TDR Targets

Basic information

Technical information

TDR Targets ID: 803150
Name: N-(2,5-dimethylphenyl)-3-methyl-2-oxo-1,3-ben zoxazole-6-sulfonamide
MW: 332.374 | Formula: C16H16N2O4S
H donors: 1 H acceptors: 3 LogP: 2.57 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C)C
InChi: 1S/C16H16N2O4S/c1-10-4-5-11(2)13(8-10)17-23(20,21)12-6-7-14-15(9-12)22-16(19)18(14)3/h4-9,17H,1-3H3
InChiKey: XHGHGZCOIBZYCX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,5-dimethylphenyl)-2-keto-3-methyl-1,3-benzoxazole-6-sulfonamide
ZINC04809180

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	voltage gated potassium channel subunit	0.0112	0.1219	0.1219
Echinococcus multilocularis	aldo keto reductase	0.0387	0.5516	0.5516
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0165	0.0165
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0203	0.0203
Mycobacterium ulcerans	oxidoreductase	0.0387	0.5516	1
Mycobacterium tuberculosis	Conserved protein	0.0112	0.1219	0.1841
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0387	0.5516	1
Giardia lamblia	Aldose reductase	0.0387	0.5516	0.5
Echinococcus multilocularis	aldo keto reductase	0.0387	0.5516	0.5516
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.066	0.5
Brugia malayi	hypothetical protein	0.0231	0.3076	0.5576
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0112	0.1219	0.2209
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.066	0.066
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0387	0.5516	1
Onchocerca volvulus		0.0387	0.5516	1
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.1219	0.2209
Loa Loa (eye worm)	oxidoreductase	0.0387	0.5516	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0112	0.1219	0.2209
Trypanosoma brucei	prostaglandin f synthase	0.0387	0.5516	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.066	0.5
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0112	0.1219	0.1219
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0387	0.5516	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0165	0.0165
Echinococcus granulosus	aldo keto reductase	0.0387	0.5516	0.5516
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0165	0.0165
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0387	0.5516	1
Leishmania major	aldo-keto reductase-like protein	0.0387	0.5516	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0387	0.5516	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0387	0.5516	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Schistosoma mansoni	pol-related	0.0387	0.5516	0.5516
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Loa Loa (eye worm)	hypothetical protein	0.0387	0.5516	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Entamoeba histolytica	aldose reductase, putative	0.0387	0.5516	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.066	0.5416
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Plasmodium falciparum	aldo-keto reductase, putative	0.0112	0.1219	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.066	0.066
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.3076	0.3076
Giardia lamblia	Aldose reductase	0.0387	0.5516	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Onchocerca volvulus		0.0387	0.5516	1
Brugia malayi	NADH-dependent xylose reductase	0.0112	0.1219	0.2209
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0112	0.1219	0.2209
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0249	0.0249
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Schistosoma mansoni	aldo-keto reductase	0.0387	0.5516	0.5516
Echinococcus granulosus	hypothetical protein	0.0387	0.5516	0.5516
Trichomonas vaginalis	aldo-keto reductase, putative	0.0112	0.1219	0.2209
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0165	0.0165
Schistosoma mansoni	hypothetical protein	0.0165	0.2053	0.2053
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0249	0.0249
Toxoplasma gondii	aldo-keto reductase	0.0112	0.1219	0.2209
Loa Loa (eye worm)	oxidoreductase	0.0387	0.5516	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.066	0.1196
Schistosoma mansoni	potassium channel beta	0.0112	0.1219	0.1219
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0112	0.1219	0.2209
Entamoeba histolytica	aldose reductase, putative	0.0387	0.5516	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus granulosus	geminin	0.0165	0.2053	0.2053
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Schistosoma mansoni	hypothetical protein	0.0047	0.0203	0.0203
Echinococcus multilocularis	aldehyde reductase	0.0275	0.3764	0.3764
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0387	0.5516	1
Trypanosoma cruzi	aldo-keto reductase	0.0387	0.5516	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.066	0.066
Echinococcus multilocularis	aldo keto reductase	0.0387	0.5516	0.5516
Plasmodium falciparum	aldehyde reductase, putative	0.0112	0.1219	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0387	0.5516	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0112	0.1219	0.2209
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0387	0.5516	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0387	0.5516	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0387	0.5516	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0112	0.1219	0.2209
Trichomonas vaginalis	aldo-keto reductase, putative	0.0112	0.1219	0.2209
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Echinococcus multilocularis	geminin	0.0165	0.2053	0.2053
Onchocerca volvulus		0.0387	0.5516	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0112	0.1219	1
Leishmania major	prostaglandin f synthase, putative	0.0387	0.5516	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0387	0.5516	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.066	0.0781
Echinococcus granulosus	aldo keto reductase	0.0387	0.5516	0.5516
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Trypanosoma cruzi	aldo/keto reductase, putative	0.0387	0.5516	1
Echinococcus multilocularis	aldo keto reductase	0.0387	0.5516	0.5516
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0165	0.0298
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.066	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0112	0.1219	0.2209
Trichomonas vaginalis	aldo-keto reductase, putative	0.0112	0.1219	0.2209
Toxoplasma gondii	aldose reductase, putative	0.0387	0.5516	1
Schistosoma mansoni	microtubule-associated protein tau	0.0674	1	1
Onchocerca volvulus		0.0387	0.5516	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0112	0.1219	0.2209
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.3076	0.3076
Loa Loa (eye worm)	oxidoreductase	0.0387	0.5516	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0165	0.0165
Echinococcus granulosus	aldehyde reductase	0.0275	0.3764	0.3764
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0203	0.0367
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0112	0.1219	0.1219
Onchocerca volvulus		0.0387	0.5516	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.066	0.1196
Mycobacterium ulcerans	hypothetical protein	0.0112	0.1219	0.115
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0387	0.5516	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0165	0.0165
Schistosoma mansoni	aldo-keto reductase	0.0387	0.5516	0.5516
Plasmodium vivax	aldehyde reductase, putative	0.0112	0.1219	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0165	0.0165
Trichomonas vaginalis	aldo-keto reductase, putative	0.0387	0.5516	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0387	0.5516	1
Entamoeba histolytica	aldose reductase, putative	0.0387	0.5516	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Echinococcus granulosus	aldo keto reductase	0.0387	0.5516	0.5516
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3076	0.5576
Loa Loa (eye worm)	oxidoreductase	0.0387	0.5516	1
Onchocerca volvulus		0.0387	0.5516	1
Mycobacterium leprae	Conserved hypothetical protein	0.0275	0.3764	0.6673
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.066	0.1196
Trypanosoma brucei	aldo-keto reductase, putative	0.0387	0.5516	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0165	0.0298
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.066	0.5
Loa Loa (eye worm)	oxidoreductase	0.0387	0.5516	1
Mycobacterium leprae	Possible oxidoreductase	0.0112	0.1219	0.1841
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0112	0.1219	0.2209
Onchocerca volvulus		0.0112	0.1219	0.1912
Echinococcus multilocularis	microtubule associated protein 2	0.0674	1	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.066	0.5416
Brugia malayi	Probable ClpP-like protease	0.0076	0.066	0.1196
Schistosoma mansoni	hypothetical protein	0.0165	0.2053	0.2053
Trypanosoma brucei	aldo/keto reductase, putative	0.0112	0.1219	0.2209
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0387	0.5516	0.5516
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0387	0.5516	0.5516

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 803150