TDR Targets

Basic information

Technical information

TDR Targets ID: 805064
Name: 8-(2-chlorophenoxy)-7-[(2-chlorophenyl)methyl ]-1,3-dimethylpurine-2,6-dione
MW: 431.272 | Formula: C20H16Cl2N4O3
H donors: 0 H acceptors: 3 LogP: 4.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1Cn1c(Oc2ccccc2Cl)nc2c1c(=O)n(c(=O)n2C)C
InChi: 1S/C20H16Cl2N4O3/c1-24-17-16(18(27)25(2)20(24)28)26(11-12-7-3-4-8-13(12)21)19(23-17)29-15-10-6-5-9-14(15)22/h3-10H,11H2,1-2H3
InChiKey: FABOFBZLTGNEDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-(2-chlorophenoxy)-7-[(2-chlorophenyl)methyl]-1,3-dimethyl-purine-2,6-dione
7-(2-chlorobenzyl)-8-(2-chlorophenoxy)-1,3-dimethyl-xanthine
Oprea1_014407
Oprea1_375474

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Toxoplasma gondii	subtilisin SUB5	0.028	0.0415	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0023	0.001	0.0015
Schistosoma mansoni	hypothetical protein	0.1269	0.1969	0.1969
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0049	0.008
Giardia lamblia	Hypothetical protein	0.0448	0.0679	0.1739
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0563	0.0859	0.0859
Entamoeba histolytica	SWIRM domain protein	0.0048	0.0049	0.0716
Toxoplasma gondii	subtilisin SUB9	0.028	0.0415	1
Schistosoma mansoni	site-1 peptidase (S08 family)	0.028	0.0415	0.0415
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.028	0.0415	1
Schistosoma mansoni	protein kinase	0.0136	0.0188	0.0188
Onchocerca volvulus		0.007	0.0084	0.0809
Onchocerca volvulus		0.0023	0.001	0.0013
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0017	0.0001	0.0001
Loa Loa (eye worm)	transcriptional regulator	0.0448	0.0679	0.0678
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0066	0.0078	0.0098
Onchocerca volvulus		0.0106	0.0142	0.1436
Entamoeba histolytica	hypothetical protein	0.0048	0.0049	0.0716
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.028	0.0415	1
Loa Loa (eye worm)	transcriptional regulator	0.0066	0.0078	0.0078
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Brugia malayi	Will die slowly protein	0.007	0.0084	0.0083
Toxoplasma gondii	aspartyl protease ASP5	0.0233	0.0341	0.8202
Loa Loa (eye worm)	hypothetical protein	0.2479	0.3872	0.3871
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0284	0.0421	0.5713
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0448	0.0679	0.1111
Toxoplasma gondii	subtilisin SUB4	0.028	0.0415	1
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.028	0.0415	1
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.155	0.241	0.241
Plasmodium falciparum	plasmepsin VII	0.0023	0.001	0.0228
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0078	0.1872
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0448	0.0679	0.0848
Plasmodium falciparum	plasmepsin IX	0.0023	0.001	0.0228
Plasmodium vivax	aspartyl proteinase, putative	0.0023	0.001	0.0228
Echinococcus multilocularis	Furin 1	0.155	0.241	0.3011
Loa Loa (eye worm)	WD40 repeat protein	0.007	0.0084	0.0083
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.155	0.241	0.3949
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0448	0.0679	0.0848
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.155	0.241	0.3949
Toxoplasma gondii	subtilisin SUB7	0.028	0.0415	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0114	0.0154	0.3703
Schistosoma mansoni	hypothetical protein	0.007	0.0084	0.0083
Echinococcus granulosus	chromatin regulatory protein sir2	0.0448	0.0679	0.0679
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.028	0.0415	0.0679
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.155	0.241	0.3949
Brugia malayi	aspartic protease BmAsp-2, identical	0.0023	0.001	0.0009
Trichomonas vaginalis	hypothetical protein	0.1269	0.1969	0.3226
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0023	0.001	0.0009
Entamoeba histolytica	SWIRM domain protein	0.0048	0.0049	0.0716
Echinococcus multilocularis		0.0114	0.0154	0.0193
Plasmodium vivax	plasmepsin V, putative	0.0256	0.0377	0.9064
Brugia malayi	hypothetical protein	0.0023	0.001	0.0009
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0066	0.0078	0.0078
Brugia malayi	celfurPC protein	0.5109	0.8005	0.8005
Loa Loa (eye worm)	endoprotease bli-4	0.6378	1	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0066	0.0078	0.1145
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.028	0.0415	0.0415
Brugia malayi	proprotein convertase 2	0.4029	0.6308	0.6307
Plasmodium vivax	subtilisin-like serine protease, putative	0.028	0.0415	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0017	0.0001	0.0001
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Schistosoma mansoni	chromatin regulatory protein sir2	0.0448	0.0679	0.0678
Plasmodium falciparum	subtilisin-like protease 2	0.028	0.0415	1
Plasmodium falciparum	plasmepsin VI	0.0023	0.001	0.0228
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Toxoplasma gondii	subtilisin SUB8	0.028	0.0415	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0448	0.0679	0.0678
Trichomonas vaginalis	conserved hypothetical protein	0.028	0.0415	0.0679
