Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4498 | 0.4131 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4225 | 0.3655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4225 | 0.4225 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4225 | 0.3642 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4498 | 0.4131 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4498 | 0.4498 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0625 | 0.0625 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0917 | 0.0311 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0917 | 0.0311 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.9595 | 0.9595 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Onchocerca volvulus | 0.0035 | 0.4225 | 0.5 | |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.052 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0122 | 0.0122 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4498 | 0.4498 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.851 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.052 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.