Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0166 | 0.113 | 0.027 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.0337 | 0.284 |
Trypanosoma cruzi | ISWI complex protein | 0.0085 | 0.0507 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0098 | 0.0608 | 0.0657 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.0281 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.1679 | 0.1882 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0779 | 0.5849 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0261 | 0.1861 | 0.2428 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.0383 | 0.4777 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0507 | 0.0812 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0125 | 0.0817 | 0.0447 |
Onchocerca volvulus | 0.0166 | 0.113 | 0.0874 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0166 | 0.113 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0332 | 0.2409 | 0.3469 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0095 | 0.0582 | 0.0941 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.02 | 0.1391 | 0.1536 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0332 | 0.2409 | 0.3469 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0383 | 0.4777 |
Brugia malayi | Bromodomain containing protein | 0.0213 | 0.1492 | 0.0731 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0383 | 0.4777 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0125 | 0.0817 | 0.0447 |
Echinococcus granulosus | zinc finger protein | 0.0109 | 0.069 | 0.0205 |
Brugia malayi | Bromodomain containing protein | 0.0417 | 0.3065 | 0.2734 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0166 | 0.113 | 0.1885 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0383 | 0.4777 |
Brugia malayi | Pre-SET motif family protein | 0.1158 | 0.8768 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0166 | 0.113 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0166 | 0.113 | 0.1885 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0261 | 0.1861 | 0.3141 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0166 | 0.113 | 0.1041 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1495 | 0.1672 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.2881 | 0.326 |
Trichomonas vaginalis | set domain proteins, putative | 0.1318 | 1 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0779 | 0.5849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.1861 | 0.2091 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0779 | 0.5849 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.016 | 0.1083 | 0.0952 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.1158 | 0.8768 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.02 | 0.1391 | 0.1536 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0281 | 0.0282 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0115 | 0.0736 | 0.0802 |
Trypanosoma cruzi | ISWI complex protein | 0.0085 | 0.0507 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0381 | 0.2788 | 0.4188 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0261 | 0.1861 | 0.3141 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0125 | 0.0817 | 0.1346 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0736 | 0.1205 |
Schistosoma mansoni | zinc finger protein | 0.0109 | 0.069 | 0.1127 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0095 | 0.0582 | 0.0941 |
Schistosoma mansoni | bromodomain containing protein | 0.0352 | 0.2563 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1597 | 0.1789 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.0507 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0261 | 0.1861 | 0.2428 |
Echinococcus granulosus | tumor protein p63 | 0.0381 | 0.2788 | 0.4188 |
Echinococcus multilocularis | zinc finger protein | 0.0109 | 0.069 | 0.0205 |
Trypanosoma brucei | ISWI complex protein | 0.0085 | 0.0507 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0085 | 0.0507 | 0.0812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.