Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0332 | 0.7382 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus granulosus | jun protein | 0.0086 | 0.1347 | 0.2275 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0075 | 0.1079 | 0.098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Onchocerca volvulus | 0.0075 | 0.1079 | 0.098 | |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0242 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | conserved hypotetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0075 | 0.1079 | 0.1333 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0848 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0173 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | ecdysteroid receptor | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | nuclear receptor NHR-67 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.129 | 0.129 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0242 | 0.0181 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0075 | 0.1079 | 0.1079 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0848 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0041 | 0.0242 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | coup transcription factor | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | nuclear receptor RXR | 0.004 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0035 | 0.011 | 0.011 |
Brugia malayi | steroid hormone receptor | 0.0075 | 0.1079 | 0.1079 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0075 | 0.1079 | 0.098 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0175 | 0.3547 | 0.4726 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 0.1347 | 0.1701 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0082 | 0.0969 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0035 | 0.011 | 0.011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1333 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0136 | 0.2578 | 0.3394 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1782 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0075 | 0.1079 | 0.1333 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0075 | 0.1079 | 0.098 |
Onchocerca volvulus | 0.0439 | 1 | 1 | |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.0848 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0242 | 0.0243 |
Brugia malayi | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.0954 | 0.1159 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0075 | 0.1079 | 0.1782 |
Echinococcus granulosus | FTZ F1 alpha | 0.0075 | 0.1079 | 0.1782 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0173 | 0.0115 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0035 | 0.011 | 0.011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0035 | 0.011 | 0.011 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0848 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.004 | 0.0214 | 0.0214 |
Brugia malayi | nuclear receptor RXR | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0848 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0896 | 0.0896 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.1079 | 0.1333 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 0.1347 | 0.2275 |
Schistosoma mansoni | hypothetical protein | 0.0257 | 0.5548 | 0.7478 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.004 | 0.0214 | 0.0191 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | ecdysone receptor | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0954 | 0.1159 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.004 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0035 | 0.011 | 0.011 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0242 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.1079 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0242 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0848 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | Protein lozenge | 0.0055 | 0.0594 | 0.0665 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | runx1 | 0.0055 | 0.0594 | 0.0594 |
Brugia malayi | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0041 | 0.0242 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | nuclear hormone receptor | 0.0035 | 0.011 | 0.011 |
Brugia malayi | bZIP transcription factor family protein | 0.0086 | 0.1347 | 0.1347 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | nuclear hormone receptor | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | thyroid hormone receptor | 0.0332 | 0.7382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0035 | 0.011 | 0.011 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0257 | 0.5548 | 0.7478 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0075 | 0.1079 | 0.1079 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0075 | 0.1079 | 0.1782 |
Brugia malayi | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0075 | 0.1079 | 0.1333 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1782 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0175 | 0.3547 | 0.632 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | lozenge | 0.0055 | 0.0594 | 0.0665 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.004 | 0.0214 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | DR-78 | 0.0035 | 0.011 | 0.011 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.1079 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | tailless protein | 0.0035 | 0.011 | 0.011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus multilocularis | jun protein | 0.0086 | 0.1347 | 0.1701 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.004 | 0.0214 | 0.0143 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0082 | 0.0969 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0075 | 0.1079 | 0.1333 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.1079 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.004 | 0.0214 | 0.0143 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0257 | 0.5548 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1333 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0848 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | nuclear receptor NHR-88 | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Schistosoma mansoni | thyroid hormone receptor | 0.0332 | 0.7382 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.011 | 0.011 |
Onchocerca volvulus | 0.0067 | 0.0896 | 0.0794 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0035 | 0.011 | 0.011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0848 | 0.0848 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.004 | 0.0214 | 0.0214 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0075 | 0.1079 | 0.1333 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0075 | 0.1079 | 0.1333 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0848 | 0.1357 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CT10 (functional) | > 2720 uM h | Cytotoxicity was measured for 90% kill in UV4 cells under aerobic conditions | ChEMBL. | 8515422 |
HF ratio (functional) | = 2.7 | Hypersensitivity factor is the ratio of IC50(AA8) to IC50(UV4) under aerobic conditions | ChEMBL. | 8515422 |
IC50 (functional) | = 650 uM | Growth inhibition against CHO-derived cell line AA8 | ChEMBL. | 8515422 |
Ratio (functional) | > 1 | Ratio of aerobic CT10 to that of hypoxic CT10 | ChEMBL. | 8515422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.