Detailed information for compound 805016

Basic information

Technical information
  • TDR Targets ID: 805016
  • Name: 3-(3-methoxyphenyl)-4-(4-methylphenyl)-4,5-di hydro-1H-pyrrolo[4,3-d]pyrazol-6-one
  • MW: 319.357 | Formula: C19H17N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1[nH]nc2c1C(NC2=O)c1ccc(cc1)C
  • InChi: 1S/C19H17N3O2/c1-11-6-8-12(9-7-11)16-15-17(21-22-18(15)19(23)20-16)13-4-3-5-14(10-13)24-2/h3-10,16H,1-2H3,(H,20,23)(H,21,22)
  • InChiKey: LEVXWIATMDPQHU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PA14 domain-containing protein 0.0051 0.0007 0.0146
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0099 0.0053 0.1758
Brugia malayi amine oxidase, flavin-containing family protein 0.0099 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.1761 0.164 0.1636
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0089 0.0043 0.1413
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0053 0.0071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0152 0.0204
Plasmodium falciparum subtilisin-like protease 2 0.0342 0.0285 0.8476
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.0285 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.0285 0.0616
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.03 0.0245 0.3928
Schistosoma mansoni amine oxidase 0.007 0.0026 0.0034
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.03 0.0245 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0372 0.0314 0.5033
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0046 0.0003 0.0003
Echinococcus multilocularis protein arginine N methyltransferase 8 0.006 0.0016 0.0022
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4778 0.4521 0.6084
Giardia lamblia hypothetical protein 0.0228 0.0176 0.0462
Brugia malayi Reprolysin 0.0141 0.0093 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0026 0.0784
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0007 0.0146
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0039 0.0053
Schistosoma mansoni hypothetical protein 0.0063 0.0019 0.0025
Echinococcus granulosus disintegrin and metalloproteinase 0.01 0.0054 0.0073
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0094 0.0048 0.1589
Brugia malayi Stress-activated protein kinase jnk-1 0.0237 0.0185 0.0185
Echinococcus multilocularis MAM 0.0091 0.0046 0.0062
Echinococcus granulosus glutamate receptor subunit protein glur 0.0046 0.0003 0.0003
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0099 0.0053 0.0071
Schistosoma mansoni site-1 peptidase (S08 family) 0.0342 0.0285 0.0384
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0099 0.0053 0.0071
Brugia malayi celfurPC protein 0.6278 0.5952 0.5952
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0076 0.0031 0.0991
Loa Loa (eye worm) hypothetical protein 0.0086 0.004 0.0036
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0056 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0074 0.003 0.0025
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0342 0.0285 0.0384
Onchocerca volvulus Fatty acid synthase homolog 0.0165 0.0116 0.357
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0146 0.0098 0.0133
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0094 0.0048 0.1589
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.079 0.0713 0.0967
Loa Loa (eye worm) reprolysin 0.0241 0.0189 0.0185
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0043 0.1396
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0026 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0146 0.0098 0.0132
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0057 0.0013 0.0346
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0342 0.0285 0.0387
Mycobacterium ulcerans dehydrogenase 0.007 0.0026 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0007 0.0146
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0072 0.0027 0.0831
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Schistosoma mansoni integrin alpha-ps 0.1199 0.1103 0.1484
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0026 0.0784
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1891 0.1763 0.3891
Trichomonas vaginalis hypothetical protein 0.0228 0.0176 0.0374
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0096 0.0092
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0023 0.003
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0342 0.0285 1
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0228 0.0176 0.0374
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0599 0.1311
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0087 0.0041 0.1342
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0026 0.0764
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0039 0.0053
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0028 0.0037
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0053 0.0479
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0172
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0026 0.0562
Onchocerca volvulus 0.0342 0.0285 0.9005
Giardia lamblia High cysteine protein 0.0228 0.0176 0.0462
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0039 0.0053
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0099 0.0053 0.0071
