Detailed information for compound 80444

Basic information

Technical information
  • TDR Targets ID: 80444
  • Name: (E)-2,2,8-trimethyl-9-naphthalen-1-ylnon-5-en -3-ynoic acid
  • MW: 320.425 | Formula: C22H24O2
  • H donors: 1 H acceptors: 2 LogP: 5.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1cccc2c1cccc2)C/C=C/C#CC(C(=O)O)(C)C
  • InChi: 1S/C22H24O2/c1-17(10-5-4-8-15-22(2,3)21(23)24)16-19-13-9-12-18-11-6-7-14-20(18)19/h4-7,9,11-14,17H,10,16H2,1-3H3,(H,23,24)/b5-4+
  • InChiKey: JOEBXYQEKIJGDH-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2,2,8-trimethyl-9-(1-naphthyl)non-5-en-3-ynoic acid
  • (E)-2,2,8-trimethyl-9-(1-naphthalenyl)non-5-en-3-ynoic acid
  • (E)-2,2,8-trimethyl-9-naphthalen-1-yl-non-5-en-3-ynoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major developmentally regulated phosphoprotein-like protein 0.002 0.0057 0.0057
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0076 0.0493 0.0493
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0008 0.0001
Toxoplasma gondii heat shock protein HSP90 0.0141 0.1006 0.241
Leishmania major mitochondrial DNA topoisomerase II 0.002 0.0057 0.0057
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.002 0.0057 0.0057
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.1006 0.1006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0021 0.003
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0046 0.026 0.0554
Mycobacterium tuberculosis Conserved protein 0.002 0.0057 0.005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0277
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0065 0.0405 0.8189
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0032 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0426 0.3238 0.3234
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0046 0.0097
Schistosoma mansoni heat shock protein 0.0094 0.0634 0.1372
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0008 0.0001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0024 0.0024
Brugia malayi hypothetical protein 0.0016 0.0021 0.0026
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.002 0.0057 0.0274
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0046 0.0046
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0094 0.0094
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0088 0.0081
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0032 0.0032
Brugia malayi jmjC domain containing protein 0.0192 0.1401 0.2652
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.002 0.0057 0.0127
Schistosoma mansoni thyroid hormone receptor 0.003 0.0131 0.0271
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0153 0.0367
Leishmania major hypothetical protein, conserved 0.0217 0.1601 0.1601
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0153 0.1097 0.2748
Entamoeba histolytica hypothetical protein 0.0046 0.026 0.026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0426 0.3238 0.3234
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0017 0.0032 0.0025
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0065 0.0405 0.0398
Loa Loa (eye worm) DR-78 0.0014 0.0008 0.0001
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0032 0.0032
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Schistosoma mansoni tar DNA-binding protein 0.0196 0.144 0.3138
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Leishmania major hypothetical protein, conserved 0.0076 0.0493 0.0493
Trypanosoma cruzi heat shock protein 90, putative 0.0059 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0077
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0046 0.0097
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0008 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0024 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.1601 0.1601
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0076 0.0493 0.0486
Brugia malayi PHD-finger family protein 0.0058 0.0357 0.0665
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0473 0.3611 0.3607
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0131 0.0312
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0094 0.0086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Schistosoma mansoni nuclear receptor 0.0014 0.0008 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Schistosoma mansoni nuclear receptor 0.0014 0.0008 0.0001
Echinococcus granulosus heat shock protein 90 0.0141 0.1006 0.2517
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0057 0.0057
Plasmodium vivax PST-A protein 0.1287 1 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0575 0.1431
Mycobacterium leprae Probable two-component sensor kinase 0.002 0.0057 0.005
Echinococcus granulosus thioredoxin glutathione reductase 0.0187 0.1366 0.3425
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0008 0.0001
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0131 0.0236
Schistosoma mansoni transcription factor LCR-F1 0.0153 0.1097 0.2388
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0575 0.1431
Leishmania major heat shock protein, putative 0.0094 0.0634 0.0634
Mycobacterium leprae Probable two component sensor kinase MprB 0.002 0.0057 0.005
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0057 0.0127
Brugia malayi Bromodomain containing protein 0.0058 0.0357 0.0665
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0032 0.0063
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0032 0.0032
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0046 0.0053
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0094 0.0634 0.3439
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0032 0.0032
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0032 0.0063
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0073
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0046 0.026 0.058
Loa Loa (eye worm) hypothetical protein 0.0086 0.0575 0.108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0066
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0008 0.0001
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0076 0.0493 0.0493
Trichomonas vaginalis chromobox protein, putative 0.0046 0.026 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0141 0.0292
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0131 0.0678
Schistosoma mansoni glutaminase 0.0279 0.2087 0.4555
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0121 0.0846 0.2113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0405 0.0405
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.002 0.0057 0.005
Brugia malayi nuclear receptor RXR 0.0014 0.0008 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0088 0.0088
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0021 0.003
Loa Loa (eye worm) TAR-binding protein 0.0196 0.144 0.2725
Plasmodium vivax heat shock protein 86, putative 0.0141 0.1006 0.0999
Leishmania major DNA topoisomerase ii 0.002 0.0057 0.0057
Onchocerca volvulus Heterochromatin protein 1 homolog 0.017 0.1234 0.6736
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0073
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0542 0.0542
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0032 0.0063
Toxoplasma gondii phospholipase/carboxylesterase 0.0076 0.0493 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0131 0.0236
Trichomonas vaginalis heat shock protein, putative 0.0121 0.0846 0.0846
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0066
Entamoeba histolytica hypothetical protein 0.0153 0.1097 0.1097
Schistosoma mansoni glutamate synthase 0.0017 0.0032 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0027
Plasmodium vivax PST-A protein 0.0076 0.0493 0.0486
Schistosoma mansoni coup transcription factor 0.003 0.0131 0.0271
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0091 0.0083
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0046 0.0053
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0076 0.0493 0.0493
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0643 0.121
