Detailed information for compound 805108

Basic information

Technical information
  • TDR Targets ID: 805108
  • Name: 2-[(2-chlorophenyl)methyl]-3-[(4-methoxypheny l)amino]-3H-isoindol-1-one
  • MW: 378.851 | Formula: C22H19ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC1N(Cc2ccccc2Cl)C(=O)c2c1cccc2
  • InChi: 1S/C22H19ClN2O2/c1-27-17-12-10-16(11-13-17)24-21-18-7-3-4-8-19(18)22(26)25(21)14-15-6-2-5-9-20(15)23/h2-13,21,24H,14H2,1H3
  • InChiKey: JMQXVSJZXIYQPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-chlorophenyl)methyl]-3-[(4-methoxyphenyl)amino]isoindolin-1-one
  • 2-[(2-chlorophenyl)methyl]-3-[(4-methoxyphenyl)amino]-1-isoindolinone
  • 2-(2-chlorobenzyl)-3-[(4-methoxyphenyl)amino]isoindolin-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0222 0.0339 0.0436
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.021 0.0318 0.0409
Toxoplasma gondii subtilisin SUB12 0.021 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0009
Echinococcus granulosus fibrillin 2 0.0112 0.0157 0.0201
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.005 0.0064
Brugia malayi hypothetical protein 0.0291 0.0452 0.0452
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.0017 0.053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0112 0.0157 0.0156
Trichomonas vaginalis hypothetical protein 0.0112 0.0157 0.0321
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0092 0.0124 0.0159
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0052 0.0052
Plasmodium falciparum subtilisin-like protease 3 0.021 0.0318 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0004 0.0125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1159 0.1886 0.3965
Toxoplasma gondii subtilisin SUB8 0.021 0.0318 1
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0062 0.0062
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0027 0.0017 0.054
Loa Loa (eye worm) integrin alpha pat-2 0.0718 0.1159 0.1158
Brugia malayi hypothetical protein 0.0023 0.001 0.0009
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0939 0.1524 0.1524
Toxoplasma gondii subtilisin SUB2 0.021 0.0318 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.005 0.0068
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0352 0.0554 0.0554
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.021 0.0318 1
Toxoplasma gondii subtilisin SUB4 0.021 0.0318 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1159 0.1886 0.3965
Onchocerca volvulus 0.0065 0.008 0.2507
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.005 0.0064
Echinococcus granulosus epidermal growth factor receptor 0.0283 0.044 0.0565
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0035 0.1106
Echinococcus multilocularis Furin 1 0.1159 0.1886 0.2561
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.003
Brugia malayi EGF-like domain containing protein 0.0112 0.0157 0.0156
Onchocerca volvulus 0.0059 0.007 0.2199
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2892 0.4751 1
Toxoplasma gondii subtilisin SUB1 0.021 0.0318 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0241 0.037 0.0475
Echinococcus multilocularis protoporphyrinogen oxidase 0.0027 0.0017 0.0023
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0014 0.045
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0949 0.154 0.3235
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0027 0.0017 0.054
Schistosoma mansoni amine oxidase 0.0027 0.0017 0.0022
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0013 0.0336
Schistosoma mansoni hypothetical protein 0.0055 0.0062 0.008
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0134 0.0194 0.0263
Toxoplasma gondii subtilisin SUB5 0.021 0.0318 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0004 0.0128
Mycobacterium ulcerans dehydrogenase 0.0027 0.0017 0.054
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0014 0.045
Giardia lamblia High cysteine protein 0.0112 0.0157 0.0538
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Schistosoma mansoni ATP-binding cassette transporter 0.0034 0.0028 0.0036
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.021 0.0318 0.0432
Giardia lamblia High cysteine membrane protein Group 2 0.1734 0.2836 1
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0291 0.0452 0.0581
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1159 0.1886 0.3965
Loa Loa (eye worm) hypothetical protein 0.0146 0.0213 0.0213
Plasmodium vivax subtilisin-like protease 1 0.021 0.0318 1
Echinococcus granulosus nmda type glutamate receptor 0.0112 0.0157 0.0201
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0013 0.0336
Schistosoma mansoni integrin alpha 0.0466 0.0742 0.0954
Loa Loa (eye worm) metalloprotease 0.0061 0.0073 0.0073
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0006 0.019
Echinococcus granulosus glutamate receptor subunit protein glur 0.0031 0.0024 0.003
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.2892 0.4751 0.6451