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.03 0.0245 0.7247
Toxoplasma gondii subtilisin SUB8 0.0342 0.0285 0.9447
Onchocerca volvulus 0.0086 0.004 0.1131
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.017 0.0121 0.0121
Echinococcus granulosus adam 17 protease 0.01 0.0054 0.0073
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0046 0.0003 0.0003
Onchocerca volvulus 0.0091 0.0046 0.1305
Toxoplasma gondii type I fatty acid synthase, putative 0.0065 0.0021 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0053 0.0049
Chlamydia trachomatis protoporphyrinogen oxidase 0.007 0.0026 0.0915
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0172
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0172
Loa Loa (eye worm) hypothetical protein 0.0118 0.0071 0.0067
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.01 0.0054 0.0073
Brugia malayi hypothetical protein 0.007 0.0026 0.0026
Schistosoma mansoni retinoic acid receptor RXR 0.01 0.0054 0.0073
Giardia lamblia Hypothetical protein 0.067 0.0599 0.2049
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0087 0.0041 0.1566
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0043 0.1396
Trypanosoma brucei subtilisin peptidase 0.0342 0.0285 0.4303
Echinococcus multilocularis tumor protein p63 0.0229 0.0177 0.0241
Plasmodium falciparum plasmepsin V 0.0395 0.0335 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0046 0.0003 0.0003
Echinococcus granulosus integrin alpha 3 0.1836 0.1711 0.2303
Echinococcus multilocularis membrane bound transcription factor site 1 0.0342 0.0285 0.0387
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0088 0.0043 0.1396
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Loa Loa (eye worm) proprotein convertase 2 0.1891 0.1763 0.176
Loa Loa (eye worm) hypothetical protein 0.0141 0.0093 0.0089
Leishmania major UDP-galactopyranose mutase 0.007 0.0026 0.0163
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0599 0.1311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1891 0.1763 0.3891
Toxoplasma gondii subtilisin SUB9 0.0342 0.0285 0.9447
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Mycobacterium ulcerans thioesterase TesA 0.0076 0.0031 0.0991
Echinococcus multilocularis thyroid hormone receptor alpha 0.0119 0.0072 0.0097
Brugia malayi Protein kinase domain containing protein 0.0051 0.0007 0.0007
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.0039 0.0053
Plasmodium vivax NAD-dependent deacetylase, putative 0.0099 0.0053 0.1398
Leishmania major hypothetical protein, conserved 0.0086 0.004 0.0415
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0342 0.0285 1
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.03 0.0245 0.8099
Brugia malayi Furin-like cysteine rich region family protein 0.0455 0.0393 0.0393
Echinococcus multilocularis epidermal growth factor receptor 0.0455 0.0393 0.0533
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0039 0.0053
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0094 0.0048 0.1589
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0043 0.1396
Leishmania major sir2-family protein-like protein 0.0099 0.0053 0.0634
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0088 0.0043 0.1396
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0088 0.0043 0.1396
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0099 0.0053 0.1398
Brugia malayi EGF-like domain containing protein 0.0228 0.0176 0.0176
Echinococcus multilocularis fibrillin 1 0.0255 0.0202 0.0274
Schistosoma mansoni hypothetical protein 0.0085 0.004 0.0054
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0053 0.0479
Schistosoma mansoni discoidin domain receptor 0.0051 0.0007 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Toxoplasma gondii histone deacetylase SIR2-like 0.0099 0.0053 0.1681
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Brugia malayi Protein kinase domain containing protein 0.0086 0.004 0.004
Schistosoma mansoni protein kinase 0.0146 0.0098 0.0132
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0046 0.0003 0.0003
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0053 0.0071
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0316 0.026 0.035
Loa Loa (eye worm) subtilase 0.0342 0.0285 0.0281
Toxoplasma gondii subtilisin SUB5 0.0342 0.0285 0.9447
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.007 0.0026 0.079
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0085 0.004 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1891 0.1763 0.3891
Loa Loa (eye worm) hypothetical protein 0.0067 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.01 0.0054 0.005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Schistosoma mansoni protein kinase 0.0146 0.0098 0.0132
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0026 0.0035
Echinococcus granulosus chromatin regulatory protein sir2 0.067 0.0599 0.0806
Loa Loa (eye worm) hypothetical protein 0.0051 0.0007 0.0003
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0099 0.0053 0.0072
Brugia malayi Kelch motif family protein 0.1646 0.153 0.153
Echinococcus multilocularis nmda type glutamate receptor 0.0133 0.0085 0.0116
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0372 0.0314 0.4826