Brugia malayi Probable DNA topoisomerase II 0.002 0.0057 0.0096
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0032 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0057 0.0057
Plasmodium falciparum lysophospholipase, putative 0.0076 0.0493 0.0486
Trypanosoma cruzi heat shock protein 90, putative 0.0121 0.0846 0.0846
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0643 0.121
Trichomonas vaginalis heat shock protein, putative 0.0132 0.0938 0.0938
Giardia lamblia NADH oxidase lateral transfer candidate 0.0065 0.0405 0.2679
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0047
Trichomonas vaginalis chromobox protein, putative 0.0282 0.2113 0.2113
Echinococcus multilocularis geminin 0.0519 0.3974 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0017 0.0032 0.0025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0705 0.1327
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0032 0.0032
Schistosoma mansoni kinase 0.0099 0.0673 0.1459
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Echinococcus granulosus abhydrolase domain containing protein 13 0.0076 0.0493 0.1224
Trichomonas vaginalis mercuric reductase, putative 0.0065 0.0405 0.0405
Toxoplasma gondii peptidase S15, putative 0.0076 0.0493 0.1151
Trypanosoma cruzi polo-like protein kinase, putative 0.0194 0.1424 0.1424
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0153 0.0277
Mycobacterium ulcerans glutaminase 0.0279 0.2087 0.2081
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0131 0.0236
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0057 0.0057
Plasmodium falciparum lysophospholipase, putative 0.1287 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.0065 0.0405 0.0935
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Echinococcus multilocularis heat shock protein 90 0.0141 0.1006 0.2517
Plasmodium vivax heat shock protein, putative 0.0535 0.4098 0.4094
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0091 0.0091
Treponema pallidum chemotaxis histidine kinase (cheA) 0.002 0.0057 0.054
Brugia malayi Thioredoxin reductase 0.0187 0.1362 0.2577
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0065 0.0405 0.0757
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.027 0.05
Brugia malayi Pre-SET motif family protein 0.0216 0.1594 0.3018
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0054
Trichomonas vaginalis glutaminase, putative 0.0279 0.2087 0.2087
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.002 0.0057 0.005
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0493 0.0486
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0024
Brugia malayi hypothetical protein 0.0014 0.0008 0.0001
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0008 0.0001
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0017 0.0032 0.0025
Entamoeba histolytica hypothetical protein 0.0153 0.1097 0.1097
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0777 0.0777
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0357 0.0817
Treponema pallidum thioredoxin reductase (trxB) 0.0017 0.0032 0.0267
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0021 0.0034
Schistosoma mansoni DNA topoisomerase II 0.002 0.0057 0.011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0091 0.0083
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.002 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.0025 0.0091 0.0083
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0065 0.0405 0.0398
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0453 0.1124
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0032 0.0032
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0032 0.0025
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Echinococcus granulosus fatty acid amide hydrolase 1 0.0116 0.0808 0.2019
Plasmodium falciparum alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Plasmodium falciparum heat shock protein 90, putative 0.0082 0.0542 0.0535
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.1287 1 1
Schistosoma mansoni hypothetical protein 0.0046 0.026 0.0554
Entamoeba histolytica hypothetical protein 0.0153 0.1097 0.1097
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0194 0.1424 0.1424
Echinococcus multilocularis Chromo domain 0.0046 0.026 0.0637
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0141 0.0292
Plasmodium falciparum endoplasmin, putative 0.0102 0.0702 0.0695
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0449 0.0841
Mycobacterium ulcerans two component regulator - sensor kinase 0.002 0.0057 0.005
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0057 0.0057
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0032 0.0032
Echinococcus multilocularis thioredoxin glutathione reductase 0.0187 0.1366 0.3425
Plasmodium vivax lysophospholipase, putative 0.0076 0.0493 0.0486
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0088 0.0081
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0088 0.0088
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0032 0.0063
Echinococcus granulosus phd:f box containing protein 0.0019 0.0046 0.0097
Schistosoma mansoni endoplasmin 0.0141 0.1006 0.2187
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0076 0.0493 0.0493
Plasmodium falciparum BEM46-like protein, putative 0.0076 0.0493 0.0486
Onchocerca volvulus 0.0246 0.1828 1
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.1006 0.1006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0008 0.0001
Chlamydia trachomatis DNA gyrase subunit B 0.002 0.0057 0.1035
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0017 0.0032 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0493 0.0486
Schistosoma mansoni hypothetical protein 0.007 0.0449 0.0968
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.087 0.1642
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0032 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0008 0.0001
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.1287 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0131 0.0236
Plasmodium vivax alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Echinococcus multilocularis abhydrolase domain containing 3 0.0076 0.0493 0.1224
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0008 0.0001
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.002 0.0057 0.054
Treponema pallidum NADH oxidase 0.0065 0.0405 0.4275
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0076 0.0493 0.0493
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0032 0.0063
Echinococcus granulosus ribosomal protein L19 0.0027 0.0111 0.0261
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0047 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0131 0.0236
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0046 0.0097
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Brugia malayi nuclear receptor NHR-67 0.0014 0.0008 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0131 0.0312
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0453 0.1124
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0046
Trichomonas vaginalis hypothetical protein 0.0046 0.026 0.026
Toxoplasma gondii heat shock protein 90, putative 0.0141 0.1006 0.241
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0032 0.0047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.1401 0.3514
Plasmodium falciparum phd finger protein, putative 0.0058 0.0357 0.035
Plasmodium falciparum thioredoxin reductase 0.0187 0.1362 0.1356
Plasmodium vivax thioredoxin reductase, putative 0.0187 0.1362 0.1356
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0357 0.0765
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0046 0.0097
Plasmodium falciparum prodrug activation and resistance esterase 0.0076 0.0493 0.0486
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0046 0.0097
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0042
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0017 0.0032 0.0267
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0088 0.0081
