Detailed information for compound 803221

Basic information

Technical information
  • TDR Targets ID: 803221
  • Name: 6-(azepan-1-ylsulfonyl)-N-(2-methoxyethyl)-4- oxo-1-prop-2-enylquinoline-3-carboxamide
  • MW: 447.548 | Formula: C22H29N3O5S
  • H donors: 1 H acceptors: 4 LogP: 2.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1cc(C(=O)NCCOC)c(=O)c2c1ccc(c2)S(=O)(=O)N1CCCCCC1
  • InChi: 1S/C22H29N3O5S/c1-3-11-24-16-19(22(27)23-10-14-30-2)21(26)18-15-17(8-9-20(18)24)31(28,29)25-12-6-4-5-7-13-25/h3,8-9,15-16H,1,4-7,10-14H2,2H3,(H,23,27)
  • InChiKey: UPJSWFZUIALIAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-allyl-6-(azepan-1-ylsulfonyl)-N-(2-methoxyethyl)-4-oxo-quinoline-3-carboxamide
  • 1-allyl-6-(1-azepanylsulfonyl)-N-(2-methoxyethyl)-4-oxo-3-quinolinecarboxamide
  • 1-allyl-6-(azepan-1-ylsulfonyl)-4-keto-N-(2-methoxyethyl)quinoline-3-carboxamide
  • 6-(azepan-1-ylsulfonyl)-N-(2-methoxyethyl)-4-oxo-1-prop-2-enyl-quinoline-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0064 0.2084
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1343 0.847 1
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0615 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0447 0.0364
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.0046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.1096 0.1294
Echinococcus multilocularis neutral amino acid transporter A 0.1343 0.847 0.8469
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0039 0.0034
Schistosoma mansoni hypothetical protein 0.0797 0.4992 0.5891
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0006
Plasmodium falciparum importin beta, putative 0.0059 0.0287 1
Schistosoma mansoni hypothetical protein 0.004 0.0163 0.0187
Schistosoma mansoni hypothetical protein 0.0068 0.0344 0.0401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0598 0.5132
Brugia malayi hypothetical protein 0.0229 0.1369 0.1616
Trichomonas vaginalis ran, putative 0.0044 0.0187 0.0654
Mycobacterium tuberculosis Conserved protein 0.0111 0.0615 0.0566
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0215 0.0753
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.116 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1343 0.847 0.8469
Leishmania major hypothetical protein, conserved 0.0015 0.0005 0.0041
Echinococcus multilocularis muscleblind protein 1 0.0322 0.1961 0.1957
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0146 0.051
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1896 0.2239
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0039 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0146 0.2309
Toxoplasma gondii thioredoxin reductase 0.0037 0.0144 0.1208
Brugia malayi hypothetical protein 0.0016 0.0008 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0797 0.4992 0.4989
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0146 0.0172
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0265 0.0308
Brugia malayi Pre-SET motif family protein 0.0059 0.0287 0.0338
Brugia malayi glutathione reductase 0.0037 0.0144 0.017
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.1023 0.1203
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0039 0.0046
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0025 0.0024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0507 0.1756
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0187 0.3037
Echinococcus granulosus neuropeptide receptor A26 0.045 0.2776 0.3273
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0709 0.4429 0.5146
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0287 0.2443
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0064 0.0509
Echinococcus multilocularis neutral amino acid transporter A 0.1343 0.847 0.8469
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0039 0.0046
Onchocerca volvulus 0.0111 0.0615 0.0727
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0507 0.0436
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0271 0.0315
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0292 0.0344
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0447 0.0364
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0146 0.2369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Brugia malayi Pre-SET motif family protein 0.0407 0.2502 0.2954
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1023 0.1019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0507 0.0436
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1896 0.2239
Echinococcus multilocularis neuropeptide s receptor 0.045 0.2776 0.2772
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0447 0.0364
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0147 0.0169
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0615 0.0566
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1896 0.6632
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0039 0.004
Schistosoma mansoni cpg binding protein 0.0059 0.0285 0.0331
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.004
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1343 0.847 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.001 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.0046
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0615 0.0611
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0155 0.2523
Brugia malayi Latrophilin receptor protein 2 0.0032 0.011 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.1096 0.1092
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.079 0.0927
Echinococcus multilocularis Excitatory amino acid transporter 0.1343 0.847 0.8469
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0155 0.0906
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0097 0.0525 0.062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.001 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0287 0.0333
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.1096 0.129
Loa Loa (eye worm) hypothetical protein 0.0111 0.0615 0.0727
Onchocerca volvulus 0.0056 0.0265 0.0313
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0155 0.1303
Echinococcus granulosus GPCR family 2 0.0032 0.011 0.0124
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0187 0.0182
Loa Loa (eye worm) hypothetical protein 0.0111 0.0615 0.0727
Onchocerca volvulus 0.0111 0.0615 0.0727
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.1096 0.1294
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1213 0.1432
Toxoplasma gondii exonuclease III APE 0.0037 0.0146 0.1221
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0039 0.004
Echinococcus granulosus neutral amino acid transporter 0.1343 0.847 1
Brugia malayi steroid hormone receptor 0.0021 0.0039 0.0046
Leishmania major trypanothione reductase 0.0037 0.0144 0.1244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1283 0.4486
Onchocerca volvulus 0.0111 0.0615 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.0046
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0006
Brugia malayi follicle stimulating hormone receptor 0.0251 0.1508 0.178
Chlamydia trachomatis glutamate symporter 0.1343 0.847 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.1961 0.2315
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0155 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.4325 0.5104
