Detailed information for compound 803999

Basic information

Technical information
  • TDR Targets ID: 803999
  • Name: 4-[(2,1,3-benzothiadiazol-7-ylsulfonylamino)m ethyl]-N-(3-methylphenyl)cyclohexane-1-carbox amide
  • MW: 444.57 | Formula: C21H24N4O3S2
  • H donors: 2 H acceptors: 5 LogP: 3.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)C1CCC(CC1)CNS(=O)(=O)c1cccc2c1nsn2
  • InChi: 1S/C21H24N4O3S2/c1-14-4-2-5-17(12-14)23-21(26)16-10-8-15(9-11-16)13-22-30(27,28)19-7-3-6-18-20(19)25-29-24-18/h2-7,12,15-16,22H,8-11,13H2,1H3,(H,23,26)
  • InChiKey: SYBTYNSLIMWPFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(2,1,3-benzothiadiazol-7-ylsulfonylamino)methyl]-N-(3-methylphenyl)-1-cyclohexanecarboxamide
  • N-(3-methylphenyl)-4-[(piazthiol-4-ylsulfonylamino)methyl]cyclohexane-1-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni furin-1 (S08 family) 0.0328 0.3385 0.4191
Toxoplasma gondii subtilisin SUB8 0.0032 0.0127 0.0927
Echinococcus granulosus beta LACTamase domain containing family member 0.0146 0.1373 0.17
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0032 0.0127 0.0158
Echinococcus multilocularis peregrin 0.0029 0.0087 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Plasmodium vivax SET domain protein, putative 0.0031 0.0117 0.0856
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0087 0.0633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Toxoplasma gondii subtilisin SUB6 0.0032 0.0127 0.0927
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0087 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0422 0.0522
Toxoplasma gondii ABC1 family protein 0.0146 0.1373 1
Loa Loa (eye worm) proprotein convertase 2 0.0178 0.1734 0.2146
Brugia malayi Pre-SET motif family protein 0.0031 0.0117 0.0145
Loa Loa (eye worm) hypothetical protein 0.0146 0.1373 0.17
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0032 0.0127 0.0114
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0032 0.0127 0.0114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0087 0.0108
Loa Loa (eye worm) hypothetical protein 0.0146 0.1373 0.17
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0459 0.482 0.5967
Loa Loa (eye worm) hypothetical protein 0.0215 0.2136 0.2644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0776 0.0884
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0178 0.1734 0.3597
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0014 0.0047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0117 0.0856
Plasmodium falciparum subtilisin-like protease 2 0.0032 0.0127 1
Toxoplasma gondii exonuclease III APE 0.0022 0.0014 0.0098
Plasmodium falciparum subtilisin-like protease 3 0.0032 0.0127 1
Schistosoma mansoni hypothetical protein 0.0099 0.0866 0.1073
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0032 0.0127 0.0158
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Mycobacterium ulcerans beta-lactamase 0.0146 0.1373 1
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.1373 1
Echinococcus granulosus geminin 0.0505 0.5329 0.6597
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0459 0.482 1
Mycobacterium tuberculosis Probable esterase LipL 0.0146 0.1373 0.1362
Schistosoma mansoni site-1 peptidase (S08 family) 0.0032 0.0127 0.0158
Brugia malayi beta-lactamase family protein 0.0146 0.1373 0.17
Echinococcus multilocularis membrane bound transcription factor site 1 0.0032 0.0127 0.0145
Plasmodium vivax subtilisin-like protease 1 0.0032 0.0127 0.0927
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0145
Brugia malayi jmjC domain containing protein 0.0035 0.0153 0.019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0776 0.0961
Schistosoma mansoni hypothetical protein 0.0029 0.0087 0.0108
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0117 0.0134
Mycobacterium leprae Probable lipase LipE 0.0146 0.1373 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0082 0.0595
Loa Loa (eye worm) hypothetical protein 0.0314 0.323 0.3999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0776 0.0961
Brugia malayi beta-lactamase 0.0146 0.1373 0.17
Leishmania major importin beta-1 subunit, putative 0.0023 0.0023 0.0169
Brugia malayi Bromodomain containing protein 0.0029 0.0087 0.0108
Toxoplasma gondii subtilisin SUB7 0.0032 0.0127 0.0927
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0178 0.1734 0.2146
Leishmania major hypothetical protein, conserved 0.0146 0.1373 1
Schistosoma mansoni hypothetical protein 0.0099 0.0866 0.1073
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0032 0.0127 0.0145
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0032 0.0127 0.0837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0776 0.0961
Echinococcus multilocularis Furin 1 0.0178 0.1734 0.1974
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0819 0.8785 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0776 0.0961
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0014 0.0015
Schistosoma mansoni hypothetical protein 0.03 0.3074 0.3806
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0064 0.5009
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0064 0.0465
Echinococcus granulosus Furin 1 0.0178 0.1734 0.2146
Echinococcus multilocularis 0.0609 0.6471 0.7367
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Mycobacterium tuberculosis Conserved protein 0.0146 0.1373 0.1362
Trypanosoma cruzi subtilisin peptidase 0.0032 0.0127 0.0927
Loa Loa (eye worm) hypothetical protein 0.0146 0.1373 0.17
Schistosoma mansoni ap endonuclease 0.0022 0.0014 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0064 0.0465
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0105 0.013
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0032 0.0127 0.0927
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Brugia malayi jmjC domain containing protein 0.0094 0.0803 0.0994
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0023 0.0048
Trichomonas vaginalis set domain proteins, putative 0.0249 0.2511 0.5209
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0032 0.0127 0.0158
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0755 0.8078 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0064 0.0465