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0076 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0096
Plasmodium vivax alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0088 0.0157
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Brugia malayi TAZ zinc finger family protein 0.047 0.3586 0.6808
Mycobacterium tuberculosis Probable two component sensor kinase 0.002 0.0057 0.005
Plasmodium vivax heterochromatin protein 1, putative 0.0046 0.026 0.0253
Trypanosoma brucei hypothetical protein, conserved 0.0217 0.1601 0.1601
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0153 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0131 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.002 0.0057 0.0057
Trypanosoma brucei DNA topoisomerase ii 0.002 0.0057 0.0057
Brugia malayi nuclear receptor NHR-88 0.0014 0.0008 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0088
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0131 0.0312
Leishmania major 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0032 0.002
Loa Loa (eye worm) CHromoDomain protein family member 0.0046 0.026 0.0481
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0008 0.0001
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0008 0.0001
Mycobacterium tuberculosis Possible two component sensor kinase 0.002 0.0057 0.005
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0008 0.0001
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0094 0.0634 0.1579
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0319
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.009 0.009
Plasmodium vivax hypothetical protein, conserved 0.002 0.0057 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0594 0.1479
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0065 0.0405 0.0935
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0065 0.0407 0.0401
Onchocerca volvulus 0.0077 0.0503 0.2723
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0493 0.0486
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0153 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0046 0.026 0.0253
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0026 0.0005
Mycobacterium tuberculosis Probable sensor protein KdpD 0.002 0.0057 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0643 0.1393
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0073
Brugia malayi steroid hormone receptor 0.003 0.0131 0.0236
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0131 0.0312
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0088 0.0081
Entamoeba histolytica disulphide oxidoreductase, putative 0.0017 0.0032 0.0032
Schistosoma mansoni zinc finger protein 0.0014 0.0008 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0091 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0131 0.0236
Leishmania major trypanothione reductase 0.0187 0.1362 0.1362
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0008 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0021 0.0026
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0076 0.0493 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0131 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0094 0.0094
Giardia lamblia Pms1-like protein 0.002 0.0057 0.0182
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Trypanosoma cruzi heat shock protein 85, putative 0.0121 0.0846 0.0846
Schistosoma mansoni thyroid hormone receptor 0.003 0.0131 0.0271
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0924
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0032 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0131 0.0312
Trichomonas vaginalis heat shock protein, putative 0.0102 0.0702 0.0702
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0046 0.0046
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.1006 0.1006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0131 0.0236
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Schistosoma mansoni endoplasmin 0.0141 0.1006 0.2187
Brugia malayi glutamate synthase 0.0017 0.0032 0.0047
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.002 0.0057 0.1035
Mycobacterium ulcerans hypothetical protein 0.0025 0.0094 0.0086
Brugia malayi conserved hypotetical protein 0.0014 0.0008 0.0001
Schistosoma mansoni heat shock protein 0.0141 0.1006 0.2187
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0076 0.0493 0.0493
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0076 0.0493 0.1064
Echinococcus multilocularis endoplasmin 0.0132 0.0938 0.2345
Chlamydia trachomatis acyltransferase family protein 0.0076 0.0493 1
Loa Loa (eye worm) heterochromatin protein 1 0.0282 0.2113 0.4006
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0046 0.0073
Onchocerca volvulus 0.003 0.0131 0.0678
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.002 0.0057 0.054
Plasmodium falciparum lysophospholipase, putative 0.0076 0.0493 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1139 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0131 0.0236
Brugia malayi PHD-finger family protein 0.0019 0.0047 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0008 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0131 0.0678
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0024 0.0017
Trypanosoma brucei developmentally regulated phosphoprotein 0.002 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Echinococcus granulosus chromobox protein 1 0.0282 0.2113 0.5308
Brugia malayi hypothetical protein 0.007 0.0444 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0196 0.144 0.3138
Echinococcus multilocularis CREB binding protein 0.047 0.3586 0.9021
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0047 0.0047
Brugia malayi DNA topoisomerase II, alpha isozyme 0.002 0.0057 0.0096
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0091 0.0083
Brugia malayi MGC79044 protein 0.0076 0.0493 0.0924
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0643 0.1603
Onchocerca volvulus 0.0025 0.0091 0.0456
Brugia malayi Heterochromatin protein 1 0.0282 0.2113 0.4006
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0135 0.096 0.0954
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0017 0.0032 0.0025
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0065 0.0405 0.0398
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.1006 0.1006
Brugia malayi hypothetical protein 0.0014 0.0008 0.0001
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.144 0.2725
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0777 0.0777
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0131 0.0312
Plasmodium falciparum thioredoxin reductase 0.0065 0.0405 0.0398
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0024 0.0017
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0536 0.1334
Schistosoma mansoni peptidase 0.0076 0.0493 0.1064
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0032 0.0032
Mycobacterium tuberculosis Possible lysophospholipase 0.1287 1 1
Brugia malayi SET domain containing protein 0.0047 0.0269 0.0498
Loa Loa (eye worm) RNA binding protein 0.0196 0.144 0.2725
Mycobacterium ulcerans DNA gyrase subunit B 0.002 0.0057 0.005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0141 0.0287
Toxoplasma gondii hypothetical protein 0.0076 0.0493 0.1151
Leishmania major hypothetical protein, conserved 0.0017 0.0032 0.0032
Plasmodium vivax PST-A protein 0.0076 0.0493 0.0486
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0091 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0017 0.0032 0.0025
Echinococcus granulosus CREB binding protein 0.047 0.3586 0.9021
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0057 0.0057
Leishmania major hypothetical protein, conserved 0.002 0.0057 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0405 0.0405
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1287 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0131 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1139 0.1139
