Detailed information for compound 802095

Basic information

Technical information
  • TDR Targets ID: 802095
  • Name: N-(4-ethoxyphenyl)-4-(1-methyl-2-oxoquinolin- 4-yl)oxybutanamide
  • MW: 380.437 | Formula: C22H24N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.71 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)CCCOc1cc(=O)n(c2c1cccc2)C
  • InChi: 1S/C22H24N2O4/c1-3-27-17-12-10-16(11-13-17)23-21(25)9-6-14-28-20-15-22(26)24(2)19-8-5-4-7-18(19)20/h4-5,7-8,10-13,15H,3,6,9,14H2,1-2H3,(H,23,25)
  • InChiKey: RIVMTRXFCUBQJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethoxyphenyl)-4-[(1-methyl-2-oxo-4-quinolyl)oxy]butanamide
  • N-(4-ethoxyphenyl)-4-[(2-keto-1-methyl-4-quinolyl)oxy]butyramide
  • N-(4-ethoxyphenyl)-4-(1-methyl-2-oxo-quinolin-4-yl)oxy-butanamide
  • MLS000520349
  • SMR000130760
  • C547-0778
  • NCGC00109748-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi intermediate filament protein 0.0027 0.0073 0.0516
Brugia malayi steroid hormone receptor 0.0034 0.0116 0.0819
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0073 0.0438
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0484 0.1968
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1672 1
Brugia malayi RNA binding protein 0.0067 0.031 0.2184
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Brugia malayi hypothetical protein 0.0018 0.0022 0.0152
Plasmodium falciparum importin beta, putative 0.0028 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.115
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.001 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0127 0.076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0116 0.0696
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0116 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0116 0.0696
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.031 0.1855
Onchocerca volvulus 0.0036 0.0127 0.0737
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0116 0.0696
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0116 0.0106
Echinococcus multilocularis snurportin 1 0.0299 0.1672 0.1664
Loa Loa (eye worm) DR-78 0.0016 0.001 0.0061
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0426 0.2419 0.2411
Brugia malayi TAR-binding protein 0.0067 0.031 0.2184
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0116 0.0441
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0478
Brugia malayi nuclear hormone receptor 0.0034 0.0116 0.0819
Entamoeba histolytica hypothetical protein 0.0076 0.0359 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0359 0.035
Brugia malayi Nuclear hormone receptor E75 0.0016 0.001 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0116 0.0441
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0116 0.0441
Echinococcus multilocularis lamin dm0 0.0027 0.0073 0.0063
Schistosoma mansoni hypothetical protein 0.0052 0.0222 0.0813
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0049 0.0079
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.001 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.115
Brugia malayi nuclear receptor RXR 0.0016 0.001 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0116 0.0696
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0116 0.0819
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0116 0.0106
Brugia malayi nuclear receptor NHR-67 0.0016 0.001 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0116 0.0441
Echinococcus multilocularis importin subunit beta 1 0.0028 0.008 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0073 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0116 0.0819
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0116 0.067
Leishmania major importin beta-1 subunit, putative 0.0023 0.0049 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0127 0.0448
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0129
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.001 0.0061
Schistosoma mansoni importin beta-1 0.0028 0.008 0.0267
Loa Loa (eye worm) RNA binding protein 0.0067 0.031 0.1855
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0127 0.0448
Brugia malayi Importin beta-1 subunit 0.0028 0.008 0.0563
Schistosoma mansoni coup transcription factor 0.0034 0.0116 0.0407
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.1421 0.5857
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0116 0.0696
Brugia malayi nuclear receptor RXR 0.0018 0.0022 0.0152
Brugia malayi Pre-SET motif family protein 0.0251 0.1391 0.9791
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0073 0.0438
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0116 0.0106
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.115
Onchocerca volvulus Huntingtin homolog 0.0148 0.0784 0.4883
Schistosoma mansoni hypothetical protein 0.0299 0.1672 0.637
Brugia malayi nuclear receptor NHR-88 0.0016 0.001 0.0072
Onchocerca volvulus 0.0052 0.0222 0.1339
Schistosoma mansoni thyroid hormone receptor 0.0461 0.262 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Onchocerca volvulus 0.0027 0.0073 0.0398
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0116 0.0407
Echinococcus granulosus tar DNA binding protein 0.0067 0.031 0.1246
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Loa Loa (eye worm) hypothetical protein 0.0148 0.0784 0.4689
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0116 0.0819
Onchocerca volvulus 0.0034 0.0116 0.067
Schistosoma mansoni intermediate filament proteins 0.0027 0.0073 0.0242
Loa Loa (eye worm) hypothetical protein 0.0256 0.1421 0.8497
Brugia malayi hypothetical protein 0.0016 0.001 0.0072
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0116 0.0407
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0127 1
Brugia malayi conserved hypotetical protein 0.0016 0.001 0.0072
Brugia malayi hypothetical protein 0.0076 0.0359 0.2529
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0127 0.0485
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0116 0.0106
Echinococcus granulosus snurportin 1 0.0299 0.1672 0.6901
Brugia malayi hypothetical protein 0.0018 0.0022 0.0152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0484 0.1817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0484 0.1817
Echinococcus multilocularis lamin 0.0027 0.0073 0.0063
Brugia malayi ecdysone receptor 0.0016 0.001 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.031 0.2184
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.001 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0116 0.0407
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0116 0.0819
Entamoeba histolytica hypothetical protein 0.0023 0.0049 0.0382
Brugia malayi ecdysteroid receptor 0.0034 0.0116 0.0819
Plasmodium vivax importin-beta 2, putative 0.0028 0.008 0.4798
