Detailed information for compound 80272

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 226.678 | Formula: C11H12ClFN2
  • H donors: 1 H acceptors: 1 LogP: 2.29 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ncc(cc1F)C1CC2NC1CC2
  • InChi: 1S/C11H12ClFN2/c12-11-9(13)3-6(5-14-11)8-4-7-1-2-10(8)15-7/h3,5,7-8,10,15H,1-2,4H2
  • InChiKey: PKAQUVZVSSGSES-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Brugia malayi Cation transporter family protein Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 497 aa 35.0 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 484 aa 34.3 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 482 aa 42.9 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 510 aa 36.1 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 552 aa 24.3 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 485 aa 32.6 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 511 aa 36.0 %
Echinococcus multilocularis nAChR subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 488 aa 27.9 %
Onchocerca volvulus Putative zinc finger protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 515 aa 36.9 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 496 aa 35.5 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 486 aa 32.9 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 511 aa 27.2 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 518 aa 24.9 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 527 aa 33.6 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 501 aa 36.5 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 513 aa 35.5 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 475 aa 36.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 513 aa 35.5 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 519 aa 25.6 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 530 aa 29.6 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 507 aa 35.3 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 501 aa 32.1 %
Loa Loa (eye worm) hypothetical protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 491 aa 36.0 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 543 aa 27.8 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 508 aa 38.6 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 486 aa 33.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0464 0.2131 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0019 0.0082
Onchocerca volvulus 0.0123 0.0524 0.321
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0276 0.148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0064 0.0406
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0049
Brugia malayi Cation transporter family protein 0.0123 0.0524 0.2809
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.021 0.1289
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0151 0.0952
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.0345
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0108 0.0103
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0467 0.0698
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0121 0.0649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0022 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0076 0.048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0112
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0062 0.1471
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0121 0.0181
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) hypothetical protein 0.0041 0.0137 0.0642
Loa Loa (eye worm) hypothetical protein 0.0026 0.0068 0.032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0121 0.0649
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0121 0.0649
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0037 0.0051
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.021 0.0314
Leishmania major cathepsin L-like protease 0.0016 0.002 0.009
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0068 0.1628
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0128 0.0122
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0168 0.1023
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.021 0.1125
Loa Loa (eye worm) hypothetical protein 0.0056 0.021 0.0985
Onchocerca volvulus 0.0038 0.0121 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.021 0.132
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0127 0.0189
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0039 0.021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0419 0.0549
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0007 0.0042
Giardia lamblia Hypothetical protein 0.0056 0.021 0.096
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0083 0.0366
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0108 0.0682
Trypanosoma brucei ingi protein (ORF1) 0.0379 0.1729 0.2821
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Mycobacterium tuberculosis Possible maturase 0.003 0.0083 0.0079
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0008
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0025 0.0038
Trypanosoma brucei unspecified product 0.0029 0.0082 0.0124
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0144 0.0872
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0089 0.0561
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0121 0.0181
Brugia malayi RNase H family protein 0.0349 0.159 0.8524
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0288 0.1813
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0128 0.0141
Echinococcus multilocularis nAChR subunit 0.002 0.0039 0.0059
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0123 0.0524 0.0783
Echinococcus multilocularis ribonuclease H1 0.0349 0.159 0.2376
Echinococcus granulosus nAChR subunit 0.002 0.0039 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0288 0.1813
Onchocerca volvulus 0.0039 0.0128 0.0687
Echinococcus multilocularis nAChR subunit 0.0038 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0123 0.0524 0.2458
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0144 0.0163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0007 0.0024
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.023 0.1028 0.1361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Loa Loa (eye worm) Smad1 0.0026 0.0064 0.0302
Brugia malayi hypothetical protein 0.0017 0.0025 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0135 0.0849
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0062 0.0092
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0006 0.0009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.021 0.0314
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0568 0.0849
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Trypanosoma brucei ingi protein (ORF1) 0.0379 0.1729 0.2821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0118
Schistosoma mansoni nAChR subunit 0.0017 0.0025 0.0038
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.003 0.0083 0.0125
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.021 0.0334
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0128 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0147 0.0892
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0122 0.019
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0144 0.0215
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.5007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0108 0.0581