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0448	0.0679	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0119	0.0162	0.0161
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0114	0.0154	0.2253
Mycobacterium ulcerans	monoamine oxidase	0.0114	0.0154	0.2253
Plasmodium falciparum	plasmepsin V	0.0256	0.0377	0.9064
Plasmodium vivax	aspartyl protease, putative	0.0023	0.001	0.0228
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0114	0.0154	0.2253
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Toxoplasma gondii	aspartyl protease	0.0023	0.001	0.0228
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0231	0.0338	0.0338
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.028	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0154	0.0154
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0114	0.0154	0.3703
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0049	0.008
Brugia malayi	SWIRM domain containing protein	0.0048	0.0049	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.028	0.0415	0.0679
Echinococcus multilocularis		0.5109	0.8005	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Schistosoma mansoni	protein kinase	0.0136	0.0188	0.0188
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0136	0.0188	0.0235
Trypanosoma brucei	SIR2-like protein 4, putative	0.0066	0.0078	0.1145
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.3898	0.6103	0.6103
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0023	0.001	0.0009
Toxoplasma gondii	subtilisin SUB6	0.028	0.0415	1
Trichomonas vaginalis	WD repeat domain, putative	0.007	0.0084	0.0136
Entamoeba histolytica	protein kinase, putative	0.0018	0.0003	0.0029
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0066	0.0078	0.0098
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0078	0.0078
Loa Loa (eye worm)	sirtuin 4	0.0066	0.0078	0.0078
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Mycobacterium ulcerans	oxidoreductase	0.0114	0.0154	0.2253
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0229	0.0228
Toxoplasma gondii	histone lysine-specific demethylase	0.0114	0.0154	0.3703
Leishmania major	UDP-galactopyranose mutase	0.0114	0.0154	0.2265
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0066	0.0078	0.008
Schistosoma mansoni	SWI/SNF complex-related	0.0048	0.0049	0.0049
Echinococcus granulosus	protein kinase c epsilon type	0.0084	0.0107	0.0107
Echinococcus multilocularis	MAM	0.0022	0.0009	0.0011
Schistosoma mansoni	protein kinase	0.0136	0.0188	0.0188
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0114	0.0154	0.2253
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.028	0.0415	0.0415
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0066	0.0078	0.1872
Brugia malayi	hypothetical protein	0.0023	0.001	0.0009
Plasmodium vivax	subtilisin-like protease 2, putative	0.028	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0008
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0049	0.0049
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.155	0.241	0.3949
Trypanosoma cruzi	subtilisin peptidase	0.028	0.0415	0.5613
Toxoplasma gondii	subtilisin SUB2	0.028	0.0415	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0066	0.0078	0.0078
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Toxoplasma gondii	aspartyl protease ASP3	0.0023	0.001	0.0228
Echinococcus multilocularis	epidermal growth factor receptor	0.0394	0.0595	0.0743
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Echinococcus granulosus	epidermal growth factor receptor	0.0394	0.0595	0.0595
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0284	0.0421	0.5713
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.028	0.0415	1
Plasmodium falciparum	plasmepsin X	0.0023	0.001	0.0228
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.3898	0.6103	1
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0563	0.0859	0.1073
Plasmodium falciparum	plasmepsin VIII, putative	0.0023	0.001	0.0228
Plasmodium vivax	hypothetical protein, conserved	0.0114	0.0154	0.3703
Echinococcus granulosus	membrane bound transcription factor site 1	0.028	0.0415	0.0415
Trypanosoma brucei	subtilisin peptidase	0.028	0.0415	0.6115
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0563	0.0859	0.0859
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0023	0.001	0.0228
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0008
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.028	0.0415	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0008
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0114	0.0154	0.0154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Schistosoma mansoni	memapsin-2 (A01 family)	0.0023	0.001	0.0009
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0066	0.0078	0.1145
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Onchocerca volvulus		0.028	0.0415	0.4392
Toxoplasma gondii	aspartyl protease ASP1	0.0023	0.001	0.0228
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0284	0.0421	0.6204
Brugia malayi	hypothetical protein	0.0114	0.0154	0.0154
