Detailed information for compound 80266

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.501 | Formula: C25H27N3O
  • H donors: 1 H acceptors: 1 LogP: 4.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc2c(c1)c(c[nH]2)[C@@H]1CC[C@@H](CC1)N1CCc2c(C1)cccc2OC
  • InChi: 1S/C25H27N3O/c1-29-25-4-2-3-19-16-28(12-11-21(19)25)20-8-6-18(7-9-20)23-15-27-24-10-5-17(14-26)13-22(23)24/h2-5,10,13,15,18,20,27H,6-9,11-12,16H2,1H3/t18-,20+
  • InChiKey: YQSJTZPMJWLLSZ-PUZFROQSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.0027 0.0216 1
Onchocerca volvulus 0.0104 0.1352 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.0087 0.012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0541 0.4
Brugia malayi follicle stimulating hormone receptor 0.0502 0.7244 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Onchocerca volvulus Slit protein homolog 0.0017 0.0074 0.0546
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Brugia malayi nuclear receptor NHR-88 0.0104 0.1352 0.1866
Leishmania major cytochrome p450-like protein 0.0018 0.0087 0.3043
Brugia malayi tailless protein 0.0049 0.0541 0.0746
Onchocerca volvulus 0.0083 0.1043 0.7721
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0104 0.1352 0.1866
Brugia malayi nuclear receptor RXR 0.0049 0.0541 0.0746
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0541 0.0746
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0074 0.0074
Schistosoma mansoni coup transcription factor 0.0104 0.1352 0.1352
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0216 0.0298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0104 0.1352 0.1866
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0751 0.0751
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0087 0.4302
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0216 0.4736
Onchocerca volvulus 0.0054 0.0613 0.4535
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0074 0.0102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0104 0.1352 0.1352
Brugia malayi Cytochrome P450 family protein 0.0027 0.0216 0.0298
Brugia malayi nuclear receptor NHR-67 0.0049 0.0541 0.0746
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0087 0.4302
Echinococcus granulosus dna polymerase kappa 0.0041 0.0423 0.0423
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0627 0.0627
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.003 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.1352 0.1352
Schistosoma mansoni loxhd1 0.0062 0.0729 0.0729
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0087 0.4302
Brugia malayi Peroxidasin 0.0054 0.0613 0.0846
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0541 0.0746
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Echinococcus granulosus delta-like protein 1 0.0017 0.0074 0.0074
Onchocerca volvulus Bile acid receptor homolog 0.0104 0.1352 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0897 0.0897
Echinococcus multilocularis dna polymerase eta 0.0014 0.003 0.003
Brugia malayi Cytochrome P450 family protein 0.0027 0.0216 0.0298
Echinococcus granulosus protein jagged 2 0.0017 0.0074 0.0074
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0729 0.1007
Loa Loa (eye worm) DR-78 0.0049 0.0541 0.0746
Schistosoma mansoni septate junction protein 0.0017 0.0074 0.0074
Schistosoma mansoni sodium/chloride dependent transporter 0.0013 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.1352 0.1866
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1043 0.1043
Schistosoma mansoni cpg binding protein 0.0035 0.0342 0.0342
Echinococcus granulosus dna polymerase eta 0.0014 0.003 0.003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0087 0.1441
Brugia malayi hypothetical protein 0.0049 0.0541 0.0746
Echinococcus multilocularis RUN 0.0062 0.0729 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0104 0.1352 0.1866
Entamoeba histolytica hypothetical protein 0.0036 0.0347 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0627 0.0627
Brugia malayi hypothetical protein 0.0062 0.0729 0.1007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0104 0.1352 0.1352
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0296
Loa Loa (eye worm) cytochrome P450 0.0018 0.0087 0.012
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074
Echinococcus granulosus dnaJ subfamily B 0.0478 0.6897 0.6897
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0169 0.2317 0.2317
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.1352 0.1352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0423 1
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0423 0.0423
Echinococcus granulosus protein jagged 1 0.0017 0.0074 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0104 0.1352 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0074 0.0074
Onchocerca volvulus 0.0049 0.0541 0.4
Brugia malayi hypothetical protein 0.0055 0.0627 0.0866
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0729 0.0729
Onchocerca volvulus 0.0054 0.0613 0.4535
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0203 0.2816 0.2816
Brugia malayi Cytochrome P450 family protein 0.0079 0.098 0.1353
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0087 0.3043
Leishmania major cytochrome p450-like protein 0.0018 0.0087 0.3043
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0062 0.0729 0.1007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Schistosoma mansoni hypothetical protein 0.0052 0.058 0.058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0104 0.1352 0.1352
Brugia malayi TAR-binding protein 0.0063 0.0751 0.1037
Brugia malayi conserved hypotetical protein 0.0049 0.0541 0.0746
