Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.6121 | 0.5 |
Echinococcus multilocularis | geminin | 0.0173 | 0.3916 | 0.6473 |
Mycobacterium ulcerans | glutaminase | 0.028 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.6121 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0211 | 0.605 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.618 | 0.618 |
Schistosoma mansoni | dihydrofolate reductase | 0.0211 | 0.605 | 0.605 |
Echinococcus granulosus | dihydrofolate reductase | 0.0211 | 0.605 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.6121 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3916 | 0.3916 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0212 | 0.6121 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0211 | 0.605 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0211 | 0.605 | 0.5 |
Onchocerca volvulus | 0.0242 | 0.7864 | 1 | |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0211 | 0.605 | 0.605 |
Schistosoma mansoni | glutaminase | 0.028 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0211 | 0.605 | 0.605 |
Brugia malayi | glutaminase DH11.1 | 0.028 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3916 | 0.3916 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.618 | 0.618 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.6121 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0211 | 0.605 | 0.605 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.6121 | 0.5 |
Echinococcus granulosus | geminin | 0.0173 | 0.3916 | 0.6473 |
Loa Loa (eye worm) | glutaminase | 0.028 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0211 | 0.605 | 0.605 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0211 | 0.605 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.