Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1588 | 0.1497 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0107 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Onchocerca volvulus | 0.0095 | 0.1588 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3261 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0107 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3261 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3261 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0095 | 0.1588 | 0.1497 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0095 | 0.1588 | 0.1497 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1588 | 0.1497 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0095 | 0.1588 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.3261 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0095 | 0.1588 | 0.1497 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1588 | 0.1497 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0107 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0095 | 0.1588 | 0.1497 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0107 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0095 | 0.1588 | 0.1497 |
Echinococcus multilocularis | serotonin transporter | 0.0095 | 0.1588 | 0.1497 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0107 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0095 | 0.1588 | 0.1497 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3261 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0095 | 0.1588 | 0.1497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 uM | In vitro inhibitory concentration against rat liver dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | = 0.5 uM | In vitro inhibitory concentration against rat liver dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | = 0.57 uM | In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9191966 |
IC50 (binding) | = 0.57 uM | In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9191966 |
Selectivity index (binding) | = 0.9 | Selectivity index measured as the ratio of IC50 for rat liver DHFR to IC50 for P. carinii DHFR. | ChEMBL. | 9191966 |
Selectivity index (binding) | = 28 | Selectivity index measured as the ratio of IC50 for rat liver DHFR to IC50 for T. gondii DHFR. | ChEMBL. | 9191966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.