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0011
Trypanosoma cruzi UDP-galactopyranose mutase 0.0027 0.0017 0.0519
Mycobacterium leprae Possible secreted protease 0.021 0.0318 1
Brugia malayi Integrin alpha pat-2 precursor 0.0466 0.0742 0.0741
Brugia malayi amine oxidase, flavin-containing family protein 0.0039 0.0036 0.0036
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.021 0.0318 1
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0007 0.0133
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0014 0.045
Loa Loa (eye worm) hypothetical protein 0.0092 0.0124 0.0124
Loa Loa (eye worm) glutamate receptor 1 0.0031 0.0024 0.0024
Echinococcus granulosus furin 0.4722 0.7774 1
Brugia malayi Disintegrin family protein 0.0092 0.0124 0.0124
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.4722 0.7774 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0017 0.053
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0014 0.045
Echinococcus multilocularis 0.3773 0.6206 0.8428
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Schistosoma mansoni site-1 peptidase (S08 family) 0.021 0.0318 0.0409
Leishmania major subtilisin-like serine peptidase 0.021 0.0318 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.021 0.0318 0.0318
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0006 0.019
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0031 0.0024 0.0032
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1159 0.1886 0.2426
Echinococcus granulosus MAM 0.0023 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0112 0.0157 0.0156
Echinococcus granulosus membrane bound transcription factor site 1 0.021 0.0318 0.0409
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0017 0.0468
Toxoplasma gondii subtilisin SUB9 0.021 0.0318 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0027 0.0017 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0686 0.1105 0.15
Plasmodium falciparum subtilisin-like protease 1 0.021 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.0576 0.0576
Toxoplasma gondii subtilisin SUB7 0.021 0.0318 1
Trypanosoma brucei subtilisin peptidase 0.021 0.0318 0.9797
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0004 0.5
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0014 0.0013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0004 0.5
Echinococcus multilocularis 0.0027 0.0017 0.0023
Toxoplasma gondii exonuclease III APE 0.002 0.0004 0.0128
Brugia malayi proprotein convertase 2 0.2988 0.491 0.491
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0017 0.046
Plasmodium vivax subtilisin-like protease 2, putative 0.021 0.0318 1
Brugia malayi EGF-like domain containing protein 0.0112 0.0157 0.0156
Trypanosoma cruzi UDP-galactopyranose mutase 0.0027 0.0017 0.0519
Brugia malayi Will die slowly protein 0.0065 0.008 0.008
Giardia lamblia Tenascin-X 0.0112 0.0157 0.0538
Echinococcus granulosus lysine specific histone demethylase 1A 0.0134 0.0194 0.0249
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0027 0.0017 0.053
Echinococcus granulosus glutamate receptor 2 0.0047 0.005 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0318 0.0662
Schistosoma mansoni hypothetical protein 0.0055 0.0062 0.008
Loa Loa (eye worm) endoprotease bli-4 0.4722 0.7774 0.7774
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0241 0.037 0.0502
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0027 0.0017 0.053
Echinococcus granulosus Furin 1 0.1159 0.1886 0.2426
Onchocerca volvulus 0.0023 0.001 0.0291
Toxoplasma gondii subtilisin SUB11 0.021 0.0318 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.021 0.0318 0.0409
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.008 0.0105 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0004 0.0005
Echinococcus granulosus fibrillin 1 0.0113 0.0159 0.0204
Giardia lamblia Tenascin-like 0.0112 0.0157 0.0538
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.021 0.0318 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.005 0.0064
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0017 0.0522
Echinococcus granulosus protein will die slowly 0.0065 0.008 0.0103
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0002 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.037 0.0475
Echinococcus granulosus integrin alpha ps 0.0209 0.0317 0.0408
Brugia malayi metalloprotease 0.0061 0.0073 0.0073
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0014 0.0014
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0027 0.0017 0.053
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0318 0.0662
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.021 0.0318 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0062 0.0062
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0017 0.0532
Chlamydia trachomatis glutamine binding protein 0.008 0.0105 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0023 0.001 0.0009
