093 0.093
Mycobacterium leprae Probable lipase LipE 0.0073 0.1051 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0489
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1579 0.1579
Echinococcus granulosus lamin dm0 0.0028 0.0172 0.0172
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0052 0.0649 0.0649
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1051 0.0906
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0238
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0247 0.028
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1051 0.0906
Echinococcus granulosus muscleblind protein 0.0147 0.2527 0.2527
Brugia malayi TAR-binding protein 0.0067 0.093 0.1042
Onchocerca volvulus 0.0073 0.1051 0.1152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0369 0.036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1051 0.1179
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0756 0.4756
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0036 0.003
Brugia malayi PHD-finger family protein 0.0057 0.075 0.0838
Brugia malayi hypothetical protein 0.0127 0.2136 0.2408
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1051 0.0906
Schistosoma mansoni cpg binding protein 0.0071 0.1023 0.1015
Brugia malayi hypothetical protein 0.0051 0.0629 0.0701
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.093 0.0922
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0036 0.0026
Loa Loa (eye worm) hypothetical protein 0.0127 0.2136 0.2416
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0036 0.0036
Schistosoma mansoni ap endonuclease 0.0058 0.0756 0.0747
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.1188 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0756 0.3731
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0036 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0036 0.0026
Echinococcus multilocularis axis inhibition protein axin 0.002 0.001 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0172 0.0195
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1051 0.6824
Loa Loa (eye worm) hypothetical protein 0.0073 0.1051 0.1189
Loa Loa (eye worm) hypothetical protein 0.0073 0.1051 0.1189
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0756 0.0855
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0369 0.036
Brugia malayi RNA binding protein 0.0067 0.093 0.1042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Onchocerca volvulus 0.0465 0.8841 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0247 0.0247
Schistosoma mansoni zinc finger protein 0.0033 0.0266 0.0257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0036 0.0036
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0342 0.0332
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0368 0.0416
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.1151 0.1151
Echinococcus multilocularis muscleblind protein 1 0.0147 0.2527 0.2527
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.001 0.001
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0495 0.056
Echinococcus granulosus dnaJ subfamily B 0.0488 0.9292 0.9292
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0585 0.3665
Loa Loa (eye worm) hypothetical protein 0.0073 0.1051 0.1189
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0356 0.0682
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0011
Echinococcus multilocularis musashi 0.0028 0.0172 0.0172
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.001 0.0011
Echinococcus multilocularis lamin dm0 0.0028 0.0172 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1051 0.6635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0036 0.0041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1579 0.1752
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0036 0.0026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0756 0.3731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0036 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0489
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0036 0.0036
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.001 0.001
Schistosoma mansoni intermediate filament proteins 0.0028 0.0172 0.0163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0756 0.056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.2098 1
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1051 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0036 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0369 0.0369
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0036 0.003
Mycobacterium ulcerans lipase LipD 0.0073 0.1051 1
Echinococcus multilocularis zinc finger protein 0.0046 0.0522 0.0522
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.093 0.1052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1051 0.1189
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0524 1 1
Echinococcus granulosus cpg binding protein 0.0071 0.1023 0.1023
Echinococcus multilocularis axis inhibition protein axin 0.002 0.001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0036 0.003
Brugia malayi hypothetical protein 0.0465 0.8841 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.2643 0.2989
Mycobacterium tuberculosis Conserved protein 0.0073 0.1051 0.0906
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0016 0.0007
Leishmania major hypothetical protein, conserved 0.008 0.1188 0.7024
Loa Loa (eye worm) TAR-binding protein 0.0067 0.093 0.1052
Loa Loa (eye worm) hypothetical protein 0.0083 0.1256 0.142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0036 0.003
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0016 0.0018
Leishmania major hypothetical protein, conserved 0.0073 0.1051 0.5978
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0756 0.5
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0342 0.0342
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0356 0.0682
Schistosoma mansoni hypothetical protein 0.0033 0.0266 0.0257
Echinococcus granulosus expressed protein 0.0392 0.7389 0.7389
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0356 0.0356
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0133 0.2242 0.2242
Loa Loa (eye worm) hypothetical protein 0.0073 0.1051 0.1189
Onchocerca volvulus 0.0073 0.1051 0.1152
Echinococcus multilocularis geminin 0.0524 1 1
Echinococcus granulosus zinc finger protein 0.0046 0.0522 0.0522
Schistosoma mansoni bromodomain containing protein 0.014 0.2395 0.2388
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0036 0.0026
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0318 0.0318
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.087 0.0984
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0247 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0067 0.093 0.0922
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0342 0.0332
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1051 1
Loa Loa (eye worm) beta-lactamase 0.0073 0.1051 0.1189
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0465 0.8841 1
Loa Loa (eye worm) inositol-1 0.0038 0.0356 0.0402
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0756 0.0845
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0016 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0489
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1051 0.6635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1623 0.1827
Schistosoma mansoni zinc finger protein 0.0046 0.0522 0.0512
Trichomonas vaginalis esterase, putative 0.0073 0.1051 0.6635
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.2282 0.2274
Echinococcus granulosus fetal alzheimer antigen falz 0.0052 0.0649 0.0649
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1051 0.5978
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0036 0.003
Brugia malayi Bromodomain containing protein 0.0083 0.1252 0.1407
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0036 0.0041
Echinococcus granulosus intermediate filament protein 0.0028 0.0172 0.0172
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0036 0.0036
Echinococcus granulosus GPCR family 2 0.0032 0.0247 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0067 0.093 0.0922
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0036 0.0026
Brugia malayi beta-lactamase 0.0073 0.1051 0.1179
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.1188 0.7024
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0756 0.0756