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0128 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0064 0.0406
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.003 0.0083 0.0525
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0022 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0363
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0032 0.0007
Trichomonas vaginalis ribonuclease H1, putative 0.0349 0.159 1
Entamoeba histolytica hypothetical protein 0.0111 0.0467 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0108 0.0648
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0108 0.2586
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0288 0.1352
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0083 0.0125
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0022 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0144 0.0872
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.002 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0068 0.0395
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) hypothetical protein 0.0127 0.0541 0.2539
Loa Loa (eye worm) hypothetical protein 0.0123 0.0524 0.2458
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0064 0.0096
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.002 0.0094
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0168 0.0265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0168 0.1023
Echinococcus granulosus jun protein 0.0085 0.0342 0.0511
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0062 0.0056
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0601 0.2779 0.2755
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0857 0.5393
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0464 0.2131 0.3185
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.003 0.0083 0.0525
Brugia malayi hypothetical protein 0.0017 0.0024 0.0129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0121 0.0649
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0065 0.0407
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0144 0.0138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0144 0.0872
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.002 0.0478
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0121 0.0181
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0128 0.0141
Trypanosoma brucei hypothetical protein, conserved 0.0379 0.1729 0.2821
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.003 0.0083 0.0127
Echinococcus multilocularis RNA directed DNA polymerase 0.003 0.0083 0.0125
Leishmania major cysteine peptidase A (CPA) 0.0016 0.002 0.009
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0123 0.0524 0.0783
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0121 0.0181
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.021 0.0314
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0128 0.0141
Plasmodium falciparum glutathione reductase 0.0035 0.0108 0.2586
Schistosoma mansoni hypothetical protein 0.0723 0.3353 0.501
Brugia malayi hypothetical protein 0.0111 0.0467 0.2506
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0568 0.3046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.06
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0062 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0121 0.0181
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0044
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0464 0.2131 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0022 0.0105
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.021 0.132
Giardia lamblia Myb 1-like protein 0.006 0.0226 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0065 0.0407
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0128 0.0771
Leishmania major calcium-translocating P-type ATPase 0.0028 0.0077 0.0452
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0479
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.026 0.0388
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0108 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0062 0.0332
Loa Loa (eye worm) RecQ helicase 0.0025 0.0062 0.0292
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0025 0.0038
Onchocerca volvulus 0.0039 0.0128 0.0687
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0601 0.2779 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.029
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0628 0.3931
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.139 0.8742
Trichomonas vaginalis MYB72, putative 0.006 0.0224 0.1411
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0419 0.1967
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0013 0.0007 0.0004
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.002 0.003
Brugia malayi polk-prov protein 0.0013 0.0006 0.0031
Trichomonas vaginalis MYB, putative 0.006 0.0226 0.1419
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0235 0.1446
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.0077 0.0072
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0064 0.0096
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0464 0.2131 0.3185
Echinococcus granulosus chromobox protein 1 0.0073 0.0288 0.0431
Leishmania major cathepsin L-like protease 0.0016 0.002 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0128 0.0804
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.029
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.0345
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0019 0.0028
Brugia malayi hypothetical protein 0.0017 0.0025 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.0949 0.5089
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.002 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.5007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0256 0.1149 0.1572
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.021 0.0314
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0128 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.008 0.0505
Brugia malayi Heterochromatin protein 1 0.0073 0.0288 0.1545
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.021 0.132
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0144 0.0215
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0168 0.0251
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.023 0.1028 0.1403
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0062 0.0092
Toxoplasma gondii hypothetical protein 0.005 0.0177 0.0637
Schistosoma mansoni hypothetical protein 0.0067 0.0262 0.0391
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.021 0.1125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Schistosoma mansoni hypothetical protein 0.0067 0.0262 0.0391
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0224 0.1411
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0276 0.0442
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0426 0.2001
Mycobacterium tuberculosis Conserved protein 0.0039 0.0128 0.0141
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0062 0.0092
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.021 0.1289
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0256 0.1149 0.1572
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0108 0.0162
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.5007
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0631 0.3383