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0287 0.0282
Echinococcus multilocularis Excitatory amino acid transporter 0.1343 0.847 0.8469
Plasmodium vivax SET domain protein, putative 0.0059 0.0287 0.4616
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0367 0.0428
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.011 0.0105
Onchocerca volvulus 0.0047 0.0206 0.0243
Brugia malayi Thioredoxin reductase 0.0037 0.0144 0.017
Echinococcus granulosus microtubule associated protein 2 0.0693 0.4325 0.5104
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0615 0.0566
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0367 0.1414
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0032 0.0027
Echinococcus granulosus neutral amino acid transporter A 0.1343 0.847 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0155 0.0543
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0187 0.2983
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0031 0.0036
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0595 0.3703 0.37
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0147 0.0143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.004
Schistosoma mansoni patched 1 0.0042 0.0173 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0155 0.0543
Loa Loa (eye worm) hypothetical protein 0.0059 0.0287 0.0338
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0077
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0146 0.1257
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0146 0.0141
Onchocerca volvulus 0.0021 0.0039 0.0046
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0146 0.4996
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.0034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0155 0.0543
Toxoplasma gondii aldehyde dehydrogenase 0.0196 0.116 1
Schistosoma mansoni hypothetical protein 0.004 0.0163 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0075
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0367 0.0428
Loa Loa (eye worm) hypothetical protein 0.01 0.0546 0.0645
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0187 0.1577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1096 0.129
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0367 0.3167
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0025 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.1096 0.129
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0187 0.6454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.1096 0.1092
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0615 0.463
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0039 0.004
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0039 0.0046
Echinococcus granulosus geminin 0.017 0.0993 0.1167
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.1023 0.1208
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1343 0.847 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Mycobacterium tuberculosis Probable reductase 0.0085 0.0447 0.0364
Schistosoma mansoni ap endonuclease 0.0037 0.0146 0.0167
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0615 0.491
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0367 0.0363
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0064 0.0963
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0546 0.0645
Schistosoma mansoni cpg binding protein 0.0056 0.0265 0.0307
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0155 0.0543
Echinococcus granulosus dnaJ subfamily B 0.0797 0.4992 0.5891
Brugia malayi CHE-14 protein 0.0042 0.0173 0.0204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.116 0.1365
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Echinococcus granulosus Excitatory amino acid transporter 0.1343 0.847 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0039 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1096 0.129
Loa Loa (eye worm) hypothetical protein 0.0072 0.0367 0.0434
Echinococcus granulosus excitatory amino acid transporter 2 0.1343 0.847 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0447 0.0364
Loa Loa (eye worm) hypothetical protein 0.0042 0.0173 0.0204
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0039 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0367 0.1285
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.001 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0144 0.017
Brugia malayi hypothetical protein 0.0024 0.0064 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1896 0.6632
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0155 0.0543
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0367 0.0363
Brugia malayi beta-lactamase 0.0111 0.0615 0.0727
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0287 0.4664
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0615 0.2152
Echinococcus granulosus sodium:dicarboxylate symporter 0.1343 0.847 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0155 0.0151
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0287 0.4664
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0146 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0447 0.0364
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0187 0.3037
Echinococcus multilocularis neutral amino acid transporter A 0.1343 0.847 0.8469
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1369 0.1365
Plasmodium vivax glutathione reductase, putative 0.0037 0.0144 0.2285
Brugia malayi jmjC domain containing protein 0.006 0.0292 0.0344
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0367 0.0363
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0064 0.2084
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0287 0.0282
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0155 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.004
Toxoplasma gondii ABC1 family protein 0.0111 0.0615 0.5286
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0525 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1896 0.6632
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0615 0.0566
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0155 0.0543
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0032 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0292 0.0339
Echinococcus multilocularis snurportin 1 0.0635 0.3956 0.3953
Loa Loa (eye worm) hypothetical protein 0.0068 0.0344 0.0406
Loa Loa (eye worm) hypothetical protein 0.0111 0.0615 0.0727
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0146 0.2369
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0292 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Plasmodium falciparum thioredoxin reductase 0.0037 0.0144 0.4943
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0155 0.2523
Trichomonas vaginalis esterase, putative 0.0111 0.0615 0.2152
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1714 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0615 0.0722
Schistosoma mansoni survival motor neuron protein 0.0047 0.0206 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Echinococcus granulosus neutral amino acid transporter A 0.1343 0.847 1
Onchocerca volvulus 0.0059 0.0287 0.0338
Echinococcus multilocularis protein dispatched 1 0.0047 0.021 0.0205
