Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.0657 | 0.1812 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.018 | 0.3628 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0025 | 0.041 | 1 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0013 | 0.0163 | 0.045 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0171 | 0.0471 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1167 | 0.1167 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0017 | 0.0247 | 0.0247 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0639 | 0.0639 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0052 | 0.0972 | 0.3819 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.0639 | 0.0578 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0047 | 0.0864 | 0.0804 |
Schistosoma mansoni | polycystin 1-related | 0.0047 | 0.0864 | 0.0864 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0052 | 0.0972 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0864 | 0.3105 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.018 | 0.3628 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0049 | 0.0904 | 0.7747 |
Schistosoma mansoni | lipoxygenase | 0.0206 | 0.4169 | 0.4169 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0741 | 0.2042 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.0639 | 0.0578 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0052 | 0.0972 | 0.3549 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0299 | 0.0824 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0017 | 0.0247 | 0.0781 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0052 | 0.0972 | 0.243 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0047 | 0.0864 | 0.0804 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0049 | 0.0904 | 0.2492 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0049 | 0.0904 | 0.7747 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0171 | 0.0471 |
Brugia malayi | Doublecortin family protein | 0.0047 | 0.0864 | 0.3107 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0467 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0017 | 0.0247 | 0.068 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0017 | 0.0247 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0864 | 0.3105 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0599 | 0.0599 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0065 | 0.0065 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.0416 | 0.3325 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0467 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0864 | 0.3107 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0107 | 0.0294 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0028 | 0.0467 | 0.1287 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0107 | 0.0042 |
Echinococcus multilocularis | thymidylate synthase | 0.0128 | 0.2545 | 0.2496 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0005 | 0.0000064291 | 0.0000064291 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.0599 | 0.2021 |
Echinococcus multilocularis | dna polymerase eta | 0.0017 | 0.0247 | 0.0183 |
Echinococcus granulosus | dna polymerase kappa | 0.0049 | 0.0904 | 0.0844 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0241 | 0.0665 |
Schistosoma mansoni | rab6-interacting | 0.0047 | 0.0864 | 0.0864 |
Schistosoma mansoni | DNA polymerase eta | 0.0017 | 0.0247 | 0.0247 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.0657 | 0.1812 |
Echinococcus granulosus | RUN | 0.0047 | 0.0864 | 0.0804 |
Loa Loa (eye worm) | thymidylate synthase | 0.0128 | 0.2545 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0107 | 0.0004 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.2415 | 0.2415 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.018 | 0.3628 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0741 | 0.2042 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0017 | 0.0247 | 0.0574 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.0107 | 0.0294 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0487 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0049 | 0.0904 | 0.3552 |
Mycobacterium ulcerans | thymidylate synthase | 0.0128 | 0.2545 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0246 | 0.0677 |
Trypanosoma brucei | unspecified product | 0.0012 | 0.0136 | 0.0374 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0099 | 0.1944 | 0.1891 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.0416 | 0.3325 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0864 | 0.3107 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0028 | 0.0467 | 0.1835 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0047 | 0.0864 | 0.0804 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.018 | 0.3628 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0052 | 0.0972 | 0.0913 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Loa Loa (eye worm) | doublecortin family protein | 0.0047 | 0.0864 | 0.3105 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0099 | 0.1944 | 0.1944 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0099 | 0.1944 | 0.7537 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0107 | 0.0107 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0025 | 0.041 | 0.1435 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0171 | 0.3657 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0107 | 0.0004 |
Leishmania major | DNA polymerase kappa, putative | 0.0025 | 0.041 | 0.113 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0017 | 0.0247 | 0.0578 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0028 | 0.0467 | 0.1287 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0049 | 0.0904 | 0.3552 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0864 | 0.0864 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0017 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0247 | 0.0574 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0017 | 0.0247 | 0.068 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.0599 | 0.2018 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0099 | 0.1944 | 0.1891 |
Schistosoma mansoni | loxhd1 | 0.0047 | 0.0864 | 0.0864 |
