Detailed information for compound 80206

Basic information

Technical information
  • TDR Targets ID: 80206
  • Name: (E)-2,2,8-trimethyl-9-naphthalen-1-ylnon-5-en -3-ynamide
  • MW: 319.44 | Formula: C22H25NO
  • H donors: 1 H acceptors: 1 LogP: 5.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1cccc2c1cccc2)C/C=C/C#CC(C(=O)N)(C)C
  • InChi: 1S/C22H25NO/c1-17(10-5-4-8-15-22(2,3)21(23)24)16-19-13-9-12-18-11-6-7-14-20(18)19/h4-7,9,11-14,17H,10,16H2,1-3H3,(H2,23,24)/b5-4+
  • InChiKey: WPXYOBQAFOKMIW-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2,2,8-trimethyl-9-(1-naphthyl)non-5-en-3-ynamide
  • (E)-2,2,8-trimethyl-9-(1-naphthalenyl)non-5-en-3-ynamide
  • (E)-2,2,8-trimethyl-9-naphthalen-1-yl-non-5-en-3-ynamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0028 0.0195 0.0222
Brugia malayi Cathepsin L-like precursor 0.0017 0.0067 0.0041
Onchocerca volvulus Putative organic anion transporter 0.0028 0.02 0.0229
Schistosoma mansoni organic anion transporter 0.0028 0.02 0.0229
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.1217 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0423
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0247 0.0335
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0247 0.0297
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.012
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0091 0.0111
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0091 0.0582
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0247 0.0297
Leishmania major cathepsin L-like protease 0.0017 0.0067 0.0549
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0247 0.0297
Loa Loa (eye worm) DR-78 0.0015 0.0041 0.0039
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.1217 1
Brugia malayi hypothetical protein 0.0017 0.0063 0.0036
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0692 0.0976
Brugia malayi Sodium Bile acid symporter family protein 0.0588 0.6965 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Mycobacterium leprae probable zinc metalloprotease 0.0093 0.0987 0.747
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0308 0.2529
Schistosoma mansoni follistatin 0.0019 0.0091 0.0072
Loa Loa (eye worm) hypothetical protein 0.0588 0.6965 1
Schistosoma mansoni organic anion transporter 0.0028 0.02 0.0229
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0068 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.0046 0.0417 0.058
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.02 0.0258
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1217 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0097 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0097 0.0085
Loa Loa (eye worm) hypothetical protein 0.0069 0.0692 0.0976
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0067 0.0549
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0063 0.0036
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0097 0.012
Brugia malayi nuclear receptor RXR 0.0017 0.0063 0.0036
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0067 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0247 0.0297
Brugia malayi beta-lactamase 0.0037 0.0308 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0247 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0308 0.2529
Onchocerca volvulus Phospholipase A2 homolog 0.0444 0.5223 0.7484
Loa Loa (eye worm) zinc metallopeptidase 4 0.0023 0.0133 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Brugia malayi Cathepsin L-like precursor 0.0017 0.0067 0.0041
Entamoeba histolytica cysteine protease, putative 0.0017 0.0067 0.0549
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0097 0.0085
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.02 0.0267
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0152 0.016
Brugia malayi nuclear receptor NHR-88 0.0032 0.0247 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.1217 1
Onchocerca volvulus Putative organic anion transporter 0.0028 0.02 0.0229
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0308 0.0389
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0067 0.0076
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.016
Onchocerca volvulus Putative organic anion transporter 0.0028 0.02 0.0229
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0247 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0247 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0063 0.0036
Echinococcus multilocularis geminin 0.0175 0.1977 0.1961
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.1004
Brugia malayi hypothetical protein 0.0017 0.0063 0.0036
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.1004
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0041 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0041 0.003
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0067 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.012
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0247 0.0327
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1217 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0063 0.0043
Onchocerca volvulus 0.0028 0.02 0.0229
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Brugia malayi Cathepsin L-like precursor 0.0017 0.0067 0.0041
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0097 0.0077
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0133 0.0132
Brugia malayi nuclear receptor RXR 0.0015 0.0041 0.0005
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0041 0.0021
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0485 0.3982
Onchocerca volvulus 0.0046 0.0417 0.0543
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0655 0.5385
Onchocerca volvulus 0.0017 0.0067 0.0037
Onchocerca volvulus 0.0037 0.0308 0.0385
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0247 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0247 0.0335
Leishmania major cathepsin L-like protease 0.0066 0.0655 0.5385
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.012
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.016
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0041 0.003
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0067 0.0037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0247 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0247 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Brugia malayi PXA domain containing protein 0.002 0.0097 0.0085
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0427 0.0558
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0097 0.012
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0097 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0423
Onchocerca volvulus 0.0017 0.0067 0.0037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0247 0.0297
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0097 0.0111
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0097 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0097 0.0798
Brugia malayi Cathepsin L-like precursor 0.0017 0.0067 0.0041
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0041 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0195 0.026
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0097 0.0077
Loa Loa (eye worm) hypothetical protein 0.0093 0.0987 0.14
Loa Loa (eye worm) phosphofructokinase 0.0113 0.1217 0.1731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0097 0.0077