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0162 0.3351
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0087 0.4302
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0104 0.1352 0.1352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0541 0.0541
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0127 0.7405
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0104 0.1352 0.1866
Loa Loa (eye worm) hypothetical protein 0.0055 0.0627 0.0866
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0162 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0301 0.4273 0.4273
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0104 0.1352 0.1352
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0613 0.0846
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0541 0.0541
Onchocerca volvulus 0.0017 0.0074 0.0546
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.0087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0104 0.1352 0.1352
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0055 0.0627 0.0866
Schistosoma mansoni cell polarity protein 0.0017 0.0074 0.0074
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0207 0.0286
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0613 0.0846
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0104 0.1352 0.1866
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0871 0.0871
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0087 0.0087
Brugia malayi nuclear hormone receptor 0.0104 0.1352 0.1866
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0541 0.0746
Onchocerca volvulus 0.0054 0.0613 0.4535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Echinococcus multilocularis fibropellin Ia 0.0017 0.0074 0.0074
Brugia malayi hypothetical protein 0.0054 0.0613 0.0846
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0541 0.0541
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.003 0.0041
Echinococcus granulosus lamin 0.0027 0.0214 0.0214
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0104 0.1352 0.1352
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0087 0.4302
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0087 0.4302
Entamoeba histolytica hypothetical protein 0.0036 0.0347 1
Onchocerca volvulus 0.0062 0.0729 0.5396
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0009 0.0009
Trypanosoma brucei unspecified product 0.0034 0.0325 0.7519
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.0613 0.4535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0541 0.0541
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0073 0.0897 0.1239
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0162 0.2231
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0613 0.0846
Schistosoma mansoni hypothetical protein 0.0169 0.2317 0.2317
Echinococcus granulosus cpg binding protein 0.0035 0.0342 0.0342
Brugia malayi Muscle positioning protein 4 0.0017 0.0074 0.0102
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0061 0.0792
Brugia malayi Cadherin domain containing protein 0.0017 0.0074 0.0102
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0074 0.0546
Echinococcus multilocularis slit 2 protein 0.0017 0.0074 0.0074
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0729 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.1352 0.1866
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.003 0.003
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0897 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0751 0.0751
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0541 0.0541
Echinococcus multilocularis lamin dm0 0.0027 0.0214 0.0214
Echinococcus multilocularis geminin 0.0169 0.2317 0.2317
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0087 0.1441
Echinococcus multilocularis notch 0.0017 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Schistosoma mansoni microtubule-associated protein tau 0.0688 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.0541 0.0541
Brugia malayi hypothetical protein 0.0049 0.0541 0.0746
Schistosoma mansoni lamin 0.0027 0.0214 0.0214
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0541 0.0746
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Schistosoma mansoni rab6-interacting 0.0062 0.0729 0.0729
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0347 0.0347
Schistosoma mansoni rab6-interacting 0.0062 0.0729 0.0729
Loa Loa (eye worm) notch protein 0.0017 0.0074 0.0102
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0613 0.4535
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0897 0.1239
Schistosoma mansoni intermediate filament proteins 0.0027 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0104 0.1352 0.1352
Schistosoma mansoni polycystin 1-related 0.0062 0.0729 0.0729
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0541 0.0541
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.6897 0.6897
Echinococcus multilocularis FTZ F1 alpha 0.0104 0.1352 0.1352
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0061 0.0792
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0216 0.4736
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0203 0.2816 0.2816
Brugia malayi intermediate filament protein 0.0027 0.0214 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.2816 0.2816
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Brugia malayi ecdysteroid receptor 0.0104 0.1352 0.1866
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0613 0.0846
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0627 0.0866
Schistosoma mansoni notch 0.0017 0.0074 0.0074
Echinococcus multilocularis protein jagged 1 0.0017 0.0074 0.0074