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.008 0.0105 1
Echinococcus multilocularis NMDA receptor 0.0031 0.0024 0.0032
Loa Loa (eye worm) hypothetical protein 0.013 0.0187 0.0186
Brugia malayi Glutamate receptor 2 precursor 0.0031 0.0024 0.0024
Toxoplasma gondii subtilisin SUB6 0.021 0.0318 1
Brugia malayi Reprolysin 0.013 0.0187 0.0187
Brugia malayi SWIRM domain containing protein 0.0146 0.0213 0.0213
Echinococcus multilocularis neuropeptides capa receptor 0.0229 0.035 0.0475
Plasmodium falciparum subtilisin-like protease 2 0.021 0.0318 1
Loa Loa (eye worm) angiogenesis inhibito 0.0061 0.0073 0.0073
Brugia malayi Kelch motif family protein 0.0939 0.1524 0.1524
Echinococcus multilocularis glutamate receptor 2 0.0031 0.0024 0.0032
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0017 0.0532
Schistosoma mansoni hypothetical protein 0.0055 0.0062 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Schistosoma mansoni amine oxidase 0.0027 0.0017 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0004 0.0063
Schistosoma mansoni hypothetical protein 0.0023 0.001 0.0012
Toxoplasma gondii hypothetical protein 0.0112 0.0157 0.4916
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Brugia malayi Glutamate receptor 1 precursor 0.0031 0.0024 0.0024
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.008 0.0105 0.3242
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0031 0.0024 0.003
Echinococcus granulosus neuropeptides capa receptor 0.0229 0.035 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0229 0.035 0.045
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0024 0.003
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1258 0.2051 0.2638
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0241 0.037 0.037
Echinococcus granulosus adam 17 protease 0.0092 0.0124 0.0159
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Mycobacterium ulcerans monoamine oxidase 0.0027 0.0017 0.054
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0318 0.0662
Schistosoma mansoni glutamate receptor NMDA 0.0265 0.0409 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0265 0.0409 0.0555
Loa Loa (eye worm) hypothetical protein 0.0257 0.0397 0.0396
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0014 0.045
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0004 0.0004
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.005 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Loa Loa (eye worm) hypothetical protein 0.0935 0.1517 0.1517
Brugia malayi neuroendocrine convertase 1 precursor 0.2988 0.491 0.491
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0017
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.005 0.0068
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0006 0.019
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0009
Brugia malayi Protein kinase domain containing protein 0.0023 0.001 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Schistosoma mansoni furin-1 (S08 family) 0.2039 0.3342 0.4299
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0027 0.0017 0.0022
Brugia malayi angiogenesis inhibito 0.013 0.0187 0.0186
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Brugia malayi ADAMTS-like protease 0.013 0.0187 0.0186
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0027 0.0017 0.054
Loa Loa (eye worm) hypothetical protein 0.013 0.0187 0.0186
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0024 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0031 0.0024 0.0032
Onchocerca volvulus 0.0112 0.0157 0.4916
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.008 0.0105 0.3294
Schistosoma mansoni ap endonuclease 0.002 0.0004 0.0005
Brugia malayi Stress-activated protein kinase jnk-1 0.0241 0.037 0.037
Echinococcus multilocularis integrin alpha ps 0.0209 0.0317 0.043
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0004 0.0128
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Loa Loa (eye worm) hypothetical protein 0.0134 0.0194 0.0194
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0112 0.0157 0.0321
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0222 0.0339 0.0436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2892 0.4751 1
Brugia malayi celfurPC protein 0.3773 0.6206 0.6206
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0214 0.0325 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.021 0.0318 0.0318
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0214 0.0325 1
Mycobacterium ulcerans oxidoreductase 0.0027 0.0017 0.054
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0068 0.0085 0.0085
Echinococcus multilocularis fibrillin 2 0.0112 0.0157 0.0212
Loa Loa (eye worm) hypothetical protein 0.0061 0.0073 0.0073
Brugia malayi EGF-like domain containing protein 0.0112 0.0157 0.0156
Echinococcus multilocularis fibrillin 1 0.0127 0.0181 0.0246
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0061 0.0073 0.0094