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0124
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0367 0.597
Echinococcus multilocularis excitatory amino acid transporter 2 0.1343 0.847 0.8469
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1343 0.847 0.8469
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0077
Loa Loa (eye worm) hypothetical protein 0.0322 0.1961 0.2315
Schistosoma mansoni hypothetical protein 0.017 0.0993 0.1167
Schistosoma mansoni alpha-glucosidase 0.0151 0.0868 0.1019
Schistosoma mansoni ap endonuclease 0.0037 0.0146 0.0167
Brugia malayi Excitatory amino acid transporter 0.1343 0.847 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0215 0.3498
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0827 0.0977
Loa Loa (eye worm) hypothetical protein 0.0111 0.0615 0.0727
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0039 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0064 0.1033
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0595 0.3703 0.4369
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1714 0.4407
Echinococcus multilocularis cpg binding protein 0.0059 0.0285 0.0281
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0173 0.0198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0039 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0615 0.2152
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0367 0.0428
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0187 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0287 0.0333
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0144 0.2285
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0615 0.0566
Schistosoma mansoni hypothetical protein 0.017 0.0993 0.1167
Schistosoma mansoni hypothetical protein 0.004 0.0163 0.0187
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.079 1
Schistosoma mansoni alpha-glucosidase 0.0151 0.0868 0.1019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0615 0.0566
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0546 0.0645
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.1023 0.1208
Echinococcus multilocularis excitatory amino acid transporter 3 0.1343 0.847 0.8469
Schistosoma mansoni hypothetical protein 0.0047 0.0206 0.0238
Leishmania major importin beta-1 subunit, putative 0.0048 0.0215 0.1856
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0173 0.0198
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0271 0.0267
Brugia malayi nuclear hormone receptor 0.0021 0.0039 0.0046
Leishmania major hypothetical protein, conserved 0.0024 0.0064 0.0548
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.1508 0.178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0039 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0064 0.1033
Echinococcus granulosus neuropeptide s receptor 0.045 0.2776 0.3273
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0367 0.1285
Schistosoma mansoni ran 0.0044 0.0187 0.0215
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0039 0.004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0196 0.116 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0615 0.0566
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0155 0.0543
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0287 0.0333
Echinococcus granulosus excitatory amino acid transporter 2 0.1343 0.847 1
Schistosoma mansoni hypothetical protein 0.004 0.0163 0.0187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0051 0.0232 0.0274
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0229 0.1369 0.1616
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0615 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.004
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0187 0.0262
Schistosoma mansoni coup transcription factor 0.0021 0.0039 0.004
Plasmodium vivax importin-beta 2, putative 0.0059 0.0287 0.4622
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0635 0.3956 0.4671
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0146 0.0851
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1343 0.847 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0146 0.0167
Echinococcus granulosus importin subunit beta 1 0.0059 0.0287 0.0333
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.011 0.013
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0039 0.0046
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0344 0.0406
Echinococcus granulosus muscleblind protein 0.0322 0.1961 0.2311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1096 0.129
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1343 0.847 0.8469
Mycobacterium ulcerans lipase LipD 0.0111 0.0615 0.463
Echinococcus multilocularis GPCR, family 2 0.0032 0.011 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0615 0.2152
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0039 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.0034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0367 0.1285
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0525 0.3063
Loa Loa (eye worm) hypothetical protein 0.0111 0.0615 0.0727
Echinococcus multilocularis protein patched 0.0042 0.0173 0.0168
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0615 0.0566
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.116 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0615 0.463
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0146 0.2369
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0124
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0039 0.0034
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0367 0.2144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1714 0.5992
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0615 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0615 0.0722
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0595 0.3703 0.37
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.0046
Treponema pallidum glutamate/aspartate transporter 0.0595 0.3703 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0367 0.0434
Loa Loa (eye worm) beta-lactamase 0.0111 0.0615 0.0727
Brugia malayi nuclear receptor NHR-88 0.0021 0.0039 0.0046
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.001 0.0005
Echinococcus multilocularis expressed conserved protein 0.0091 0.0487 0.0483
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0146 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0173 0.0604
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.0046
Leishmania major GTP-binding protein, putative 0.0044 0.0187 0.1611
Brugia malayi beta-lactamase family protein 0.0111 0.0615 0.0727
Brugia malayi beta-lactamase family protein 0.0111 0.0615 0.0727
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0196 0.116 0.1156
Trichomonas vaginalis set domain proteins, putative 0.0463 0.286 1
Schistosoma mansoni cpg binding protein 0.0059 0.0285 0.0331
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0635 0.3956 0.4668
Brugia malayi jmjC domain containing protein 0.0057 0.0271 0.032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0271 0.0267
Loa Loa (eye worm) hypothetical protein 0.0111 0.0615 0.0727
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0146 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.0046