Echinococcus granulosus protein jagged 1 0.0017 0.0074 0.0074
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.003 0.0042
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0147 0.1995 0.1995
Loa Loa (eye worm) hypothetical protein 0.0055 0.0627 0.0866
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0541 0.0541
Brugia malayi ecdysone receptor 0.0049 0.0541 0.0746
Brugia malayi notch-like transmembrane receptor 0.0017 0.0074 0.0102
Brugia malayi hypothetical protein 0.0062 0.0729 0.1007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0627 0.0866
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0423 1
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0074 0.0074
Schistosoma mansoni lamin 0.0027 0.0214 0.0214
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0104 0.1352 0.1352
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0897 0.1239
Loa Loa (eye worm) hypothetical protein 0.0083 0.1043 0.144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0751 0.1037
Schistosoma mansoni hypothetical protein 0.0062 0.0729 0.0729
Onchocerca volvulus 0.0034 0.0314 0.2321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0104 0.1352 0.1866
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0162 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0104 0.1352 0.1866
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0104 0.1352 0.1352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0423 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.1352 0.1866
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0423 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.0751 0.1037
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0162 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Onchocerca volvulus 0.0027 0.0214 0.1587
Echinococcus multilocularis ecdysone induced protein 78C 0.0104 0.1352 0.1352
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0897 0.1239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.1352 0.1866
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0751 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0104 0.1352 0.1866
Onchocerca volvulus 0.0062 0.0729 0.5396
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0502 0.7244 1
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0613 0.0846
Echinococcus multilocularis protein jagged 2 0.0017 0.0074 0.0074
Onchocerca volvulus 0.0027 0.0214 0.1587
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0087 0.4302
Brugia malayi Blistered cuticle protein 3 0.0054 0.0613 0.0846
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0104 0.1352 0.1866
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1043 0.1043
Onchocerca volvulus 0.0017 0.0074 0.0546
Echinococcus granulosus neural cadherin 0.0017 0.0074 0.0074
Loa Loa (eye worm) Notch2 0.0017 0.0074 0.0102
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0074 0.0546
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Schistosoma mansoni peroxidasin 0.0054 0.0613 0.0613
Brugia malayi hypothetical protein 0.0036 0.0347 0.048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0627 0.0627
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0613 0.0846
Schistosoma mansoni nuclear hormone receptor 0.0104 0.1352 0.1352
Schistosoma mansoni lipoxygenase 0.0301 0.4273 0.4273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0423 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0074 0.0074
Echinococcus multilocularis 0.0018 0.0087 0.0087
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0541 0.0746
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0541 0.0746
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0087 0.4302
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0087 0.4302
Schistosoma mansoni thyroid hormone receptor 0.0104 0.1352 0.1352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0104 0.1352 0.1866
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Echinococcus multilocularis thyroid hormone receptor alpha 0.0104 0.1352 0.1352
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1043 0.144
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0729 0.0729
Schistosoma mansoni hypothetical protein 0.0036 0.0347 0.0347
Onchocerca volvulus 0.0017 0.0074 0.0546
Echinococcus granulosus slit 2 protein 0.0017 0.0074 0.0074
Brugia malayi polk-prov protein 0.0031 0.0275 0.038
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Brugia malayi EGF-like domain containing protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0214 0.0296
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Echinococcus multilocularis musashi 0.0027 0.0214 0.0214
Brugia malayi hypothetical protein 0.0055 0.0627 0.0866
Brugia malayi nuclear receptor RXR 0.0055 0.0627 0.0866
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0301 0.4273 0.4273
Entamoeba histolytica hypothetical protein 0.0023 0.0162 0.4143
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1043 0.1043
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0087 0.4302
Brugia malayi photoreceptor-specific nuclear receptor 0.0104 0.1352 0.1866
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0423 1
Onchocerca volvulus Putative cubilin 0.0017 0.0074 0.0546
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Schistosoma mansoni nuclear receptor 0.0049 0.0541 0.0541
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0897 0.0897
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0073 0.0897 0.1239
Echinococcus granulosus intermediate filament protein 0.0027 0.0214 0.0214
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0729 0.0729
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0087 0.4302