Schistosoma mansoni intermediate filament proteins 0.0028 0.0195 0.0222
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0247 0.0302
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0225 0.1847
Trypanosoma cruzi MFS transporter, putative 0.0028 0.02 0.1641
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0225 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0091 0.0582
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0308 0.2529
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0247 0.0327
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0092 0.1587
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Schistosoma mansoni sodium-bile acid cotransporter related 0.0588 0.6965 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0586 0.4816
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.1004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0067 0.0047
Onchocerca volvulus 0.0028 0.02 0.0229
Leishmania major cathepsin L-like protease 0.0066 0.0655 0.5385
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0308 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0097 0.012
Brugia malayi hypothetical protein 0.0028 0.02 0.0233
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0041 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0247 0.0327
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.1004
Schistosoma mansoni regulator of G protein signaling 0.002 0.0097 0.0081
Mycobacterium ulcerans zinc metalloprotease 0.0093 0.0987 0.747
Brugia malayi Peptidase family M13 containing protein 0.0093 0.0987 0.137
Loa Loa (eye worm) hypothetical protein 0.0069 0.0692 0.0976
Echinococcus granulosus agrin 0.0019 0.0091 0.0102
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0067 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0423
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0097 0.0111
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.016
Echinococcus granulosus lamin 0.0028 0.0195 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi 6-phosphofructokinase 0.0113 0.1217 0.1702
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0041 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0247 0.0302
Echinococcus granulosus bloom syndrome protein 0.0022 0.0124 0.015
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0047 0.0427 0.0558
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.02 0.0233
Brugia malayi steroid hormone receptor 0.0032 0.0247 0.0302
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0124 0.0124
Echinococcus multilocularis cysteine protease 0.0017 0.0067 0.0047
Brugia malayi nuclear receptor NHR-88 0.0015 0.0041 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0225 0.1847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0097 0.0085
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.02 0.0233
Brugia malayi Cathepsin L-like precursor 0.0017 0.0067 0.0041
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.1217 0.1199
Entamoeba histolytica hypothetical protein 0.002 0.0097 0.0798
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0308 0.0423
Onchocerca volvulus 0.0017 0.0067 0.0037
Onchocerca volvulus 0.0037 0.0308 0.0385
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0247 0.0297
Brugia malayi peptidase family M13 containing protein 0.0023 0.0133 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0655 0.5385
Schistosoma mansoni sodium-bile acid cotransporter related 0.0339 0.3952 0.5648
Brugia malayi tailless protein 0.0015 0.0041 0.0005
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0041 0.0021
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0225 0.1987
Echinococcus multilocularis sodium bile acid cotransporter 0.0588 0.6965 0.6959
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0133 0.0132
Onchocerca volvulus 0.0019 0.0091 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1217 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0247 0.0302
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Brugia malayi nuclear hormone receptor 0.0032 0.0247 0.0302
Echinococcus multilocularis lamin dm0 0.0028 0.0195 0.0175
Loa Loa (eye worm) hypothetical protein 0.0069 0.0692 0.0976
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0111
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.02 0.018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0247 0.0227
Schistosoma mansoni regulator of G protein signaling 0.002 0.0097 0.0081
Brugia malayi 6-phosphofructokinase 0.0113 0.1217 0.1702
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0097 0.0111
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0067 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0097 0.0798
Brugia malayi intermediate filament protein 0.0028 0.0195 0.0226
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0091 0.0111
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0076
Brugia malayi Cathepsin L-like precursor 0.0017 0.0067 0.0041
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.002 0.0097 0.0798
Echinococcus granulosus geminin 0.0175 0.1977 0.2817
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0097 0.012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0247 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0225 0.1847
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0047 0.0427 0.0558
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0067 0.0549
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0067 0.0037
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0097 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0308 0.2529
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0423
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0308 0.2529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0247 0.0297
Leishmania major cathepsin L-like protease 0.0017 0.0067 0.0549
Onchocerca volvulus 0.0037 0.0308 0.0385
Loa Loa (eye worm) cysteine protease 0.0017 0.0067 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0247 0.0297
Brugia malayi ecdysteroid receptor 0.0032 0.0247 0.0302
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0041 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0308 0.2529
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0067 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0063 0.0032
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0225 0.1847
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0195 0.026
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0041 0.003
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1217 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0041 0.0039
Schistosoma mansoni regulator of G protein signaling 0.002 0.0097 0.0081
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0091 0.0077
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0225 0.6923
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0067 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0247 0.0302
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0071
Loa Loa (eye worm) RecQ helicase 0.0022 0.0124 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0041 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0247 0.0302
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0423
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0247 0.0302
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0097 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0247 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0247 0.0302