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0091 0.0091
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0032 0.0054
Leishmania major monoglyceride lipase, putative 0.1287 1 1
Trypanosoma brucei heat shock protein 84, putative 0.0094 0.0634 0.0634
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0057 0.0274
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0046 0.026 0.0253
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0017 0.0032 0.0025
Toxoplasma gondii phospholipase 0.0076 0.0493 0.1151
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0046 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.009 0.0157
Entamoeba histolytica hypothetical protein 0.0076 0.0493 0.0493
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0131 0.0236
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1594 0.3018
Brugia malayi Protein C20orf22 0.0076 0.0493 0.0924
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0091 0.0159
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0426 0.3238 0.3234
Echinococcus granulosus Chromobox protein 3 0.0046 0.026 0.0637
Echinococcus multilocularis tar DNA binding protein 0.0196 0.144 0.3611
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0088 0.0868
Brugia malayi Valyl-tRNA synthetase 0.0046 0.026 0.0481
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0046 0.0084
Plasmodium vivax PST-A protein 0.0076 0.0493 0.0486
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0017 0.0032 0.0032
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0135 0.096 0.0954
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0032 0.0032
Giardia lamblia Grp94/Hsp90 0.0132 0.0938 0.6506
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0131 0.0236
Trichomonas vaginalis glutathione reductase, putative 0.0065 0.0405 0.0405
Echinococcus multilocularis heat shock protein 0.0141 0.1006 0.2517
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0094 0.0634 0.0634
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0032 0.0032
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0132 0.0938 1
Trypanosoma cruzi monoglyceride lipase, putative 0.1287 1 1
Schistosoma mansoni glutamate synthase 0.0017 0.0032 0.0054
Brugia malayi Associated with TFs and helicases family protein 0.0046 0.026 0.0481
Trichomonas vaginalis chromobox protein, putative 0.0046 0.026 0.026
Mycobacterium ulcerans putative regultory protein 0.002 0.0057 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0131 0.0236
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0026
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1287 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0131 0.0236
Schistosoma mansoni nuclear hormone receptor 0.003 0.0131 0.0271
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0094 0.0218
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0046 0.026 0.058
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0194 0.1424 0.3571
Schistosoma mansoni chromobox protein 0.0282 0.2113 0.4613
Brugia malayi glutaminase DH11.1 0.0279 0.2087 0.3956
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0131 0.0312
Plasmodium vivax unspecified product 0.0076 0.0493 0.0486
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0056 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0196 0.144 0.3138
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0088 0.0157
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0094 0.0086
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0575 0.108
Entamoeba histolytica hypothetical protein 0.0046 0.026 0.026
Plasmodium falciparum heat shock protein 90, putative 0.0535 0.4098 0.4094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0091 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0282 0.2113 0.2113
Brugia malayi RNA binding protein 0.0196 0.144 0.2725
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0094 0.0086
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.1287 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0131 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0131 0.0236
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0131 0.0271
Echinococcus granulosus CREB binding protein 0.047 0.3586 0.9021
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1828 0.1828
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0094 0.0218
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0032 0.0047
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0008 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0153 0.0367
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0924
Loa Loa (eye worm) hypothetical protein 0.0103 0.0705 0.1327
Toxoplasma gondii hypothetical protein 0.0076 0.0493 0.1151
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0046 0.026 0.058
Echinococcus granulosus endoplasmin 0.0132 0.0938 0.2345
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0032 0.0063
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0032 0.0025
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0017 0.0032 0.0025
Toxoplasma gondii hypothetical protein 0.0076 0.0493 0.1151
Echinococcus granulosus FTZ F1 alpha 0.003 0.0131 0.0312
Echinococcus multilocularis chromobox protein 1 0.0282 0.2113 0.5308
Onchocerca volvulus Alhambra homolog 0.0058 0.0357 0.1917
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0357 0.0665
Brugia malayi Protein cec-1. 0.0046 0.026 0.0481
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.009 0.009
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1287 1 1
Mycobacterium ulcerans heat shock protein 90 0.0132 0.0938 0.0931
Entamoeba histolytica hypothetical protein 0.0024 0.0088 0.0088
Echinococcus multilocularis ribosomal protein L19 0.0027 0.0111 0.0261
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.002 0.0057 0.005
Trichomonas vaginalis heat shock protein, putative 0.0132 0.0938 0.0938
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0065 0.0405 0.4275
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0046 0.0084
Schistosoma mansoni hypothetical protein 0.0519 0.3974 0.869
Schistosoma mansoni 60S ribosomal protein L19 0.0027 0.0111 0.0227
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0032 0.0032
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0057 0.0082
Trichomonas vaginalis endoplasmin, putative 0.0102 0.0702 0.0702
Brugia malayi Hsp90 protein 0.0094 0.0634 0.1192
Brugia malayi MH2 domain containing protein 0.0124 0.087 0.1642
Brugia malayi CHD4 protein 0.0046 0.026 0.0481
Loa Loa (eye worm) glutaminase 2 0.0279 0.2087 0.3956
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0027
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0187 0.1362 0.1356
Onchocerca volvulus 0.0017 0.0032 0.0134
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0046 0.026 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0008 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0131 0.0271
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0076 0.0493 0.0493
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0065 0.0405 0.4275
Brugia malayi ecdysteroid receptor 0.003 0.0131 0.0236
Trypanosoma cruzi serine peptidase, putative 0.0076 0.0493 0.0493
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1287 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0124 0.0871 0.1643
Entamoeba histolytica DNA topoisomerase II, putative 0.002 0.0057 0.0057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0024
Plasmodium falciparum exported lipase 1 0.0076 0.0493 0.0486
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0032
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.002 0.0057 0.005
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0032 0.002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0141 0.0336
Plasmodium vivax DNA topoisomerase II, putative 0.002 0.0057 0.005
Schistosoma mansoni jumonji domain containing protein 0.0152 0.1092 0.2377
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0132 0.0938 0.0931