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0099 0.0053 0.0634
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.03 0.0245 0.033
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0099 0.0053 0.0885
Schistosoma mansoni hypothetical protein 0.0068 0.0023 0.0031
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0063 0.0019 0.0019
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.03 0.0245 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0225 0.0174 0.0234
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0023 0.003
Brugia malayi EGF-like domain containing protein 0.0228 0.0176 0.0176
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0342 0.0285 1
Onchocerca volvulus 0.0171 0.0121 0.3742
Schistosoma mansoni hypothetical protein 0.0063 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0375 0.0316 0.0312
Schistosoma mansoni hypothetical protein 0.0051 0.0007 0.001
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0241 0.0189 0.0257
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0086 0.004 0.0036
Echinococcus multilocularis Tolloid protein 1 0.0056 0.0012 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0088 0.0043 0.1396
Echinococcus granulosus glutamate NMDA receptor subunit 0.0318 0.0262 0.0353
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0241 0.0189 0.0254
Toxoplasma gondii subtilisin SUB4 0.0342 0.0285 0.9447
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Plasmodium falciparum cysteine repeat modular protein 1 0.0086 0.004 0.101
Schistosoma mansoni hypothetical protein 0.0091 0.0046 0.0061
Loa Loa (eye worm) TK/ALK protein kinase 0.0091 0.0046 0.0041
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.007 0.0026 0.079
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0066 0.0021 0.0634
Loa Loa (eye worm) integrin alpha pat-2 0.3578 0.3374 0.3371
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0053 0.0885
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0342 0.0285 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0342 0.0285 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0088 0.0043 0.0043
Mycobacterium ulcerans polyketide synthase 0.0088 0.0043 0.1396
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0007 0.001
Plasmodium vivax subtilisin-like protease 2, putative 0.0342 0.0285 0.8476
Schistosoma mansoni tyrosine kinase 0.0455 0.0393 0.0529
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0028 0.0465
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.03 0.0245 0.0241
Loa Loa (eye worm) metalloprotease 0.0067 0.0022 0.0018
Plasmodium vivax subtilisin-like protease 1 0.0342 0.0285 0.8476
Mycobacterium tuberculosis Probable thioesterase TesA 0.0076 0.0031 0.0991
Schistosoma mansoni furin-1 (S08 family) 0.339 0.3195 0.43
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0094 0.0048 0.0399
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0026 0.0784
Toxoplasma gondii subtilisin SUB6 0.0342 0.0285 0.9447
Echinococcus multilocularis adam 0.0544 0.0478 0.0648
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0253 0.02 0.0427
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0053 0.0053
Toxoplasma gondii hypothetical protein 0.0228 0.0176 0.5799
Giardia lamblia Neurogenic locus Notch protein precursor 0.0228 0.0176 0.0462
Giardia lamblia Tenascin precursor 0.0228 0.0176 0.0462
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0342 0.0285 0.0285
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.079 0.0713 0.0959
Schistosoma mansoni ATP-binding cassette transporter 0.007 0.0025 0.0034
Plasmodium vivax hypothetical protein, conserved 0.007 0.0026 0.0562
Giardia lamblia High cysteine protein 0.0228 0.0176 0.0462
Trichomonas vaginalis WD repeat domain, putative 0.0068 0.0023 0.0036
Schistosoma mansoni amine oxidase 0.007 0.0026 0.0034
Toxoplasma gondii kringle domain-containing protein 0.0086 0.004 0.1254
Trypanosoma cruzi subtilisin peptidase 0.0342 0.0285 0.4531
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0007 0.001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.006 0.0016 0.002
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Toxoplasma gondii subtilisin SUB7 0.0342 0.0285 0.9447
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0046 0.0003 0.0003
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0023 0.0023
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0342 0.0285 0.0384
Plasmodium falciparum protein arginine N-methyltransferase 1 0.006 0.0016 0.0273
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0039 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.0285 0.0616
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0023 0.0031
Plasmodium vivax plasmepsin V, putative 0.0395 0.0335 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0345 0.0288 0.0391
Trichomonas vaginalis hypothetical protein 0.1548 0.1437 0.3168
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0318 0.0262 0.0356
Brugia malayi Protein kinase domain containing protein 0.0091 0.0046 0.0046
Mycobacterium ulcerans polyketide synthase Pks9 0.0057 0.0013 0.0346
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0128 0.008 0.008