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0155 0.0906
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0615 1
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1283 0.4486
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.4325 0.4323
Entamoeba histolytica Ran family GTPase 0.0044 0.0187 0.1091
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0292 0.0339
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1896 0.6632
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.2502 0.2954
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0507 0.0436
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0525 0.052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0196 0.116 0.122
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0615 0.2152
Brugia malayi RNA, U transporter 1 0.0169 0.0986 0.1164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0039 0.004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.0046
Schistosoma mansoni ran 0.0044 0.0187 0.0215
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0215 0.0753
Brugia malayi Importin beta-1 subunit 0.0059 0.0287 0.0339
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.116 0.1365
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0287 0.0333
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0173 0.0168
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0287 0.244
Mycobacterium ulcerans beta-lactamase 0.0111 0.0615 0.463
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0032 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0615 0.2152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.004
Brugia malayi MH2 domain containing protein 0.0144 0.0827 0.0977
Mycobacterium ulcerans hypothetical protein 0.0111 0.0615 0.463
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0196 0.116 0.1365
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1213 0.424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.0046
Schistosoma mansoni alpha glucosidase 0.0039 0.0155 0.0178
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0187 0.0221
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1369 0.1611
Echinococcus granulosus expressed conserved protein 0.0091 0.0487 0.057
Mycobacterium leprae Probable lipase LipE 0.0111 0.0615 0.491
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0039 0.004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1714 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0595 0.3703 0.4369
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0367 0.0428
Loa Loa (eye worm) hypothetical protein 0.0059 0.0287 0.0339
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0155 0.0543
Echinococcus granulosus excitatory amino acid transporter 3 0.1343 0.847 1
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0155 0.1338
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0271 0.0315
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0287 0.0333
Echinococcus granulosus snurportin 1 0.0635 0.3956 0.4668
Brugia malayi CXXC zinc finger family protein 0.0056 0.0265 0.0313
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0206 0.0243
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.079 0.0785
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0077
Brugia malayi Muscleblind-like protein 0.0322 0.1961 0.2315
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0173 0.0204
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.2776 0.2772
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0039 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0155 0.0543
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0144 0.2344
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.011 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0039 0.004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0367 0.597
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.011 0.0124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0039 0.004
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0615 0.0722
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0827 0.0977
Trypanosoma brucei glucosidase, putative 0.0039 0.0155 0.2523
Leishmania major hypothetical protein, conserved 0.0111 0.0615 0.5305
Onchocerca volvulus 0.0463 0.286 0.3376
Loa Loa (eye worm) glutathione reductase 0.0037 0.0144 0.017
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.079 0.0775
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0039 0.004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0187 0.0215
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0187 0.3037
Loa Loa (eye worm) excitatory amino acid transporter 0.1343 0.847 1
Plasmodium falciparum glutathione reductase 0.0037 0.0144 0.4943
Echinococcus granulosus Excitatory amino acid transporter 0.1343 0.847 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1896 0.6632
Echinococcus multilocularis geminin 0.017 0.0993 0.0988
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.079 0.635
Trypanosoma brucei trypanothione reductase 0.0037 0.0144 0.2344
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0525 0.062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0039 0.004
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1023 0.1019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.011 0.013
Echinococcus multilocularis muscleblind protein 0.0322 0.1961 0.1957
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0367 0.597
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1896 0.6632
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0039 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.011 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046
Mycobacterium tuberculosis Conserved protein 0.0111 0.0615 0.0566
Schistosoma mansoni importin beta-1 0.0059 0.0287 0.0333
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0367 0.0428
Onchocerca volvulus 0.0101 0.0553 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.0046
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0124
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0546 0.0645
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.116 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0155 0.0183
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0064 0.1033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0679 0.0796
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0215 0.0753
Echinococcus granulosus cpg binding protein 0.0059 0.0285 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0615 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0615 0.0727
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0615 0.0566
Brugia malayi ecdysteroid receptor 0.0021 0.0039 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0006
Entamoeba histolytica hypothetical protein 0.0048 0.0215 0.1257
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0265 0.0313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0287 0.0282
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0534 0.0626
Treponema pallidum glutamate transporter 0.0595 0.3703 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1714 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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