TDR Targets

Basic information

Technical information

TDR Targets ID: 804611
Name: N-cyclohexyl-N',N'-di(propan-2-yl)benzene-1,4 -dicarboxamide
MW: 330.464 | Formula: C20H30N2O2
H donors: 1 H acceptors: 2 LogP: 4.07 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(N(C(=O)c1ccc(cc1)C(=O)NC1CCCCC1)C(C)C)C
InChi: 1S/C20H30N2O2/c1-14(2)22(15(3)4)20(24)17-12-10-16(11-13-17)19(23)21-18-8-6-5-7-9-18/h10-15,18H,5-9H2,1-4H3,(H,21,23)
InChiKey: DOQXCIUYMFAWEW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclohexyl-N',N'-diisopropyl-terephthalamide
N-cyclohexyl-N',N'-diisopropylterephthalamide
Oprea1_353110

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0043	0.0307	0.5773
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0124	0.1142	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0132
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0098	0.0196
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0124	0.1142	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0429	0.0444
Leishmania major	hypothetical protein, conserved	0.0025	0.0113	0.005
Schistosoma mansoni	hypothetical protein	0.0049	0.0366	0.0425
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0318	0.3148	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0307	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0504	0.1791
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0307	0.0896
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.1088	0.9484
Brugia malayi	beta-lactamase	0.0043	0.0307	0.0975
Echinococcus multilocularis	neuropeptide receptor A26	0.046	0.4623	0.4553
Brugia malayi	beta-lactamase family protein	0.0043	0.0307	0.0975
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0318	0.3148	1
Echinococcus multilocularis	protein patched	0.0051	0.0385	0.0259
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0318	0.3148	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0124	0.1142	0.1026
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0307	0.0868
Brugia malayi	CHE-14 protein	0.0051	0.0385	0.1223
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0307	0.0638
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0385	0.0259
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.1088	0.0972
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0307	0.0896
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0037	0.0032
Schistosoma mansoni	hypothetical protein	0.0049	0.0366	0.0425
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0307	0.0638
Onchocerca volvulus		0.0043	0.0307	0.5773
Brugia malayi	hypothetical protein	0.0043	0.0307	0.0974
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0429	0.0517
Schistosoma mansoni	hypothetical protein	0.0049	0.0366	0.0425
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0318	0.3148	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0132
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0098	0.0196
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0113	0.0245
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0307	0.0638
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0098	0.0312
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0318	0.3148	1
Brugia malayi	hypothetical protein	0.0025	0.0113	0.036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0132
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0307	0.018
Echinococcus multilocularis	microtubule associated protein 2	0.0679	0.6886	0.6845
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0429	0.1524
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0307	0.0868
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0307	0.1091
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0318	0.3148	1
Onchocerca volvulus		0.0043	0.0307	0.5773
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0098	0.0349
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0307	0.0685
Leishmania major	dihydroorotate dehydrogenase	0.0318	0.3148	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0098	0.0196
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0124	0.1142	1
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2815	0.3975
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.1617	0.1507
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.046	0.1461
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0098	0.0196
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0429	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0098	0.0349
Entamoeba histolytica	hypothetical protein	0.0043	0.0307	0.1998
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0318	0.3148	1
Leishmania major	hypothetical protein, conserved	0.0043	0.0307	0.0685
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0318	0.3148	1
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0318	0.3148	1
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0124	0.1142	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0307	0.1091
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0429	0.1362
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0307	0.1091
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0307	0.0338
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0113	0.0245
Entamoeba histolytica	hypothetical protein	0.0043	0.0307	0.1998
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0307	0.1091
Schistosoma mansoni	microtubule-associated protein tau	0.0679	0.6886	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0307	0.0263
Schistosoma mansoni	hypothetical protein	0.0058	0.046	0.0563
Schistosoma mansoni	hypothetical protein	0.0043	0.0307	0.0338
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0307	0.0868
Echinococcus granulosus	microtubule associated protein 2	0.0679	0.6886	1
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0318	0.3148	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0307	0.0975
Echinococcus multilocularis	expressed conserved protein	0.0112	0.1014	0.0896
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0098	0.0196
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0098	0.0227
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0307	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2815	1
Schistosoma mansoni	survival motor neuron protein	0.0058	0.046	0.0563
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0307	0.018
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0429	0.0304
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0124	0.1142	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0307	0.0896
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.1088	0.3456
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0307	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0113	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0307	0.1091
Schistosoma mansoni	metabotropic glutamate receptor	0.0177	0.1686	0.2364
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0307	0.0338
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0307	0.0896
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0098	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0307	0.1091
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0429	0.0517
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.1088	0.1419
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0385	0.0379
Brugia malayi	hypothetical protein	0.0016	0.0022	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1088	0.3866
Mycobacterium ulcerans	lipase LipD	0.0043	0.0307	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0129	0.0459
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0124	0.1142	1
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0318	0.3148	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0098	0.0196
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0098	0.0196
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0429	0.0517
Echinococcus multilocularis	protein dispatched 1	0.0058	0.046	0.0335
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0124	0.1142	0.1026
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0385	0.1369
Schistosoma mansoni	patched 1	0.0051	0.0385	0.0453
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0124	0.1142	1
Brugia malayi	hypothetical protein	0.0286	0.2815	0.894
Entamoeba histolytica	hypothetical protein	0.0043	0.0307	0.1998
Echinococcus granulosus	neuropeptide s receptor	0.046	0.4623	0.6652
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0385	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0385	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0132
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0318	0.3148	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0098	0.0312
Loa Loa (eye worm)	glutamate receptor	0.0021	0.0077	0.0272
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2815	0.2721
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0429	0.0304
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0307	0.0338
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.1617	0.2202
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0307	0.0896
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0385	0.0936
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.2734	0.8672
Echinococcus granulosus	expressed conserved protein	0.0112	0.1014	0.1309
Brugia malayi	Zinc finger, C2H2 type family protein	0.0124	0.1142	0.3627
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0307	0.0896
Echinococcus granulosus	neuropeptide receptor A26	0.046	0.4623	0.6652
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0307	0.0896
Brugia malayi	beta-lactamase family protein	0.0043	0.0307	0.0975
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0318	0.3148	0.4511
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0124	0.1142	0.3389
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0098	0.0349
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0307	0.0263
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0318	0.3148	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0113	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0307	0.1091
Onchocerca volvulus		0.0058	0.046	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0366	0.0425
Entamoeba histolytica	hypothetical protein	0.0043	0.0307	0.1998
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0124	0.1142	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.1107	0.1514
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0307	0.0868
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0307	0.0868
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0098	0.0227
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0307	0.0685
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0124	0.1142	0.1499
Brugia malayi	metabotropic glutamate receptor type 2	0.0026	0.0129	0.041
Toxoplasma gondii	ABC1 family protein	0.0043	0.0307	0.0638
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0037	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0307	0.0896
Echinococcus multilocularis	neuropeptide s receptor	0.046	0.4623	0.4553
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0098	0.0312

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 804611