Onchocerca volvulus 0.0073 0.0897 0.6639
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0541 0.0541
Echinococcus granulosus tar DNA binding protein 0.0063 0.0751 0.0751
Onchocerca volvulus 0.0017 0.0074 0.0546
Echinococcus granulosus peroxidasin 0.0054 0.0613 0.0613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.1352 0.1352
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0104 0.1352 0.1352
Echinococcus multilocularis neural cadherin 0.0017 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0104 0.1352 0.1352
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0347 0.0347
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0751 0.0751
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0074 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0104 0.1352 0.1866
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0613 0.0846
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Echinococcus multilocularis microtubule associated protein 2 0.0688 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0104 0.1352 0.1866
Echinococcus granulosus protein jagged 2 0.0017 0.0074 0.0074
Onchocerca volvulus 0.0017 0.0074 0.0546
Schistosoma mansoni slit 0.0017 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0087 0.4302
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0087 0.4302
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.1352 0.1352
Giardia lamblia DINP protein human, muc B family 0.0021 0.0127 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0314 0.0433
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0087 0.4302
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0202 0.2806 0.2806
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0541 0.0541
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0074 0.0974
Brugia malayi Doublecortin family protein 0.0062 0.0729 0.1007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Onchocerca volvulus Peroxidase homolog 0.0054 0.0613 0.4535
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0104 0.1352 0.1352
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0087 0.1441
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0104 0.1352 0.1352
Schistosoma mansoni notch 0.0017 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0031 0.0275 0.038
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Schistosoma mansoni notch 0.0017 0.0074 0.0074
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0541 0.0746
Echinococcus multilocularis lamin 0.0027 0.0214 0.0214
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0541 0.0541
Schistosoma mansoni notch 0.0017 0.0074 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0627 0.0866
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0061 0.0792
Brugia malayi Steroid receptor seven-up type 2 0.0104 0.1352 0.1866
Onchocerca volvulus 0.0049 0.0541 0.4
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0127 0.2481
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0087 0.4302
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0162 0.2231
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0325 0.7519
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0074 0.0074
Echinococcus multilocularis cpg binding protein 0.0035 0.0342 0.0342
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0216 0.385
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0104 0.1352 0.1352
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0074 0.0074
Echinococcus granulosus RUN 0.0062 0.0729 0.0729
Brugia malayi map kinase activated protein kinase protein 2 0.0203 0.2816 0.3887
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0613 0.0846
Loa Loa (eye worm) hypothetical protein 0.0073 0.0897 0.1239
Entamoeba histolytica hypothetical protein 0.0036 0.0347 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0751 0.0751
Echinococcus granulosus geminin 0.0169 0.2317 0.2317
Brugia malayi Cadherin domain containing protein 0.0017 0.0074 0.0102
Echinococcus multilocularis protein jagged 1 0.0017 0.0074 0.0074
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0074 0.0102
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0127 0.5238
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0162 0.5
Brugia malayi CXXC zinc finger family protein 0.0034 0.0314 0.0433
Entamoeba histolytica hypothetical protein 0.0036 0.0347 1
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.098 0.1353
Onchocerca volvulus Protein ultraspiracle homolog 0.0104 0.1352 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0216 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.1352 0.1866
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0162 0.2216
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Brugia malayi Delta serrate ligand family protein 0.0017 0.0074 0.0102
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0087 0.1441
Brugia malayi nuclear receptor NHR-88 0.0049 0.0541 0.0746
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0729 0.0729
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0729 0.0729
Loa Loa (eye worm) hypothetical protein 0.0062 0.0729 0.1007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0758 1
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0613 0.0846
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0087 0.4302
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0541 0.0746
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0087 0.4302
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0214 0.0296
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0074 0.0102
