Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0062 | 0.0464 | 0.072 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.0503 | 0.0779 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.067 | 0.1038 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.1143 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0712 | 0.1103 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.0015 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0039 | 0.0266 | 0.0412 |
Loa Loa (eye worm) | beta-lactamase | 0.0062 | 0.0464 | 0.1036 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0024 | 0.013 | 0.0289 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.1143 | 1 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.1143 | 1 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.1143 | 1 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.1143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Brugia malayi | beta-lactamase family protein | 0.0062 | 0.0464 | 0.1036 |
Onchocerca volvulus | 0.0077 | 0.0597 | 0.3249 | |
Brugia malayi | intermediate filament protein | 0.0045 | 0.0314 | 0.0699 |
Echinococcus multilocularis | musashi | 0.0045 | 0.0314 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0101 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0396 | 0.3412 | 0.3091 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0464 | 0.2526 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0039 | 0.0266 | 0.0412 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0025 | 0.0141 | 0.0219 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0712 | 0.1103 |
Brugia malayi | follicle stimulating hormone receptor | 0.0207 | 0.1745 | 0.389 |
Brugia malayi | hypothetical protein | 0.0378 | 0.3251 | 0.7249 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0045 | 0.0314 | 0.0699 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.019 | 0.0423 |
Loa Loa (eye worm) | TAR-binding protein | 0.0057 | 0.0423 | 0.0943 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0057 | 0.0423 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1078 | 0.2404 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0378 | 0.3251 | 0.5036 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0378 | 0.3251 | 0.5036 |
Onchocerca volvulus | 0.0045 | 0.0314 | 0.1705 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0039 | 0.0266 | 0.0593 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0712 | 0.1587 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0057 | 0.0423 | 0.0943 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.1143 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0039 | 0.0266 | 0.0412 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.1143 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0478 | 0.1065 |
Brugia malayi | Pax transcription factor protein 2 | 0.0218 | 0.1839 | 0.41 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0064 | 0.0478 | 0.074 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0173 | 0.1443 | 0.3218 |
Brugia malayi | MH2 domain containing protein | 0.0108 | 0.087 | 0.1941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0712 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0266 | 0.0593 |
Brugia malayi | hypothetical protein | 0.0518 | 0.4485 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0741 | 0.6455 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0741 | 0.6455 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0057 | 0.0423 | 0.0656 |
Brugia malayi | TAR-binding protein | 0.0057 | 0.0423 | 0.0943 |
Brugia malayi | hypothetical protein | 0.0137 | 0.1124 | 0.2506 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.145 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.019 | 0.0423 |
Mycobacterium ulcerans | hypothetical protein | 0.1143 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0057 | 0.0423 | 0.0943 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0116 | 0.0936 | 1 |
Brugia malayi | hypothetical protein | 0.0132 | 0.1078 | 0.2404 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0025 | 0.0141 | 0.0219 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0597 | 0.0926 |
Schistosoma mansoni | lamin | 0.0045 | 0.0314 | 0.0486 |
Echinococcus multilocularis | GPCR, family 2 | 0.0039 | 0.0266 | 0.0412 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1078 | 0.5863 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Brugia malayi | Pre-SET motif family protein | 0.0025 | 0.0141 | 0.0315 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0741 | 0.6455 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0712 | 0.1103 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0141 | 0.0219 |
Onchocerca volvulus | 0.0218 | 0.1839 | 1 | |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1078 | 0.5863 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0207 | 0.1745 | 0.389 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0022 | 0.0109 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0478 | 0.074 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.145 |
Echinococcus multilocularis | tar DNA binding protein | 0.0057 | 0.0423 | 0.0656 |
Schistosoma mansoni | hypothetical protein | 0.0439 | 0.3792 | 0.5875 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0085 | 0.067 | 0.1494 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0116 | 0.0936 | 0.145 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0101 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.067 | 0.1494 |