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0067 0.0067
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1217 0.1731
Brugia malayi prostaglandin transporter 0.0028 0.02 0.0233
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0091 0.0582
Echinococcus granulosus axis inhibition protein axin 0.002 0.0097 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.02 0.0258
Echinococcus granulosus follistatin 0.0019 0.0091 0.0102
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0692 0.0976
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0067 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0071
Onchocerca volvulus 0.0028 0.02 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0247 0.0302
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0097 0.0111
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0023 0.0133 0.0132
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0067 0.0037
Echinococcus multilocularis endothelin converting enzyme 1 0.0093 0.0987 0.0969
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0225 0.1987
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0247 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0067 0.0549
Toxoplasma gondii cathepsin CPL 0.0017 0.0067 0.0327
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.016
Echinococcus multilocularis cysteine protease 0.0017 0.0067 0.0047
Echinococcus multilocularis sodium bile acid cotransporter 0.0588 0.6965 0.6959
Onchocerca volvulus 0.0028 0.02 0.0229
Onchocerca volvulus 0.0017 0.0067 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi hypothetical protein 0.0015 0.0041 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0247 0.0327
Brugia malayi hypothetical protein 0.002 0.0097 0.0085
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0097 0.0081
Schistosoma mansoni endothelin-converting enzyme-related 0.0023 0.0133 0.0132
Toxoplasma gondii ABC1 family protein 0.0037 0.0308 0.286
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0097 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0041 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0225 0.6923
Leishmania major cathepsin L-like protease 0.0017 0.0067 0.0549
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0247 0.0227
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0655 0.5385
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0195 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0247 0.0335
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0041 0.0021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0091 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0247 0.0302
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0225 0.1987
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0247 0.0297
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0097 0.0077
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0091 0.0582
Schistosoma mansoni regulator of G protein signaling 0.002 0.0097 0.0081
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0091 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0308 0.2529
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0308 0.0414
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0124 0.1021
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1217 0.1698
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0111
Onchocerca volvulus 0.0017 0.0067 0.0037
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0247 0.0297
Echinococcus granulosus lamin dm0 0.0028 0.0195 0.0251
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0308 0.2529
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0111
Loa Loa (eye worm) hypothetical protein 0.0093 0.0987 0.14
Brugia malayi SPARC precursor 0.0019 0.0091 0.0077
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0225 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0041 0.0005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0097 0.0081
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0067 0.0047
Brugia malayi beta-lactamase family protein 0.0037 0.0308 0.0389
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0097 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0247 0.0227
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0247 0.0227
Loa Loa (eye worm) RGS-3 protein 0.002 0.0097 0.012
Schistosoma mansoni sodium-bile acid cotransporter 0.0249 0.2871 0.4087
Onchocerca volvulus 0.0028 0.0195 0.0222
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1217 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0097 0.0081
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.02 0.1724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.1217 0.3747
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0097 0.0798
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0097 0.0077
Loa Loa (eye worm) hypothetical protein 0.0093 0.0987 0.14
Echinococcus granulosus cathepsin l1 0.0017 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0093 0.0987 0.14
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0308 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.02 0.0233
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0041 0.003
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0097 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0247 0.0327
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.012
Echinococcus multilocularis lamin 0.0028 0.0195 0.0175
Leishmania major cathepsin L-like protease 0.0017 0.0067 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0067 0.0549
Schistosoma mansoni lamin 0.0028 0.0195 0.0222
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0093 0.0987 0.1366
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1217 1
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0041 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0247 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0247 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi beta-lactamase family protein 0.0037 0.0308 0.0389
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0335
Onchocerca volvulus Phospholipase A2 homolog 0.0093 0.0987 0.1366
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1217 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Plasmodium vivax vivapain-2 0.0017 0.0067 0.1073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0097 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0097 0.0798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0097 0.0798
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Echinococcus multilocularis expressed protein 0.0386 0.4526 0.4515
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1217 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Echinococcus granulosus sodium bile acid cotransporter 0.0588 0.6965 1
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1217 0.1698
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0097 0.0798
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0247 0.0327
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0023 0.0133 0.0132
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0124 0.1021
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0247 0.0297
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0041 0.0039
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0097 0.0085