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0023 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Entamoeba histolytica hypothetical protein 0.0023 0.0023 1
Schistosoma mansoni hypothetical protein 0.0215 0.2136 0.2644
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0145
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0032 0.0127 0.0158
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Toxoplasma gondii subtilisin SUB11 0.0032 0.0127 0.0927
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0014 0.1061
Mycobacterium tuberculosis Probable lipase LipE 0.0146 0.1373 0.1362
Loa Loa (eye worm) hypothetical protein 0.0146 0.1373 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Plasmodium vivax subtilisin-like protease 2, putative 0.0032 0.0127 0.0927
Loa Loa (eye worm) hypothetical protein 0.0146 0.1373 0.17
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.1373 0.2849
Onchocerca volvulus 0.0249 0.2511 1
Schistosoma mansoni hypothetical protein 0.0505 0.5329 0.6597
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0178 0.1734 0.3597
Mycobacterium tuberculosis Probable lipase LipD 0.0146 0.1373 0.1362
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0153 0.0174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0146 0.1373 0.1362
Loa Loa (eye worm) hypothetical protein 0.0146 0.1373 0.17
Schistosoma mansoni hypothetical protein 0.0099 0.0866 0.1073
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0014 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0014 0.0098
Toxoplasma gondii subtilisin SUB2 0.0032 0.0127 0.0927
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0032 0.0127 0.0158
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0032 0.0127 0.0114
Echinococcus multilocularis neuroendocrine convertase 2 0.0474 0.4992 0.5682
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0117 0.0145
Brugia malayi celfurPC protein 0.0609 0.6471 0.8011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0145
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0146 0.1373 0.1362
Onchocerca volvulus 0.0146 0.1373 0.5306
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0032 0.0127 0.0837
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.1373 0.2849
Echinococcus granulosus furin 0.0755 0.8078 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0087 0.0633
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0014 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.1373 0.2849
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0023 0.0169
Toxoplasma gondii subtilisin SUB10 0.0032 0.0127 0.0927
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0014 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0146 0.1373 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0776 0.0884
Loa Loa (eye worm) hypothetical protein 0.0099 0.0866 0.1073
Mycobacterium leprae conserved hypothetical protein 0.0146 0.1373 1
Echinococcus granulosus neuroendocrine convertase 2 0.0474 0.4992 0.6179
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0776 0.0961
Brugia malayi beta-lactamase family protein 0.0146 0.1373 0.17
Plasmodium falciparum importin beta, putative 0.0028 0.0082 0.6412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0178 0.1734 0.3597
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.0866 0.0986
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.1373 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0459 0.482 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0082 0.0595
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0032 0.0127 0.0837
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0146 0.1379 0.2861
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.1373 0.2849
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0153 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0776 0.0961
Schistosoma mansoni hypothetical protein 0.0146 0.1379 0.1707
Echinococcus multilocularis snurportin 1 0.03 0.3074 0.3499
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0014 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0014 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0087 0.0633
Leishmania major hypothetical protein, conserved 0.0026 0.0064 0.0465
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.3074 0.3806
Brugia malayi proprotein convertase 2 0.0474 0.4992 0.6179
Loa Loa (eye worm) hypothetical protein 0.0032 0.0127 0.0158
Plasmodium vivax subtilisin-like serine protease, putative 0.0032 0.0127 0.0927
Echinococcus granulosus peregrin 0.0029 0.0087 0.0108
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0146 0.1373 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0127 0.0264
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0153 0.019
Mycobacterium tuberculosis Probable hydrolase 0.0146 0.1373 0.1362
Echinococcus multilocularis jumonji domain containing protein 0.004 0.021 0.0239
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0082 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0127 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.1373 0.17
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0064 0.5009
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0064 0.0465
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0153 0.019
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0146 0.1379 0.2861
Trichomonas vaginalis hypothetical protein 0.0146 0.1379 0.2861
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0082 0.0595
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0178 0.1734 0.3597
Loa Loa (eye worm) hypothetical protein 0.0049 0.0312 0.0386
Loa Loa (eye worm) hypothetical protein 0.0296 0.303 0.3751
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0127 0.0264
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0023 0.0048
Giardia lamblia Furin precursor putative serine protease 0.0146 0.1379 0.4824
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.0866 0.0986
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.2179 0.2697
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0127 0.0264
Loa Loa (eye worm) hypothetical protein 0.0755 0.8078 1