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0121 0.0649
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0082 0.0124
Schistosoma mansoni hypothetical protein 0.1309 0.6116 0.914
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0121 0.0181
Schistosoma mansoni hypothetical protein 0.0067 0.0262 0.0391
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0121 0.0568
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0138 0.0496
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.0077 0.0279
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.002 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0062 0.0354
Schistosoma mansoni jun-related protein 0.0069 0.0267 0.04
Mycobacterium tuberculosis Putative ferredoxin reductase 0.023 0.1028 0.1403
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.002 0.003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.021 0.1125
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0628 0.1019
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.026 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1532 0.7165 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.021 0.1289
Leishmania major cathepsin L-like protease 0.0016 0.002 0.009
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0013 0.0007 0.001
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0006 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0419 0.0626
Schistosoma mansoni Smad4 0.0026 0.0064 0.0096
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0168 0.1023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1265 0.7958
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0168 0.0787
Schistosoma mansoni phosphoglucomutase 0.0349 0.159 0.2376
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0144 0.0905
Schistosoma mansoni hypothetical protein 0.0069 0.0267 0.04
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0025 0.0038
Echinococcus multilocularis dna polymerase eta 0.007 0.0276 0.0412
Brugia malayi hypothetical protein 0.003 0.0083 0.0447
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.021 0.0314
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0601 0.2779 0.2774
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0018 0.0027 0.0136
Trichomonas vaginalis MYB3r3, putative 0.006 0.0224 0.1411
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0062 0.0331
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.021 0.0314
Schistosoma mansoni hypothetical protein 0.003 0.0083 0.0125
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.021 0.1289
Brugia malayi hypothetical protein 0.003 0.0083 0.0447
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0039 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Brugia malayi Cathepsin L-like precursor 0.0016 0.002 0.0107
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0062 0.0092
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0022 0.0078
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0121 0.0568
Leishmania major DNA polymerase eta, putative 0.007 0.0276 0.1706
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.021 0.1289
Echinococcus granulosus ribonuclease H1 0.0349 0.159 0.2376
Mycobacterium tuberculosis Probable oxidoreductase 0.0256 0.1149 0.1572
Leishmania major P-type ATPase, putative 0.0013 0.0007 0.0006
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0121 0.0181
Echinococcus multilocularis cysteine protease 0.0016 0.002 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0426 0.0637
Loa Loa (eye worm) beta-lactamase 0.0039 0.0128 0.06
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0022 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Brugia malayi Cathepsin L-like precursor 0.0016 0.002 0.0107
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0062 0.1324
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Loa Loa (eye worm) hypothetical protein 0.0082 0.0331 0.1553
Trypanosoma brucei SLACS reverse transcriptase, putative 0.003 0.0083 0.0127
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0078 0.0488
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.011 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.002 0.0126
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0019 0.0088
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0108 0.0168
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0019 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Brugia malayi MH2 domain containing protein 0.0376 0.1716 0.9202
Leishmania major cathepsin L-like protease 0.0062 0.0235 0.1446
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0857 0.5393
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0121 0.0649
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.026 0.0388
Echinococcus multilocularis tumor protein p63 0.0343 0.1562 0.2335
Trichomonas vaginalis reverse transcriptases, putative 0.003 0.0083 0.0525
Trypanosoma brucei ribonuclease H1 0.0349 0.159 0.2592
Schistosoma mansoni nAChR subunit 0.0017 0.0025 0.0038
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0121 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Entamoeba histolytica hypothetical protein 0.0111 0.0467 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.021 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Loa Loa (eye worm) cysteine protease 0.0016 0.002 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0065 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.139 0.8742
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2133 1 1
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0013 0.0007 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0168 0.1055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.015
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0601 0.2779 0.3825
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0121 0.0181
Echinococcus granulosus dna polymerase kappa 0.0042 0.0144 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0144 0.0872
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0062 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0147 0.0231
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0128 0.0191
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0224 0.1411
Echinococcus granulosus bloom syndrome protein 0.0025 0.0062 0.0093
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.021 0.1287
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Onchocerca volvulus 0.0123 0.0524 0.321
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0262 0.1228
Onchocerca volvulus 0.0017 0.0022 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.139 0.2266
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.021 0.0314
Brugia malayi reverse transcriptase 0.003 0.0083 0.0447
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Leishmania major cathepsin L-like protease 0.0062 0.0235 0.1446
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0168 0.09
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0128 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0262 0.1403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Onchocerca volvulus 0.0017 0.0025 0.0034
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0121 0.0181
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.021 0.0334
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0121 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.008 0.0505
