Detailed information for compound 80462
Basic information
Technical information
Network
Hover on a compound node to display the structore
Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta2 | Starlite/ChEMBL | References |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha2/beta2 | Starlite/ChEMBL | References |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta4 | Starlite/ChEMBL | References |
| Rattus norvegicus | Neuronal acetylcholine receptor | Starlite/ChEMBL | References |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta4 | Starlite/ChEMBL | References |
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Loa Loa (eye worm) | ACC-1 protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | glycine receptor subunit beta | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0128 | 1 | 1 |
| Onchocerca volvulus | Putative nachr subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0059 | 0.3451 | 0.3451 |
| Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0059 | 0.3451 | 0.3144 |
| Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.4083 | 0.3963 |
| Schistosoma mansoni | nAChR subunit | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0128 | 1 | 1 |
| Brugia malayi | Cation transporter family protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0059 | 0.3451 | 0.3144 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.02 | 0.02 |
| Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1854 | 0.1854 |
| Onchocerca volvulus | 0.0128 | 1 | 1 | |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 1 | |
| Brugia malayi | hypothetical protein | 0.0059 | 0.3451 | 0.3144 |
| Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0059 | 0.3451 | 0.3451 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Brugia malayi | hypothetical protein | 0.0059 | 0.3451 | 0.3144 |
| Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0128 | 1 | 1 |
| Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus granulosus | nAChR subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Brugia malayi | hypothetical protein | 0.0059 | 0.3451 | 0.3144 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1599 | 0.1428 |
| Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.4458 | 0.4458 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0059 | 0.3451 | 0.3318 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus multilocularis | glycine receptor subunit beta | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neurotransmitter gated ion channel | 0.0069 | 0.4392 | 0.4392 |
| Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0069 | 0.4392 | 0.413 |
| Loa Loa (eye worm) | GABA receptor subunit | 0.0069 | 0.4392 | 0.4392 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0069 | 0.4392 | 0.413 |
| Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0059 | 0.3451 | 0.3318 |
| Onchocerca volvulus | 0.0069 | 0.4392 | 0.1438 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | nAChR subunit | 0.0128 | 1 | 1 |
| Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0069 | 0.4392 | 0.4392 |
| Schistosoma mansoni | acetylcholine receptor-related | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0128 | 1 | 1 |
| Echinococcus granulosus | glycine receptor subunit beta | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0069 | 0.4392 | 0.413 |
| Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0069 | 0.4392 | 0.4392 |
| Echinococcus granulosus | nAChR subunit | 0.0069 | 0.4392 | 0.4278 |
| Brugia malayi | hypothetical protein | 0.0059 | 0.3451 | 0.3144 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Onchocerca volvulus | 0.0128 | 1 | 1 | |
| Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0128 | 1 | 1 |
| Brugia malayi | Cation transporter family protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Schistosoma mansoni | neurotransmitter gated ion channel | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0059 | 0.3451 | 0.3318 |
| Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0128 | 1 | 1 |
| Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0128 | 1 | 1 |
| Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1846 | 0.1465 |
| Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Brugia malayi | hypothetical protein | 0.0059 | 0.3451 | 0.3144 |
| Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | acetylcholine receptor protein | 0.0059 | 0.3451 | 0.3451 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0059 | 0.3451 | 0.3318 |
| Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0069 | 0.4392 | 0.413 |
| Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0128 | 1 | 1 |
| Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.4083 | 0.3963 |
| Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0128 | 1 | 1 |
| Brugia malayi | Cation transporter family protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0128 | 1 | 1 |
| Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2301 | 0.2301 |
| Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neurotransmitter gated ion channel | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0059 | 0.3451 | 0.3144 |
| Onchocerca volvulus | 0.0069 | 0.4392 | 0.1438 | |
| Loa Loa (eye worm) | LGC-31 protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0128 | 1 | 1 |
| Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1599 | 0.1428 |
| Echinococcus granulosus | glycine receptor subunit beta | 0.0128 | 1 | 1 |
| Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0059 | 0.3451 | 0.3144 |
| Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0059 | 0.3451 | 0.3318 |
| Echinococcus multilocularis | nAChR subunit | 0.0069 | 0.4392 | 0.4278 |
| Schistosoma mansoni | nAChR subunit | 0.0059 | 0.3451 | 0.3451 |
| Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2101 | 0.2101 |
| Entamoeba histolytica | hypothetical protein | 0.0069 | 0.4392 | 0.5 |
| Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0128 | 1 | 1 |
| Brugia malayi | Bromodomain containing protein | 0.0083 | 0.5682 | 0.548 |
| Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0059 | 0.3451 | 0.3144 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0059 | 0.3451 | 0.3144 |
| Onchocerca volvulus | 0.0128 | 1 | 1 | |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5235 | 0.5235 |
| Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 1 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4392 | 0.4392 |
| Schistosoma mansoni | nAChR subunit | 0.0128 | 1 | 1 |
| Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 1 | |
| Loa Loa (eye worm) | ACC-1 protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3451 | 0.3451 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Ki (binding) | = 0.031 nM | Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.031 nM | Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.062 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.062 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.14 nM | Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.14 nM | Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.42 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 0.42 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 24 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 24 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 47 nM | Binding affinity towards rat alpha2-beta4 nACh receptor expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 290 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ki (binding) | = 290 nM | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ratio (binding) | = 387 | Ratio between the binding affinities towards rat alpha4-beta4 and alpha4-beta2 nACh receptor using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ratio (binding) | = 690 | Ratio between the binding affinities towards rat alpha3-beta4 and alpha3-beta2 nACh receptor using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ratio (binding) | = 1516 | Ratio between the binding affinities towards rat alpha2-beta4 and alpha2-beta2 nACh receptor using [3H]-EB as radioligand | ChEMBL. | 15050613 |
| Ratio (binding) | = 2071 | Ratio between the binding affinities towards rat alpha3-beta4 and forebrain nACh receptor using [3H]-EB as radioligand | ChEMBL. | 15050613 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
No external resources registered for this compound
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.