Brugia malayi endoprotease bli-4 precursor 0.0755 0.8078 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0032 0.0127 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0014 0.0098
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0803 0.0994
Echinococcus multilocularis geminin 0.0505 0.5329 0.6066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0776 0.0961
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0178 0.1734 0.3597
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Plasmodium falciparum subtilisin-like protease 1 0.0032 0.0127 1
Schistosoma mansoni importin beta-1 0.0028 0.0082 0.0101
Echinococcus granulosus membrane bound transcription factor site 1 0.0032 0.0127 0.0158
Loa Loa (eye worm) subtilase 0.0032 0.0127 0.0158
Brugia malayi RNA, U transporter 1 0.008 0.0652 0.0807
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0314 0.323 0.3999
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.1373 0.2849
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0014 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0314 0.323 0.3999
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0146 0.1373 0.17
Onchocerca volvulus 0.0146 0.1373 0.5306
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Schistosoma mansoni ap endonuclease 0.0022 0.0014 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0146 0.1373 0.17
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0459 0.482 0.5487
Loa Loa (eye worm) hypothetical protein 0.0029 0.0087 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0591 0.0731
Brugia malayi neuroendocrine convertase 1 precursor 0.0474 0.4992 0.6179
Giardia lamblia PHD finger protein 15 0.0029 0.0087 0.0304
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Mycobacterium ulcerans lipase LipD 0.0146 0.1373 1
Loa Loa (eye worm) endoprotease bli-4 0.0755 0.8078 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0082 0.0595
Echinococcus granulosus importin subunit beta 1 0.0028 0.0082 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.0866 0.1073
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0032 0.0127 0.0114
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0032 0.0127 0.0927
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Toxoplasma gondii subtilisin SUB1 0.0032 0.0127 0.0927
Giardia lamblia High cysteine membrane protein Group 2 0.0281 0.2859 1
Echinococcus granulosus snurportin 1 0.03 0.3074 0.3806
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0014 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Toxoplasma gondii subtilisin SUB5 0.0032 0.0127 0.0927
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Brugia malayi Latrophilin receptor protein 2 0.0099 0.0866 0.1073
Toxoplasma gondii subtilisin SUB12 0.0032 0.0127 0.0927
Loa Loa (eye worm) beta-lactamase 0.0146 0.1373 0.17
Toxoplasma gondii subtilisin SUB9 0.0032 0.0127 0.0927
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.1373 0.17
Echinococcus granulosus jumonji domain containing protein 0.004 0.021 0.026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Echinococcus multilocularis GPCR, family 2 0.0099 0.0866 0.0986
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0087 0.0108
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0146 0.1379 0.2861
Plasmodium falciparum phd finger protein, putative 0.0029 0.0087 0.6824
Onchocerca volvulus 0.0146 0.1373 0.5306
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0153 0.019
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0032 0.0127 0.0927
Echinococcus multilocularis beta LACTamase domain containing family member 0.0146 0.1373 0.1563
Mycobacterium tuberculosis Conserved protein 0.0146 0.1373 0.1362
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0178 0.1734 0.3597
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0014 0.0098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0014 0.5
Onchocerca volvulus 0.0031 0.0117 0.0126
Echinococcus granulosus GPCR family 2 0.0099 0.0866 0.1073
Leishmania major subtilisin-like serine peptidase 0.0032 0.0127 0.0927
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.2136 0.2644
Mycobacterium tuberculosis Conserved protein 0.0146 0.1373 0.1362
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.0866 0.1073
Toxoplasma gondii subtilisin SUB4 0.0032 0.0127 0.0927
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0146 0.1373 0.1362
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.0866 0.1073
Brugia malayi Calcitonin receptor-like protein seb-1 0.0314 0.323 0.3999
Brugia malayi hypothetical protein 0.0026 0.0064 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1379 0.2861
Brugia malayi Pre-SET motif family protein 0.0219 0.2179 0.2697
Schistosoma mansoni hypothetical protein 0.0505 0.5329 0.6597
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0064 0.0465
Schistosoma mansoni hypothetical protein 0.0099 0.0866 0.1073
Mycobacterium ulcerans hypothetical protein 0.0146 0.1373 1
Trypanosoma brucei hypothetical protein, conserved 0.0146 0.1373 1
Brugia malayi PHD-finger family protein 0.0029 0.0087 0.0108
Mycobacterium ulcerans esterase/lipase LipP 0.0146 0.1373 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Trichomonas vaginalis esterase, putative 0.0146 0.1373 0.2849
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0032 0.0127 0.0264
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0087 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0127 0.0264
Brugia malayi Importin beta-1 subunit 0.0028 0.0082 0.0101
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0032 0.0127 0.0927
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.0866 0.1073
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0803 0.0914
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0014 0.5835
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0117 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0117 0.0145
Trypanosoma brucei subtilisin peptidase 0.0032 0.0127 0.0927
Brugia malayi Subtilase family protein 0.0032 0.0127 0.0158
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0014 0.0017
Onchocerca volvulus 0.0032 0.0127 0.0167

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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