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.028 0.1265 0.5936
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0082 0.0124
Brugia malayi Smad1 0.0026 0.0064 0.0345
Brugia malayi hypothetical protein 0.003 0.0083 0.0447
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0121 0.0649
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.003 0.0083 0.0127
Leishmania major hypothetical protein, conserved 0.0026 0.0068 0.0395
Loa Loa (eye worm) nuclear factor I 0.0014 0.001 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0128 0.0141
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0025 0.0038
Entamoeba histolytica hypothetical protein 0.002 0.0039 0.0838
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.0949 0.5089
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.0007 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0128 0.02
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0141
Onchocerca volvulus 0.0038 0.0121 0.0643
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Echinococcus granulosus Smad4 0.0026 0.0064 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0426 0.0637
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.06
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0062 0.0056
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0022 0.0081
Plasmodium vivax vivapain-2 0.0016 0.002 0.0478
Brugia malayi hypothetical protein 0.0017 0.0025 0.0136
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2133 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.021 0.1289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Onchocerca volvulus 0.0017 0.0025 0.0034
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0224 0.1411
Brugia malayi MH1 domain containing protein 0.0014 0.001 0.0056
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0007 0.001
Giardia lamblia DINP protein human, muc B family 0.0042 0.0144 0.065
Loa Loa (eye worm) RNA binding protein 0.0132 0.0568 0.2666
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0019 0.0082
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.021 0.0314
Schistosoma mansoni microtubule-associated protein tau 0.1432 0.6692 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0108 0.0077
Trichomonas vaginalis esterase, putative 0.0039 0.0128 0.0804
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0342 0.0511
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.026 0.1604
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0025 0.0136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0426 0.0637
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0022 0.0033
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0007 0.015
Brugia malayi Zinc knuckle family protein 0.003 0.0083 0.0447
Mycobacterium leprae Probable lipase LipE 0.0039 0.0128 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.021 0.132
Mycobacterium tuberculosis Probable reductase 0.023 0.1028 0.1403
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0083 0.049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.021 0.1125
Entamoeba histolytica hypothetical protein 0.0111 0.0467 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0121 0.0181
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.021 0.5007
Loa Loa (eye worm) hypothetical protein 0.0213 0.0949 0.4453
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0007 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0108 0.0648
Plasmodium vivax P-type ATPase4, putative 0.0028 0.0077 0.1847
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.026 0.1604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Onchocerca volvulus 0.0123 0.0524 0.321
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.021 0.0314
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0083 0.0125
Onchocerca volvulus Ribonuclease H1 homolog 0.0349 0.159 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.002 0.003
Leishmania major cathepsin L-like protease 0.0062 0.0235 0.1446
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0025 0.0136
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0022 0.0081
Brugia malayi beta-lactamase family protein 0.0039 0.0128 0.0686
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0419 0.0626
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0464 0.2131 0.3185
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0048 0.1143
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Giardia lamblia Ribonuclease H 0.0349 0.159 0.7452
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0224 0.1411
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0262 0.1403
Loa Loa (eye worm) hypothetical protein 0.0106 0.0442 0.2074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0426 0.0637
Leishmania major ribonuclease H1, putative 0.0349 0.159 1
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0446
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0121 0.0649
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Mycobacterium tuberculosis Conserved protein 0.0039 0.0128 0.0141
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0128 0.0141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0108 0.0648
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0022 0.0141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Leishmania major hypothetical protein, conserved 0.0056 0.021 0.1289
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0108 0.0648
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0062 0.0392
Schistosoma mansoni phosphoglucomutase 0.0349 0.159 0.2376
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0064 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0122 0.0767
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0068 0.1628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Trichomonas vaginalis reverse transcriptases, putative 0.003 0.0083 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Brugia malayi Zinc knuckle family protein 0.003 0.0083 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0004 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0108 0.0168
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0408 0.1865 0.2787
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.026 0.1219
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0022 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.002 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Onchocerca volvulus Putative nachr subunit 0.0038 0.0121 0.0643
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0256 0.1149 0.1531
Loa Loa (eye worm) hypothetical protein 0.0056 0.021 0.0985
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.021 0.0985
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.002 0.003
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0168 0.0265
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.0345
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.002 0.0036 0.0195
Trypanosoma cruzi ribonuclease H1, putative 0.0349 0.159 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0025 0.0119
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0168 0.1023
Trypanosoma brucei trypanothione reductase 0.0101 0.0419 0.0677
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.021 0.5007
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0128 0.0191
