Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.053 | 0.053 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0857 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2953 | 0.2953 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7793 | 0.7793 |
Echinococcus granulosus | peregrin | 0.0039 | 0.0307 | 0.0318 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.5729 | 0.5937 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.053 | 0.053 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9649 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7793 | 0.7793 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7793 | 0.7793 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.5729 | 0.5729 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1799 | 0.1799 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2953 | 0.2953 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2953 | 0.2953 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2953 | 0.2953 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1163 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0986 | 0.1022 |
Echinococcus multilocularis | peregrin | 0.0039 | 0.0307 | 0.0307 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.4034 | 0.4034 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.053 | 0.053 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1163 | 0.1206 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.5729 | 0.5729 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.2681 | 0.2681 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2953 | 0.2953 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.0857 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2953 | 0.2953 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2953 | 0.2953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2953 | 0.2953 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1163 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0857 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.053 | 0.0549 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1163 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2953 | 0.2953 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0307 | 0.0307 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.053 | 0.053 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2953 | 0.2953 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2953 | 0.2953 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2953 | 0.2953 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.1163 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.1163 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.053 | 0.053 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2953 | 0.306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.