Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0143 | 0.0155 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.4198 | 0.4198 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.2961 | 0.3215 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0143 | 0.0155 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4198 | 0.4198 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0143 | 0.0155 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.4198 | 0.5325 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4198 | 0.4198 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.4858 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0143 | 0.0143 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0143 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.4858 | 0.4858 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4198 | 0.4198 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 0.5276 |
Brugia malayi | RNA binding protein | 0.0067 | 0.4198 | 0.5325 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0143 | 0.0155 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0143 | 0.0143 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.2961 | 0.6095 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0143 | 0.0143 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0143 | 0.0143 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.2961 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0143 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0143 | 0.0143 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.2961 | 0.2961 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0143 | 0.0155 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0136 | 0.9209 | 0.9209 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0026 | 0.1249 | 0.257 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.1249 | 0.257 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4198 | 0.4198 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.4858 | 0.6192 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.4198 | 0.5325 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.9209 | 0.9209 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0143 | 0.0143 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.4198 | 0.4559 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0143 | 0.0155 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.2961 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0143 | 0.0143 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.4198 | 0.5325 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0143 | 0.0143 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0143 | 0.0143 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 0.4858 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0143 | 0.0155 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0143 | 0.0155 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.4858 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.4858 | 0.6192 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.4198 | 0.5325 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.4858 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0143 | 0.0143 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0143 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7758 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7758 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7758 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0136 | 0.9209 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.4858 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4198 | 0.4198 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0143 | 0.0143 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0143 | 0.0143 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.4858 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0143 | 0.5 | |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0143 | 0.0155 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0143 | 0.0143 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.4198 | 0.5325 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.