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0062 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0062 0.0354
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0226 0.1419
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0096
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0121 0.0568
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0068 0.1628
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0408 0.1865 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.021 0.5007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0147 0.0892
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.021 0.1125
Schistosoma mansoni ATPase 0.0028 0.0077 0.0116
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0138 0.0834
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Loa Loa (eye worm) ctsf protein 0.0016 0.002 0.0094
Trichomonas vaginalis C-MYB, putative 0.006 0.0224 0.1411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.002 0.003
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.0077 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0064 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0137 0.086
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.021 0.0314
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Brugia malayi chromobox protein homolog 3 0.0041 0.0137 0.0733
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0276 0.1706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0137 0.086
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1265 0.7958
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0019 0.0021
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0108 0.0162
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0062 0.0392
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0121 0.0649
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0224 0.1411
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Schistosoma mansoni phosphoglucomutase 0.0349 0.159 0.2376
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0121 0.0649
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0262 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0062 0.0056
Onchocerca volvulus 0.0039 0.0128 0.0687
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.0077 0.0452
Plasmodium vivax vivapain-2 0.0016 0.002 0.0478
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0224 0.4798
Echinococcus granulosus smad 0.0026 0.0064 0.0096
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0064 0.0302
Leishmania major hypothetical protein, conserved 0.0056 0.021 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0019 0.0082
Brugia malayi reverse transcriptase 0.003 0.0083 0.0447
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0151 0.0952
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Echinococcus multilocularis chromobox protein 1 0.0073 0.0288 0.0431
Echinococcus granulosus nAChR subunit 0.0038 0.0121 0.0181
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0144 0.0215
Leishmania major DNA polymerase eta, putative 0.0041 0.0138 0.0834
Onchocerca volvulus 0.003 0.0083 0.0404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0083 0.0366
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.002 0.003
Onchocerca volvulus 0.003 0.0083 0.0404
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0108 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0262 0.0391
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0121 0.0649
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0065 0.0347
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.5007
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0151 0.0837
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0128 0.0804
Onchocerca volvulus 0.002 0.0039 0.0122
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0121 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Echinococcus granulosus cathepsin l1 0.0016 0.002 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0083 0.0366
Echinococcus granulosus KRAB A domain containing protein 0.003 0.0083 0.0125
Brugia malayi TAR-binding protein 0.0132 0.0568 0.3046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0062 0.0332
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0168 0.0251
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0068 0.0395
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.06
Toxoplasma gondii ribonuclease HI protein 0.0349 0.159 0.5721
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Brugia malayi Cation transporter family protein 0.0038 0.0121 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0144 0.0163
Onchocerca volvulus 0.0038 0.0121 0.0643
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.0334
Schistosoma mansoni DNA polymerase eta 0.007 0.0276 0.0412
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.003 0.0083 0.0404
Echinococcus granulosus RNA directed DNA polymerase 0.003 0.0083 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0144 0.0675
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0108 0.0103
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0144 0.0215
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.002 0.0429
Leishmania major cathepsin L-like protease 0.0016 0.002 0.009
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2133 1 1
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.021 0.1289
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.1716 0.8053
Loa Loa (eye worm) hypothetical protein 0.0146 0.0631 0.296
Mycobacterium ulcerans lipase LipD 0.0039 0.0128 0.0122
Trichomonas vaginalis C-MYB, putative 0.006 0.0224 0.1411
Brugia malayi RNase H family protein 0.0349 0.159 0.8524
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0007 0.0036
Onchocerca volvulus 0.002 0.0039 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0062 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.002 0.0126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0062 0.0049
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.0077 0.1847
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0137 0.0743
Toxoplasma gondii thioredoxin reductase 0.0101 0.0419 0.1508
Mycobacterium ulcerans hypothetical protein 0.0039 0.0128 0.0122
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.021 0.0334
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.021 0.1289
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.021 0.1125
Echinococcus granulosus microtubule associated protein 2 0.1432 0.6692 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0235 0.1446
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0083 0.0125
Trypanosoma brucei unspecified product 0.0042 0.0144 0.0226
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0342 0.0511
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.021 0.0314
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0128 0.0093
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Toxoplasma gondii cathepsin CPL 0.0016 0.002 0.0072
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0108 0.039
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0121 0.0568
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.028 0.1265 0.6784
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0121 0.0181
Brugia malayi beta-lactamase 0.0039 0.0128 0.0686
Echinococcus multilocularis jun protein 0.0085 0.0342 0.0511
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0121 0.0568