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0022 0.0152
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0116 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0116 0.0819
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0116 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0127 0.0448
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0119 0.0453
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.001 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0127 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0127 0.0117
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.001 0.0072
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0116 0.067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0022 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0484 0.2896
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0037 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0116 0.0819
Entamoeba histolytica hypothetical protein 0.0076 0.0359 1
Schistosoma mansoni ran 0.0021 0.0037 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0116 0.0819
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0116 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0116 0.0696
Echinococcus multilocularis tar DNA binding protein 0.0067 0.031 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0022 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0116 0.0819
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0116 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0116 0.0819
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Echinococcus multilocularis thyroid hormone receptor alpha 0.0461 0.262 0.2612
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0116 0.0407
Schistosoma mansoni hypothetical protein 0.0076 0.0359 0.1338
Brugia malayi hypothetical protein 0.0148 0.0784 0.5519
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0116 0.0407
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0484 0.0475
Echinococcus multilocularis musashi 0.0027 0.0073 0.0063
Schistosoma mansoni ran 0.0021 0.0037 0.0101
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0359 0.145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0116 0.0819
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0116 0.0819
Onchocerca volvulus Huntingtin homolog 0.0148 0.0784 0.4883
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0022 0.0047
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.001 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0116 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0116 0.0819
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0116 0.0696
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0421
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0022 0.0044
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.008 0.4798
Schistosoma mansoni lamin 0.0027 0.0073 0.0242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0484 0.1817
Brugia malayi tailless protein 0.0016 0.001 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0484 0.3408
Echinococcus granulosus intermediate filament protein 0.0027 0.0073 0.0262
Brugia malayi hypothetical protein 0.0016 0.001 0.0072
Loa Loa (eye worm) hypothetical protein 0.0148 0.0784 0.4689
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0484 0.1968
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1595 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0116 0.0441
Echinococcus granulosus lamin dm0 0.0027 0.0073 0.0262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0129
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0116 0.0106
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0022 0.0129
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.008 1
Brugia malayi hypothetical protein 0.0256 0.1421 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0067 0.031 0.1855
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.115
Brugia malayi Nuclear hormone receptor E75 0.0016 0.001 0.0072
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0116 0.0106
Schistosoma mansoni hypothetical protein 0.0426 0.2419 0.923
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0116 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0022 0.0044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0116 0.0441
Entamoeba histolytica hypothetical protein 0.0076 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0129
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.1421 0.1412
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0257
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0049 0.0079
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0037 0.0109
Onchocerca volvulus 0.0027 0.0073 0.0398
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0696
Schistosoma mansoni survival motor neuron protein 0.0052 0.0222 0.0813
Plasmodium vivax SET domain protein, putative 0.0036 0.0127 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0049 1
Schistosoma mansoni thyroid hormone receptor 0.0461 0.262 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0116 0.0407
Schistosoma mansoni lamin 0.0027 0.0073 0.0242
Brugia malayi Pre-SET motif family protein 0.0036 0.0127 0.0894
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0218
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0049 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0116 0.0819
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0426 0.2419 1
Entamoeba histolytica hypothetical protein 0.0076 0.0359 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1391 0.8319
Onchocerca volvulus 0.0286 0.1595 1
Brugia malayi RNA, U transporter 1 0.008 0.0383 0.2698
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0359 0.1338
Brugia malayi nuclear receptor NHR-88 0.0034 0.0116 0.0819
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0061
Echinococcus granulosus lamin 0.0027 0.0073 0.0262
Brugia malayi nuclear hormone receptor 0.0016 0.001 0.0072
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0116 0.0441
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0116 0.067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0127 0.0448
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0116 0.0441
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0116 0.0819
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0222 0.1566
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0116 0.0407
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0116 0.0819
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0116 0.0819
Echinococcus granulosus importin subunit beta 1 0.0028 0.008 0.029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0484 0.0475

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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