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0091 0.0091
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0066 0.0059
Toxoplasma gondii heat shock protein 75, putative 0.0094 0.0634 0.1497
Plasmodium falciparum heterochromatin protein 1 0.0046 0.026 0.0253
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0094 0.0634 0.1579
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Brugia malayi amidase 0.0116 0.0808 0.1523
Schistosoma mansoni hypothetical protein 0.0058 0.0357 0.0765
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0091 0.0091
Plasmodium falciparum lysophospholipase, putative 0.1287 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Echinococcus granulosus fatty acid amide hydrolase 1 0.0116 0.0808 0.2019
Echinococcus granulosus chromobox protein 1 0.0282 0.2113 0.5308
Plasmodium falciparum lysophospholipase, putative 0.1287 1 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0141 0.1006 0.1006
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0057 0.0082
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Brugia malayi jmjC domain containing protein 0.0071 0.0453 0.0848
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0141 0.0336
Plasmodium vivax SET domain protein, putative 0.0031 0.0141 0.0134
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0065 0.0405 0.0398
Mycobacterium ulcerans hypothetical protein 0.0076 0.0493 0.0486
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0032 0.002
Mycobacterium ulcerans hydrolase 0.0076 0.0493 0.0486
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0091 0.0159
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0046 0.0038
Trypanosoma cruzi serine peptidase, putative 0.0076 0.0493 0.0493
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.002 0.0057 0.054
Schistosoma mansoni tar DNA-binding protein 0.0196 0.144 0.3138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0643 0.1603
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0032 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0032 0.0054
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Mycobacterium ulcerans two component sensor kinase MprB 0.002 0.0057 0.005
Plasmodium vivax JmjC domain containing protein 0.0019 0.0046 0.0038
Loa Loa (eye worm) hypothetical protein 0.01 0.0685 0.1289
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0076 0.0493 0.0493
Mycobacterium ulcerans dehydrogenase 0.0017 0.0032 0.0025
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0017 0.0032 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0453 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0042 0.0035
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Trichomonas vaginalis chromobox protein, putative 0.017 0.1234 0.1234
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.002 0.0057 0.0127
Brugia malayi 60S ribosomal protein L19 0.0027 0.0111 0.0197
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0197
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.002 0.0057 0.005
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0194 0.1424 0.2695
Loa Loa (eye worm) CBP-B 0.047 0.3586 0.6808
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0065 0.0405 0.1002
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0047 0.004
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0426 0.3238 0.3234
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0153 0.0367
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0158 0.1139 0.6218
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0032 0.0025
Plasmodium falciparum exported lipase 2 0.0076 0.0493 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Trypanosoma cruzi trypanothione reductase, putative 0.0065 0.0405 0.0405
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0032 0.0063
Brugia malayi Pre-SET motif family protein 0.0031 0.0141 0.0254
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0046 0.0097
Plasmodium vivax 60S ribosomal protein L19, putative 0.0027 0.0111 0.0104
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1287 1 1
Loa Loa (eye worm) glutaminase 0.0279 0.2087 0.3956
Loa Loa (eye worm) endoplasmin 0.0141 0.1006 0.1899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Trypanosoma cruzi amidase, putative 0.0014 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0131 0.0236
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0132 0.0938 0.0938
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0091 0.0083
Onchocerca volvulus 0.007 0.0444 0.2399
Trypanosoma cruzi polo-like protein kinase, putative 0.0194 0.1424 0.1424
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0046 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1424 0.3103
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0042 0.0035
Trypanosoma cruzi amidase, putative 0.0014 0.0007 0.0007
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Schistosoma mansoni chromobox protein 0.0046 0.026 0.0554
Plasmodium falciparum DNA topoisomerase 2 0.002 0.0057 0.005
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0057 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Loa Loa (eye worm) heat shock protein 75 0.0094 0.0634 0.1192
Loa Loa (eye worm) thioredoxin reductase 0.0187 0.1362 0.2577
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Plasmodium falciparum esterase, putative 0.0076 0.0493 0.0486
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0046 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0131 0.0312
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0008 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0653 0.0653
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.027 0.05
Trypanosoma brucei Heat shock protein 83, putative 0.0141 0.1006 0.1006
Plasmodium falciparum glutathione reductase 0.0065 0.0405 0.0398
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0453 0.0977
Entamoeba histolytica hypothetical protein 0.0153 0.1097 0.1097
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0008 0.0001
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0017 0.0032 0.0025
Trypanosoma brucei DNA topoisomerase II beta, putative 0.002 0.0057 0.0057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0132 0.0314
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0575 0.1244
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0076 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0017 0.0032 0.0032
Trypanosoma cruzi heat shock protein 90, putative 0.0141 0.1006 0.1006
Brugia malayi M-phase phosphoprotein, mpp8 0.0046 0.026 0.0481
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0076 0.0493 0.1151
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0032 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0196 0.144 0.3138
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0076 0.0493 0.0493
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0046 0.026 0.0554
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0065 0.0405 0.0405
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0131 0.0312
Plasmodium falciparum alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0131 0.0236
Plasmodium vivax PST-A protein 0.0076 0.0493 0.0486
Trypanosoma brucei trypanothione reductase 0.0187 0.1362 0.1362
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0042 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0643 0.1603
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0088 0.0868
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.002 0.0057 0.005
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0046 0.026 0.0637
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Trypanosoma brucei polo-like protein kinase 0.0194 0.1424 0.1424
Brugia malayi serine/threonine-protein kinase plk-2 0.0194 0.1424 0.2695
Schistosoma mansoni glutamate synthase 0.0017 0.0032 0.0054
Mycobacterium ulcerans NADH dehydrogenase 0.0017 0.0032 0.0025
Entamoeba histolytica thioredoxin reductase, putative 0.0017 0.0032 0.0032
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.144 0.2725
