Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1425 | 0.2699 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.1425 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0205 | 0.0788 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2605 | 0.4933 |
Echinococcus multilocularis | CCR4 NOT transcription complex subunit 6 | 0.0004 | 0.0002 | 0.0007 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.1425 | 0.2699 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1425 | 0.1424 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1425 | 0.2699 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0205 | 0.0788 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0205 | 0.0788 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2605 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2605 | 0.4933 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2605 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0205 | 0.0389 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1425 | 0.1424 |
Onchocerca volvulus | 0.0036 | 0.1425 | 1 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.1425 | 0.5472 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0665 | 0.466 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1425 | 0.5472 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0665 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.528 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2605 | 0.4933 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.1425 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0665 | 0.466 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1425 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.1425 | 0.1424 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.1425 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1835 | 0.7044 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.1162 | 0.4461 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0205 | 0.0389 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1425 | 0.5472 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1425 | 0.2699 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1835 | 0.7044 |
Schistosoma mansoni | cript-related | 0.0004 | 0.0002 | 0.0007 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0039 | 0.0075 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0004 | 0.0002 | 0.0007 |
Brugia malayi | beta-lactamase | 0.0036 | 0.1425 | 0.2699 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2605 | 1 |
Echinococcus multilocularis | deoxyribonuclease 1 2 | 0.0004 | 0.0002 | 0.0007 |
Echinococcus multilocularis | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0004 | 0.0002 | 0.0007 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0665 | 0.466 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0004 | 0.0002 | 0.0007 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1425 | 0.2699 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0146 | 0.0561 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1425 | 0.2699 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.1425 | 1 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0004 | 0.0002 | 0.0004 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0004 | 0.0002 | 0.0004 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0004 | 0.0002 | 0.0007 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1835 | 0.7044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0205 | 0.0389 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Brugia malayi | Smad1 | 0.0008 | 0.0205 | 0.0389 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0146 | 0.0561 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.1425 | 0.1424 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0205 | 0.0788 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0665 | 0.126 |
Echinococcus granulosus | CCR4 NOT transcription complex subunit 6 | 0.0004 | 0.0002 | 0.0007 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0004 | 0.0002 | 0.0004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2605 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2605 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2605 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2605 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.109 | 0.2065 |
Brugia malayi | CCR4 | 0.0004 | 0.0002 | 0.0004 |
Echinococcus multilocularis | neutral sphingomyelinase | 0.0004 | 0.0002 | 0.0007 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0665 | 0.466 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Schistosoma mansoni | synaptojanin | 0.0004 | 0.0002 | 0.0007 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1425 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2605 | 0.4933 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.1425 | 0.1424 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1162 | 0.4461 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0665 | 0.126 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0205 | 0.0389 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.1425 | 0.6435 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1835 | 0.3475 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1425 | 0.2699 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1835 | 0.7044 |
Echinococcus granulosus | smad | 0.0008 | 0.0205 | 0.0788 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0205 | 0.0788 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Onchocerca volvulus | Putative neutral sphingomyelinase | 0.0004 | 0.0002 | 0.0014 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1835 | 0.3475 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.1425 | 0.5472 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.1425 | 0.1424 |
Echinococcus multilocularis | synaptojanin 1 | 0.0004 | 0.0002 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0039 | 0.0075 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0205 | 0.0389 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.109 | 0.4186 |
Loa Loa (eye worm) | CCR4-NOT transcription complex subunit 6 family protein | 0.0004 | 0.0002 | 0.0004 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0223 | 0.0422 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0004 | 0.0002 | 0.0007 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1425 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.109 | 0.2065 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0218 | 0.0412 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0205 | 0.0788 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.1425 | 0.1424 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.1425 | 1 |
Echinococcus granulosus | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0004 | 0.0002 | 0.0007 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.528 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0665 | 0.466 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0004 | 0.0002 | 0.0007 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.1162 | 0.4461 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0146 | 0.0561 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1835 | 0.7044 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1162 | 0.4461 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.1425 | 0.2699 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0665 | 0.2554 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1425 | 0.2699 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0665 | 0.2554 |
Echinococcus granulosus | neutral sphingomyelinase | 0.0004 | 0.0002 | 0.0007 |
Echinococcus multilocularis | smad | 0.0008 | 0.0205 | 0.0788 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1835 | 0.7044 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0665 | 0.0663 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1425 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.1425 | 0.2699 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1425 | 0.2699 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.1425 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0002 | 0.0004 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0146 | 0.0561 |
Schistosoma mansoni | smad | 0.0008 | 0.0205 | 0.0788 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0039 | 0.0075 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2605 | 0.4933 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0002 | 0.0004 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0119 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0002 | 0.0004 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.1425 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.1425 | 0.1424 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1425 | 1 |
Schistosoma mansoni | nocturnin | 0.0004 | 0.0002 | 0.0007 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1835 | 0.7044 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0205 | 0.0788 |
Onchocerca volvulus | 0.0004 | 0.0002 | 0.0014 | |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0004 | 0.0002 | 0.0004 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0014 | 0.0055 |
Schistosoma mansoni | synaptojanin | 0.0004 | 0.0002 | 0.0007 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.1425 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0002 | 0.0004 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1425 | 0.1424 |
Schistosoma mansoni | hypothetical protein | 0.0004 | 0.0002 | 0.0007 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0004 | 0.0002 | 0.0007 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0205 | 0.0788 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2605 | 0.4933 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0205 | 0.0788 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0205 | 0.0788 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0665 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.1425 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0223 | 0.0855 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0004 | 0.0002 | 0.0007 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0119 | 0.0821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.1425 | 0.1424 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1425 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0665 | 0.2554 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0665 | 0.466 |
Echinococcus granulosus | synaptojanin 1 | 0.0004 | 0.0002 | 0.0007 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.2499 | 0.9592 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Onchocerca volvulus | 0.0004 | 0.0002 | 0.0014 | |
Onchocerca volvulus | 0.0036 | 0.1425 | 1 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.2214 | 1 |
Onchocerca volvulus | 0.0036 | 0.1425 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.1425 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1425 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0146 | 0.0561 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.528 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.1425 | 0.5 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0004 | 0.0002 | 0.0004 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0205 | 0.0788 |
Onchocerca volvulus | 0.0028 | 0.109 | 0.7649 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0119 | 0.0821 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0223 | 0.0855 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0039 | 0.0075 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0665 | 0.2999 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0665 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0205 | 0.0389 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0665 | 0.466 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0205 | 0.0389 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0665 | 0.2554 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0665 | 1 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0004 | 0.0002 | 0.0004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.