Plasmodium vivax | hypothetical protein, conserved | 0.0062 | 0.0464 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0062 | 0.0464 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0125 | 0.1018 | 0.227 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0116 | 0.0936 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Echinococcus granulosus | intermediate filament protein | 0.0045 | 0.0314 | 0.0486 |
Onchocerca volvulus | 0.0062 | 0.0464 | 0.2526 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0025 | 0.0141 | 0.0219 |
Onchocerca volvulus | 0.0197 | 0.1653 | 0.8991 | |
Echinococcus granulosus | lamin | 0.0045 | 0.0314 | 0.0486 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0062 | 0.0464 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0057 | 0.0423 | 0.0943 |
Schistosoma mansoni | intermediate filament proteins | 0.0045 | 0.0314 | 0.0486 |
Mycobacterium ulcerans | putative regulatory protein | 0.1143 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Onchocerca volvulus | 0.0025 | 0.0141 | 0.0769 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0025 | 0.0141 | 0.0219 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Onchocerca volvulus | 0.0137 | 0.1124 | 0.6112 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0141 | 0.0219 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0039 | 0.0266 | 0.0593 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0024 | 0.013 | 0.0289 |
Brugia malayi | beta-lactamase family protein | 0.0062 | 0.0464 | 0.1036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.0441 | 0.3769 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0062 | 0.0464 | 0.1036 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0039 | 0.0266 | 0.0412 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0064 | 0.0478 | 0.074 |
Echinococcus multilocularis | lamin dm0 | 0.0045 | 0.0314 | 0.0486 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0077 | 0.0597 | 0.1332 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.1143 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0045 | 0.0314 | 0.0486 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0125 | 0.1018 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1124 | 0.2506 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0039 | 0.0266 | 0.0593 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0712 | 0.1103 |
Echinococcus granulosus | dnaJ subfamily B | 0.0439 | 0.3792 | 0.5875 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0712 | 0.1103 |
Onchocerca volvulus | 0.0031 | 0.019 | 0.1031 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0109 | 0.0242 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0439 | 0.3792 | 0.5875 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0062 | 0.0464 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1078 | 0.2404 |
Toxoplasma gondii | ABC1 family protein | 0.0062 | 0.0464 | 0.4066 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1018 | 0.227 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0064 | 0.0478 | 0.074 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0024 | 0.0127 | 0.0197 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0218 | 0.1839 | 0.41 |
Onchocerca volvulus | 0.0045 | 0.0314 | 0.1705 | |
Schistosoma mansoni | survival motor neuron protein | 0.0077 | 0.0597 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0141 | 0.0315 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0022 | 0.0109 | 0.0168 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.0015 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0062 | 0.0464 | 0.072 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0009 | 0.0019 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.1143 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0125 | 0.1018 | 0.227 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0712 | 0.1103 |
Schistosoma mansoni | lamin | 0.0045 | 0.0314 | 0.0486 |
Onchocerca volvulus | 0.0062 | 0.0464 | 0.2526 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0712 | 0.1587 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.001 | 0.0022 |
Brugia malayi | beta-lactamase | 0.0062 | 0.0464 | 0.1036 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.019 | 0.0294 |
Loa Loa (eye worm) | intermediate filament protein | 0.0045 | 0.0314 | 0.0699 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3251 | 0.7249 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0141 | 0.0219 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0116 | 0.0936 | 0.145 |
Trichomonas vaginalis | set domain proteins, putative | 0.0197 | 0.1653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0306 | 0.0683 |
Brugia malayi | Pre-SET motif family protein | 0.0173 | 0.1443 | 0.3218 |
Echinococcus granulosus | GPCR family 2 | 0.0039 | 0.0266 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 0.4485 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0045 | 0.0314 | 0.0699 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Echinococcus granulosus | lamin dm0 | 0.0045 | 0.0314 | 0.0486 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0062 | 0.0464 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0108 | 0.087 | 0.1941 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0314 | 0.0699 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0108 | 0.087 | 0.1941 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Schistosoma mansoni | amine GPCR | 0.0149 | 0.1228 | 0.1902 |
Mycobacterium ulcerans | hydrolase/amidase | 0.0271 | 0.231 | 0.1935 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0062 | 0.0464 | 0.072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.