Echinococcus granulosus jun protein 0.0089 0.0594 0.1479
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0088 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Plasmodium falciparum glutathione reductase 0.0187 0.1362 0.1356
Plasmodium falciparum alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Plasmodium vivax hypothetical protein, conserved 0.0046 0.026 0.0253
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0131 0.0678
Mycobacterium ulcerans lipoprotein LpqF 0.0065 0.0407 0.0401
Plasmodium vivax unspecified product 0.0076 0.0493 0.0486
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0594 0.1479
Mycobacterium tuberculosis Conserved protein 0.0025 0.0094 0.0086
Trypanosoma cruzi heat shock protein, putative 0.0094 0.0634 0.0634
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0046 0.0097
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0076 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Schistosoma mansoni chromobox protein 0.0282 0.2113 0.4613
Mycobacterium tuberculosis Probable reductase 0.0426 0.3238 0.3234
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0024 0.0032
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0008 0.0001
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.002 0.0057 0.0096
Entamoeba histolytica hypothetical protein 0.0046 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0519 0.3974 0.869
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.0057 0.005
Brugia malayi AF-10 protein 0.0019 0.0047 0.0077
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0076 0.0493 0.0493
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0705 0.1327
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0032 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0008 0.0001
Treponema pallidum heat shock protein 90 0.0132 0.0938 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0017 0.0032 0.0025
Onchocerca volvulus 0.0046 0.026 0.1387
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0141 0.0292
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0032 0.0063
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0032 0.0032
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0017 0.0032 0.0025
Leishmania major 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Loa Loa (eye worm) helicase 0.0046 0.026 0.0481
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0091 0.0091
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0024 0.0024
Chlamydia trachomatis hydrolase 0.0076 0.0493 1
Echinococcus granulosus heat shock protein 90 0.0121 0.0846 0.2113
Trypanosoma brucei monoglyceride lipase, putative 0.1287 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0049 0.0092
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0046 0.026 0.0637
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.002 0.0057 0.005
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0536 0.1334
Plasmodium falciparum 60S ribosomal protein L19 0.0027 0.0111 0.0104
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0008 0.0001
Trichomonas vaginalis chromobox protein, putative 0.017 0.1234 0.1234
Entamoeba histolytica ;Alias 0.0076 0.0493 0.0493
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0116 0.0808 0.2019
Mycobacterium ulcerans ferredoxin reductase 0.0017 0.0032 0.0025
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0042
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0065 0.0405 0.0405
Brugia malayi ecdysone receptor 0.0014 0.0008 0.0001
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0017 0.0032 0.0267
Plasmodium falciparum alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Echinococcus granulosus ribosomal protein L19 0.0027 0.0111 0.0261
Loa Loa (eye worm) hypothetical protein 0.0684 0.5264 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0066
Schistosoma mansoni amidase 0.0116 0.0808 0.1754
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0032 0.0063
Brugia malayi nuclear hormone receptor 0.0014 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0116 0.0808 0.1523
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0159
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0131 0.0271
Trichomonas vaginalis heat shock protein, putative 0.0141 0.1006 0.1006
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0131 0.0312
Schistosoma mansoni CREB-binding protein 2 0.047 0.3586 0.7839
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.1401 0.3514
Toxoplasma gondii DNA topoisomerase 2, putative 0.002 0.0057 0.0082
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0076 0.0493 0.0493
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0091 0.0083
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0032 0.002
Giardia lamblia Kinase, PLK 0.0194 0.1424 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0065 0.0405 0.0398
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0153 0.1097 0.2388
Echinococcus multilocularis GPCR, family 2 0.0033 0.0153 0.0367
Brugia malayi MGC83647 protein 0.0076 0.0493 0.0924
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0008 0.0001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0065 0.0405 0.1002
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0032 0.0032
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0057 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0846 0.1595
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0091 0.0083
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0057 0.0057
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0017 0.0032 0.0025
Schistosoma mansoni hypothetical protein 0.0072 0.0463 0.0999
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.087 0.1642
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0076 0.0493 0.0486
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0032 0.0025
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0057 0.0274
Trypanosoma cruzi trypanothione reductase, putative 0.0187 0.1362 0.1362
Toxoplasma gondii selenide, water dikinase 0.0017 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Echinococcus granulosus heat shock protein 0.0141 0.1006 0.2517
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0405 0.0405
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0057 0.0057
Treponema pallidum oxidoreductase 0.0017 0.0032 0.0267
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0096
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0073
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0032 0.0032
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0032 0.0025
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.002 0.0057 0.054
Onchocerca volvulus 0.0124 0.0871 0.4743
Schistosoma mansoni heat shock protein 0.0141 0.1006 0.2187
Brugia malayi tailless protein 0.0014 0.0008 0.0001
Brugia malayi hypothetical protein 0.0046 0.026 0.0481
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0065 0.0407 0.0401
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0057 0.0127
Brugia malayi hypothetical protein 0.0016 0.0021 0.0026
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0057 0.005
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Leishmania major NADH dehydrogenase, putative 0.0017 0.0032 0.0032
Trichomonas vaginalis DNA topoisomerase II, putative 0.002 0.0057 0.0057
Echinococcus granulosus peregrin 0.0058 0.0357 0.0881
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0026
Brugia malayi nuclear hormone receptor 0.003 0.0131 0.0236
Brugia malayi isocitrate dehydrogenase 0.0016 0.0024 0.0032
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0032 0.0032
Echinococcus granulosus Phospholipase carboxylesterase 0.0076 0.0493 0.1224
Plasmodium vivax heat shock protein 90, putative 0.0094 0.0634 0.0627
Giardia lamblia PHD finger protein 15 0.0058 0.0357 0.2332
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0076 0.0493 0.0493
Echinococcus multilocularis heat shock protein 90 0.0121 0.0846 0.2113