Loa Loa (eye worm) hypothetical protein 0.0056 0.021 0.0985
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.002 0.0036 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0082 0.0124
Schistosoma mansoni hypothetical protein 0.0111 0.0467 0.0698
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0262 0.0391
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0006 0.0021
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.021 0.1289
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.023 0.1028 0.1403
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.021 0.0314
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.1716 0.8053
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.029
Treponema pallidum ribonuclease H (rnhA) 0.0349 0.159 0.1497
Giardia lamblia hypothetical protein 0.0056 0.021 0.096
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.026 0.0416
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0144 0.0226
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Brugia malayi RNase H family protein 0.0349 0.159 0.8524
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0108 0.0168
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0121 0.0568
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0108 0.2586
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0024 0.057
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0039 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0464 0.2131 0.767
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Schistosoma mansoni chromobox protein 0.0073 0.0288 0.0431
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.0077 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1265 0.7958
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Brugia malayi Cation transporter family protein 0.0038 0.0121 0.0649
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.006 0.0226 0.0812
Brugia malayi Thioredoxin reductase 0.0101 0.0419 0.2248
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0039 0.0184
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0121 0.0649
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0007 0.001
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.0007 0.001
Echinococcus multilocularis geminin 0.0723 0.3353 0.501
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0128 0.0686
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0122 0.0735
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0007 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0467 0.0698
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.021 0.1289
Entamoeba histolytica cysteine protease, putative 0.0016 0.002 0.0429
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0127 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0094 0.0591
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.002 0.0429
Entamoeba histolytica hypothetical protein 0.0111 0.0467 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0023 0.0083
Leishmania major trypanothione reductase 0.0101 0.0419 0.261
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0568 0.0849
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0022 0.0105
Schistosoma mansoni hypothetical protein 0.0067 0.0262 0.0391
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0379 0.1729 0.2821
Giardia lamblia Reverse transcriptase/endonuclease 0.003 0.0083 0.0366
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0121 0.0181
Plasmodium falciparum glutathione reductase 0.0101 0.0419 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0224 0.4798
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0062 0.0049
Plasmodium falciparum thioredoxin reductase 0.0101 0.0419 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Toxoplasma gondii ABC1 family protein 0.0039 0.0128 0.046
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0628 0.3931
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0121 0.0649
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0121 0.0649
Giardia lamblia GTOR 0.0048 0.0168 0.0762
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0064 0.0302
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0025 0.0136
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0121 0.0181
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0121 0.0568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0062 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0224 0.4798
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0224 0.1411
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Mycobacterium ulcerans beta-lactamase 0.0039 0.0128 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0426 0.0637
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0077 0.0116
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.026 0.556
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0568 0.0849
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0168 0.1055
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1265 0.7958
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.139 0.8742
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0408 0.1865 0.2787
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0144 0.0771
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0025 0.0136
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0022 0.0141
Brugia malayi glutathione reductase 0.0101 0.0419 0.2248
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0121 0.0649
Echinococcus granulosus geminin 0.0723 0.3353 0.501
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0419 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Loa Loa (eye worm) glutathione reductase 0.0101 0.0419 0.1967
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0128 0.0191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0077 0.0487
Brugia malayi reverse transcriptase 0.003 0.0083 0.0447
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.021 0.5007
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0007 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0568 0.2666
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0019 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0568 0.0849
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Trypanosoma brucei RNA helicase, putative 0.1309 0.6116 1
Echinococcus multilocularis chromobox protein 1 0.0073 0.0288 0.0431
Schistosoma mansoni protein kinase 0.003 0.0083 0.0125
Trypanosoma cruzi ribonuclease H1, putative 0.0349 0.159 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0168 0.359
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.002 0.0478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0426 0.0637
Plasmodium falciparum thioredoxin reductase 0.0035 0.0108 0.2586
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1265 0.7958
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0464 0.2131 0.3185
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.0949 0.4453
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.021 0.1289
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0025 0.0038
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.021 0.1289
Echinococcus multilocularis cysteine protease 0.0016 0.002 0.003
Mycobacterium ulcerans hypothetical protein 0.0025 0.0062 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0025 0.0119
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0025 0.0038
