Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0016 | 0.0283 | 0.0364 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.002 | 0.0509 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.002 | 0.0509 | 0.5 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0016 | 0.0283 | 0.0364 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0015 | 0.0184 | 0.5 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0016 | 0.0283 | 0.0283 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.6702 | 0.8636 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0016 | 0.0283 | 0.0283 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0016 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0008 |
Toxoplasma gondii | AGC kinase | 0.0016 | 0.0283 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0033 | 0.136 | 0.136 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0184 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0509 | 0.0655 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0062 | 0.3224 | 0.3224 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0062 | 0.3224 | 0.3224 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0016 | 0.0283 | 0.0283 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.002 | 0.0509 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0283 | 0.0283 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0016 | 0.0283 | 0.0283 |
Schistosoma mansoni | serine/threonine kinase | 0.0016 | 0.0283 | 0.0283 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0013 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.002 | 0.0509 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0029 | 0.1088 | 0.1088 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0009 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.002 | 0.0509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.6702 | 0.8636 |
Schistosoma mansoni | atypical protein kinase C | 0.0028 | 0.102 | 0.102 |
Brugia malayi | AMP-binding enzyme family protein | 0.002 | 0.0509 | 0.0746 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.7438 | 0.9585 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0051 | 0.2487 | 0.2487 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0015 | 0.0184 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0283 | 0.0283 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0029 | 0.1088 | 0.1088 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0033 | 0.136 | 0.136 |
Echinococcus granulosus | protein kinase C gamma type | 0.0051 | 0.2487 | 0.2487 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0028 | 0.102 | 0.102 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0283 | 0.0283 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0013 | 0.0029 | 0.0029 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0016 | 0.0283 | 0.0283 |
Onchocerca volvulus | 0.002 | 0.0509 | 0.0719 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3224 | 0.3224 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.002 | 0.0509 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3224 | 0.3224 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.6816 | 0.8783 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0016 | 0.0283 | 0.0415 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0509 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0016 | 0.0283 | 0.0283 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.002 | 0.0509 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.002 | 0.0509 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0033 | 0.136 | 0.136 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.136 | 0.1753 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.002 | 0.0509 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.6816 | 0.8783 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0016 | 0.0283 | 0.0364 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0015 | 0.0184 | 0.139 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0035 | 0.1468 | 0.1891 |
Onchocerca volvulus | 0.0116 | 0.6702 | 1 | |
Brugia malayi | protein kinase C II. | 0.0029 | 0.1088 | 0.1596 |
Echinococcus granulosus | unc 13 munc13 | 0.0013 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0008 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0016 | 0.0283 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0184 | 0.0237 |
Brugia malayi | Protein kinase c protein 2 | 0.0046 | 0.2204 | 0.3234 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.002 | 0.0509 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.002 | 0.0509 | 0.0746 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.002 | 0.0509 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0509 | 0.0655 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.002 | 0.0509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0184 | 0.0237 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0006 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0283 | 0.0283 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.002 | 0.0509 | 0.0746 |
Schistosoma mansoni | unc-13 (munc13) | 0.0013 | 0.0029 | 0.0029 |
Schistosoma mansoni | unc-13 (munc13) | 0.0013 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0016 | 0.0283 | 0.0364 |
Brugia malayi | Hr1 repeat family protein | 0.0016 | 0.0283 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0184 | 0.0237 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0006 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0006 | 0.0008 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.002 | 0.0509 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0015 | 0.0184 | 0.3535 |
Echinococcus granulosus | protein kinase c iota type | 0.0028 | 0.102 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0184 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2097 | 0.2703 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0016 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0016 | 0.0283 | 0.0364 |
Echinococcus granulosus | NDR protein kinase | 0.0016 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0016 | 0.0283 | 0.0364 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0013 | 0.0029 | 0.0029 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.6816 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0029 | 0.1088 | 0.1402 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0006 | 0.0009 |
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0.0509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0029 | 0.0037 |
Schistosoma mansoni | protein kinase C | 0.0013 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.776 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.6702 | 0.8636 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.002 | 0.0509 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0016 | 0.0283 | 0.0283 |
Brugia malayi | Protein kinase domain containing protein | 0.0016 | 0.0283 | 0.0415 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0016 | 0.0283 | 0.0415 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0016 | 0.0283 | 0.0283 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.002 | 0.0509 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0016 | 0.0283 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.0283 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0015 | 0.0184 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0016 | 0.0283 | 0.0364 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0029 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0509 | 0.0655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.