Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma japonicum | ko:K09435 transcriptional regulator ERG, putative | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Brugia malayi | Fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma mansoni | ets-related | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0216 | 0.7404 | 0.722 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0216 | 0.7404 | 0.722 |
Echinococcus granulosus | acetylcholinesterase | 0.0216 | 0.7404 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.0665 | 0.0665 |
Echinococcus granulosus | carboxylesterase 5A | 0.0216 | 0.7404 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0216 | 0.7404 | 0.722 |
Echinococcus granulosus | acetylcholinesterase | 0.0216 | 0.7404 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0216 | 0.7404 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | ets-related | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.7404 | 0.7404 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0216 | 0.7404 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0216 | 0.7404 | 0.7404 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.7404 | 0.7404 |
Loa Loa (eye worm) | carboxylesterase | 0.0216 | 0.7404 | 0.7404 |
Echinococcus multilocularis | acetylcholinesterase | 0.0216 | 0.7404 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.