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.003 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0423 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0216 0.4736
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.1352 0.1866
Onchocerca volvulus Dual oxidase homolog 0.0054 0.0613 0.4535
Loa Loa (eye worm) hypothetical protein 0.0055 0.0627 0.0866
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0216 0.0298
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0541 0.4
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.1352 0.1866
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0162 0.2131
Brugia malayi cytochrome P450 0.0018 0.0087 0.012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.003 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0275 0.6246
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0751 0.1037
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0087 0.1143
Echinococcus multilocularis serotonin transporter 0.0073 0.0897 0.0897
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0214 0.0296
Schistosoma mansoni notch 0.0017 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Schistosoma mansoni thyroid hormone receptor 0.0104 0.1352 0.1352
Echinococcus granulosus ecdysone induced protein 78C 0.0104 0.1352 0.1352
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0541 0.0541
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Schistosoma mansoni nuclear receptor 0.0049 0.0541 0.0541
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0087 0.4302
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0275 0.6246
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0162 0.7074
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0729 0.0729
Leishmania major DNA polymerase kappa, putative 0.0021 0.0127 0.5238
Echinococcus granulosus lamin dm0 0.0027 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.0746
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0897 0.1239
Schistosoma mansoni notch 0.0017 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0104 0.1352 0.1866
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.0613 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0104 0.1352 0.1866
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0087 0.4302
Schistosoma mansoni peroxidasin 0.0054 0.0613 0.0613
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0541 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Onchocerca volvulus Peroxidase homolog 0.0054 0.0613 0.4535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0162 0.2216
Schistosoma mansoni zinc finger protein 0.0049 0.0541 0.0541
Brugia malayi RNA binding protein 0.0063 0.0751 0.1037
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0102
Schistosoma mansoni DNA polymerase eta 0.0014 0.003 0.003
Loa Loa (eye worm) steroid hormone receptor 0.0104 0.1352 0.1866
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0423 0.5
Echinococcus granulosus fibropellin Ia 0.0017 0.0074 0.0074
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0541 0.0541
Schistosoma mansoni cytochrome P450 0.0018 0.0087 0.0087
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0162 0.2131
Schistosoma mansoni cpg binding protein 0.0034 0.0314 0.0314
Echinococcus multilocularis peroxidasin 0.0054 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0012
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0203 0.2816 0.3887
Loa Loa (eye worm) hypothetical protein 0.0054 0.0613 0.0846
Schistosoma mansoni RAR-like nuclear receptor 0.0104 0.1352 0.1352
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0627 0.0627
Schistosoma mansoni lipoxygenase 0.019 0.263 0.263
Schistosoma mansoni hypothetical protein 0.0478 0.6897 0.6897
Loa Loa (eye worm) hypothetical protein 0.0104 0.1352 0.1866
Schistosoma mansoni cpg binding protein 0.0035 0.0342 0.0342
Brugia malayi nuclear hormone receptor 0.0049 0.0541 0.0746
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0627 0.0866
Echinococcus granulosus FTZ F1 alpha 0.0104 0.1352 0.1352
Echinococcus granulosus notch 0.0017 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0087 0.4302
Echinococcus granulosus serotonin transporter 0.0073 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0423 1
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0613 0.4535
Schistosoma mansoni retinoic acid receptor RXR 0.0202 0.2806 0.2806
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0423 0.5
Brugia malayi steroid hormone receptor 0.0104 0.1352 0.1866
Schistosoma mansoni hypothetical protein 0.0017 0.0074 0.0074

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 7 % Binding affinity for 5-hydroxytryptamine 1A receptor was determined by incubating human 5-hydroxytryptamine 1A receptor transfected CHO cells with [3H]-8-OH-DPAT ChEMBL. 11459653
Inhibition (binding) = 7 % Binding affinity for 5-hydroxytryptamine 1A receptor was determined by incubating human 5-hydroxytryptamine 1A receptor transfected CHO cells with [3H]-8-OH-DPAT ChEMBL. 11459653
Inhibition (binding) = 920 % In vitro inhibition of [3H]-Prazosin binding to rat Alpha-1 adrenergic receptors on cortical membranes at 1 uM. ChEMBL. 11459653
Inhibition (binding) = 920 % In vitro inhibition of [3H]-Prazosin binding to rat Alpha-1 adrenergic receptors on cortical membranes at 1 uM. ChEMBL. 11459653
Ki (binding) = 0.61 nM In vitro for its binding affinity for serotonin transporter RB5-HT-T in rat cortical membranes ChEMBL. 11459653
Ki (binding) = 0.61 nM In vitro for its binding affinity for serotonin transporter RB5-HT-T in rat cortical membranes ChEMBL. 11459653

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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