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.047 0.3586 0.7839
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0065 0.0405 0.0871
Brugia malayi kinase, mitochondrial precursor 0.002 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0066
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0032 0.0063
Loa Loa (eye worm) heat shock protein 90 0.0141 0.1006 0.1899
Leishmania major hypothetical protein, conserved 0.0076 0.0493 0.0493
Brugia malayi Endoplasmin precursor 0.0141 0.1006 0.1899
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0008 0.0001
Chlamydia trachomatis DNA gyrase subunit B 0.002 0.0057 0.1035
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0046 0.026 0.0554
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0357 0.0817
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0065 0.0405 0.0405
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0008 0.0001
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0032 0.0032
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.002 0.0057 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0131 0.0236
Plasmodium falciparum esterase, putative 0.1287 1 1
Echinococcus multilocularis peregrin 0.0058 0.0357 0.0881
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0426 0.3238 0.3234
Loa Loa (eye worm) hypothetical protein 0.0123 0.0865 0.1632
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0065 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0653 0.0653
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0131 0.0271
Giardia lamblia Heat shock protein HSP 90-alpha 0.0121 0.0846 0.5845
Trichomonas vaginalis chromobox protein, putative 0.0046 0.026 0.026
Plasmodium falciparum epoxide hydrolase 2 0.0076 0.0493 0.0486
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0032 0.002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0024 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0131 0.0236
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0153 0.0277
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0027 0.002
Onchocerca volvulus 0.0086 0.0575 0.3117
Echinococcus granulosus abhydrolase domain containing 3 0.0076 0.0493 0.1224
Mycobacterium ulcerans monoxygenase 0.0017 0.0032 0.0025
Brugia malayi hypothetical protein 0.0153 0.1097 0.2074
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0046 0.0073
Echinococcus multilocularis glutamate synthase 0.0017 0.0032 0.0063
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0076 0.0493 0.1151
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0924
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0032 0.0032
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.002 0.0057 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0066
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0034 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0032 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0088 0.0081
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0032 0.0025
Mycobacterium ulcerans hypothetical protein 0.0017 0.0032 0.0025
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0046 0.0084
Brugia malayi TAR-binding protein 0.0196 0.144 0.2725
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0065 0.0405 0.0398
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0032 0.0032
Brugia malayi chromobox protein homolog 3 0.0158 0.1139 0.2154
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0024 0.0032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0131 0.0271
Schistosoma mansoni jun-related protein 0.0072 0.0463 0.0999
Trichomonas vaginalis Heterochromatin protein, putative 0.0046 0.026 0.026
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Echinococcus granulosus GPCR family 2 0.0033 0.0153 0.0367
Echinococcus multilocularis ribosomal protein L19 0.0027 0.0111 0.0261
Mycobacterium ulcerans hypothetical protein 0.0025 0.0094 0.0086
Brugia malayi glutathione reductase 0.0187 0.1362 0.2577
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0643 0.1393
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Loa Loa (eye worm) hypothetical protein 0.007 0.0449 0.0841
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.002 0.0057 0.005
Leishmania major hypothetical protein, conserved 0.0014 0.0007 0.0007
Brugia malayi nuclear receptor NHR-88 0.003 0.0131 0.0236
Toxoplasma gondii Hsp90 domain-containing protein 0.0535 0.4098 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0493 0.0493
Loa Loa (eye worm) glutathione reductase 0.0187 0.1362 0.2577
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0076 0.0493 0.3311
Plasmodium falciparum esterase, putative 0.0076 0.0493 0.0486
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0131 0.0236
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Trichomonas vaginalis sensor histidine kinase, putative 0.002 0.0057 0.0057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0091 0.0083
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.1006 0.1006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0065 0.0405 0.0398
Toxoplasma gondii protein c14orf29, putative 0.0076 0.0493 0.1151
Brugia malayi bZIP transcription factor family protein 0.0089 0.0594 0.1116
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0042 0.0711
Loa Loa (eye worm) hypothetical protein 0.0158 0.1139 0.2154
Echinococcus multilocularis bloom syndrome protein 0.0024 0.009 0.0208
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0076 0.0493 0.0493
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0042
Mycobacterium tuberculosis Probable dehydrogenase 0.0426 0.3238 0.3234
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0076 0.0493 0.1224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0705 0.1327
Toxoplasma gondii hypothetical protein 0.0076 0.0493 0.1151
Brugia malayi nuclear receptor RXR 0.0016 0.0021 0.0026
Trichomonas vaginalis valacyclovir hydrolase, putative 0.1287 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.002 0.0057 0.011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0473 0.3611 0.3607
Loa Loa (eye worm) RecQ helicase 0.0024 0.009 0.0157
Onchocerca volvulus 0.0046 0.026 0.1387
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.0057 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1424 0.1424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.026 0.026
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0473 0.3611 0.3607
Echinococcus multilocularis chromobox protein 1 0.0282 0.2113 0.5308
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0032 0.0063
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0032 0.0047
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0046 0.0097
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0405 0.0405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0643 0.1603
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.002 0.0057 0.0057
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0017 0.0032 0.0025
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0131 0.0312
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.0473 0.3611 0.3607
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0032 0.0054
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1287 1 1
Mycobacterium ulcerans lysophospholipase 0.1287 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0357 0.0665
Schistosoma mansoni chromobox protein 0.0046 0.026 0.0554
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.0076 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Leishmania major hypothetical protein, conserved 0.0017 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0357 0.0881
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0357 0.0881
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0021 0.0026
Giardia lamblia Heat shock protein HSP 90-alpha 0.0141 0.1006 0.6996
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0024 0.0042
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0046 0.026 0.0481
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0017 0.0032 0.0025