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0099 0.0053 0.0082
Schistosoma mansoni btb and poz domain-containing protein 0.0051 0.0007 0.001
Echinococcus granulosus integrin beta 2 0.7762 0.7369 0.9917
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0099 0.0053 0.0885
Brugia malayi AMP-binding enzyme family protein 0.0086 0.004 0.004
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0051 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0172
Schistosoma mansoni hypothetical protein 0.0575 0.0507 0.0682
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0052 0.0008 0.017
Schistosoma mansoni glutamate receptor NMDA 0.0318 0.0262 0.0353
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.03 0.0245 0.0245
Schistosoma mansoni thyroid hormone receptor 0.0119 0.0072 0.0097
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.0693 0.062 0.0616
Loa Loa (eye worm) TK/ROR protein kinase 0.0086 0.004 0.0036
Mycobacterium ulcerans monoamine oxidase 0.007 0.0026 0.0784
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0026 0.0562
Toxoplasma gondii histone deacetylase SIR2 0.0099 0.0053 0.1681
Plasmodium vivax hypothetical protein, conserved 0.007 0.0026 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0043 0.0058
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0026 0.0562
Loa Loa (eye worm) TK/EGFR protein kinase 0.0455 0.0393 0.0389
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.03 0.0245 0.3828
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1239 0.1142 0.1536
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0039 0.0053
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0053 0.0071
Schistosoma mansoni integrin beta subunit 0.6146 0.5826 0.7841
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Brugia malayi metalloprotease 0.0067 0.0022 0.0022
Schistosoma mansoni apoptosis regulator bax 0.0063 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.7827 0.7431 0.743
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.03 0.0245 0.0332
Echinococcus granulosus Furin 1 0.1891 0.1763 0.2373
Brugia malayi ADAMTS-like protease 0.0141 0.0093 0.0093
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1548 0.1437 0.3168
Loa Loa (eye worm) hypothetical protein 0.1885 0.1758 0.1755
Mycobacterium ulcerans polyketide synthase Pks13 0.0134 0.0086 0.293
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Brugia malayi MH2 domain containing protein 0.0144 0.0096 0.0096
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Echinococcus granulosus tumor protein p63 0.0229 0.0177 0.0239
Loa Loa (eye worm) sirtuin 4 0.0099 0.0053 0.0049
Echinococcus granulosus c-Jun N-terminal kinases 0.0237 0.0185 0.0249
Mycobacterium ulcerans polyketide synthase 0.0094 0.0048 0.1589
Loa Loa (eye worm) hypothetical protein 0.0643 0.0573 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.004 0.0256
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0056 0.0012 0.0008
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0039 0.0053
Echinococcus granulosus adam 0.0544 0.0478 0.0643
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0007 0.0146
Loa Loa (eye worm) hypothetical protein 0.007 0.0026 0.0021
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0026 0.0034
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0051 0.0007 0.001
Loa Loa (eye worm) glutamate receptor 2 0.0067 0.0023 0.0018
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0046 0.0003 0.0003
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0099 0.0053 0.1398
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0078 0.0033 0.0123
Echinococcus multilocularis protein arginine methyltransferase 0.006 0.0016 0.0022
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0099 0.0053 0.0072
Loa Loa (eye worm) hypothetical protein 0.0094 0.0048 0.0044
Schistosoma mansoni integrin alpha 0.246 0.2307 0.3104
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Loa Loa (eye worm) hypothetical protein 0.3048 0.2869 0.2866
Toxoplasma gondii subtilisin SUB12 0.0356 0.0298 0.9888
Echinococcus granulosus nmda type glutamate receptor 0.0133 0.0085 0.0115
Echinococcus multilocularis integrin alpha ps 0.1199 0.1103 0.1497
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0026 0.0784
Schistosoma mansoni dihydroceramide desaturase 0.01 0.0054 0.0073
Echinococcus granulosus epidermal growth factor receptor 0.0455 0.0393 0.0529
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0094 0.0048 0.0809
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Loa Loa (eye worm) fatty acid synthase 0.009 0.0045 0.004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0039 0.0053
Mycobacterium leprae Probable polyketide synthase Pks1 0.0094 0.0048 0.1589
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0342 0.0285 0.0384
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0053 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Schistosoma mansoni hypothetical protein 0.0086 0.004 0.0054
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0067 0.0022 0.003
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1891 0.1763 0.2373
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0039 0.0053
Schistosoma mansoni septate junction protein 0.0069 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.007 0.0026 0.0021