Schistosoma mansoni | rab6-interacting | 0.0047 | 0.0864 | 0.0864 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.1153 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0025 | 0.041 | 0.113 |
Echinococcus granulosus | dna polymerase eta | 0.0017 | 0.0247 | 0.0183 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0467 | 0.1835 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0467 | 0.1287 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0017 | 0.0247 | 0.0183 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.0416 | 0.127 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0128 | 0.2545 | 0.2545 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0052 | 0.0972 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0025 | 0.041 | 0.113 |
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.0416 | 0.0353 |
Schistosoma mansoni | hypothetical protein | 0.0487 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0128 | 0.2545 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.0416 | 0.1273 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0028 | 0.0467 | 0.1664 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0061 | 0.1153 | 0.3177 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0017 | 0.0247 | 0.5284 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0109 | 0.0044 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Schistosoma mansoni | dihydrofolate reductase | 0.0052 | 0.0972 | 0.0972 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0107 | 0.0294 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0639 | 0.0639 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0657 | 0.2258 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0061 | 0.1153 | 0.4414 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0014 | 0.0171 | 0.1097 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0107 | 0.0042 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0107 | 0.0107 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0467 | 0.1287 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0047 | 0.0864 | 0.0804 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0072 | 0.1395 | 0.1395 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.018 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1944 | 0.7536 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0109 | 0.0008 |
Onchocerca volvulus | 0.0099 | 0.1944 | 0.6912 | |
Plasmodium falciparum | LCCL domain-containing protein | 0.0047 | 0.0864 | 0.2381 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0047 | 0.0864 | 0.2381 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.018 | 0.3628 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0017 | 0.0247 | 0.068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0049 | 0.0904 | 0.2492 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0171 | 0.0471 |
Onchocerca volvulus | 0.0128 | 0.2545 | 1 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0107 | 0.0042 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0128 | 0.2545 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0107 | 0.2603 |
Brugia malayi | Dihydrofolate reductase | 0.0052 | 0.0972 | 0.3551 |
Trypanosoma brucei | unspecified product | 0.0012 | 0.0136 | 0.0374 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Onchocerca volvulus | 0.0047 | 0.0864 | 0.1361 | |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0107 | 0.0042 |
Echinococcus multilocularis | RUN | 0.0047 | 0.0864 | 0.0804 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.005 | 0.00000000081418 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.031 | 0.0832 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0206 | 0.4169 | 0.4131 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0028 | 0.0467 | 0.1287 |
Brugia malayi | polk-prov protein | 0.0037 | 0.0657 | 0.2261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0047 | 0.0864 | 0.0804 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0206 | 0.4169 | 0.4131 |
Echinococcus granulosus | thymidylate synthase | 0.0128 | 0.2545 | 0.2496 |
Brugia malayi | dihydrofolate reductase family protein | 0.0052 | 0.0972 | 0.3551 |
Brugia malayi | thymidylate synthase | 0.0128 | 0.2545 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0052 | 0.0972 | 0.369 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0109 | 0.0044 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0352 | 0.0971 |
Brugia malayi | hypothetical protein | 0.0061 | 0.1153 | 0.4291 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0467 | 0.1287 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0065 | 0.1234 | 0.3401 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0299 | 0.0824 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0299 | 0.0824 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0017 | 0.0247 | 0.0183 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.0416 | 0.0353 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0306 | 0.0306 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0049 | 0.0904 | 0.2492 |
Echinococcus multilocularis | dna polymerase kappa | 0.0049 | 0.0904 | 0.0844 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0047 | 0.0864 | 0.0804 |
Onchocerca volvulus | 0.0047 | 0.0864 | 0.1361 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Ability to inhibit microPa (calbiochem) and S-2444 (quadratech) as substrate at concentration of 1 microM | ChEMBL. | 11755349 |
Inhibition (binding) | < 50 % | Ability to inhibit human tissue plasminogen activator stimulator at concentration of 1 microM | ChEMBL. | 11755349 |
Inhibition (binding) | < 50 % | Ability to inhibit human plasmin using Chromozym-PL as substrate at concentration of 1 uM | ChEMBL. | 11755349 |
Inhibition (binding) | < 50 % | Ability to inhibit microPa (calbiochem) and S-2444 (quadratech) as substrate at concentration of 1 microM | ChEMBL. | 11755349 |
Inhibition (binding) | < 50 % | Ability to inhibit human tissue plasminogen activator stimulator at concentration of 1 microM | ChEMBL. | 11755349 |
Inhibition (binding) | < 50 % | Ability to inhibit human plasmin using Chromozym-PL as substrate at concentration of 1 uM | ChEMBL. | 11755349 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.