Loa Loa (eye worm) hypothetical protein 0.183 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0011
Schistosoma mansoni integrin alpha-ps 0.0209 0.0317 0.0408
Echinococcus multilocularis integrin alpha 3 0.0357 0.0562 0.0763
Schistosoma mansoni hypothetical protein 0.0949 0.154 0.1981
Echinococcus multilocularis epidermal growth factor receptor 0.0283 0.044 0.0597
Plasmodium vivax subtilisin-like serine protease, putative 0.021 0.0318 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0283 0.044 0.0439
Schistosoma mansoni hypothetical protein 0.0065 0.008 0.0103
Loa Loa (eye worm) hypothetical protein 0.0134 0.0194 0.0194
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.021 0.0318 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.008 0.0105 1
Echinococcus multilocularis protein will die slowly 0.0065 0.008 0.0108
Brugia malayi Subtilase family protein 0.021 0.0318 0.0318
Onchocerca volvulus 0.0146 0.0213 0.6685
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0012 0.0289
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0027 0.0017 0.054
Onchocerca volvulus 0.021 0.0318 1
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0024 0.003
Loa Loa (eye worm) proprotein convertase 2 0.1159 0.1886 0.1886
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0222 0.0339 0.0436
Echinococcus granulosus integrin alpha ps 0.01 0.0137 0.0176
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0027 0.0017 0.053
Echinococcus multilocularis integrin beta 2 0.4473 0.7364 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0949 0.154 0.3235
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.005 0.0068
Echinococcus multilocularis glutamate receptor 2 0.0047 0.005 0.0068
Plasmodium falciparum protoporphyrinogen oxidase 0.0027 0.0017 0.053
Echinococcus multilocularis nmda type glutamate receptor 0.0112 0.0157 0.0212
Loa Loa (eye worm) WD40 repeat protein 0.0065 0.008 0.008
Onchocerca volvulus Fatty acid synthase homolog 0.0046 0.0048 0.1506
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0024 0.003
Giardia lamblia Tenascin precursor 0.0112 0.0157 0.0538
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0014 0.0377
Giardia lamblia hypothetical protein 0.0112 0.0157 0.0538
Echinococcus granulosus disintegrin and metalloproteinase 0.0092 0.0124 0.0159
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0062 0.0084
Mycobacterium ulcerans thioesterase 0.0021 0.0007 0.0228
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.021 0.0318 1
Trypanosoma cruzi subtilisin peptidase 0.021 0.0318 0.98
Trichomonas vaginalis WD repeat domain, putative 0.0065 0.008 0.0159
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0007 0.0154
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0017 0.0532
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0112 0.0157 0.0212
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0062 0.008
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0035 0.1038
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.021 0.0318 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1159 0.1886 0.3965
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Loa Loa (eye worm) hypothetical protein 0.0055 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0318 0.0662
Onchocerca volvulus 0.0024 0.0012 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Loa Loa (eye worm) hypothetical protein 0.0112 0.0157 0.0156
Loa Loa (eye worm) integrin beta-2 0.6069 1 1
Toxoplasma gondii subtilisin SUB10 0.021 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0152 0.0151
Schistosoma mansoni ap endonuclease 0.002 0.0004 0.0005
Giardia lamblia Furin precursor putative serine protease 0.0949 0.154 0.5422
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0318 0.0662
Brugia malayi ADAM-TS Spacer 1 family protein 0.013 0.0187 0.0186
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0004 0.0128
Giardia lamblia Tenascin-37 0.0112 0.0157 0.0538
Echinococcus granulosus glutamate NMDA receptor subunit 0.0265 0.0409 0.0526
Toxoplasma gondii histone lysine-specific demethylase 0.0027 0.0017 0.053
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0004 0.0006
Echinococcus granulosus integrin alpha 3 0.0357 0.0562 0.0723
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.021 0.0318 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0009
Brugia malayi EGF-like domain containing protein 0.0112 0.0157 0.0156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0004 0.0125
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0004 0.0138
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0017 0.0532
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0949 0.154 0.3235
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0017
Schistosoma mansoni integrin beta subunit 0.3538 0.5818 0.7484
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1159 0.1886 0.3965