Loa Loa (eye worm) endoprotease bli-4 0.7827 0.7431 0.743
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0237 0.0185 0.0181
Brugia malayi endoprotease bli-4 precursor 0.7827 0.7431 0.7431
Loa Loa (eye worm) hypothetical protein 0.0049 0.0005 0.0001
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0342 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0046 0.0041
Plasmodium falciparum subtilisin-like protease 3 0.0342 0.0285 0.8476
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0253 0.02 0.5
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0599 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0026 0.0764
Brugia malayi Kringle domain containing protein 0.0086 0.004 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0232 0.018 0.0243
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0053 0.1398
Loa Loa (eye worm) WD40 repeat protein 0.0068 0.0023 0.0019
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.03 0.0245 0.3571
Echinococcus granulosus glutamate receptor 2 0.0084 0.0039 0.0053
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0007 0.001
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0026 0.0784
Loa Loa (eye worm) hypothetical protein 0.0091 0.0046 0.0041
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1548 0.1437 0.3168
Echinococcus multilocularis NMDA receptor 0.0046 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1891 0.1763 0.3891
Loa Loa (eye worm) hypothetical protein 0.0202 0.0152 0.0147
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0087 0.0041 0.1342
Loa Loa (eye worm) angiogenesis inhibito 0.0067 0.0022 0.0018
Echinococcus granulosus protein arginine N methyltransferase 8 0.006 0.0016 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Mycobacterium leprae Polyketide synthase Pks13 0.0134 0.0086 0.293
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0133 0.0085 0.0116
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1891 0.1763 0.3891
Schistosoma mansoni integrin alpha-ps 0.0693 0.062 0.0834
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4778 0.4521 1
Echinococcus granulosus Tolloid protein 1 0.0056 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0063 0.0019 0.0014
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0253 0.02 0.6976
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0023 0.003
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.067 0.0599 0.0812
Toxoplasma gondii subtilisin SUB10 0.0342 0.0285 0.9447
Onchocerca volvulus 0.0159 0.0111 0.3395
Onchocerca volvulus 0.0375 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0012 0.0008
Trypanosoma brucei SIR2-like protein 4, putative 0.0099 0.0053 0.0082
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0342 0.0285 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Loa Loa (eye worm) hypothetical protein 0.0345 0.0288 0.0284
Echinococcus multilocularis protein jagged 2 0.0228 0.0176 0.0239
Onchocerca volvulus 0.0228 0.0176 0.5499
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Echinococcus multilocularis disintegrin and metalloproteinase 0.01 0.0054 0.0073
Brugia malayi Subtilase family protein 0.0342 0.0285 0.0285
Onchocerca volvulus 0.0051 0.0007 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Brugia malayi Disintegrin family protein 0.01 0.0054 0.0054
Giardia lamblia Tenascin-37 0.0228 0.0176 0.0462
Loa Loa (eye worm) hypothetical protein 0.0342 0.0285 0.0281
Mycobacterium leprae Possible secreted protease 0.0342 0.0285 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0083 0.0037 0.0051
Trypanosoma brucei Silent information regulator 2 related protein 1 0.067 0.0599 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Loa Loa (eye worm) hypothetical protein 0.1616 0.1501 0.1497
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0599 1
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0053 0.0049
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0094 0.0048 0.1589
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.03 0.0245 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.0285 0.0616
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0599 0.0806
Giardia lamblia High cysteine membrane protein Group 2 0.2888 0.2716 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.067 0.0599 0.0806
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0096 0.0092
Mycobacterium ulcerans NAD-dependent deacetylase 0.0099 0.0053 0.1758
Brugia malayi proprotein convertase 2 0.4939 0.4674 0.4674
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0599 0.0806
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0094 0.0048 0.1589
Onchocerca volvulus 0.0086 0.004 0.1132
Toxoplasma gondii type I fatty acid synthase, putative 0.0094 0.0048 0.1522
Trichomonas vaginalis conserved hypothetical protein 0.0342 0.0285 0.0616
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.0043 0.0039
Schistosoma mansoni hypothetical protein 0.0063 0.0019 0.0025
Schistosoma mansoni protein arginine N-methyltransferase 1 0.006 0.0016 0.0022
Plasmodium falciparum subtilisin-like protease 1 0.0342 0.0285 0.8476
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0063 0.0019 0.0025