Schistosoma mansoni	amine oxidase	0.0114	0.0154	0.0154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.0107	0.0106
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.028	0.0415	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.4029	0.6308	0.788
Giardia lamblia	High cysteine membrane protein Group 2	0.2349	0.3667	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Brugia malayi	Subtilase family protein	0.028	0.0415	0.0415
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.155	0.241	0.3949
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0017	0.0001	0.0001
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0114	0.0154	0.0193
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Schistosoma mansoni	amine oxidase	0.0114	0.0154	0.0154
Brugia malayi	hypothetical protein	0.0022	0.0009	0.0008
Plasmodium vivax	aspartyl protease, putative	0.0023	0.001	0.0228
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0114	0.0154	0.1265
Leishmania major	sir2-family protein-like protein	0.0066	0.0078	0.1145
Schistosoma mansoni	cathepsin D (A01 family)	0.0023	0.001	0.0009
Echinococcus granulosus	serine:threonine protein kinase N2	0.0069	0.0083	0.0083
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.1269	0.1969	0.3226
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0114	0.0154	0.3703
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0066	0.0078	0.1872
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0066	0.0078	0.1145
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0119	0.0162	0.0161
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0114	0.0154	0.0154
Schistosoma mansoni	site-1 peptidase (S08 family)	0.028	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.0009
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.028	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0078	0.0078
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0069	0.0083	0.1211
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0017	0.0001	0.0001
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0066	0.0078	0.1872
Echinococcus multilocularis	protein will die slowly	0.007	0.0084	0.0105
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0114	0.0154	0.5
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Mycobacterium ulcerans	dehydrogenase	0.0114	0.0154	0.2253
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0448	0.0679	1
Echinococcus granulosus	Furin 1	0.155	0.241	0.241
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Toxoplasma gondii	subtilisin SUB1	0.028	0.0415	1
Leishmania major	silent information regulator 2, putative	0.0448	0.0679	1
Schistosoma mansoni	tyrosine kinase	0.0394	0.0595	0.0594
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0066	0.0078	0.008
Echinococcus granulosus	MAM	0.0022	0.0009	0.0009
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0066	0.0078	0.0078
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0114	0.0154	0.1265
Plasmodium falciparum	plasmepsin III	0.0023	0.001	0.0228
Plasmodium vivax	aspartyl proteinase, putative	0.0023	0.001	0.0228
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Plasmodium falciparum	protoporphyrinogen oxidase	0.0114	0.0154	0.3703
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.028	0.0415	0.5613
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0066	0.0078	0.1145
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0023	0.001	0.0228
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Plasmodium falciparum	subtilisin-like protease 3	0.028	0.0415	1
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.1273	0.1976	0.1975
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.028	0.0415	0.0519
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0066	0.0078	0.0078
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.1269	0.1969	0.3226
Echinococcus granulosus	neuroendocrine convertase 2	0.4029	0.6308	0.6308
Loa Loa (eye worm)	aspartyl protease 6	0.0023	0.001	0.0009
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0048	0.0049	0.0062
Loa Loa (eye worm)	hypothetical protein	0.061	0.0934	0.0933
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0078	0.0078
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.6378	1	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0066	0.0078	0.0078
Brugia malayi	amine oxidase, flavin-containing family protein	0.0162	0.0229	0.0228
Onchocerca volvulus		0.061	0.0934	1
Leishmania major	subtilisin-like serine peptidase	0.028	0.0415	0.6115
Toxoplasma gondii	subtilisin SUB12	0.028	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0154	0.0154
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0114	0.0154	0.3703
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0394	0.0595	0.0594
Loa Loa (eye worm)	transcriptional regulator	0.0066	0.0078	0.0078
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Toxoplasma gondii	subtilisin SUB10	0.028	0.0415	1
Plasmodium vivax	subtilisin-like protease 1	0.028	0.0415	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0023	0.001	0.0009
Brugia malayi	protein kinase C II.	0.0084	0.0107	0.0106
