TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 446.561 | Formula: C26H26N2O3S
H donors: 1 H acceptors: 3 LogP: 4.19 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)c1ccc2c(c1)N(Cc1cc(C)ccc1C)C(=O)c1c(S2=O)cccc1
InChi: 1S/C26H26N2O3S/c1-4-13-27-25(29)19-11-12-24-22(15-19)28(16-20-14-17(2)9-10-18(20)3)26(30)21-7-5-6-8-23(21)32(24)31/h5-12,14-15H,4,13,16H2,1-3H3,(H,27,29)
InChiKey: WUGDACZNHULRIJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Echinococcus multilocularis	cpg binding protein	0.0031	0.0313	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0437	0.1039
Brugia malayi	steroid hormone receptor	0.001	0.0037	0.006
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0359	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0674	0.0674
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0037	0.0037
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0012	0.0025
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0269	0.0627
Echinococcus multilocularis	Smad4	0.0008	0.0012	0.0012
Echinococcus granulosus	acetylcholinesterase	0.0326	0.4097	0.8195
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0123	0.0247
Schistosoma mansoni	coup transcription factor	0.001	0.0037	0.0074
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0012	0.0025
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0437	0.0437
Brugia malayi	Carboxylesterase family protein	0.0326	0.4097	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0044	0.0078
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.1136	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0359	0.0849
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0215
Schistosoma mansoni	acetylcholinesterase	0.0055	0.0619	0.1237
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0022	0.0023
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0107	0.0233
Loa Loa (eye worm)	hypothetical protein	0.005	0.0555	0.1329
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0037	0.0074
Echinococcus granulosus	expressed conserved protein	0.0089	0.1062	0.2124
Loa Loa (eye worm)	hypothetical protein	0.0326	0.4097	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0618	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0037	0.0074
Schistosoma mansoni	hypothetical protein	0.0039	0.0418	0.0836
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0107	0.0107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0055	0.0619	0.1237
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0168	0.0381
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0037	0.0074
Echinococcus multilocularis	carboxylesterase 5A	0.0326	0.4097	0.4097
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0055	0.0619	0.1075
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.1662	0.1662
Loa Loa (eye worm)	carboxylesterase	0.0055	0.0619	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1136	0.2751
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0107	0.0215
Echinococcus granulosus	neuroligin	0.0055	0.0619	0.1237
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0037	0.006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0212	0.0212
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0358	0.0717
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0012	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Echinococcus multilocularis	acetylcholinesterase	0.0326	0.4097	0.4097
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.1136	0.2751
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0123	0.0247
Trichomonas vaginalis	spcc417.12 protein, putative	0.0055	0.0619	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0012	0.0012
Loa Loa (eye worm)	carboxylesterase	0.0055	0.0619	0.1484
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0437	0.0874
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0335	0.079
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Onchocerca volvulus		0.0055	0.0619	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0418	0.0993
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0037	0.006
Schistosoma mansoni	hypothetical protein	0.0039	0.0418	0.0836
Echinococcus granulosus	Smad4	0.0008	0.0012	0.0025
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0037	0.006
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0131	0.0291
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0531	0.1271
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0669	0.1338
Schistosoma mansoni	hypothetical protein	0.0164	0.2019	0.4039
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0359	0.0718
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0037	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0037	0.006
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0037	0.0074
Schistosoma mansoni	cpg binding protein	0.0028	0.0269	0.0537
Schistosoma mansoni	hypothetical protein	0.0396	0.5	1
Echinococcus multilocularis	smad	0.0008	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0359	0.0849
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0037	0.0074
Mycobacterium ulcerans	carboxylesterase, LipT	0.0055	0.0619	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0037	0.006
Echinococcus granulosus	cpg binding protein	0.0031	0.0313	0.0625
Brugia malayi	PHD-finger family protein	0.0026	0.0242	0.0561
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0531	0.1271
Brugia malayi	Carboxylesterase family protein	0.0055	0.0619	0.1484
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0037	0.006
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0037	0.0074
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0215
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0037	0.0074
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0123	0.0247
Schistosoma mansoni	hypothetical protein	0.0164	0.2019	0.4039
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0389	0.0921
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Schistosoma mansoni	zinc finger protein	0.0015	0.0102	0.0203
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0055	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.1136	0.2272
Echinococcus multilocularis	zinc finger protein	0.0021	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0037	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0037	0.006
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0359	0.0359
Brugia malayi	Carboxylesterase family protein	0.0055	0.0619	0.1484
Schistosoma mansoni	BC026374 protein (S09 family)	0.0055	0.0619	0.1237
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0437	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Echinococcus multilocularis	expressed conserved protein	0.0089	0.1062	0.1062
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0022	0.0044
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0037	0.0037
Schistosoma mansoni	hypothetical protein	0.0033	0.0335	0.067
Brugia malayi	Carboxylesterase family protein	0.0055	0.0619	0.1484
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0037	0.006
Echinococcus multilocularis	geminin	0.0164	0.2019	0.2019
Brugia malayi	hypothetical protein	0.0055	0.0619	0.1484
Echinococcus multilocularis	neuroligin	0.0055	0.0619	0.0619
Schistosoma mansoni	cpg binding protein	0.0031	0.0313	0.0625
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0107	0.0107
Echinococcus granulosus	BC026374 protein S09 family	0.0055	0.0619	0.1237
Brugia malayi	Bromodomain containing protein	0.0074	0.0865	0.2086
Onchocerca volvulus		0.0055	0.0619	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0037	0.0074
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0012	0.0025
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0037	0.006
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0037	0.0074
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0037	0.0074
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0359	1
Leishmania major	hypothetical protein, conserved	0.0035	0.0359	1
Echinococcus granulosus	carboxylesterase 5A	0.0326	0.4097	0.8195
Schistosoma mansoni	gliotactin	0.0055	0.0619	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0359	0.0849