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Echinococcus granulosus integrin alpha ps 0.1268 0.1169 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.1548 0.1437 0.3168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Brugia malayi Calcium binding EGF domain containing protein 0.0049 0.0005 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0057 0.0013 0.0346
Toxoplasma gondii subtilisin SUB2 0.0342 0.0285 0.9447
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0026 0.0784
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0063 0.0019 0.0025
Brugia malayi neuroendocrine convertase 1 precursor 0.4939 0.4674 0.4674
Echinococcus granulosus membrane bound transcription factor site 1 0.0342 0.0285 0.0384
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.006 0.0016 0.0273
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0051 0.0007 0.0129
Onchocerca volvulus 0.0202 0.0152 0.4711
Echinococcus granulosus furin 0.7827 0.7431 1
Leishmania major silent information regulator 2, putative 0.067 0.0599 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0081 0.0036 0.0049
Schistosoma mansoni protein arginine N-methyltransferase 1 0.006 0.0016 0.0022
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0026 0.0562
Chlamydia trachomatis glutamine binding protein 0.0087 0.0041 0.1566
Giardia lamblia Neurogenic locus notch-like protein 0.0228 0.0176 0.0462
Mycobacterium ulcerans thioesterase 0.0076 0.0031 0.0991
Loa Loa (eye worm) hypothetical protein 0.0091 0.0046 0.0041
Loa Loa (eye worm) apoptosis regulator protein 0.0063 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0099 0.0053 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1891 0.1763 0.3891
Echinococcus granulosus discoidin domain receptor 0.0051 0.0007 0.001
Schistosoma mansoni protein kinase 0.0146 0.0098 0.0132
Loa Loa (eye worm) hypothetical protein 0.0241 0.0189 0.0185
Echinococcus multilocularis integrin beta 2 0.7762 0.7369 1
Brugia malayi hypothetical protein 0.0316 0.026 0.026
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0023 0.003
Echinococcus granulosus fibrillin 2 0.0228 0.0176 0.0237
Loa Loa (eye worm) hypothetical protein 0.0141 0.0093 0.0089
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0241 0.0189 0.0254
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0007 0.001
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0342 0.0285 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.007 0.0026 0.079
Mycobacterium ulcerans Sir2-like regulatory protein 0.0099 0.0053 0.1758
Echinococcus granulosus fibrillin 1 0.0229 0.0177 0.0239
Schistosoma mansoni hypothetical protein 0.0091 0.0046 0.0061
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0342 0.0285 1
Onchocerca volvulus 0.0091 0.0046 0.1305
Brugia malayi Integrin alpha pat-2 precursor 0.246 0.2307 0.2307
Echinococcus granulosus protein will die slowly 0.0068 0.0023 0.0031
Giardia lamblia Tenascin-like 0.0228 0.0176 0.0462
Loa Loa (eye worm) hypothetical protein 0.0345 0.0288 0.0284
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0134 0.0086 0.293
Onchocerca volvulus 0.0051 0.0007 0.0067
Giardia lamblia Furin precursor putative serine protease 0.1548 0.1437 0.5197
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0094 0.0048 0.1589
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0086 0.004 0.101
Leishmania major subtilisin-like serine peptidase 0.0342 0.0285 0.462
Brugia malayi transcriptional regulator, Sir2 family protein 0.067 0.0599 0.0599
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0026 0.0034
Loa Loa (eye worm) integrin beta-2 1.0518 1 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0007 0.001
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0088 0.0043 0.1396
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0099 0.0053 0.0072
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.0043 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Echinococcus multilocularis integrin alpha 3 0.1836 0.1711 0.2322
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0372 0.0314 0.5033
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0023 0.003
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0128 0.008 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0253 0.02 0.6976
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.01 0.0054 0.0073
Brugia malayi EGF-like domain containing protein 0.0228 0.0176 0.0176
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1761 0.164 0.164
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0051 0.0007 0.0129
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Toxoplasma gondii subtilisin SUB11 0.0342 0.0285 0.9447
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0599 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0599 1
Echinococcus multilocularis 0.6278 0.5952 0.8078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4778 0.4521 1
Echinococcus granulosus integrin alpha ps 0.0575 0.0507 0.0682
Mycobacterium ulcerans oxidoreductase 0.007 0.0026 0.0784
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0253 0.02 0.6976
Echinococcus multilocularis fibrillin 2 0.0228 0.0176 0.0239
Echinococcus multilocularis integrin alpha ps 0.1268 0.1169 0.1586