Toxoplasma gondii	histone deacetylase SIR2-like	0.0066	0.0078	0.1872
Echinococcus multilocularis	membrane bound transcription factor site 1	0.028	0.0415	0.0519
Plasmodium falciparum	plasmepsin I	0.0023	0.001	0.0228
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.155	0.241	0.3949
Toxoplasma gondii	SWIRM domain-containing protein	0.0048	0.0049	0.1171
Plasmodium falciparum	subtilisin-like protease 1	0.028	0.0415	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0017	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0008
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.3898	0.6103	1
Trichomonas vaginalis	conserved hypothetical protein	0.1269	0.1969	0.3226
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0448	0.0679	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.028	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.028	0.0415	0.0415
Mycobacterium leprae	Possible secreted protease	0.028	0.0415	1
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.028	0.0415	1
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.028	0.0415	0.0415
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0017	0.0001	0.0001
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0448	0.0679	0.0678
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0077	0.0096	0.012
Plasmodium vivax	plasmepsin IV, putative	0.0023	0.001	0.0228
Loa Loa (eye worm)	subtilase	0.028	0.0415	0.0415
Entamoeba histolytica	hypothetical protein, conserved	0.0066	0.0078	0.1145
Loa Loa (eye worm)	TK/ALK protein kinase	0.0022	0.0009	0.0008
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0084	0.0107	0.0106
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0078	0.0078
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0448	0.0679	0.1111
Plasmodium falciparum	plasmepsin IV	0.0023	0.001	0.0228
Onchocerca volvulus		0.0023	0.001	0.0013
Echinococcus granulosus	furin	0.6378	1	1
Echinococcus granulosus	protein will die slowly	0.007	0.0084	0.0084
Giardia lamblia	Furin precursor putative serine protease	0.1269	0.1969	0.5308
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.0009
Brugia malayi	Pepsin A precursor	0.0023	0.001	0.0009
Giardia lamblia	Sirtuin type 2	0.0066	0.0078	0.008
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.1269	0.1969	0.3226
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0023	0.001	0.0013
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0563	0.0859	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.0009
Toxoplasma gondii	histone deacetylase SIR2	0.0066	0.0078	0.1872
Brugia malayi	SWIRM domain containing protein	0.061	0.0934	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.028	0.0415	0.0679
Toxoplasma gondii	subtilisin SUB11	0.028	0.0415	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0023	0.001	0.0009
Schistosoma mansoni	furin-1 (S08 family)	0.276	0.4313	0.4312
Schistosoma mansoni	chromatin regulatory protein sir2	0.0448	0.0679	0.0678
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0448	0.0679	1
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0114	0.0154	0.3703
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0048	0.0049	0.0049
Loa Loa (eye worm)	proprotein convertase 2	0.155	0.241	0.241
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0448	0.0679	0.0679
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.001	0.0009
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0008
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0136	0.0188	0.0188
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.028	0.0415	0.0679
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.028	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.6378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0563	0.0859	0.0859
Mycobacterium tuberculosis	Possible oxidoreductase	0.0114	0.0154	0.2253
Echinococcus multilocularis	protein kinase c epsilon type	0.0084	0.0107	0.0134
Brugia malayi	Furin-like cysteine rich region family protein	0.0394	0.0595	0.0594
Plasmodium falciparum	plasmepsin II	0.0023	0.001	0.0228
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0448	0.0679	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0023	0.001	0.001
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0078	0.0127
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0066	0.0078	0.0098
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.3898	0.6103	0.7623
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0066	0.0078	0.0078
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0114	0.0154	0.2253
Plasmodium vivax	hypothetical protein, conserved	0.0114	0.0154	0.3703
Plasmodium vivax	aspartyl protease, putative	0.0023	0.001	0.0228
Schistosoma mansoni	cathepsin D (A01 family)	0.0023	0.001	0.0009
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0078	0.0078
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.028	0.0415	1
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0009	0.0008
Brugia malayi	neuroendocrine convertase 1 precursor	0.4029	0.6308	0.6307

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 805064