Detailed information for compound 803670

Basic information

Technical information
  • TDR Targets ID: 803670
  • Name: N-(2-methoxyethyl)-2-[[2-(3-methylphenyl)-5-p henyl-1H-imidazol-4-yl]sulfanyl]acetamide
  • MW: 381.491 | Formula: C21H23N3O2S
  • H donors: 2 H acceptors: 2 LogP: 3.61 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)CSc1[nH]c(nc1c1ccccc1)c1cccc(c1)C
  • InChi: 1S/C21H23N3O2S/c1-15-7-6-10-17(13-15)20-23-19(16-8-4-3-5-9-16)21(24-20)27-14-18(25)22-11-12-26-2/h3-10,13H,11-12,14H2,1-2H3,(H,22,25)(H,23,24)
  • InChiKey: WPHXHMRZMMNXRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxyethyl)-2-[[2-(3-methylphenyl)-5-phenyl-1H-imidazol-4-yl]thio]acetamide
  • N-(2-methoxyethyl)-2-[[2-(3-methylphenyl)-5-phenyl-1H-imidazol-4-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0134 0.159 0.1783
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0468 0.1128
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.085 0.1093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.2387 0.46
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0805 0.0805
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.3016 0.3841
Schistosoma mansoni hypothetical protein 0.0036 0.033 0.0636
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0329 0.0424
Echinococcus multilocularis caspase 2 0.0091 0.1033 0.1328
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Schistosoma mansoni cpg binding protein 0.0065 0.0698 0.1345
Schistosoma mansoni caspase-3 (C14 family) 0.0124 0.1465 0.2824
Leishmania major metacaspase, putative 0.0047 0.0468 0.1751
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.085 0.1093
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.0468 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0662 0.1275
Brugia malayi PHD-finger family protein 0.0029 0.023 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.085 0.2125
Loa Loa (eye worm) hypothetical protein 0.0071 0.0783 0.0783
Schistosoma mansoni hypothetical protein 0.0015 0.0061 0.0117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.085 0.2125
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0468 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0355 0.0457
Entamoeba histolytica serine/threonine protein kinase, putative 0.0196 0.2387 0.5991
Echinococcus multilocularis Kelch repeat type 1 0.0096 0.1095 0.1408
Trichomonas vaginalis esterase, putative 0.0038 0.0355 0.0834
Loa Loa (eye worm) hypothetical protein 0.0038 0.0355 0.0355
Onchocerca volvulus 0.0038 0.0355 0.0355
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0016 0.0021
Loa Loa (eye worm) beta-lactamase 0.0038 0.0355 0.0355
Schistosoma mansoni kinase 0.0099 0.1145 0.2207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.01 0.0193
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Mycobacterium ulcerans lipoprotein LpqF 0.0064 0.0691 0.0485
Trypanosoma cruzi metacaspase, putative 0.0047 0.0468 0.1751
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0207 0.0629
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0355 0.0355
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.085 0.1093
Trypanosoma brucei polo-like protein kinase 0.0196 0.2387 1
Loa Loa (eye worm) fli-1 protein 0.0222 0.2725 0.2725
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0124 0.1465 0.1884
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0079 0.0101
Schistosoma mansoni caspase-7 (C14 family) 0.0091 0.1033 0.1991
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.085 0.2125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0084 0.0107
Brugia malayi Ets-domain containing protein 0.0073 0.0805 0.0805
Mycobacterium ulcerans glutaminase 0.029 0.361 0.4699
Echinococcus granulosus caspase 8 0.0047 0.0468 0.0602
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0662 0.1275
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0575 0.7281 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0662 0.1275
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0052 0.0067
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0084 0.0107
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1819 0.2114
Onchocerca volvulus Serine\/threonine kinase homolog 0.0196 0.2387 0.2387
Trypanosoma cruzi metacaspase, putative 0.0047 0.0468 0.1751
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Brugia malayi hypothetical protein 0.0144 0.1721 0.1721
Loa Loa (eye worm) hypothetical protein 0.0613 0.7777 0.7777
Onchocerca volvulus Huntingtin homolog 0.013 0.1541 0.1541
Loa Loa (eye worm) hypothetical protein 0.0062 0.0668 0.0668
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Echinococcus multilocularis caspase 8 0.0047 0.0468 0.0602
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0662 0.1275
Loa Loa (eye worm) hypothetical protein 0.0038 0.0355 0.0355
Brugia malayi MH1 domain containing protein 0.0017 0.0079 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0247 0.3054 0.3054
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0099 0.0127