Loa Loa (eye worm) hypothetical protein 0.0352 0.0554 0.0554
Schistosoma mansoni integrin alpha-ps 0.0109 0.0152 0.0195
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Loa Loa (eye worm) hypothetical protein 0.0222 0.0339 0.0339
Loa Loa (eye worm) subtilase 0.021 0.0318 0.0318
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0222 0.0339 0.046
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.021 0.0318 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0007 0.0228
Echinococcus multilocularis adam 0.0402 0.0637 0.0864
Onchocerca volvulus 0.0045 0.0046 0.1424
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0035 0.1106
Brugia malayi endoprotease bli-4 precursor 0.4722 0.7774 0.7774
Giardia lamblia Neurogenic locus Notch protein precursor 0.0112 0.0157 0.0538
Leishmania major UDP-galactopyranose mutase 0.0027 0.0017 0.053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1159 0.1886 0.3965
Loa Loa (eye worm) hypothetical protein 0.0039 0.0036 0.0036
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0014 0.0377
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0017 0.046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0004 0.0004
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0092 0.0124 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0035 0.1038
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0007 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.005 0.0068
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0031 0.0024 0.003
Loa Loa (eye worm) reprolysin 0.0222 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.01 0.0137 0.0176
Mycobacterium ulcerans polyketide synthase 0.0027 0.0017 0.0532
Loa Loa (eye worm) hypothetical protein 0.0112 0.0157 0.0156
Echinococcus multilocularis integrin alpha ps 0.01 0.0137 0.0186
Mycobacterium ulcerans polyketide synthase 0.0026 0.0014 0.045
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.021 0.0318 0.0409
Onchocerca volvulus 0.0023 0.001 0.0291
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0017 0.0468
Echinococcus granulosus adam 0.0402 0.0637 0.0819
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0031 0.0024 0.0032
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.021 0.0318 0.98
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0017 0.0532
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Trichomonas vaginalis hypothetical protein 0.0949 0.154 0.3235
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0062 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.021 0.0318 0.0662
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.021 0.0318 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0017 0.046
Echinococcus multilocularis neuroendocrine convertase 2 0.2988 0.491 0.6667
Brugia malayi hypothetical protein 0.0935 0.1517 0.1517
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0686 0.1105 0.1421
Giardia lamblia Neurogenic locus notch-like protein 0.0112 0.0157 0.0538
Echinococcus multilocularis MAM 0.0023 0.001 0.0013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.005 0.0064
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.2892 0.4751 0.6111
Loa Loa (eye worm) hypothetical protein 0.021 0.0318 0.0318
Echinococcus multilocularis membrane bound transcription factor site 1 0.021 0.0318 0.0432
Schistosoma mansoni dihydroceramide desaturase 0.0092 0.0124 0.0159
Echinococcus granulosus neuroendocrine convertase 2 0.2988 0.491 0.6315
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0014 0.0377
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0134 0.0194 0.0249
Loa Loa (eye worm) hypothetical protein 0.01 0.0137 0.0137
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0024 0.003
Echinococcus multilocularis integrin alpha ps 0.0209 0.0317 0.043
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0031 0.0024 0.003
Echinococcus multilocularis disintegrin and metalloproteinase 0.0092 0.0124 0.0168
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0214 0.0325 1
Brugia malayi hypothetical protein 0.0027 0.0017 0.0017
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0014 0.045
Echinococcus granulosus integrin beta 2 0.4473 0.7364 0.9472
Loa Loa (eye worm) hypothetical protein 0.4722 0.7774 0.7774
Trichomonas vaginalis conserved hypothetical protein 0.0949 0.154 0.3235
Schistosoma mansoni hypothetical protein 0.0023 0.001 0.0012
Giardia lamblia High cysteine protein 0.0112 0.0157 0.0538
Echinococcus multilocularis protein jagged 2 0.0112 0.0157 0.0212
Brugia malayi Furin-like cysteine rich region family protein 0.0283 0.044 0.0439
Loa Loa (eye worm) hypothetical protein 0.0043 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0283 0.044 0.0565
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0062 0.008
Loa Loa (eye worm) glutamate receptor 2 0.0031 0.0024 0.0024

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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