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0019 0.0028
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Leishmania major hypothetical protein, conserved 0.0039 0.0128 0.0771
Echinococcus multilocularis Smad4 0.0026 0.0064 0.0096
Brugia malayi hypothetical protein 0.0017 0.0025 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.015
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0062 0.0332
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0083 0.0366
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0144 0.0226
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0181 0.027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0128 0.06
Schistosoma mansoni smad 0.0026 0.0064 0.0096
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.021 0.1289
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0426 0.0637
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0235 0.0375
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0224 0.4798
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0094
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.132
Leishmania major cathepsin L-like protease 0.0016 0.002 0.009
Onchocerca volvulus 0.0017 0.0025 0.0034
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Plasmodium vivax glutathione reductase, putative 0.0101 0.0419 1
Schistosoma mansoni chromobox protein 0.0073 0.0288 0.0431
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Mycobacterium tuberculosis Conserved protein 0.0039 0.0128 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0064 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0122 0.0767
Brugia malayi hypothetical protein 0.0066 0.0256 0.1375
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.021 0.0314
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0039 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0076 0.048
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.0007 0.001
Schistosoma mansoni scy1(yeast) protein kinase-like 0.003 0.0083 0.0125
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0025 0.0136
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0168 0.359
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.021 0.0314
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0025 0.0136
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0144 0.3076
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0144 0.0138
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0025 0.0038
Brugia malayi Cathepsin L-like precursor 0.0016 0.002 0.0107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0019 0.0101
Schistosoma mansoni hypothetical protein 0.0146 0.0631 0.0943
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0105
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0122 0.0767
Loa Loa (eye worm) hypothetical protein 0.005 0.0181 0.0847
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0077 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0065 0.0407
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0168 0.0251
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0062 0.0056
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0419 0.261
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0121 0.0181
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0121 0.0649
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0065 0.0347
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0128 0.0141
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Mycobacterium tuberculosis Probable dehydrogenase 0.023 0.1028 0.1403
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0144 0.0872
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0062 0.1324
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0108 0.2586
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0224 0.1411
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0108 0.0648
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0068 0.0102
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0032 0.0763
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0141
Onchocerca volvulus 0.0066 0.0256 0.1506
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0083 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0568 0.2666
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0144 0.0905
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.002 0.0126
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0108 0.0483
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.002 0.0478
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.005 0.0072
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0108 0.039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.021 0.1289
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.06
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0025 0.0038
Mycobacterium ulcerans hypothetical protein 0.0162 0.0706 0.07
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0108 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1265 0.7958
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0464 0.2131 0.3185
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0078 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.011 0.0694
Onchocerca volvulus 0.0025 0.0062 0.0267
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.021 0.1289
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1532 0.7165 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0568 0.0849
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0147 0.0892
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0121 0.0181
Echinococcus granulosus calcium transporting atpase 0.0025 0.0062 0.0092
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.023 0.1028 0.1403
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0062 0.0092
Echinococcus multilocularis GPCR, family 2 0.0067 0.0262 0.0391
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0172 0.1053
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0022 0.0105
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.002 0.003
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0121 0.0181
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0349 0.159 0.1497
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0064 0.0096
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0121 0.0181
Brugia malayi Cathepsin L-like precursor 0.0016 0.002 0.0107
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.026 0.1604
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0083 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0144 0.0226
Trypanosoma brucei unspecified product 0.0029 0.0082 0.0124
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0022 0.0479
Brugia malayi hypothetical protein 0.0026 0.0068 0.0366
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.021 0.132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0467 0.0698
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.007 0.0276 0.1295
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0184
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0121 0.0181
Onchocerca volvulus 0.0032 0.0095 0.0478
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.06
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.021 0.5007
Brugia malayi MH1 domain containing protein 0.0014 0.001 0.0056
Echinococcus granulosus Na:K ATPase alpha subunit 0.0013 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0062 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0118