Loa Loa (eye worm) hypothetical protein 0.0077 0.085 0.085
Onchocerca volvulus 0.0785 1 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.085 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1112 0.2807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0172 0.048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0064 0.0691 0.0485
Schistosoma mansoni hypothetical protein 0.0044 0.0426 0.0822
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0355 0.1266
Brugia malayi hypothetical protein 0.0044 0.0426 0.0426
Echinococcus multilocularis cpg binding protein 0.0065 0.0698 0.0898
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.1092 0.1404
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0662 0.1275
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0426 0.0548
Brugia malayi Bromodomain containing protein 0.0039 0.036 0.036
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0046 0.0456 0.1699
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.5189 0.6673
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.0468 0.0902
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Echinococcus granulosus geminin 0.0351 0.4392 0.5648
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0575 0.7281 1
Leishmania major hypothetical protein, conserved 0.0027 0.0207 0.0629
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0016 0.0021
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0098 0.1126 0.258
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0196 0.2387 1
Brugia malayi Ets-domain containing protein 0.0073 0.0805 0.0805
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Schistosoma mansoni smad1 5 8 and 0.0017 0.0079 0.0152
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.085 0.1093
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0032
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.1092 0.1404
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0805 0.1035
Echinococcus granulosus kelch ECH associated protein 1 0.0095 0.1092 0.1404
Trypanosoma cruzi metacaspase, putative 0.0047 0.0468 0.1751
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0613 0.7777 0.7777
Brugia malayi MH2 domain containing protein 0.0017 0.0079 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0662 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0468 0.1128
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0199 0.0256
Toxoplasma gondii ABC1 family protein 0.0038 0.0355 0.1299
Loa Loa (eye worm) glutaminase 2 0.029 0.361 0.361
Brugia malayi TAR-binding protein 0.0062 0.0662 0.0662
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.1092 0.1404
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0468 0.1751
Echinococcus multilocularis zinc finger protein 0.0023 0.016 0.0206
Entamoeba histolytica hypothetical protein 0.0036 0.033 0.0426
Brugia malayi Muscleblind-like protein 0.0613 0.7777 0.7777
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.085 0.1093
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0468 0.1751
Loa Loa (eye worm) hypothetical protein 0.0046 0.0461 0.0461
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0052 0.0067
Brugia malayi hypothetical protein 0.0017 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0355 0.0355
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0079 0.0079
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0355 0.0457
Schistosoma mansoni tsg101-related 0.012 0.141 0.2717
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0196 0.2387 0.307
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.085 0.3394
Plasmodium falciparum metacaspase-like protein 0.0047 0.0468 1
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0805 0.1035
Brugia malayi CXXC zinc finger family protein 0.0059 0.0629 0.0629
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0575 0.7281 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0079 0.0101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.033 0.0424
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0361
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0355 0.1266
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0468 0.2289
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0134 0.159 0.1783
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0351 0.4392 0.8464
Giardia lamblia Kinase, PLK 0.0196 0.2387 0.5091
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0629 0.0629
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0662 0.0851
Loa Loa (eye worm) Smad1 0.0017 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0172 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0052 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0355 0.0684
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.085 0.3394
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.085 0.1638
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.3869 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Schistosoma mansoni tsg101-related 0.0098 0.1126 0.217
