Detailed information for compound 804539

Basic information

Technical information
  • TDR Targets ID: 804539
  • Name: 6-bromo-2-oxo-N'-(4-prop-2-enoxybenzoyl)chrom ene-3-carbohydrazide
  • MW: 443.248 | Formula: C20H15BrN2O5
  • H donors: 2 H acceptors: 3 LogP: 4.42 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccc(cc1)C(=O)NNC(=O)c1cc2cc(Br)ccc2oc1=O
  • InChi: 1S/C20H15BrN2O5/c1-2-9-27-15-6-3-12(4-7-15)18(24)22-23-19(25)16-11-13-10-14(21)5-8-17(13)28-20(16)26/h2-8,10-11H,1,9H2,(H,22,24)(H,23,25)
  • InChiKey: VMFJLLWSFPDJLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-(4-allyloxybenzoyl)-6-bromo-2-oxo-chromene-3-carbohydrazide
  • N'-[(4-allyloxyphenyl)-oxomethyl]-6-bromo-2-oxo-3-chromenecarbohydrazide
  • N'-(4-allyloxybenzoyl)-6-bromo-2-keto-chromene-3-carbohydrazide
  • 6-bromo-2-oxo-N'-(4-prop-2-enoxyphenyl)carbonyl-chromene-3-carbohydrazide
  • A2032/0085358

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0082 0.2954 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.2886 0.2816
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0098 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0239 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0098 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0406 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.148 0.1396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.148 0.148
Loa Loa (eye worm) hypothetical protein 0.0034 0.0778 0.0686
Schistosoma mansoni lamin 0.0082 0.2954 1
Echinococcus granulosus muscleblind protein 0.0151 0.6045 0.6006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1411 0.1326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1411 0.1411
Echinococcus granulosus intermediate filament protein 0.0082 0.2954 0.2884
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1411 0.1326
Brugia malayi intermediate filament protein 0.0082 0.2954 0.2954
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.148 0.148
Loa Loa (eye worm) hypothetical protein 0.0082 0.2954 0.2884
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0406 1
Echinococcus multilocularis musashi 0.0082 0.2954 0.2884
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0406 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1411 0.4598
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.1239 0.1239
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0406 1
Onchocerca volvulus 0.0082 0.2954 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1411 0.1326
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.1239 0.1152
Brugia malayi Muscleblind-like protein 0.0151 0.6045 0.6045
Loa Loa (eye worm) intermediate filament protein 0.0082 0.2954 0.2884
Brugia malayi hypothetical protein 0.0026 0.0406 0.0406
Echinococcus granulosus survival motor neuron protein 1 0.0239 1 1
Leishmania major hypothetical protein, conserved 0.0026 0.0406 1
Echinococcus multilocularis muscleblind protein 0.0151 0.6045 0.6006
Loa Loa (eye worm) hypothetical protein 0.0239 1 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.1451 0.4739
Onchocerca volvulus 0.0082 0.2954 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0778 0.0778
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1411 0.1326
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0406 1
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.2954 0.2954
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.2954 0.2884
Schistosoma mansoni hypothetical protein 0.0034 0.0778 0.2381
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1043 0.0954
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0406 1
Echinococcus multilocularis muscleblind protein 1 0.0151 0.6045 0.6006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0975 0.0886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1411 0.4598
Loa Loa (eye worm) hypothetical protein 0.0049 0.148 0.1396
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0975 0.0886
Echinococcus granulosus lamin 0.0082 0.2954 0.2884
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.1043 0.0954
Echinococcus multilocularis lamin dm0 0.0082 0.2954 0.2884
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0098 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0098 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1411 0.1326
Echinococcus granulosus lamin dm0 0.0082 0.2954 0.2884
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0098 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1451 0.1451
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0406 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0098 0.0098
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0098 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.1043 0.0954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1411 0.4598
Schistosoma mansoni intermediate filament proteins 0.0082 0.2954 1
Schistosoma mansoni hypothetical protein 0.0049 0.1451 0.4739
Loa Loa (eye worm) hypothetical protein 0.0026 0.0406 0.0311
Loa Loa (eye worm) hypothetical protein 0.0151 0.6045 0.6006
Echinococcus multilocularis lamin 0.0082 0.2954 0.2884
Loa Loa (eye worm) hypothetical protein 0.0151 0.6045 0.6006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.