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0224 0.1411
Loa Loa (eye worm) fibroinase 0.0016 0.002 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0128 0.0771
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0568 0.0849
Echinococcus granulosus dna polymerase eta 0.007 0.0276 0.0412
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0013 0.0007 0.001
Onchocerca volvulus 0.005 0.0181 0.1023
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0077 0.0116
Brugia malayi Cathepsin L-like precursor 0.0016 0.002 0.0107
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0083 0.0125
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0121 0.0649
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Brugia malayi Cathepsin L-like precursor 0.0016 0.002 0.0107
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.1121 0.1532
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.0077 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0168 0.1055
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0025 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0068 0.0246
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.021 0.0314
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0062 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0226 0.1419
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.06
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0262 0.0391
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0235 0.1446
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0121 0.0181
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0022 0.0033
Brugia malayi bZIP transcription factor family protein 0.0085 0.0342 0.1834
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0096
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0007 0.0006
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0022 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0039 0.021
Echinococcus granulosus GPCR family 2 0.0067 0.0262 0.0391
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0039 0.0059
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.021 0.0334
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.021 0.132
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0121 0.0181
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0479
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0108 0.0682
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0121 0.0568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0426 0.2286
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0108 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0122 0.0767
Leishmania major DNA polymerase kappa, putative 0.0042 0.0144 0.0872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0078 0.0488
Echinococcus granulosus tar DNA binding protein 0.0132 0.0568 0.0849
Schistosoma mansoni ATPase 0.0028 0.0077 0.0116
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0121 0.0181
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0121 0.0181
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0032 0.0763
Brugia malayi hypothetical protein 0.003 0.0083 0.0447
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0121 0.0181
Echinococcus granulosus chromobox protein 1 0.0073 0.0288 0.0431
Schistosoma mansoni hypothetical protein 0.003 0.0083 0.0125
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0006 0.0137
Brugia malayi RNA binding protein 0.0132 0.0568 0.3046
Echinococcus multilocularis smad 0.0026 0.0064 0.0096
Schistosoma mansoni hypothetical protein 0.0723 0.3353 0.501
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0192 0.1173
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0144 0.0215
Loa Loa (eye worm) PDE1B protein 0.0056 0.021 0.0985
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0128 0.0804
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0108 0.2586
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0224 0.4798
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.0811 0.5037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.002 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0122 0.0767
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.0345
Trypanosoma brucei unspecified product 0.0379 0.1729 0.2821
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0128 0.305
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0235 0.1446
Echinococcus granulosus tumor protein p63 0.0343 0.1562 0.2335
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0039 0.0059
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.021 0.0314
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0408 0.1865 0.8751
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0025 0.0038
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.026 0.1393
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0032 0.0026
Brugia malayi hypothetical protein 0.0017 0.0025 0.0136
Echinococcus multilocularis microtubule associated protein 2 0.1432 0.6692 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0121 0.0181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.021 0.0755
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.021 0.1289
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0006 0.0137
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0706 0.0951
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0144 0.0226
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0128 0.0804
Brugia malayi beta-lactamase family protein 0.0039 0.0128 0.0686
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0568
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.021 0.5007
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0067 0.0262 0.1228
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0122 0.0735
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0022 0.0141
Schistosoma mansoni nAChR subunit 0.0038 0.0121 0.0181
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0108 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0811 0.51
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0083 0.0447

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.008 mg kg-1 Antinociceptive activity was tested in the mouse tail-flick test ChEMBL. 15050621
ED50 (functional) = 0.008 mg kg-1 Antinociceptive activity was tested in the mouse tail-flick test ChEMBL. 15050621
ED50 (functional) = 0.009 mg kg-1 Antinociceptive activity was tested in the mouse hot plate test ChEMBL. 15050621
ED50 (functional) = 0.009 mg kg-1 Antinociceptive activity was tested in the mouse hot plate test ChEMBL. 15050621
Ki (binding) = 0.025 nM Inhibition of [3H]-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes ChEMBL. 15050621
Ki (binding) = 0.025 nM Inhibition of [3H]-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes ChEMBL. 15050621
Ki (binding) = 3.43 nM Inhibition of [125I]-iodo-MLA binding to Nicotinic acetylcholine receptor alpha7 from rat brain membranes ChEMBL. 15050621
Ki (binding) = 3.43 nM Inhibition of [125I]-iodo-MLA binding to Nicotinic acetylcholine receptor alpha7 from rat brain membranes ChEMBL. 15050621
Ki (binding) = 3.43 nM Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha7 (nAChR) in male rat cerebral cortex ChEMBL. 12361403

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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