Echinococcus multilocularis muscleblind protein 0.0613 0.7777 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0355 0.0834
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1819 0.2114
Brugia malayi Bromodomain containing protein 0.0079 0.0882 0.0882
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0355 0.0684
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0468 0.2289
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0079 0.0101
Schistosoma mansoni caspase-7 (C14 family) 0.0124 0.1465 0.2824
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0468 0.1128
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Trypanosoma cruzi polo-like protein kinase, putative 0.0196 0.2387 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.033 0.0424
Schistosoma mansoni Smad4 0.0017 0.0079 0.0152
Echinococcus multilocularis geminin 0.0351 0.4392 0.5648
Schistosoma mansoni glutaminase 0.029 0.361 0.6957
Schistosoma mansoni hypothetical protein 0.0096 0.1095 0.211
Trypanosoma brucei beta lactamase 0.0064 0.0691 0.271
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.013 0.013
Brugia malayi Fli-1 protein 0.0222 0.2725 0.2725
Schistosoma mansoni smad1 5 8 and 0.0017 0.0079 0.0152
Brugia malayi MH2 domain containing protein 0.0247 0.3054 0.3054
Echinococcus multilocularis caspase 3 0.0077 0.0859 0.1104
Onchocerca volvulus 0.0044 0.0426 0.0426
Echinococcus multilocularis muscleblind protein 1 0.0613 0.7777 1
Entamoeba histolytica hypothetical protein 0.0036 0.033 0.0426
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0683 0.0878
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0426 0.0548
Brugia malayi hypothetical protein 0.0027 0.0207 0.0207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0329 0.0424
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0199 0.0256
Schistosoma mansoni hypothetical protein 0.0021 0.013 0.0251
Brugia malayi beta-lactamase family protein 0.0038 0.0355 0.0355
Brugia malayi RNA binding protein 0.0062 0.0662 0.0662
Echinococcus granulosus caspase 3 0.0077 0.0859 0.1104
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0207 0.0629
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0196 0.2387 0.307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0662 0.0662
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0084 0.0161
Brugia malayi beta-lactamase family protein 0.0038 0.0355 0.0355
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0199 0.0383
Schistosoma mansoni hypothetical protein 0.0413 0.5189 1
Onchocerca volvulus 0.0038 0.0355 0.0355
Trichomonas vaginalis hypothetical protein 0.007 0.0767 0.1908
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1112 0.2807
Schistosoma mansoni zinc finger protein 0.0023 0.016 0.0309
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.3869 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0207 0.0629
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0662 0.0662
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0144 0.1721 0.2213
Echinococcus multilocularis caspase 0.0124 0.1465 0.1884
Brugia malayi Cell death protein 3 precursor 0.0091 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0468 0.1128
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Loa Loa (eye worm) hypothetical protein 0.0047 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0091 0.1033 0.1033
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1819 0.2114
Echinococcus granulosus caspase 2 0.0091 0.1033 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0468 0.1128
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0355 0.0355
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Schistosoma mansoni smad1 5 8 and 0.0017 0.0079 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0172 0.048
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0355 0.0834
Loa Loa (eye worm) hypothetical protein 0.013 0.1541 0.1541
Trypanosoma brucei Metacaspase-4 0.0047 0.0468 0.1751
Echinococcus granulosus muscleblind protein 0.0613 0.7777 1
Echinococcus granulosus Smad4 0.0017 0.0079 0.0101
Echinococcus granulosus tar DNA binding protein 0.0062 0.0662 0.0851
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0084 0.0161
Loa Loa (eye worm) hypothetical protein 0.013 0.1541 0.1541
Trypanosoma cruzi metacaspase, putative 0.0047 0.0468 0.1751
Brugia malayi hypothetical protein 0.013 0.1541 0.1541
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0468 0.1128
Brugia malayi glutaminase DH11.1 0.029 0.361 0.361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Entamoeba histolytica hypothetical protein 0.0036 0.033 0.0426
Trypanosoma cruzi polo-like protein kinase, putative 0.0196 0.2387 1
Trypanosoma brucei metacaspase MCA2 0.0047 0.0468 0.1751
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0683 0.0878
Schistosoma mansoni tsg101-related 0.012 0.141 0.2717
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Brugia malayi MH1 domain containing protein 0.0017 0.0079 0.0079
Onchocerca volvulus Cell death protein 3 homolog 0.0091 0.1033 0.1033