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0358	0.0358
Brugia malayi	beta-lactamase family protein	0.0035	0.0359	0.0849
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0037	0.0074
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0037	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0437	0.2996
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0037	0.006
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0107	0.0233
Onchocerca volvulus		0.0055	0.0619	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0037	0.006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0037	0.006
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0037	0.0074
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0511	0.0511
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0055	0.0619	0.1237
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0359	0.0718
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0674	0.1349
Brugia malayi	Carboxylesterase family protein	0.0055	0.0619	0.1484
Onchocerca volvulus		0.0035	0.0359	0.554
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0107	0.0233
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1155	0.231
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0012	0.0025
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0012	0.0025
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1397	0.3388
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0055	0.0619	0.0619
Schistosoma mansoni	cpg binding protein	0.0031	0.0313	0.0625
Schistosoma mansoni	hypothetical protein	0.0039	0.0418	0.0836
Echinococcus granulosus	geminin	0.0164	0.2019	0.4039
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0107	0.0107
Schistosoma mansoni	Smad4	0.0008	0.0012	0.0025
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0212	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0359	0.0849
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0037	0.0074
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0055	0.0619	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0212	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0791	0.1906
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0037	0.0074
Echinococcus granulosus	acetylcholinesterase	0.0326	0.4097	0.8195
Echinococcus granulosus	zinc finger protein	0.0021	0.0175	0.035
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0359	0.0718
Brugia malayi	nuclear hormone receptor	0.001	0.0037	0.006
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0215
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0055	0.0619	0.1237
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0037	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0037	0.006
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0123	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0037	0.006
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0055	0.0619	0.1075
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0131	0.029
Loa Loa (eye worm)	acetylcholinesterase 1	0.0326	0.4097	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0359	0.0849
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0719	0.1438
Brugia malayi	nuclear receptor NHR-88	0.001	0.0037	0.006
Onchocerca volvulus		0.0028	0.0269	0.3982
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0037	0.0074
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0012	0.0012
Brugia malayi	beta-lactamase	0.0035	0.0359	0.0849
Brugia malayi	Bromodomain containing protein	0.0037	0.0388	0.0919
Echinococcus multilocularis	para nitrobenzyl esterase	0.0055	0.0619	0.0619
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0055	0.0619	0.1237
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0531	0.1271
Onchocerca volvulus		0.0035	0.0359	0.554
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0055	0.0619	0.1237
Brugia malayi	MH2 domain containing protein	0.0116	0.1397	0.3388
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0359	0.0849
Onchocerca volvulus		0.0055	0.0619	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.1101
Echinococcus multilocularis	acetylcholinesterase	0.0326	0.4097	0.4097
Loa Loa (eye worm)	carboxylesterase	0.0326	0.4097	1
Echinococcus granulosus	smad	0.0008	0.0012	0.0025
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0359	0.5
Echinococcus granulosus	para nitrobenzyl esterase	0.0055	0.0619	0.1237
Echinococcus granulosus	GPCR family 2	0.0015	0.0107	0.0215
Brugia malayi	CHE-14 protein	0.0041	0.0437	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0359	0.0849
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.5	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0037	0.006
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0437	0.0874
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0359	0.5
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.1662	0.3323
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0107	0.0215
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.5	1
Echinococcus multilocularis	protein patched	0.0041	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0359	0.0849
Schistosoma mansoni	hypothetical protein	0.0039	0.0418	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0335	0.079
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0037	0.0037
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0037	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0037	0.006
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0269	0.0627
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0037	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0037	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0037	0.006
Schistosoma mansoni	zinc finger protein	0.0021	0.0175	0.035
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1397	0.3388
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0326	0.4097	0.8195
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0037	0.006
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0359	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0037	0.0037
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0131	0.0262
Onchocerca volvulus		0.0035	0.0359	0.554
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.2773	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0037	0.0037
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0037	0.0037
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0055	0.0619	0.1075
Brugia malayi	ecdysteroid receptor	0.001	0.0037	0.006
Schistosoma mansoni	smad	0.0008	0.0012	0.0025
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0037	0.0074
Brugia malayi	Carboxylesterase family protein	0.0326	0.4097	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0037	0.0074
Schistosoma mansoni	hypothetical protein	0.002	0.0168	0.0336
Onchocerca volvulus		0.0055	0.0619	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0131	0.0262
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0359	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0359	0.0849
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0037	0.0074
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0037	0.0074
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0131	0.0131
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0022	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0037	0.006
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0131	0.0262
Schistosoma mansoni	patched 1	0.0041	0.0437	0.0874
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.1136	0.1136
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0037	0.006
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0359	0.0849
Schistosoma mansoni	hypothetical protein	0.0015	0.0102	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0326	0.4097	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0107	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0619	0.1484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0037	0.006
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0531	0.1271
Loa Loa (eye worm)	hypothetical protein	0.001	0.0037	0.006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 802795