Leishmania major cathepsin L-like protease 0.0066 0.0655 0.5385
Brugia malayi nuclear receptor NHR-67 0.0015 0.0041 0.0005
Schistosoma mansoni axis inhibition protein axin 0.002 0.0097 0.0081
Onchocerca volvulus 0.0017 0.0067 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0097 0.0081
Echinococcus multilocularis follistatin 0.0019 0.0091 0.0071
Schistosoma mansoni coup transcription factor 0.0032 0.0247 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi PXA domain containing protein 0.002 0.0097 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0063 0.0071
Echinococcus granulosus sodium bile acid cotransporter 0.0588 0.6965 1
Echinococcus multilocularis musashi 0.0028 0.0195 0.0175
Loa Loa (eye worm) beta-lactamase 0.0037 0.0308 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0247 0.0335
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0063 0.0032
Echinococcus granulosus expressed protein 0.0386 0.4526 0.6488
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0247 0.0335
Leishmania major cathepsin L-like protease 0.0017 0.0067 0.0549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0423
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.02 0.018
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0247 0.0302
Onchocerca volvulus 0.0032 0.0247 0.0297
Onchocerca volvulus 0.0588 0.6965 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0247 0.0227
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0225 0.1847
Leishmania major hypothetical protein, conserved 0.0037 0.0308 0.2529
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0247 0.0302
Entamoeba histolytica hypothetical protein 0.002 0.0097 0.0798
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0041 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0091 0.0077
Echinococcus multilocularis agrin 0.0019 0.0091 0.0071
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0041 0.0021
Echinococcus granulosus intermediate filament protein 0.0028 0.0195 0.0251
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.1217 1
Brugia malayi Phospholipase A2 family protein 0.0093 0.0987 0.137
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1217 0.1731
Brugia malayi conserved hypotetical protein 0.0015 0.0041 0.0005
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.016
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0247 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Schistosoma mansoni regulator of G protein signaling 0.002 0.0097 0.0081
Echinococcus multilocularis expressed protein 0.0019 0.0091 0.0071
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0097 0.0111
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0093 0.0987 0.137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0041 0.0021
Toxoplasma gondii peptidase family M13 protein 0.0093 0.0987 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0308 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0247 0.0302
Loa Loa (eye worm) ctsf protein 0.0017 0.0067 0.0076
Schistosoma mansoni hypothetical protein 0.0175 0.1977 0.2796
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0009
Echinococcus multilocularis sodium bile acid cotransporter 0.0588 0.6965 0.6959
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0308 0.0385
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1217 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.1004
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0067 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0247 0.0302
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.016
Schistosoma mansoni hypothetical protein 0.0175 0.1977 0.2796
Echinococcus granulosus sodium bile acid cotransporter 0.0588 0.6965 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0655 0.5385
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0093 0.0987 0.2799
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0097 0.0798
Schistosoma mansoni lamin 0.0028 0.0195 0.0222
Loa Loa (eye worm) fibroinase 0.0017 0.0067 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0247 0.0227
Echinococcus granulosus endothelin converting enzyme 1 0.0093 0.0987 0.1392
Echinococcus granulosus axis inhibition protein axin 0.002 0.0097 0.0111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0655 0.5385
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0133 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0225 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Brugia malayi hypothetical protein 0.002 0.0097 0.0085
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0091 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0267
Loa Loa (eye worm) hypothetical protein 0.0028 0.0195 0.026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.1004
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0225 0.1847
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0039
Onchocerca volvulus 0.0028 0.02 0.0229
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0247 0.0327
Brugia malayi hypothetical protein 0.0028 0.02 0.0233
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0097 0.0081
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.1217 0.1723
Loa Loa (eye worm) hypothetical protein 0.0069 0.0692 0.0976
Schistosoma mansoni axis inhibition protein axin 0.002 0.0097 0.0081
Brugia malayi phosphofructokinase 0.0113 0.1217 0.1702
Schistosoma mansoni neprilysin 0.0024 0.0152 0.016
Onchocerca volvulus 0.0017 0.0067 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0225 0.1847
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.2735 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0225 0.1847
Brugia malayi nuclear hormone receptor 0.0015 0.0041 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0067 0.0549
Brugia malayi hypothetical protein 0.0015 0.0041 0.0005
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0427 0.0558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0067 0.0549
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0124 0.0104
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0081
Schistosoma mansoni agrin 0.0019 0.0091 0.0072
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0225 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0247 0.0335
Loa Loa (eye worm) hypothetical protein 0.0444 0.5223 0.7493
Brugia malayi ecdysone receptor 0.0015 0.0041 0.0005
Schistosoma mansoni neprilysin-2 (M13 family) 0.0047 0.0427 0.0558
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0097 0.0085
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0097 0.0111
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0063 0.0062
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0091 0.0582
Plasmodium vivax vivapain-2 0.0017 0.0067 0.1073
Trichomonas vaginalis esterase, putative 0.0037 0.0308 0.2529

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Trichophyton mentagrophytes ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Microsporum canis ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Aspergillus fumigatus ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Sporothrix schenck ii ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Candida albicans 124 ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Candida parapsilosis 39 ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Candida albicans 124 ChEMBL. 7752208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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