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0342 0.0285 0.0616
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Loa Loa (eye worm) transcriptional regulator 0.067 0.0599 0.0594
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1646 0.153 0.1526
Schistosoma mansoni protein arginine N-methyltransferase 1 0.006 0.0016 0.0022
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0342 0.0285 0.4531
Echinococcus granulosus lysine specific histone demethylase 1A 0.0345 0.0288 0.0388
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0026 0.0562
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0094 0.0048 0.0399
Giardia lamblia Tenascin-X 0.0228 0.0176 0.0462
Toxoplasma gondii subtilisin SUB1 0.0342 0.0285 0.9447
Schistosoma mansoni thyroid hormone receptor 0.0119 0.0072 0.0097
Loa Loa (eye worm) hypothetical protein 0.0099 0.0053 0.0049
Entamoeba histolytica hypothetical protein 0.0094 0.0048 0.0809
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0053 0.0102
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0342 0.0285 0.0285
Brugia malayi SWIRM domain containing protein 0.0375 0.0316 0.0316
Schistosoma mansoni dock 0.0051 0.0007 0.001
Echinococcus granulosus neuroendocrine convertase 2 0.4939 0.4674 0.629
Echinococcus multilocularis 0.007 0.0026 0.0035
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0063 0.0019 0.0025
Schistosoma mansoni hypothetical protein 0.1548 0.1437 0.1934
Loa Loa (eye worm) hypothetical protein 0.0202 0.0152 0.0147
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4778 0.4521 0.6135
Toxoplasma gondii aspartyl protease ASP5 0.0359 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.015 0.0102 0.0098
Echinococcus granulosus protein arginine methyltransferase 0.006 0.0016 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.01 0.0054 0.0073
Echinococcus granulosus tissue type plasminogen activator 0.0086 0.004 0.0054
Brugia malayi EGF-like domain containing protein 0.0228 0.0176 0.0176
Echinococcus multilocularis neuroendocrine convertase 2 0.4939 0.4674 0.6342
Plasmodium vivax subtilisin-like serine protease, putative 0.0342 0.0285 0.8476
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0185 0.0249
Brugia malayi hypothetical protein 0.0094 0.0048 0.0048
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0086 0.004 0.1304
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0085 0.004 0.0054
Echinococcus multilocularis protein will die slowly 0.0068 0.0023 0.0031
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0599 0.0806
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7827 0.7431 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1548 0.1437 0.3168
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0091 0.0045 0.1487
Brugia malayi Trypsin family protein 0.0202 0.0152 0.0152
Brugia malayi ADAM-TS Spacer 1 family protein 0.0141 0.0093 0.0093
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.006 0.0016 0.002
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0043 0.1396
Loa Loa (eye worm) hypothetical protein 0.1261 0.1163 0.1159
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0089 0.0043 0.1413
Brugia malayi hypothetical protein 0.0091 0.0046 0.0046
Onchocerca volvulus 0.0068 0.0023 0.0585
Brugia malayi Will die slowly protein 0.0068 0.0023 0.0023
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0241 0.0189 0.0254
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0051 0.0007 0.001
Brugia malayi hypothetical protein 0.1616 0.1501 0.1501
Brugia malayi NAD-dependent deacetylase SIRT1 0.0099 0.0053 0.0053
Echinococcus multilocularis tissue type plasminogen activator 0.0086 0.004 0.0055
Echinococcus multilocularis Furin 1 0.1891 0.1763 0.2393
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0345 0.0288 0.0388
Echinococcus multilocularis integrin alpha ps 0.0575 0.0507 0.0688
Echinococcus multilocularis chromatin regulatory protein sir2 0.067 0.0599 0.0812
Schistosoma mansoni site-1 peptidase (S08 family) 0.0342 0.0285 0.0384
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0053 0.0053
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0094 0.0048 0.1589
Brugia malayi protein kinase C II. 0.0089 0.0043 0.0043
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0134 0.0086 0.293
Brugia malayi angiogenesis inhibito 0.0141 0.0093 0.0093
Echinococcus granulosus MAM 0.0091 0.0046 0.0061
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.0043 0.0058
Schistosoma mansoni hypothetical protein 0.0046 0.0003 0.0003
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.03 0.0245 0.7247
Onchocerca volvulus 0.0133 0.0086 0.2601
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.006 0.0016 0.002
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0237 0.0185 0.0251
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0059 0.0015 0.0419
Echinococcus multilocularis discoidin domain receptor 0.0051 0.0007 0.001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0051 0.0007 0.0003
Schistosoma mansoni discoidin domain receptor 0.0051 0.0007 0.001
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.006 0.0016 0.0446

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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