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0036 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1051 0.1042
Loa Loa (eye worm) hypothetical protein 0.0127 0.2136 0.2416
Mycobacterium tuberculosis Conserved protein 0.0073 0.1051 0.0906
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0036 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0498 0.0498
Mycobacterium ulcerans beta-lactamase 0.0073 0.1051 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0498 0.0564
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.1188 0.7024
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1579 0.1777
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0036 0.0036
Brugia malayi beta-lactamase family protein 0.0073 0.1051 0.1179
Echinococcus multilocularis Protein lozenge 0.0058 0.0768 0.0768
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0036 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0247 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0036 0.0036
Brugia malayi Bromodomain containing protein 0.0166 0.2898 0.327
Echinococcus multilocularis dnaJ subfamily B 0.0488 0.9292 0.9292
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0036 0.003
Echinococcus multilocularis regulator of G protein signaling 0.002 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0036 0.0318 0.0309
Schistosoma mansoni cpg binding protein 0.0063 0.087 0.0861
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0036 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0036 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0036 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0172 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0756 0.3731
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1051 0.5978
Brugia malayi CXXC zinc finger family protein 0.0063 0.087 0.0974
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0036 0.0041
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1579 0.1579
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1579 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0036 0.0026
Echinococcus multilocularis cpg binding protein 0.0071 0.1023 0.1023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0028 0.0162 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0585 0.3665
Mycobacterium tuberculosis Conserved protein 0.0073 0.1051 0.0906
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0016 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0036 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0036 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0036 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0498 0.0553
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0036 0.0036
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1579 1
Echinococcus multilocularis muscleblind protein 0.0147 0.2527 0.2527
Loa Loa (eye worm) hypothetical protein 0.0101 0.1623 0.1836
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.001 0.0011
Onchocerca volvulus Huntingtin homolog 0.0127 0.2136 0.2385
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0465 0.8841 1
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1051 0.5978
Loa Loa (eye worm) hypothetical protein 0.0028 0.0172 0.0195
Loa Loa (eye worm) hypothetical protein 0.0073 0.1051 0.1189
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.1188 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.2527 0.2859
Schistosoma mansoni hypothetical protein 0.0045 0.0495 0.0486
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1051 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0067 0.093 0.0922
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0369 0.0369
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1051 0.1051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0036 0.0036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1051 0.0906
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1623 0.1836
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.1151 0.1151
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1051 0.0906
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.1188 0.7024
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0036 0.0036
Schistosoma mansoni coup transcription factor 0.0021 0.0036 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0036 0.003
Onchocerca volvulus 0.0028 0.0172 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0172 0.0195
Brugia malayi nuclear hormone receptor 0.0021 0.0036 0.003
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1579 1
Echinococcus multilocularis expressed protein 0.0392 0.7389 0.7389
Loa Loa (eye worm) hypothetical protein 0.0073 0.1051 0.1189
Schistosoma mansoni cpg binding protein 0.0071 0.1023 0.1015
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0247 0.0269
Brugia malayi steroid hormone receptor 0.0021 0.0036 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.1188 0.4779
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1623 0.1827
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1051 0.0906
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0052 0.0649 0.064
Schistosoma mansoni tar DNA-binding protein 0.0067 0.093 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0036 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0498 0.0498
Echinococcus granulosus axis inhibition protein axin 0.002 0.001 0.001
Onchocerca volvulus 0.0028 0.0172 0.0155
Brugia malayi intermediate filament protein 0.0028 0.0172 0.0184
Toxoplasma gondii ABC1 family protein 0.0073 0.1051 0.3991
Brugia malayi nuclear receptor NHR-88 0.0021 0.0036 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0036 0.0041
Schistosoma mansoni hypothetical protein 0.0524 1 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0036 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0011
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.093 0.1042
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0036 0.0041
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0096 0.1511 0.1709
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0036 0.003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1579 0.1786
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1051 0.6635
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0756 0.3731
Brugia malayi Inositol-1 0.0038 0.0356 0.0392
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Toxoplasma gondii exonuclease III APE 0.0058 0.0756 0.2298
Schistosoma mansoni lamin 0.0028 0.0172 0.0163
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0356 0.2205
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0041
Loa Loa (eye worm) RNA binding protein 0.0067 0.093 0.1052
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0356 0.0682
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.001 0.001
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.001
Brugia malayi Muscleblind-like protein 0.0147 0.2527 0.2851
Loa Loa (eye worm) hypothetical protein 0.0088 0.1357 0.1535
Schistosoma mansoni kinase 0.005 0.0611 0.0602
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0247 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0016 0.0006
Echinococcus multilocularis GPCR, family 2 0.0032 0.0247 0.0247
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0073 0.1051 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0036 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0356 0.2205
Loa Loa (eye worm) hypothetical protein 0.0038 0.0369 0.0417
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1579 1
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0756 0.4756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0036 0.0041
Onchocerca volvulus Huntingtin homolog 0.0127 0.2136 0.2385
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.001
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0077 0.0076
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0356 0.0682
Brugia malayi hypothetical protein 0.008 0.1188 0.1334
Brugia malayi ecdysteroid receptor 0.0021 0.0036 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0756 0.0756
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1051 0.6635
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0147 0.2527 0.2859
Schistosoma mansoni lozenge 0.0058 0.0768 0.0759
Echinococcus multilocularis lamin 0.0028 0.0172 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0498 0.0498

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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