Onchocerca volvulus Serine\/threonine kinase homolog 0.0194 0.1424 0.778
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.1006 0.1006
Trypanosoma brucei beta lactamase 0.0065 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0236
Plasmodium falciparum heat shock protein 90 0.0141 0.1006 0.0999
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0065 0.0405 0.0398
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0076 0.0493 0.0493
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0453 0.0977
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0076 0.0493 0.1064
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0091 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Plasmodium falciparum alpha/beta hydrolase, putative 0.0076 0.0493 0.0486
Echinococcus multilocularis Chromobox protein 3 0.0046 0.026 0.0637
Brugia malayi heat shock protein 90 0.0141 0.1006 0.1899
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0131 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0131 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0131 0.0271
Echinococcus granulosus geminin 0.0519 0.3974 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0643 0.1393
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0924
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0924
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0032 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.026 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0131 0.0312
Echinococcus granulosus DNA topoisomerase 2 alpha 0.002 0.0057 0.0127
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0094 0.0086
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0032 0.0032
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.002 0.0057 0.005
Echinococcus multilocularis chromobox protein 2 0.0046 0.026 0.0637
Toxoplasma gondii thioredoxin reductase 0.0187 0.1362 0.3285
Mycobacterium tuberculosis Two component sensor kinase MprB 0.002 0.0057 0.005
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0042 0.0035
Trypanosoma brucei monoglyceride lipase, putative 0.1287 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0131 0.0312
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.002 0.0057 0.005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0131 0.0271
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.002 0.0057 0.005
Loa Loa (eye worm) TOPoisomerase family member 0.002 0.0057 0.0096
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0131 0.0312
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.002 0.0057 0.005
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0032 0.0032
Echinococcus multilocularis Phospholipase carboxylesterase 0.0076 0.0493 0.1224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0091 0.0083
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0057 0.0057
Plasmodium vivax endoplasmin, putative 0.0141 0.1006 0.0999
Chlamydia trachomatis thioredoxin reductase 0.0017 0.0032 0.0512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0046 0.026 0.0554
Plasmodium vivax lysophospholipase, putative 0.0076 0.0493 0.0486
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0032 0.0025
Echinococcus granulosus glutamate synthase 0.0017 0.0032 0.0063
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0076 0.0493 0.0493
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0024 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0091 0.0159
Leishmania major heat shock protein 83-1 0.0141 0.1006 0.1006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0131 0.0271
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0021 0.0034
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.002 0.0057 0.005
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.002 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.1287 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0575 0.108
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0131 0.0312
Trypanosoma brucei heat shock protein, putative 0.0141 0.1006 0.1006
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0076 0.0493 0.1224
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0046 0.0073
Plasmodium vivax glutathione reductase, putative 0.0187 0.1362 0.1356
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0008 0.0001
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0057 0.0082
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0131 0.0236
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0141 0.0336
Schistosoma mansoni fatty-acid amide hydrolase 0.0116 0.0808 0.1754
Toxoplasma gondii ribosomal protein RPL19 0.0027 0.0111 0.0213
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0047 0.0058
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.002 0.0057 0.005
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0046 0.026 0.0637
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0017 0.0032 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0077 0.0503 0.1087
Giardia lamblia Ribosomal protein L19 0.0027 0.0111 0.0566
Echinococcus granulosus tar DNA binding protein 0.0196 0.144 0.3611
Echinococcus granulosus bloom syndrome protein 0.0024 0.009 0.0208
Echinococcus granulosus Chromo domain 0.0046 0.026 0.0637
Leishmania major hypothetical protein, conserved 0.0017 0.0032 0.0032
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.002 0.0057 0.005
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.1006 0.1006
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0493 0.0486
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0116 0.0808 0.2019
Echinococcus granulosus chromobox protein 2 0.0046 0.026 0.0637
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0047 0.0058
Echinococcus multilocularis jun protein 0.0089 0.0594 0.1479
Plasmodium vivax lysophospholipase, putative 0.0076 0.0493 0.0486
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0056 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.1601 0.1601
Brugia malayi small heat shock protein 0.0684 0.5264 1
Plasmodium vivax PST-A protein 0.0076 0.0493 0.0486
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0153 0.1097 0.2748
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0021 0.0026
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0046 0.026 0.0481
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0057 0.0057
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0076 0.0493 0.1151
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0094 0.0094
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0046 0.0084
Entamoeba histolytica serine/threonine protein kinase, putative 0.0194 0.1424 0.1424
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0046 0.026 0.026
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0046 0.026 0.0637
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0132 0.0938 0.0931
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0131 0.0236
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0073
Mycobacterium ulcerans hypothetical protein 0.0076 0.0493 0.0486
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0088 0.1662
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0357 0.035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0131 0.0271
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0194 0.1424 0.3571

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Trichophyton mentagrophytes ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Microsporum canis ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Aspergillus fumigatus ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Sporothrix schenck ii ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Candida albicans 124 ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Candida parapsilosis 39 ChEMBL. 7752208
MIC (functional) > 100 mg l-1 In vitro antifungal activity against Candida albicans 124 ChEMBL. 7752208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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