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.3869 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0355 0.5674
Onchocerca volvulus 0.0059 0.0629 0.0629
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0468 0.2289
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Leishmania major hypothetical protein, conserved 0.0038 0.0355 0.1266
Brugia malayi beta-lactamase 0.0038 0.0355 0.0355
Echinococcus multilocularis smad 0.0017 0.0079 0.0101
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0046 0.0456 0.1699
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0079 0.0152
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.085 0.3394
Schistosoma mansoni ets-related 0.0222 0.2725 0.5252
Loa Loa (eye worm) RNA binding protein 0.0062 0.0662 0.0662
Plasmodium falciparum metacaspase 1 0.0047 0.0468 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.01 0.0129
Schistosoma mansoni zinc finger protein 0.0015 0.0061 0.0117
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.3869 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0172 0.0357
Echinococcus granulosus zinc finger protein 0.0023 0.016 0.0206
Loa Loa (eye worm) transcription factor SMAD2 0.0247 0.3054 0.3054
Schistosoma mansoni cpg binding protein 0.0059 0.0629 0.1213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1347 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0355 0.1266
Trypanosoma brucei metacaspase MCA3 0.0047 0.0468 0.1751
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0064 0.0691 0.0485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.01 0.0193
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0355 0.0834
Schistosoma mansoni gabp alpha 0.0073 0.0805 0.1551
Schistosoma mansoni smad 0.0017 0.0079 0.0152
Trypanosoma brucei metacaspase 0.0047 0.0468 0.1751
Leishmania major hypothetical protein, conserved 0.0046 0.0456 0.1699
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.3869 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0052 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.085 0.3394
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0355 0.0834
Brugia malayi Smad1 0.0017 0.0079 0.0079
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.033 0.0636
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Loa Loa (eye worm) hypothetical protein 0.0785 1 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0052 0.0067
Echinococcus granulosus cpg binding protein 0.0065 0.0698 0.0898
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0092 0.0092
Onchocerca volvulus 0.0038 0.0355 0.0355
Brugia malayi MH2 domain containing protein 0.0017 0.0079 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0099 0.0127
Trichomonas vaginalis glutaminase, putative 0.029 0.361 0.9324
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.01
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0196 0.2387 0.2387
Schistosoma mansoni cpg binding protein 0.0065 0.0698 0.1345
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0124 0.1465 0.1884
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0468 0.1128
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.01 0.0129
Echinococcus granulosus smad 0.0017 0.0079 0.0101
Loa Loa (eye worm) hypothetical protein 0.0038 0.0355 0.0355
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0355 0.0834
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0079 0.0101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0355 0.0355
Entamoeba histolytica hypothetical protein 0.0036 0.033 0.0426
Echinococcus granulosus dnaJ subfamily B 0.0413 0.5189 0.6673
Brugia malayi serine/threonine-protein kinase plk-2 0.0196 0.2387 0.2387
Loa Loa (eye worm) hypothetical protein 0.0038 0.0355 0.0355
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.085 0.1638
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.085 0.1093
Loa Loa (eye worm) glutaminase 0.029 0.361 0.361
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.1092 0.1404
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0144 0.1721 0.2213
Loa Loa (eye worm) hypothetical protein 0.0144 0.1721 0.1721
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2387 0.6134
Echinococcus multilocularis Smad4 0.0017 0.0079 0.0101
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Brugia malayi hypothetical protein 0.0036 0.033 0.033
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0099 0.0099
Onchocerca volvulus Huntingtin homolog 0.013 0.1541 0.1541
Plasmodium vivax metacaspase 1, putative 0.0047 0.0468 1
Schistosoma mansoni hypothetical protein 0.0351 0.4392 0.8464
Schistosoma mansoni bromodomain containing protein 0.0067 0.0729 0.1406
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0121 0.0121
Trypanosoma brucei metacaspase 5, putative 0.0047 0.0468 0.1751
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.149 0.2872
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0172 0.048
Echinococcus granulosus caspase 0.0124 0.1465 0.1884

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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